Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar; Kirpekar, Finn; Klungland, Arne; Alsøe, Lene; Nilsen, Hilde; Bjelland, Svein (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-22)
Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative
incorporation of deoxyuridine monophosphate opposite adenine. The former generates
C ! thymine transition mutations if uracil is not removed by uracil-DNA glycosylase (UDG)
and replaced by C by the base excision repair (BER) pathway. The primary human UDG is
hUNG. During immunoglobulin gene diversification in ...