Nestvold, Janne M.; Wang, Mengyu; Camilio, Ketil Andre; Zinöcker, Severin; Tjelle, Torunn Elisabeth; Lindberg, Alf; Haug, Bengt Erik; Kvalheim, Gunnar; Sveinbjørnsson, Baldur; Rekdal, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-17)
LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we
demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic
immune response in a rat fibrosarcoma model. The treatment was T-cell dependent, and also resulted
in an abscopal effect as demonstrated by the regression of distal non-treated lesions. Significant
infiltration ...