Bioactive secondary metabolites from bacteria. Natural products from marine and terrestrial bacteria, dereplication, isolation and investigation of bacterial secondary metabolites

Abstract

The thesis gives an introduction to natural product drug discovery and the underlying chemical principles that make natural products privileged structures for drug discovery. Paper I deals with the isolation of Lipid 430 from cultures of two <i>Algibacter</i> sp. isolates and the investigation of their anti-proliferative and anti-bacterial effect. Paper II describes the isolation of Serratiochelin A and C and investigation of the specific anti-bacterial and anti-proliferative effect of the siderophore Serratiochelin A. Paper III deals with the isolation of new Suomilides from a <i>Nostoc</i> sp. isolate and the investigation of their bioactivity. In addition, it proposes a biosynthetic pathway for Banyaside/Suomilide like molecules and their characteristic azabicyclononane moiety.