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Novel targets for delaying aging: The importance of the liver and advances in drug delivery

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https://hdl.handle.net/10037/15993
DOI
https://doi.org/10.1016/j.addr.2018.09.006
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Submitted manuscript version (PDF)
Date
2018-09-21
Type
Journal article
Tidsskriftartikkel

Author
Hunt, Nicholas J; McCourt, Peter Anthony; Le Couteur, David George; Cogger, Victoria C
Abstract
Age-related changes in liver function have a significant impact on systemic aging and susceptibility to age-related diseases. Nutrient sensing pathways have emerged as important targets for the development of drugs that delay aging and the onset age-related diseases. This supports a central role for the hepatic regulation of metabolism in the association between nutrition and aging. Recently, a role for liver sinusoidal endothelial cells (LSECs) in the relationship between aging and metabolism has also been proposed. Age-related loss of fenestrations within LSECs impairs the transfer of substrates (such as lipoproteins and insulin) between sinusoidal blood and hepatocytes, resulting in post-prandial hyperlipidemia and insulin resistance. Targeted drug delivery methods such as nanoparticles and quantum dots will facilitate the direct delivery of drugs that regulate fenestrations in LSECs, providing an innovative approach to ameliorating age-related diseases and increasing healthspan.
Description
Submitted manuscript version. Published version in Advanced Drug Delivery Reviews, 135, 39-49, is available at https://doi.org/10.1016/j.addr.2018.09.006.
Publisher
Elsevier
Citation
Hunt, N.J., McCourt, P.A.G., Le Couteur, D.G. & Cogger, V.C. (2018). Novel targets for delaying aging: The importance of the liver and advances in drug delivery. Advanced Drug Delivery Reviews, 135, 39-49. https://doi.org/10.1016/j.addr.2018.09.006
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