Natural products (NPs) have been the major source for the development of new small molecule drugs in modern medicine. Despite NPs being so prominent, marine natural products (MNPs) and derivatives thereof are hardly found in clinically approved agents. Therefore, using bioactive MNPs as structural guidance for drug development is a largely untapped source. The focus of the presented thesis is on ...

This article explores how teacher education institutions can better prepare teachers to help to create inclusive and sustainable self-determined Arctic communities. Building on the theoretical concepts of just sustainabilities, transgressive learning, the capabilities approach, and relational thinking within inclusive pedagogy, we propose that education for sustainable development (ESD) and inclusive ...

Many severe inflammation conditions are complement-dependent with the complement component C5a-C5aR1 axis as an important driver. At the RNA level, the blood transcriptome undergoes programmed expression of coding and long non-coding RNAs to combat invading microorganisms. Understanding the expression of long non-coding RNAs containing Alu elements in inflammation is important for reconstructing ...

Background: Capacity-based mental health legislation was introduced in Norway on 1 September 2017. The aim was to increase the autonomy of patients with severe mental illness and to bring mental health care in line with human rights. The aim of this study is to explore patient experiences of how far the new legislation has enabled them to be involved in decisions on their treatment after they ...

We study how risk conditions derived from the COVID-19 pandemic may impact on both the desire to travel and intention to visit of tourists and, therefore, on different stages of the destination choice process. We analyse 5134 million flight searches and 379 million flight picks during 2020 for the 17 largest European tourism source markets. An unweighted index number is employed to measure the ...

Recent research suggests that island effects may vary as a function of dependency type, potentially challenging accounts that treat island effects as reflecting uniform constraints on all filler-gap dependency formation. Some authors argue that cross-dependency variation is more readily accounted for by discourse-functional constraints that take into account the discourse status of both the ...

<p><i>Aims</i> This study aimed to identify risk factors (patient, healthcare system, and socioeconomic) for mortality after hip fractures and estimate their relative importance. Further, we aimed to elucidate mortality and survival patterns following fractures and the duration of excess mortality. <p><i>Methods</i> Data on 37,394 hip fractures in the Norwegian Hip Fracture Register from January ...

There has been a considerable number of reports on Hg concentrations in Arctic mammals since the last Arctic Monitoring and Assessment Programme (AMAP) effort to review biological effects of the exposure to mercury (Hg) in Arctic biota in 2010 and 2018. Here, we provide an update on the state of the knowledge of health risk associated with Hg concentrations in Arctic marine and terrestrial mammal ...

Electric aviation has become an important area of research following the rapid growth of the aviation industry, which directly corresponds to significant growth in aviation-related emissions. Despite the promising emission reduction potential of electric airplanes, several technological and regulatory challenges restrict the realization of this new regime of sustainable air transport. Significant ...