Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines
Permanent link
https://hdl.handle.net/10037/23695Date
2020-03-17Type
Journal articleTidsskriftartikkel
Peer reviewed
Author
Isaksson, Johan; Rylandsholm, Fredrik G.; Bouř, Petr; Svendsen, John Sigurd Mjøen; Brichtová, Eva; Choi, Sng Un; Lee, Sang‑Ho; Jung, Young-Sik; No, Zae Sung; Aasen, Arne Jørgen; Dekebo, Aman; Dinku, WorkuAbstract
Myrrh, a resin derived from the damaged bark of Commiphora genus, has traditionally been used for treatment of
various human diseases, such as amenorrhea, ache, tumors, fever, and stomach pains. In spite of this widespread use
of the myrrh in Ethiopia, the pharmacological activity and chemical composition have not been studied in detail. A
new tricyclic triterpene acid (3S,4S,14S,7E,17E,21Z)-3,30-dihydroxypodioda-7,17,21-trien-4-carboxylic acid (commafric
A) has been isolated from a crude methanolic extract of Commiphora africana (A. Rich.) Engl. resin along with the
known pentacyclic triterpene α-amyrin. The structure of commafric A was characterized using diferent spectroscopic
techniques such as 1D and 2D NMR, IR, and VCD combined with computations. The anti-proliferative activity of both
isolated compounds was evaluated using SRB based colorimetric cellular assay against four human cancer cell lines.
Etoposide was used as a positive control. Commafric A showed signifcant anti-proliferative efects against non-small
cell lung cancer (A549) with IC50 values of 4.52 μg/ml. The pentacyclic triterpene α-amyrin showed a weak antiproliferative activity against A2780 (ovarian cancer), MIA-PaCa-2 (pancreatic cancer), and SNU638 (stomach cancer)
cell lines tested with IC50 values ranging 9.28 to 28.22 μg/ml. Commafric A possessed anti-proliferative activity against
non-small cell lung cancer (A549), which suggests that commafric A has potential to be further optimized being a
lead compound in the search for new drugs against cancer diseases.
Is part of
Rylandsholm, F.G. (2024). Structural characterisation and drug-lipid interaction by NMR spectroscopy. (Doctoral thesis). https://hdl.handle.net/10037/33752Publisher
SpringerCitation
Dinku, Isaksson, Rylandsholm, Bouř, Svendsen. Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines. Applied Biological Chemistry. 2020;63(1):16-27Metadata
Show full item recordCollections
Copyright 2020 The Author(s)