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dc.contributor.authorPandey, Sunil Kumar
dc.contributor.authorGuttormsen, Yngve
dc.contributor.authorHaug, Bengt Erik
dc.contributor.authorHedberg, Christian
dc.contributor.authorBayer, Annette
dc.date.accessioned2015-01-02T07:30:41Z
dc.date.available2015-12-16T06:50:04Z
dc.date.issued2014
dc.description.abstractThe first total synthesis of breitfussin A and B is described. The approach features two palladium-catalyzed cross-couplings installing the indole and pyrrole onto the oxazole core and selective lithiation/iodination of a common indole–oxazole fragment providing 2,4-diiodinated or 2-iodinated oxazoles as potential precursors for breitfussin A and B, respectively. An unexpected acid promoted deiodination was utilized in the synthesis of breitfussin B. Comparison of the synthetic material with previously reported spectral data of isolated breitfussin A and B verified the structure of the breitfussin framework.
dc.identifier.citationOrganic Letters, 2015, 17 (1), pp 122–125.en
dc.identifier.cristinIDFRIDAID 1184158
dc.identifier.doi10.1021/ol503348n
dc.identifier.issn1523-7060
dc.identifier.urihttps://hdl.handle.net/10037/6971
dc.identifier.urnURN:NBN:no-uit_munin_6571
dc.language.isoengen
dc.publisherAmerican Chemical Societyen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Organisk kjemi: 441en
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Organic chemistry: 441en
dc.titleA Concise Total Synthesis of Breitfussin A and Ben
dc.type.versionacceptedVersion
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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