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    • Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort 

      van Roekel, Eline H.; Trijsburg, Laura; Assi, Nada; Carayol, Marion; Achaintre, David; Murphy, Neil; Rinaldi, Sabina; Schmidt, Julie A.; Stepien, Magdalena; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Iqbal, Khalid; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Ricceri, Fulvio; Panico, Salavatore; Peeters, Petra H.; Bueno-De-Mesquita, Hendrik Bastiaan; Ardanaz, Eva; Lujan-Barroso, Leila; Quirós, José Ramón; Huerta, José María; Molina-Portillo, Elena; Dorronsoro, Miren; Tsilidis, Konstantinos K.; Riboli, Elio; Rostgaard-Hansen, Agnetha Linn; Tjønneland, Anne; Overvad, Kim; Weiderpass, Elisabete; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Trichopoulou, Antonia; Karakatsani, Anna; Kotanidou, Anastasia; Håkansson, Anders; Malm, Johan; Weijenberg, Matty P.; Gunter, Marc J.; Jenab, Mazda; Johansson, Mattias; Travis, Ruth C.; Scalbert, Augustin; Ferrari, Pietro (Journal article; Peer reviewed, 2018-05-22)
      Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at ...

    • Estimated 8-year cumulative incidence of diabetes mellitus among Sami and non-Sami inhabitants of Northern Norway - The SAMINOR Study 

      Naseribafrouei, Ali; Eliassen, Bent Martin; Melhus, Marita; Svartberg, Johan; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-24)
      <i>Background</i>: The aim of the study was to estimate and compare the 8-year cumulative incidence of diabetes mellitus (DM) among Sami and non-Sami inhabitants of rural districts in Northern Norway.<p> <p><i>Methods</i>: Longitudinal study based on linkage of two cross-sectional surveys, the SAMINOR 1 Survey (2003–2004) and the SAMINOR 2 Clinical Survey (2012–2014). Ten municipalities in rural ...

    • Differential prognostic impact of platelet-derived growth factor receptor Expression in NSCLC 

      Kilvær, Thomas Karsten; Rakaee, Mehrdad; Hellevik, Turid; Vik, Jørg; de Petris, Luigi; Dønnem, Tom; Strell, Carina; Østman, Arne; Busund, Lill-Tove; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-15)
      Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain. Tumor specimens from 553 patients with primary operable stage I-IIIB NSCLC was obtained and tissue micro-arrays (TMA) ...

    • Exploring the gender specific association between use of complementary and alternative medicine and alcohol consumption and injuries caused by drinking. The sixth Tromsø study 

      Sivertsen, Kristina (Master thesis; Mastergradsoppgave, 2017-08-25)
      Background: Previous studies have found that the use of complementary and alternative medicine (CAM) is associated with several characteristic, such as female gender, higher education and higher income. However, studies investigating the relationship between alcohol consumption patterns and different CAM approaches have so far been limited. Harmful use of alcohol has detrimental consequences to ...

    • Individual Development and Collective Change: A Dynamic Approach to University Teacher Training 

      Dørum, Kine; Larsen, Jelena Nikolajevna Tsjasjina (Chapter; Bokkapittel, 2019-06-24)
      University teacher training is often centered around extensive courses and seminars, and may have limited impact on improving teaching practice. We suggest this may be due to faculty perceiving what is being taught as not immediately relevant for solving concrete, practical challenges they face in their everyday practice. Further, lasting change in teaching practice requires a collective effort. We ...

    • Données de recherche: La transparence et les meilleures pratiques 

      Andreassen, Helene N. (Conference object; Konferansebidrag, 2019-07)

    • Hydrate occurrence in Europe: A review of available evidence 

      Minshull, Timothy A.; Marin-Moreno, Hector; Betlem, Peter; Bialas, Joerg; Bünz, Stefan; Burwicz, Ewa; Cameselle, Alejandra L.; Cifci, Gunay; Giustiniani, Michela; Hillman, Jess I.T.; Hölz, Sebastian; Hopper, John R.; Ion, Gabriel; Leon, Ricardo; Magalhaes, Vitor; Makovsky, Yizhaq; Mata, Maria-Pilar; Max, Michael D.; Nielsen, Tove; Okay, Seda; Ostrovsky, Ilia; O'Neil, Nick; Pinheiro, Luis M.; Plaza-Faverola, Andreia; Rey, Daniel; Roy, Srikumar; Schwalenberg, Katrin; Senger, Kim; Vadakkepuliyambatta, Sunil; Vasilev, Atanas; Vázquez, Juan-Tomás (Journal article; Tidsskriftartikkel, 2019-08-16)
      Large national programs in the United States and several Asian countries have defined and characterised their marine methane hydrate occurrences in some detail, but European hydrate occurrence has received less attention. The European Union-funded project “Marine gas hydrate – an indigenous resource of natural gas for Europe” (MIGRATE) aimed to determine the European potential inventory of exploitable ...

