The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab (Soliris®), which is used clinically to block complement factor C5, as well as anti-human CD14 (r18D11) and anti-porcine CD14 (rMIL2) produced in our laboratory. So far, no proper IgG2/4 control antibody has been available for controlled ...

Purpose: Type 2 diabetes mellitus is associated with increased fracture risk and recent studies show crosstalk between bone and glucose metabolism. Few studies have investigated the effect of vitamin D supplementation on bone without additional calcium. In the present study, we aimed to determine whether a high dose of vitamin D3 could improve bone mass density (BMD) in prediabetic subjects. Methods: ...

Background: In Norway, it is widely agreed that health services should be available for all, irrespective of place of residence, gender, income or socioeconomic status. It seems that the use of general practitioners is equally distributed, while the better-off are more likely to use specialist healthcare. There is limited knowledge of the equity of other aspects of health care, such as physiotherapy ...

Intensjonen med denne oppgaven har vært å utforske hvordan ansvarlig reiseliv forhandles i en kommune med sterke verne – og utbyggerinteresser. For å belyse dette har fokuset vært å studere hvilke stedskvaliteter som vektlegges i forhold til vern, og hvordan disse forhandles i arbeidet med reiselivsutvikling. Det har også vært viktig å se på hvordan begrepet bærekraft artikuleres, samt hvordan verne ...

Sammendrag Denne oppgaven utforsker hvordan Tromsø kommune skal realisere nullvekstmålet, og prøver å besvare hvorfor dette har blitt så vanskelig. For at Tromsø kommune skal lykkes i å oppnå nullvekst i personbiltrafikken er innføring av bompenger et av de sterkeste virkemidlene. Staten har tilbudt Tromsø å søke om en byvekstavtale, og gjennom prosjekt Tenk Tromsø er det utarbeidet delprosjekter, ...

1. Ecosystems at high latitudes are exposed to some of the highest rates of climate warming on earth, and freshwater ecosystems in those regions are already experiencing extended ice‐free seasons and warmer waters. The dominant fish species in these ecosystems are cold‐water salmonids, which play a central ecological role in lake ecosystems, where they are often exposed to size‐selective fisheries ...

<i>Aim</i>: The aim of this study is to evaluate a feeding regimen routinely providing >180 ml/kg/d fortified human milk to very preterm infants and impact on in-hospital growth, osteopenia, and neurodevelopment.<p> <p><i>Method</i>: Retrospective population-based descriptive study of infants <30-week gestation admitted within 24 h of birth and discharged during the 6-year period 2005–2010. ...

Changes in fish distribution are being observed across the globe. In Europe's Common Fisheries Policy, the share of the catch of each fish stock is split among management areas using a fixed allocation key known as ‘Relative Stability’: in each management area, member states get the same proportion of the total catch each year. That proportion is largely based on catches made by those member states ...

<i>Objective</i>: Severe hypoglycemia is the most serious acute complication for people with type 1 diabetes (T1D). Approximately 25% of people with T1D have impaired ability to recognize impending hypoglycemia, and nocturnal episodes are feared.<p> <p><i>Approach</i>: We have investigated the use of non-invasive sensors for detection of hypoglycemia based on a mathematical model which combines ...

<i>Aim</i> - Trends in spatial patterns of diversity in macroscopic organisms can be well predicted from correlative models, using topo‐climatic variables for plants and animals allowing inference over large scales. By contrast, diversity in soil microorganisms is generally considered as mostly driven by edaphic variables and, therefore, difficult to extrapolate on a large spatial scale based on ...