Background - We have recently constructed a DNA methylation classifier that can discriminate between pancreatic ductal adenocarcinoma (PAAD) liver metastasis and intrahepatic cholangiocarcinoma (iCCA) with high accuracy (PAAD-iCCA-Classifier). PAAD is one of the leading causes of cancer of unknown primary and diagnosis is based on exclusion of other malignancies. Therefore, our focus was to investigate ...

Introduction: Reading is a fundamental cognitive activity that is influenced by both textual and external environmental factors, although the latter has been less thoroughly explored. This study aims to examine the impact of environmental visual conditions on reading performance using Virtual Reality (VR) technology.<p> <p>Methods: We conducted two experiments to assess the effects of visual ...

BK polyomavirus (BKPyV) is a ubiquitous human virus that establishes a persistent infection in renal tubular epithelial cells and mainly causes disease in kidney transplant recipients. The closely related simian polyomavirus SV40 is known to cause cytoplasmic vacuolization in simian kidney cells, possibly increasing progeny release and cell death. This study aimed to determine whether BKPyV causes ...

In coordination chemistry, 2,2′:6′,2″-terpyridine is a versatile and extensively studied tridentate ligand. Terpyridine forms stable complexes with a variety of metal ions through coordination sites provided by the three nitrogen atoms in its pyridine rings. This paper presents an electrochemical study on various bis(terpyridine)osmium(II) complexes, addressing the absence of a systematic investigation ...

Continuous glucose monitoring (CGM) represents a significant advancement in diabetes management, playing an important role in glycemic control for patients with type 1 diabetes (T1D). Despite their benefits, their performance is affected by numerous factors such as the carbohydrate intake, alcohol consumption, and physical activity (PA). Among these, PA could cause hypoglycemic episodes, which ...

The evolutionary origins of Bilateria remain enigmatic. One of the more enduring proposals highlights similarities between a cnidarian-like planula larva and simple acoel-like flatworms. This idea is based in part on the view of the Xenacoelomorpha as an outgroup to all other bilaterians which are themselves designated the Nephrozoa (protostomes and deuterostomes). Genome data can provide important ...

Aim: To explore the challenges and strategies among new and experienced nursing leaders in mental healthcare; furthermore, to identify factors that support or hinder their leadership roles. Background: Strong nursing leadership is crucial for the quality of patient care and is associated with higher job security and better patient outcomes. Understanding what factors contribute to effective leadership ...

I denne oppgaven er de tre organisasjonsperspektivene som presenteres av Scott og Davis (2016), det rasjonelle, det naturlige, og det åpne perspektivet, benyttet for å undersøke styringsutfordringer ved avstandsledelse. Gjennom en litteraturstudie av relevant forskning har oppgaven undersøkt ulike styringsutfordringer og tiltak for å møte disse utfordringene, i offentlige organisasjoner i ...

Tema for oppgaven er energiomstillingsprosessen på Svalbard i perioden fra fremleggelsen av Meld. St. 32 (2015 – 2016) frem til den nye «Svalbard-meldingen», Meld. St. 26 (2023 – 2024) ble lagt frem. Det argumenteres for at Meld. St. 32 (2015 – 2016) ble et startpunkt for visjonen om et nullutslippssamfunn på Svalbard, og videre belyses energiomstillingsprosessen fram til den nye meldingen ble fremmet ...

Satellite radar altimeters like CryoSat‐2 estimate sea ice thickness by measuring the returntime of transmitted radar pulses, reflected from the sea ice and ocean surface, to measure the radar freeboard. Converting freeboard to thickness requires an assumption regarding the fractional depth of the snowpack from which the radar waves backscatter (α). We derive sea ice thickness from CryoSat‐2 radar ...