    • Prognostic biomarkers for immunotherapy with ipilimumab in metastatic melanoma 

      Nyakas, Marta Sølvi; Aamdal, Elin; Jacobsen, Kari Dolven; Guren, Tormod Kyrre; Aamdal, Steinar; Hagene, Kirsten Thorin; Brunsvig, Paal Fr.; Yndestad, Arne; Halvorsen, Bente; Tasken, Kristin Austlid; Aukrust, Pål; Mælandsmo, Gunhild Mari; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-01)
      New therapies, including the anti‐cytotoxic T lymphocyte antigen (CTLA)‐4 antibody, ipilimumab, is approved for metastatic melanoma. Prognostic biomarkers need to be identified, because the treatment has serious side effects. Serum samples were obtained before and during treatment from 56 patients with metastatic or unresectable malignant melanoma, receiving treatment with ipilimumab in a national ...

    • Gammarid amphipods (Crustacea) in Norway, with a key to the species 

      Vader, Wim; Tandberg, Anne Helene Solberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-28)
      Thirteen species in the amphipod family Gammaridae have been reported from Norway. This paper gives a survey of the distribution and habitat of all 13 species of the family Gammaridae occurring or expected to occur in Norwegian waters: both marine, brackish and fresh, including Svalbard, in addition to four species found in close neighbouring waters. It also provides a short history of the study of ...

    • Management of patients with metastatic prostate cancer (mPC) in a rural part of North Norway with a scattered population: does living near the department of oncology translate into a different pattern of care and survival? 

      Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor Christin; Norum, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-23)
      The goal of the Norwegian Ministry of Health and Care Services is to offer an equal health-care service with the same outcomes wherever people are living within the country. The aim of this study was to evaluate whether this was true for patients diagnosed with metastatic prostate cancer (mPC) and living in Nordland County, a region with a challenging geography and climate and having, several small ...

    • The art of untangling: High North SME board directors' challenges in understanding strategy, control, and service tasks 

      Fjellvær, Hilde; Olsen, Trude Høgvold; Solstad, Elsa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      Boards of directors represent an important, but understudied, resource for business development of High North SMEs. We studied board director perceptions of what constitutes the most important board tasks and which activities each major task actually involved. We followed a local board development project with participants from several industries and companies in Northern Norway over a two-year ...

    • Effekt av basaltfiber for betongkvalitet = Effect of basalt fiber for quality of concrete 

      Ha, Duy Quang (Master thesis; Mastergradsoppgave, 2019-06-27)
      The need of concrete is getting more and more, experts have researched new materials to improve the good properties of concrete. Basalt fiber is a new additive in the concrete industry, so researches on basalt fiber concrete is not many. Previous research results have shown positive effects of basalt fiber on the mechanical strengths of the concrete. This task is performed by experiments to confirm ...

    • Samspillskontrakter – en vei å forene ulike interesser 

      Nielsen, Håvard Johannes (Master thesis; Mastergradsoppgave, 2019-06-27)
      Samspill i norsk bygg- og anleggsbransje øker i omfang. Hensikten med samspillsmodellene er å sørge for mer innovasjon i byggeprosjekter, samtidig som modellen skal motivere til kostnadseffektive løsninger. Tema for denne oppgaven er hvordan samspill kan nyttiggjøres i byggeprosjekter, og hvilke utfordringer og fordeler samspill kan medføre for byggherre. Oppgaven tar også for seg karakteristiske ...

    • Novel targets for delaying aging: The importance of the liver and advances in drug delivery 

      Hunt, Nicholas J; McCourt, Peter Anthony; Le Couteur, David George; Cogger, Victoria C (Journal article; Tidsskriftartikkel, 2018-09-21)
      Age-related changes in liver function have a significant impact on systemic aging and susceptibility to age-related diseases. Nutrient sensing pathways have emerged as important targets for the development of drugs that delay aging and the onset age-related diseases. This supports a central role for the hepatic regulation of metabolism in the association between nutrition and aging. Recently, a role ...

