Purpose: 3-Methylcrotonyl-CoA carboxylase deficiency (MCCD) is an autosomal recessive disorder of leucine catabolism that has a highly variable clinical phenotype, ranging from acute metabolic acidosis to nonspecific symptoms such as developmental delay, failure to thrive, hemiparesis, muscular hypotonia, and multiple sclerosis. Implementation of newborn screening for MCCD has resulted in broadening ...

This article researches patronymics in a broad sense – taken as components of a proper name that, morphologically, can be decomposed in a first name and a morpheme – with a focus on Spanish and Belarusian – the second conforming to a narrow definition of patronymic, where it is a component of a proper name distinct from both the first name and the surname. Our claim is that patronymics are the ...

I denne studien diskuterer vi studentrespons på formativ vurdering i forbindelse med et bachelorkurs i akademisk skriving. Formativ vurdering er underveisvurdering og -veiledning, den former læring og bringer den lærende fremover (Bennett, 2011, 2018; Wiliam, 2018). Vårt formål med studien er å utforske hvilke typer formativ vurdering studenter opplever som verdifulle for utvikling av ferdigheter i ...

G-protein koblet østrogenreseptor (GPER) har vist å ha en fysiologisk rolle i det reproduktive systemet, nervesystemet, endokrine systemet, immunsystemet og karsystemet. Den har også patofysiologisk rolle i flere forskjellige sykdommer inkludert kreft. G-protein koblet østrogenreseptor har blitt identifisert i nesten alle systemer i kroppen. Dermed er det en stor interesse for å få kjennskap til ...

γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the CNS. GABA exerts its function on both ionotropic ligand-gated GABAA receptors and metabotropic GABAB G-protein coupled receptors (GPCRs). Disruption in the GABAergic system has been associated with numerous neurological and psychiatric disorders in humans. These include developmental dysfunctions, epilepsy, sleep disorders, ...

Bakgrunn: Ettårig periodeprevalens for bruk av antibakterielle midler til barn i Norge er høyest før tre års alder. Forskriving av antibakterielle midler påvirkes av mange faktorer, og kartlegging av disse kan gi mulighet til å målrette intervensjoner for å redusere forskriving. Formål: De primære målene var å undersøke om fødselssesong predikerer alder ved første utlevering av antibakterielle midler, ...

In vitro lipolysis models are commonly used to assess the performance of lipid-based drug delivery systems (LbDDSs) in terms of their drug absorption potential; however, this in vitro approach has not always shown to correlate well with in vivo data. Several studies suggest that adding an absorption step to the in vitro lipolysis model would give a better estimation of absorption for drugs incorporated ...

-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter of the central nervous system (CNS). GABA exhibits its function by binding to either the ionotropic GABAA receptor or the metabotropic GABAB receptor, causing a decrease in activity in the nervous system. Disruption in the GABAergic system has been associated with various neurological conditions, including Alzheimer’s disease, anxiety, ...

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a condition where the mother produces alloantibodies against fetal platelets during pregnancy most commonly due to an incompatibility in the human platelet antigen (HPA)-1 system; a single amino acid polymorphism located on integrin β3 with two common variants, HPA-1a and HPA-1b. Antibody responses against HPA-1a can be formed in women who ...

This master thesis presents an original analysis of how branding is produced through verbal and non-verbal communication in the context of so-called Marketing 4.0, whose main differential properties are the extensive use of digital media and a horizontal distribution on information that privileges the interaction with consumers. Both properties make establishing a brand image more crucial, and make ...