• NMR Backbone Assignment of VIM-2 and Identification of the Active Enantiomer of a Potential Inhibitor 

      Wieske, Lianne H. E.; Bogaerts, Jonathan; Leding, Albin A. M.; Wilcox, Scott; Rasmussen, Anna Andersson; Leszczak, Kinga; Turunen, Lotta; Herrebout, Wouter A.; Hubert, Madlen; Bayer, Annette; Erdelyi, Mate (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-28)
      Carbapenem resistance caused by metallo-β-lactamases is a serious global challenge that, if not tackled efficiently, is expected to lead to millions of deaths in the coming decades. Verona-integron encoded metallo-β-lactamase 2 (VIM-2) is a bacterial enzyme that has been reported from multidrug-resistant nosocomial isolates of Pseudomonas aeruginosa and other Gram-negative pathogens. As it hydrolyzes ...