    • Research Funding is Critical to Societally Relevant Research 

      Benneworth, Paul; Maxwell, Kate (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-13)
      There has been increasing concern recently in ensuring that public funding for science and innovation creates truly public benefits. This has emerged at a time of an uneasy feeling emerging in society that it is private corporations and patent holders that reap the rewards, particularly in new drugs which may be generally unaffordable despite being ‘discovered’ by public funding (Gronde et ...

    • Sandpits Can Develop Cross-Disciplinary Projects, but Funders Need to be as Open-Minded as Researchers 

      Maxwell, Kate; Benneworth, Paul; Siefkes, Martin (Journal article; Tidsskriftartikkel; Peer reviewed; Others; Andre, 2018-10-15)
      The research “sandpit”, where a cross-disciplinary group of academics and practitioners come together for a short time to create new projects around a given theme, is gaining ground as a way to foster innovation and creativity in research design. While sandpits can spark ideas for novel projects better suited to tackling grand challenges and urgent questions, research from Kate Maxwell, Paul Benneworth, ...

    • Evolución ambiental de los estuarios del Geoparque de la costa Vasca durante el Holoceno y el Antropoceno 

      Cearreta, A.; Irabien, M.J.; Gómez Arozamena, J.; El Bani Altuna, Naima; Goffard, A.; Fernández Martín-Consuegra, A.; Hilario, A. (Chapter; Bokkapittel, 2019-07)
      In order to reconstruct the environmental evolution of the estuaries in the Basque Coast Geopark at different temporal scales (millennial, centennial, decadal), different long and short cores and surface samples were retrieved and studied. Their multiproxy analysis (metals, foraminifera, pollen and radioisotopes) shows their temporal transformation in response to regional sea-level variations ...

    • Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status 

      Fedirko, Veronika; Jenab, Mazda; Méplan, Catherine; Jones, Jeb S.; Zhu, Wanzhe; Schomburg, Lutz; Siddiq, Afshan; Hybsier, Sandra; Overvad, Kim; Tjønneland, Anne; Omichessan, Hanane; Perduca, Vittorio; Boutron-Ruault, Marie-Christine; Kühn, Tilman; Katzke, Verena; Aleksandrova, Krasimira; Trichopoulou, Antonia; Karakatsani, Anna; Kotanidou, Anastasia; Tumino, Rosario; Panico, Salvatore; Masala, Giovanna; Agnoli, Claudia; Naccarati, Alessio; Bueno-De-Mesquita, Bas; Vermeulen, Roel C.H.; Weiderpass, Elisabete; Skeie, Guri; Nøst, Therese Haugdahl; Lujan-Barroso, Leila; Quirós, Jose Ramón; Huerta, José María; Rodríguez-Barranco, Miguel; Barricarte, Aurelio; Gylling, Björn; Harlid, Sophia; Bradbury, Kathryn Erica; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc J.; Murphy, Neil; Freisling, Heinz; Tsilidis, Kostas; Aune, Dagfinn; Riboli, Elio; Hesketh, John E.; Hughes, David J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-25)
      Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. <i>Illumina Goldengate</i> assays were designed and resulted in the genotyping of 1040 variants in 154 genes ...

    • Experimental grain growth of quartz aggregates under wet conditions and its application to deformation in nature 

      Fukuda, Junichi; Raimbourg, Hugues; Shimizu, Ichiko; Neufeld, Kai; Stünitz, Holger (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-13)
      Grain growth of quartz was investigated using two quartz samples (powder and novaculite) with water under pressure and temperature conditions of 1.0–2.5 GPa and 800–1100 ∘C. The compacted powder preserved a substantial porosity, which caused a slower grain growth than in the novaculite. We assumed a grain growth law of <i>d<sup>n</sup>−d<sup>n</sup><sub>0</sub>=k</i><sub>0</sub><i>f<sup>r</sup><su ...

    • "We can work it out!" Collaborating on Research Data Management Services at UiT The Arctic University of Norway 

      Østhus, Randi; Andreassen, Helene N. (Conference object; Konferansebidrag, 2019-08)