This review focuses on the role of adipose tissue in obese individuals in the development of metabolic diseases, and their consequences for metabolic and functional derangements in the heart. The general idea is that the expansion of adipocytes during the development of obesity gives rise to unhealthy adipose tissue, characterized by low-grade inflammation and the release of proinflammatory ...

Clinical reasoning is a core activity in everyday clinical work, but is also a well-developed field of research with scholarly papers, reviews, books, conferences and medical curriculum activities. In this body of knowledge, and although it remains a complex construct [1], clinical reasoning is generally defined as the cognitive processes and mental structures that physicians mobilise to decide on ...

<br> 1. Ecological opportunity (i.e. the diversity of available resources) has a pivotal role in shaping niche variation and trophic specialisation of animals. However, ecological opportunity can be described with regard to both diversity and abundance of resources. The degree to which these two components contribute to niche variation remains unexplored. <br>2. To address this, we used an ...

The purpose of this action research project is to study the possibilities of the concept of experiential Education (in German: Erlebnispädagogik) for compensatory support in schoolwork. The article describes the experiences at a German secondary school. The main aim was to use the idea of experiential education to develop the social abilities of pupils who showed deviant behaviour at school and ...

Environmental change and increasing levels of human activity are threats to marine mam- mals in the Arctic. Identifying marine mammal hot - spots and areas of high species richness are essential to help guide management and conservation efforts. Herein, space use based on biotelemetric tracking devices deployed on 13 species (ringed seal <i>Pusa hispida</i>, bearded seal <i>Erignathus ...

Background. Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective ...

Cultural sensitivity is highly relevant but inadequately conceptualized in tourism contexts. This article explores and advances understanding of cultural sensitivity in relation to Arctic tourism where local and Indigenous livelihoods and environments are tethered to dynamics of recent tourism growth and decline, climate change, and colonial power relations. Framing cultural sensitivity as a ...

How can we maximize what is learned from a replication study? In the creative destruction approach to replication, the original hypothesis is compared not only to the null hypothesis, but also to predictions derived from multiple alternative theoretical accounts of the phenomenon. To this end, new populations and measures are included in the design in addition to the original ones, to help determine ...

Major ice loss in the Amundsen Sea sector of the West Antarctic Ice Sheet (WAIS) is hypothesized to have triggered ice sheet collapses during past warm periods such as those in the Pliocene. International Ocean Discovery Program (IODP) Expedition 379 recovered continuous late Miocene to Holocene sediments from a sediment drift on the continental rise, allowing assessment of sedimentation processes ...

Stomach content analyses are a valuable tool in human forensic science to interpret perimortem events. While the identifcation of food components of plant and animal origin has traditionally been conducted by macro- and microscopical approaches in case of incomplete digestion, molecular methods provide the potential to increase sensitivity and taxonomic resolution. In particular, DNA metabarcoding ...