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Coastal Polynya Disrupts the Acoustic Backscatter Diurnal Signal Over the Eastern Laptev Sea Shelf
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)The diel vertical migration (DVM) of zooplankton is one of the largest species migrations to occur globally and is a key driver of regional ecosystems and the marine carbon pump. The dramatic changes in the Arctic environment in recent years, mainly associated with sea-ice decline, may have wide significance for the Arctic shelf ecosystems including DVM. Observations have revealed the occurrence of ... -
Linking sea ice deformation to ice thickness redistribution using high-resolution satellite and airborne observations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-04)An unusual, large, latent-heat polynya opened and then closed by freezing and convergence north of Greenland’s coast in late winter 2018. The closing presented a natural but well-constrained full-scale ice deformation experiment. We observed the closing of and deformation within the polynya with satellite synthetic-aperture radar (SAR) imagery and measured the accumulated effects of dynamic ... -
The third age On old age in a comparative anthropological perspective
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-17)dag regnes uttrykket «den tredje alder» gjerne som ensbetydende med pensjonisttilværelsen, selv om forestillingen om at menneskelivet kan deles inn i tre aldre er svært my e eldre enn pensjonsinstituttet. Denne forestillingen kan spores til tidlig i menneskeslektas utvikling, da behovet for «reservemødre» nødvendiggjorde sosial integrering av tre (snarere enn bare to) generasjoner. Denne integreringen ... -
Inflammation, hypertension, and microRNA and Prostate Cancer. The Prostate Cancer throughout life (PROCA-life) study
(Doctoral thesis; Doktorgradsavhandling, 2022-03-31)<p><i>Background/Aims:</i> Prostate cancer (PCa) is the most common cancer among men in Norway as well as world-wide, and a major cause of health loss and death with 1.4 million new cases and 375 000 deaths world-wide in 2020. Biological mechanisms involved in PCa development are mainly unknown, but chronic inflammation, one hallmark of cancer development, has been questioned to play a key role in ... -
A synoptic history of the development, production and environmental oversight of hydropower in Brazil, Canada, and Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-17)Sustainable global energy production is back-stopped by hydropower which is responsible for a significant share of the green energy produced worldwide. Hydropower, however, does not come without some environmental impacts but has worked to reduce those impacts. Here, we discuss the historical, legislative, and design configurations of hydropower facilities located in three of the world’s ... -
Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-19)The Golgi complex is essential for the processing, sorting, and trafficking of newly synthesized proteins and lipids. Golgi turnover is regulated to meet different cellular physiological demands. The role of autophagy in the turnover of Golgi, however, has not been clarified. Here we show that CALCOCO1 binds the Golgi-resident palmitoyltransferase ZDHHC17 to facilitate Golgi degradation by autophagy ... -
Population genetic structure of a major reef-building coral species Acropora downingi in northeastern Arabian Peninsula
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-03)Current seawater temperatures around the northeastern Arabian Peninsula resemble future global forecasts as temperatures [35 C are commonly observed in summer. To provide a more fundamental aim of understanding the structure of wild populations in extreme environmental conditions, we conducted a population genetic study of a widespread, regional endemic table coral species, Acropora downingi, ... -
Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-24)Oncolytic peptides represent a novel, promising cancer treatment strategy with activity in a broad spectrum of cancer entities, including colorectal cancer (CRC). Cancer cells are killed by immunogenic cell death, causing long-lasting anticancer immune responses, a feature of particular interest in non-immunogenic CRC. Oncolytic peptides DTT-205 and DTT-304 were administered by intratumoral injection ... -
Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-04)<b>Background</b> Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral ... -
Cosheaves
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-21)The categories pCS(X,Pro(k)) of precosheaves and CS(X,Pro(k)) of cosheaves on a small Grothendieck site X, with values in the category Pro(k) of prok-modules, are constructed. It is proved that pCS(X,Pro(k)) satisfies the AB4 and AB5* axioms, while CS(X,Pro(k)) satisfies AB3 and AB5*. Homology theories for cosheaves and precosheaves, based on quasi-projective resolutions, are constructed and investigated. -
Joint optimization of an autoencoder for clustering and embedding
