Nanocarriers have brought several medical advances through better diagnostics and improved drug therapy. Yet, many promising preclinical findings were never translated into clinical success, consequently slowing drug development, and increasing its financial burden. By reliably predicting the nanoparticle fate at in vitro stages, the disappointment of suboptimal in vivo outcome could be avoided. To ...

As was discussed in the section on verb particles in active clauses, the verb particle always precedes the direct objects in Swedish, while it often follows the direct object in the other Nordic varieties, especially when the direct object is a non­stressed pronoun. When it comes to simple reflexive direct objects (sig) [1] , the pattern in Swedish is more complex. Depending on verb class, the ...

Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport. The mammalian ULK complex involved in autophagy consists of ULK1, ULK2, ATG13, FIP200, and ATG101. We have used pulldown and peptide array overlay assays to ...

Small rodents are some of the most important elements of boreal/arctic food webs, where they play essential functional roles. Their population dynamics are characterized by large amplitude multi-annual cycles regulated by direct and delayed density-dependence. These drastic variations in abundance have deep cascading effects into the whole ecosystem. Hence, the study boreal rodent population processes ...

The syntax of Scandinavian verb particles has been described by a number of researchers, and seminal work include Johannisson (1939), Sandøy (1976), Svenonius (1996, 2003 and 2005), Taraldsen (1983) and Åfarli (1985).

The evacuation of passengers from a ship in distress is an essential measure in marine safety. Safety is only guaranteed when the passengers are evacuated to shore, especially in remote areas like the arctic region. There has been growing awareness with lack of knowledge, standards, routine, and documentation regarding marine search and rescue in the arctic region in recent years. This has been the ...

Objective To assess the efficacy of caudal epidural steroid or saline injection in chronic lumbar radiculopathy in the short (6 weeks), intermediate (12 weeks), and long term (52 weeks).<p> <p>Design Multicentre, blinded, randomised controlled trial. <p>Setting Outpatient multidisciplinary back clinics of five Norwegian hospitals. <p>Participants Between October 2005 and February 2009, 461 ...

This dissertation investigates the role of the clergymen in Finnmark in the witchcraft prosecutions that took place in the region from 1620–1692. The dissertation builds on a large amount of primary evidence from both judicial and ecclesiastical archives. The topic is approached through a qualitative critical contextual reading of the sources, this strong basis in the sources enables an investigation ...

Mind wandering (MW) is a mental phenomenon humans experience daily. Yet, we lack a complete understanding of the neural basis of this pervasive mental state. Over the past decade there has been an increase in publications using transcranial direct current stimulation (tDCS) to modulate the propensity to mind wander, but findings are diverse, and a satisfactory conclusion is missing. Recently, Boayue ...

Organizations often experience problems and challenges due to the development of rigid bureaucratic rules and procedures, which may represent obstacles to creativity and innovation. In a global knowledge economy, innovation is an important competitive parameter. Consequently, anything that may stimulate innovation in an organization’s creative energy fields is valuable. This paper addresses one ...