• Mechanisms of enzyme adaptation to extreme environments: The rational design of a thermophilic chorismate mutase 

      Wilkins, Ryan Scott (Doctoral thesis; Doktorgradsavhandling, 2024-02-26)
      <p>Extremophiles, especially those living in high-temperature environments, exhibit unique enzymatic mechanisms that allow survival under conditions detrimental to most life forms. Of particular interest is thermophiles, which are able to thrive at temperatures at which psychrophiles and mesophiles unfold and cease to function. The mechanisms by which these enzymes are able to overcome this temperature ...