• Two approaches to novel anticancer agents. Small-molecule library synthesis and evaluation 

      Boomgaren, Marc (Doctoral thesis; Doktorgradsavhandling, 2020-03-06)
      <p>The work presented in this dissertation combines two fully independent approaches to achieve compound libraries for anticancer drug research. <p>Project 1: Development of compounds inhibiting human dUTPase as an amplifier of a thymidylate synthase inhibitor based cancer therapy <p>The human dUTPase has received increased attention as a drug target in the recent years. Its inhibition can ...