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dc.contributor.authorHjerde, Erik
dc.contributor.authorKarlsen, Christian
dc.contributor.authorSørum, Henning
dc.contributor.authorParkhill, Julian
dc.contributor.authorWillassen, Nils Peder
dc.contributor.authorThomson, Nicholas R.
dc.date.accessioned2015-10-07T08:40:56Z
dc.date.available2015-10-07T08:40:56Z
dc.date.issued2015-06-10
dc.description.abstractBackground: Aliivibrio wodanis and Moritella viscosa have often been isolated concurrently from fish with winterulcer disease. Little is known about the interaction between the two bacterial species and how the presence of one bacterial species affects the behaviour of the other. Results: The impact on bacterial growth in co-culture was investigated in vitro, and the presence of A. wodanis has an inhibitorial effect on M. viscosa. Further, we have sequenced the complete genomes of these two marine Gram-negative species, and have performed transcriptome analysis of the bacterial gene expression levels from in vivo samples. Using bacterial implants in the fish abdomen, we demonstrate that the presence of A. wodanis is altering the gene expression levels of M. viscosa compared to when the bacteria are implanted separately. Conclusions: From expression profiling of the transcriptomes, it is evident that the presence of A. wodanis is altering the global gene expression of M. viscosa. Co-cultivation studies showed that A. wodanis is impeding the growth of M. viscosa, and that the inhibitorial effect is not contact-dependenten_US
dc.identifier.citationBMC Genomics (2015) 16:447en_US
dc.identifier.cristinIDFRIDAID 1277870
dc.identifier.doi10.1186/s12864-015-1669-z
dc.identifier.issn1471-2164
dc.identifier.urihttps://hdl.handle.net/10037/8198
dc.identifier.urnURN:NBN:no-uit_munin_7781
dc.language.isoengen_US
dc.rights.accessRightsopenAccess
dc.subjectAliivibrioen_US
dc.subjectMoritellaen_US
dc.subjectComplete genomeen_US
dc.subjectRNA sequencingen_US
dc.subjectCo-cultureen_US
dc.subjectCo-infectionen_US
dc.subjectBacteriocinen_US
dc.subjectWinter-ulceren_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474en_US
dc.titleCo-cultivation and transcriptome sequencing of two co-existing fish pathogens Moritella viscosa and Aliivibrio wodanisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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