The endonucleases A from Aliivibrio salmonicida (VsEndA, cold-adapted) and Vibrio cholerae (VcEndA, warm-adapted) have been studied in this work. The goal was to compare these two systems, in order to find structural differences that could explain the mechanism of cold adaptation in the psychrophilic EndA. These two enzymes have previously been studied experimentally and the crystal structures have ...