Doktorgradsavhandlinger (NT-fak): Nye registreringer
Viser treff 101-120 av 305
-
Performance Measurement System in complex environment: observed and unobserved risk factors
(Doctoral thesis; Doktorgradsavhandling, 2020-12-04)<p>World demand for energy leads industry to harvest energy in complex environment with harsh conditions and sensitive areas, such as the Arctic region – one of the last remaining wild places in the world – with potentially harmful consequences. Moreover, over the past few decades, the increasing trend of melting sea ice in the Arctic has provided increased access and has created new opportunities ... -
Diggi: A Distributed Serverless Runtime for Developing Trusted Cloud Services
(Doctoral thesis; Doktorgradsavhandling, 2020-10-30)Cloud computing offers the convenience of outsourcing storage and processing power to a public shared environment. Physical infrastructure is managed by the cloud provider, allowing hosted services to be deployed without any upfront investment. Cloud infrastructure may additionally manage deployment, migration, scalability, and fault tolerance, transparently from the hosted service. Serverless ... -
Method development towards synthesis of carbapenemase inhibitors
(Doctoral thesis; Doktorgradsavhandling, 2020-10-26)Carbapenemases are enzymes able to hydrolyze the last resort b-lactam antibiotics (carbapenems), which are used for the treatment of infections caused by resistant bacteria. Carbapenemases are structurally and mechanistically classified into serine-b-lactamases (SBLs) and metallo-b-lactamases (MBLs). In order to combat the hydrolytic activity of these enzymes, combination therapy of b-lactam with ... -
On polar lows and their formation
(Doctoral thesis; Doktorgradsavhandling, 2020-09-18)Polar lows are small, but extreme cyclones that develop in marine polar air mass. They feature one of the largest natural hazards in the polar regions. Their associated strong winds, high waves, substantial amounts of snow fall, low visibility and possibility for ice accumulation on ships and airplanes cause threats for coastal communities and marine operations. Hence, accurate prediction of polar ... -
Operationalising Critical Infrastructure Resilience. From Assessment to Management
(Doctoral thesis; Doktorgradsavhandling, 2020-09-03)Over recent decades, it has been evident that society relies heavily on critical infrastructures (CIs) to provide and maintain vital societal functions, such as water, electricity and transportation. Traditionally, in order to ensure the delivery of such functions, the focus has been on protecting the infrastructures’ systems from adverse and extreme events. However, large-scale events, such as ... -
Homogeneous Metal-Mediated Carboxylation with Carbon Dioxide
(Doctoral thesis; Doktorgradsavhandling, 2020-09-04)CO<sub>2</sub> is a non-toxic, abundant and readily available gas, which has the potential to become an important carbon source in chemical synthesis. The clear advantage of CO<sub>2</sub> is its sustainability, in contrast to typical carbon sources such as oil, coal, or natural gas, which are in the process of depletion. However, the use of CO<sub>2</sub> also poses a big challenge as it features ... -
Towards Enantioselective Carboxylation and Hydrogenation Reactions (Quantum Chemical Modelling of Homogeneous Reactions)
(Doctoral thesis; Doktorgradsavhandling, 2020-08-21)With the aid of DFT methods, it is possible to get insights into the mechanistic details of homogeneous reactions, the substrate preferences and activities of catalysts. Computational methods can also help to identify the selectivity-determining factors that govern asymmetric reactions. In this thesis, DFT methods are applied in order to study the enantioselective addition of small molecules, such ... -
Unsupervised Change Detection in Heterogeneous Remote Sensing Imagery
(Doctoral thesis; Doktorgradsavhandling, 2020-06-16)<p><i>Change detection</i> is a thriving and challenging topic in remote sensing for Earth observation. The goal is to identify changes that happen on the Earth by comparing two or more satellite or aerial images acquired at different times. Traditional methods rely on homogeneous data, that is, images acquired by the same sensor, under the same geometry, seasonal conditions,and recording ... -
Efficient Bayesian analysis of long memory processes applied to climate
(Doctoral thesis; Doktorgradsavhandling, 2020-05-22)Temperature fluctuations can be described by a persistent correlation structure known as long-range dependence (LRD). This is a phenomenon which implies that the autocorrelation function follows a power-law decay and that observations may still be significantly correlated even if the temporal or spatial distance between them is large. Moreover, temperature is known to be influenced by radiative ... -
On sea-ice forecasting
(Doctoral thesis; Doktorgradsavhandling, 2020-05-15)Accurate sea-ice prediction is essential for safe operations in the Arctic and potentially also for weather forecast at high-latitudes. The increasing number of sea-ice related satellite observations in the Arctic can be used to improve the model predictions through data assimilation. For sea ice, sea-ice concentration (SIC) observations have been available for many years. Observational information ... -
Using FullFlow to manage the overwhelming flood of patients’ self-collected health data: A system that addresses acceptance barriers regarding the introduction of diabetes patients’ self-collected health data into electronic health records and medical consultations
