Viser treff 11661-11680 av 36996

    • Novel screening methods for nanoscale changes in liver cell fenestrations elicited by pharmaceuticals 

      Szafranska, Karolina (Doctoral thesis; Doktorgradsavhandling, 2022-08-19)
      This thesis focuses on liver sinusoidal endothelial cells (LSEC) and one of their characteristic features called fenestrations. LSEC line the hepatic sinusoids and filter solutes from the plasma. The bidirectional transport of solutes between the bloodstream and the interior of the liver is facilitated via transcellular nanopores called fenestrations. Fenestrations are dynamic structures with diameters ...
    • Electron-neutral collisions effects on Langmuir probe in the lower E-region ionosphere 

      Brask, Steffen Mattias; Marholm, Sigvald; Di Mare, Francesca; Adhikari, Sayan; Spicher, Andres; Takahashi, T.; Miloch, Wojciech Jacek (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-21)
      We present the first set of particle-in-cell simulations including Monte Carlo collisions between charged and neutral particles used to simulate a cylindrical Langmuir probe in the electron saturation regime with a collisional electron sheath. We use a setup focused on the E-region ionosphere; however, the results of these simulations are analyzed in a general sense using dimensionless values. We ...
    • Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome 

      Winkler, Juliane; Liu, Pengyuan; Phong, Kiet; Hinrichs, Johanna H.; Ataii, Nassim; Williams, Katherine; Hadler-Olsen, Elin Synnøve; Samson, Susan; Gartner, Zev J.; Fisher, Susan; Werb, Zena (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-09)
      Environmental chemicals such as bisphenol A (BPA) are thought to contribute to carcinogenesis through their endocrine-disrupting properties. Due to accumulating evidence about negative human health effects, BPA is being phased out, but in parallel, exposures to replacement chemicals such as bisphenol S (BPS) and bisphenol F (BPF) are increasing. Little is known about their biologic effects, but ...
    • Dental plaque and gingival bleeding in adolescents with juvenile idiopathic arthritis and controls: a multilevel analysis 

      Gil, Elisabeth Grut; Åstrøm, Anne-Kristine N; Lie, Stein Atle; Rygg, Marite; Fischer, Johannes; Rosén, Annika; Bletsa, Athanasia; Luukko, Keijo Aukusti; Shi, Xie-Qi; Halbig, Josefine Mareile; Frid, Paula Hanna Therese; Cetrelli, Lena Elisabet; Tylleskär, Karin; Rosendahl, Karen; Skeie, Marit Slåttelid (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-30)
      Objective - To explore whether plaque and gingival bleeding are more frequently experienced by adolescents with juvenile idiopathic arthritis (JIA) compared to matched controls without JIA; explore whether surface- and site-specific periodontal outcomes vary between the two groups; and for participants with JIA, investigate associations between disease-specific features and periodontal outcomes.<p ...
    • Occupational cold exposure is associated with neck pain, low back pain, and lumbar radiculopathy 

      Stjernbrandt, Albin; Farbu, Erlend Hoftun (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-24)
      Ambient cold exposure can pose health risks, and this study was aimed at investigating associations with musculoskeletal disorders. A postal survey was performed on 12,627 men and women, ages 18–70 years, living in northern Sweden. Statistical associations were determined using multiple logistic regression. The study sample consisted of 6,886 women (54.5%), and 5,741 men. Reporting high occupational ...
    • Targeting Internalizing Symptoms in Children: What is the Impact on School Functioning? 

      Pedersen, Marit Løtveit; Holen, Solveig; Sund, Anne Mari; Adolfsen, Frode; Løvaas, Mona Elisabeth S; Martinsen, Kristin; Neumer, Simon-Peter; Patras, Joshua; Rasmussen, Lene-Mari Potulski; Lydersen, Stian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-13)
      Internalizing problems may be associated with poor academic performance and school absenteeism among youth. This study investigated the impact of the EMOTION: “Coping Kids” Managing Anxiety and Depression Program on academic achievement and school adaptation in children. Data were collected in a national cluster-randomized controlled trial at three time points in Norway. Children (N = 688, 8–12 ...
    • “It was an important part of my treatment”: a qualitative study of Norwegian breast Cancer patients’ experiences with mainstreamed genetic testing 