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-21)Deep embedded clustering has become a dominating approach to unsupervised categorization of objects with deep neural networks. The optimization of the most popular methods alternates between the training of a deep autoencoder and a k-means clustering of the autoencoder’s embedding. The diachronic setting, however, prevents the former to beneft from valuable information acquired by the latter. In ... -
Formation of Stanley Patch volcanic cone: New insights into the evolution of Deception Island caldera (Antarctica)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-16)Deception Island (South Shetland Islands) is one of the most active volcanoes in Antarctica, with more than 20 explosive eruptive events registered over the past centuries. Recent eruptions (1967, 1969, and 1970) and volcanic unrest episodes (1992, 1999, and 2014–2015) demonstrate that volcanic activity is likely occurring in the future. This is of special concern for scientists, logistic personnel, ... -
Protein signature predicts response to neoadjuvant treatment with chemotherapy and bevacizumab in HER2-negative breast cancers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-28)<p>PURPOSE: Antiangiogenic therapy using bevacizumab has proven effective for a number of cancers; however, in breast cancer (BC), there is an unmet need to identify patients who benefit from such treatment. <p>PATIENTS AND METHODS: In the NeoAva phase II clinical trial, patients (N = 132) with large (≥ 25 mm) human epidermal growth factor receptor 2 (HER2)-negative primary tumors were randomly ... -
Covid-19 transmission in fitness centers in Norway - a randomized trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-16)Background: Closed fitness centers during the Covid-19 pandemic may negatively impact health and wellbeing. We assessed whether training at fitness centers increases the risk of SARS-CoV-2 virus infection.<p> <p>Methods: In a two-group parallel randomized controlled trial, fitness center members aged 18 to 64 without Covid-19-relevant comorbidities, were randomized to access to training at a ... -
Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-14)Enzyme-linked immunosorbent assay (ELISA) enables fast and simple quantification of analytes in the pico- to nanogram range in complex samples. Here, we describe an ELISA for the detection of porcine C3a as a marker for complement activation. Antibody specificity is critical for a robust assay. This assay is based on a pair of antibodies specific for the porcine C3a molecule and thus does not react ... -
«På lik linje med oss andre» - hvilke vurderinger arbeidsgivere gjør i arbeidet med å inkludere personer med nedsatt funksjonsevne i ordinært arbeid
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-24)The Norwegian welfare and labor market policy has as its focus to “get everyone at work”. Employers in ordinary companies are given a central role because ordinary work is seen both as a goal and as a method to get more people with disabilities at work. This article examines employers’ experiences and understandings of how they do the inclusive work, and how governance practices and institutional ... -
On the temporal evolution of turbopause altitude, 1996-2021, 70 N, 19 E
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-04)Medium frequency radars with multiple receivers are able to track the movement of the interference pattern on the ground from echoes from irregularities in refractive index. In particular, refractive index in the mesosphere is determined by electron density – commonly known as the ionospheric D-region. Thus using this technique it is possible to determine winds in the height regime 70-90 km, ... -
Can bryophyte groups increase functional resolution in tundra ecosystems?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-30)The relative contribution of bryophytes to plant diversity, primary productivity, and ecosystem functioning increases towards colder climates. Bryophytes respond to environmental changes at the species level, but because bryophyte species are relatively difficult to identify, they are often lumped into one functional group. Consequently, bryophyte function remains poorly resolved. Here, we explore ... -
Next-generation cophylogeny: unravelling eco-evolutionary processes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-07)A fundamental question in evolutionary biology is how microevolutionary processes translate into species diversification. Cophylogeny provides an appropriate framework to address this for symbiotic associations, but historically has been primarily limited to unveiling patterns. We argue that it is essential to integrate advances from ecology and evolutionary biology into cophylogeny, to gain ... -
Antioxidant Activities and Selenogene Transcription in the European Sea Bass (Dicentrarchus labrax) Liver Depend, in a Non-linear Manner, on the Se/Hg Molar Ratio of the Feeds
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-31)Feeding 3.9 and 6.7 mg Hg/kg (Se/Hg molar ratios of 0.8 and 0.4, respectively) for 14 days negatively afected Dicentrarchus labrax growth and total DNTB- and thioredoxin-reductase (TrxR) activities and the transcription of four redox genes (txn1, gpx1, txnrd3, and txnrd2) in the liver, but a diet with 0.5 mg Hg/kg (Se/Hg molar ratio 6.6) slightly increased both reductase activities and the ...