Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages. To enhance our understanding of the sarcoma immune landscape, we quantified and characterized tumor-associated macrophage infiltration and expression of the targetable ...

This paper discusses findings from online surveys completed by parents of 0–3-year-old children in Norway, Portugal and Japan concerning their young children’s use of touchscreen technology. The study investigated parental practices, views and perspectives related to children’s digital practices and explored these in relation to wider cultural discourses around early childhood in the participant ...

The coastal areas of Finnmark have deep Sámi roots. With the Norwegian assimilation policy—Norwegianization—the transition to the Norwegian language has been extensive here, placing the region outside Sámi core areas. Nevertheless, indigenous Sea Sámi identity still exists, and language vitalization and raising awareness of culture are shown in Sámi institution building. Within these frames, ...

Early identification of autism spectrum disorder (ASD) is regarded as crucial for swift access to early intervention and, subsequently, better outcomes later in life. However, current instruments miss large proportions of children who later go on to be diagnosed with ASD, raising a question of what these instruments measure. The present study utilized data from the Norwegian Mother, Father, and Child ...

Based on phylogenetic analyses of the ITS, nuclear large subunit rRNA, mitochondrial small subunit rRNA, and MCM7 genes, species previously treated as <i>Pannaria hispidula</i> and <i>P. isabellina</i> are shown to represent two new Pannariaceae genera, <i>Hispidopannaria</i> and <i>Phormospsora</i>. Each genus forms monophyletic clades, both in multilocus phylogeny and in single gene phylogenies. ...

In the last decade, in particular, understanding technology use within children’s play-based experiences has been an important concern for early childhood education researchers and practitioners (Danby et al. 2018; Stephen and Edwards 2018). The World Economic Forum (2019) has highlighted the pressing issue of the twenty-first-century skills gap related to the digital revolution and ways that educators ...

This article revisits marine bioprospecting in the Southern Ocean in the context of the efforts to develop an international legally binding instrument (ILBI) under the United Nations Convention on the Law of the Sea on the conservation and sustainable use of marine biological diversity in areas beyond national jurisdiction. After briefly introducing the Antarctic Treaty System (ATS), this article ...

As children become older, they better maintain task-relevant information in preparation of upcoming cognitive demands. This is referred to as proactive control, which is a key component of cognitive control development. However, it is still uncertain whether children engage in proactive control consistently across different contexts and how proactive control relates to academic abilities. This study ...

Aerosolutvikling i sammenheng med behandling i munnhulen kan innebære risiko for smitteoverføring mellom pasienter og tannhelsepersonell. Denne artikkelen (Del 1) beskriver hva aerosol er og mulig innvirkning for helse. Hovedfokus i denne artikkelen er mikrobielle aerosoler, og hvilke situasjoner og prosedyrer som forårsaker mikrobielle aerosoler i tannhelseklinikken. Det produseres forskjellige ...

The article is an analytical state-of-the-art review of the Russian Federation’s critical infrastructure policy, starting from the 1990s but zooming in on the current situation. The article discusses what does critical infrastructure mean in the Russian context. It explores the country’s threat scenarios in this field, and asks what part is played by cyber security threats in this context. Further, ...