(Doctoral thesis; Doktorgradsavhandling, 2020-03-31)Patients increasingly collect lifestyle and health-related data thanks to the explosion of sensors and healthcare applications. Multiple studies have shown that this data can be useful during consultations, resulting in more customised medical services. Moreover, this data permits clinicians to gain an overview of the patients’ conditions and enables patients to gain knowledge about the consequences ... -
Context Centric Approach of Semantic Image Annotation and Retrieval
(Doctoral thesis; Doktorgradsavhandling, 2020-03-27)This thesis proposes a novel approach to explore and extract context information attached with images, mainly gathered from social network sites. I first performed a user study, to understand the user behavior on social network sites. I inferred that the relationship among users have central importance.<p> <p>To assist users to annotate images in social network, I use existing metadata gathered ... -
Reconstruction of past and present methane emission in the Arctic cold seeps using biogeochemical proxies
(Doctoral thesis; Doktorgradsavhandling, 2020-03-26)Global warming is now highly concerned by society as extreme weather is more often than ever, and the Arctic is experiencing warming twice as fast as the global mean. A large amount of carbon is stored in the forms of methane and methane hydrate in the continental margins worldwide. Methane is the most predominant gaseous compound in natural gas hydrate, which is stable under low temperature and ... -
Structurally controlled hydrothermal mineralization: A case study from Vanna island, northern Norway
(Doctoral thesis; Doktorgradsavhandling, 2020-02-27)The formation of metal and mineral deposits is closely related to the tectonic setting in which they form. Structures create avenues of net permeability that allow ore-bearing fluids to transport and deposit mineralization. In a deeper crustal setting these structures can be ductile shear zones, while brittle faults and fractures are the dominant fluid pathways in the upper continental crust. This ... -
Two approaches to novel anticancer agents. Small-molecule library synthesis and evaluation
(Doctoral thesis; Doktorgradsavhandling, 2020-03-06)<p>The work presented in this dissertation combines two fully independent approaches to achieve compound libraries for anticancer drug research. <p>Project 1: Development of compounds inhibiting human dUTPase as an amplifier of a thymidylate synthase inhibitor based cancer therapy <p>The human dUTPase has received increased attention as a drug target in the recent years. Its inhibition can ... -
New Corrole Analogues: Isocorroles and Azulicorrole
(Doctoral thesis; Doktorgradsavhandling, 2020-02-25)Porphyrinoids are a family of molecules, which consist of large ring structures or macrocycles. One of the oldest, and most important, of the porphyrinoids is the biological molecule called porphyrin. Since the dawn of life, porphyrins have orchestrated photosynthesis and oxygen respiration, two of the most important energy-generating processes in nature. In addition to porphyrins, other porphyrinoids ... -
A functional and structural study of three bacterial nucleic acid-interacting proteins. The story of a Ferric Uptake Regulator, an Oligoribonuclease and an ATP-dependent DNA ligase
(Doctoral thesis; Doktorgradsavhandling, 2020-02-07)Nucleic acid-interacting proteins are essential players in cellular processes of all living organisms. In the present study, we explore three psychrophilic-derived proteins involved in gene regulation, RNA degradation and DNA ligation in bacterial cells, with one common feature; they perform their activity by interacting with nucleic acids. The Ferric uptake regulator (Fur) is a global transcription ... -
Novel strategies for super-resolution fluorescence microscopy
(Doctoral thesis; Doktorgradsavhandling, 2019-12-11)<p>Minimally invasive technologies to characterize the structure and functionality of biological samples on the cellular and molecular scale are fundamental to life sciences. Optical fluorescence imaging at visible wavelengths is able to acquire to do so. Due to the wavelike nature of light the maximum achievable resolution in conventional microscopy is limited by diffraction, about half the wavelength ... -
Analysis of Oil Spill and Sea Ice Measurements Using Full-Polarimetric and Hybrid-Polarity Synthetic Aperture Radar data
(Doctoral thesis; Doktorgradsavhandling, 2019-12-05)Synthetic Aperture Radar (SAR) data has been used for decades to detect oil slicks and monitoring sea ice. With increased oil and gas exploration in the Arctic follows higher risk for oil spills. Knowledge of the sea ice and oil spills is important for making clever and efficient decisions in a hectic and non-hectic operational situation. The potential and limitations of the hybrid-polarity (HP) SAR ... -
Spatial extent of solar proton impact in the Earth's atmosphere - Observations and modeling
(Doctoral thesis; Doktorgradsavhandling, 2019-12-18)Solar proton events cause large-scale ionization in the Earth's middle atmosphere leading to chemical changes, changes in the energy budget of the middle atmosphere, and radio wave absorption. The accurate implementation of the spatial impact of solar protons and other particle ionization sources in climate models is necessary to understand the role of energetic particle precipitation in natural ...