      Strømsvik, Nina; Olsson, Pernilla Marie A.; Gravdehaug, Berit; Lurås, Hilde; Schlichting, Ellen; Jørgensen, Kjersti; Wangensteen, Teresia; Vamre, Tone; Heramb, Cecilie; Mæhle, Lovise Olaug; Grindedal, Eli Marie (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-05)
      Background - In South-Eastern Norway, genetic testing for BRCA1 and BRCA2 is offered to breast cancer patients by their treating surgeon or oncologist. Genetic counselling from a geneticist or a genetic counsellor is offered only to those who test positive for a pathogenic variant or have a family history of cancer. This practice is termed “mainstreamed genetic testing”. The aim of this study was ...
    • Sámi Traditional Knowledge of Reindeer Meat Smoking 

      Krarup Hansen, Kia; Sara, Ravdna Biret Marja Eira; Smuk, Inger Anita; Brattland, Camilla (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)
      Reindeer meat, traditional food and knowledge are vital for the culture, health, and economy of Sámi reindeer herders. Nevertheless, the practices of reindeer meat smoking have barely been part of scientific research or reindeer herding management. We investigated Sámi reindeer herders’ approach to meat smoking in Northern Norway performed in the traditional Sámi tent, the lávvu. The investigation ...
    • The impact of case factors on the initial screening decision in child welfare investigations in Norway 

      Rustad, Kirsten Buck; Lauritzen, Camilla; Havnen, Karen J Skaale; Fossum, Sturla; Christiansen, Øivin; Vis, Svein Arild (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-15)
      Background - When a child welfare service agency receives a report of concern, there is an initial screening to decide whether an investigation needs to be initiated. In addition to the decision maker, case factors, external factors, and organizational factors have an impact on decision making in Child Welfare Services (CWS). Few recent studies have considered the impact of case factors on the initial ...
    • Role of conical intersection seam topography in the chemiexcitation of 1,2-dioxetanes 

      Fdez. Galván, Ignacio; Brakestad, Anders; Vacher, Morgane (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-06)
      Chemiexcitation, the generation of electronic excited states by a thermal reaction initiated on the ground state, is an essential step in chemiluminescence, and it is mediated by the presence of a conical intersection that allows a nonadiabatic transition from ground state to excited state. Conical intersections classified as sloped favor chemiexcitation over ground state relaxation. The chemiexcitation ...
    • Synthesis of substituted (N,C) and (N,C,C) Au(iii) complexes: the influence of sterics and electronics on cyclometalation reactions 

      Hylland, Knut Tormodssønn; Schmidtke, Inga; Wragg, David Stephen; Nova, Ainara; Tilset, Mats (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-04)
      Cyclometalated Au(III) complexes are of interest due to their catalytic, medicinal, and photophysical properties. Herein, we describe the synthesis of derivatives of the type (N,C)Au(OAcF)2 (OAcF = trifluoroacetate) and (N,C,C)AuOAcF by a cyclometalation route, where (N,C) and (N,C,C) are chelating 2-arylpyridine ligands. The scope of the synthesis is explored by substituting the 2-arylpyridine core ...
    • Er det forskjell i behandlingsresultat mellom pasienter som besvarer spørreskjema om utfall etter nakkekirurgi og pasienter som ikke gjør det? 

      Aune, Grethe; Karlsen, Martine Eriksen (Master thesis; Mastergradsoppgave, 2020-08-05)
      Bakgrunn og formål: Oppgaven er en valideringsstudie basert på data fra Nasjonalt kvalitetsregister for rygg- og nakkekirurgi (NKR). Validiteten til kvalitetsregistre er avhengig av tilstrekkelig høy responsrate for at konklusjonene som trekkes angående effekt av en behandling skal være korrekte. Formålet med studien er å analysere om det er forskjell i behandlingsresultat mellom pasienter som ...
    • Seeing minds – a signal detection study of agency attribution along the autism-psychosis continuum 

