Heestermans, Marco; Naudin, Clement; Mailer, Reiner K.; Konrath, Sandra; Klaetschke, Kristin; Jämsä, Anne; Frye, Maike; Deppermann, Carsten; Pula, Giordano; Kuta, Piotr; Friese, Manuel A.; Gelderblom, Mathias; Sickmann, Albert; Preston, Roger J. S.; Nofer, Jerzy-Roch; Rose-John, Stefan; Butler, Lynn; Salomon, Ophira; Stavrou, Evi X.; Renné, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-22)
Contact activation refers to the process of surface-induced activation of factor XII (FXII),
which initiates blood coagulation and is captured by the activated partial thromboplastin time
(aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact
activation. Screening of recombinant FXII mutants identified a continuous stretch of residues
Gln317–Ser339 that was essential ...