      Lisøy, Rebekka Solvik; Biegler, Robert; Ebad Fardzadeh, Haghish; Veckenstedt, Ruth; Moritz, Steffen; Pfuhl, Gerit (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-17)
      Introduction - Diametrically aberrant mentalising biases, namely hypermentalising in psychosis and hypomentalising in autism, are postulated by some theoretical models. To test this hypothesis, we measured psychotic-like experiences, autistic traits and mentalising biases in a visual chasing paradigm.<p> <p>Methods - Participants from the general population (N = 300) and psychotic patients (N=26) ...
    • Interprofessional care for the ICU patient’s family: solitary teamwork 

      Nygaard, Anne Mette; Haugdahl, Hege Selnes; Brinchmann, Berit Støre; Lind, Ranveig (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-13)
      The aim of this study was to explore how interprofessional family care by ICU teams was reflected in their daily work. Data were collected from four ICUs in Norway. Fieldwork and focus groups with ICU nurses and physicians were conducted in addition to dyadic and individual interviews of surgeons and internists. In line with a constructivist grounded theory approach, the core category “solitary ...
    • Sensemaking of causality in agent-based models 

      Antosz, Patrycja; Szczepanska, Timo; Bouman, Loes; J. Gareth, Polhill; Jager, Wander (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-25)
      Even though agent-based modelling is seen as committing to a mechanistic, generative type of causation, the methodology allows for representing many other types of causal explanations. Agent-based models are capable of integrating diverse causal relationships into coherent causal mechanisms. They mirror the crucial, multi-level component of emergent phenomena and recognize the important role of ...
    • GAM on! Six ways to explore social complexity by combining games and agent-based models 

      Szczepanska, Timo; Antosz, Patrycja; Berndt, Jan Ole; Borit, Melania; Chattoe-Brown, Edmund; Mehryar, Sara; Meyer, Ruth; Onngo, Stephan; Verhagen, Harko (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-27)
      GAM, combining games and agent-based models, shows potential for investigating complex social phenomena. Games offer engaging environments generating insights into social dynamics, perceptions, and behaviours, while agent-based models support the analysis of complexity. Games and agent-based models share the important ability both to input and output qualitative and quantitative data. Currently, ...
    • Care-full academic activism for sustainable transformations in tourism 

      Bertella, Giovanna (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-02)
      The urgent need for radical changes towards sustainability provides an opportunity to reconsider the epistemology and methodology of tourism research. The present study discusses this opportunity by adopting the concept of deep leverage points for sustainable transformations and an ethic of care perspective. The discussion highlights the vital role that a deep form of reflexivity plays in care-based ...
    • Statistical Curve Analysis: Developing Methods and Expanding Knowledge in Health 

      Uteng, Stig (Doctoral thesis; Doktorgradsavhandling, 2022-08-19)
      <p>The analysis of curves can be claimed to be the core of most scientific ventures. In this dissertation, we focus on the statistical aspect of this type of analysis. Here, the curves originate from health and food-related areas and include improvements in blood glucose measurements, classification of moles, measurements of parameters during liver transplants in pigs, and data from the monitoring ...
    • The impact of atmospheric Rossby waves and cyclones on the Arctic sea ice variability 

      Hofsteenge, Marte G.; Graversen, Rune Grand; Rydsaa, Johanne Hope; Rey, Zoé (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-17)
      The Arctic sea-ice extent has strongly declined over recent decades. A large inter-annual variability is superimposed on this negative trend. Previous studies have emphasised a significant warming effect associated with latent energy transport into the Arctic region, in particular due to an enhanced greenhouse effect associated with the convergence of the humidity transport over the Arctic. The ...
    • Identifying predictive signalling networks for Vedolizumab response in ulcerative colitis. 

      Singh, A.; Fenton, Christopher Graham; Anderssen, Endre; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-11)
      Background - In ulcerative colitis (UC), the molecular mechanisms that drive disease development and patient response to therapy are not well understood. A significant proportion of patients with UC fail to respond adequately to biologic therapy. Therefore, there is an unmet need for biomarkers that can predict patients’ responsiveness to the available UC therapies as well as ascertain the most ...