Recent additions

  • A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment 

    Dragomir, Mihnea Paul; Moisoiu, Vlad; Manaila, Roxana; Pardini, Barbara; Knutsen, Erik; Anfossi, Simone; Amit, Moran; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-31)
    One of the limitations of cancer research has been the restricted focus on tumor cells and the omission of other non-malignant cells that are constitutive elements of this systemic disease. Current research is focused on the bidirectional communication between tumor cells and other components of the tumor microenvironment (TME), such as immune and endothelial cells, and nerves. A major success of ...
  • Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies 

    Tellez Gabriel, Marta; Knutsen, Erik; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
    Breast cancer is the most common cancer among women worldwide. Although the five-, ten- and fifteen-year survival rates are good for breast cancer patients diagnosed with early-stage disease, some cancers recur many years after completion of primary therapy. Tumor heterogeneity and clonal evolution may lead to distant metastasis and therapy resistance, which are the main causes of breast cancer-associated ...
  • Protein kinase C isozymes associated with relapse free survival in non-small cell lung cancer patients 

    Halvorsen, Ann Rita; Haugen, Mads Haugland; Øjlert, Åsa Kristina; Lund-Iversen, Marius; Jørgensen, Lars Hilmar; Solberg, Steinar; Mælandsmo, Gunhild Mari; Brustugun, Odd Terje; Helland, Åslaug (Journal article; Tidsskriftartikkel, 2020-11-25)
    <i>Introduction</i>: Protein expression is deregulated in cancer, and the proteomic changes observed in lung cancer may be a consequence of mutations in essential genes. The purpose of this study was to identify protein expression associated with prognosis in lung cancers stratified by smoking status, molecular subtypes, and EGFR-, TP53-, and KRAS-mutations.<p> <p><i>Methods</i>: We performed ...
  • NADPH oxidase 2 mediates myocardial oxygen wasting in obesity 

    Hafstad, Anne Dragøy; Hansen, Synne Simonsen; Lund, Jim; Santos, Celio X.C.; Boardman, Neoma Tove; Shah, Ajay M.; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-19)
    Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO<sub>2</sub>) and impaired cardiac efficiency. Although the pathophysiology of this cardiomyopathy is multifactorial and complex, reactive oxygen species (ROS) may play an important role. One of the ...
  • Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution 

    Alakunle, Emmanuel; Moens, Ugo; Nchinda, Godwin; Okeke, Malachy Ifeanyi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-05)
    Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is a member of orthopoxvirus genus. The reemergence of MPXV in 2017 (at Bayelsa state) after 39 years of no reported case in Nigeria, and the export of travelers’ monkeypox (MPX) from Nigeria to other parts of the world, in 2018 and 2019, respectively, have raised concern that MPXV may have emerged to occupy the ecological and ...
  • Data on RT-qPCR assay of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) from human uterine endometrial tissue and cancer cells of the uterine cervix 

    Smaglyukova, Natalia; Sletten, Elise Thoresen; Ørbo, Anne; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-25)
    A previous investigation showed that the endometrium normalized in women with endometrial hyperplasia after three months treatment with high dose levonorgestrel IUS (intrauterine system). The effect was maintained even if immunohistochemical analyses of the endometrium showed that nuclear progesterone receptors (nPRs) were completely downregulated. These observations indicated that some type of ...
  • Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease 

    Mercado, Nicolas; Colley, Thomas; Baker, Jonathan R.; Vuppussetty, Chaitanya; Kono, Yuta; Clarke, Colin; Tooze, Sharon A; Johansen, Terje; Barnes, Peter J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
    Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD, in which oxidative stress‐induced misfolded proteins accumulate into toxic aggregates dependent on the accumulation of the autophagic cargo receptor p62. Defective ...
  • From Differential Stains to Next Generation Physiology: Chemical Probes to Visualize Bacterial Cell Structure and Physiology 

    Hira, Jonathan; Uddin, Md Jalal; Haugland, Marius Myreng; Lentz, Christian Stephan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-26)
    Chemical probes have been instrumental in microbiology since its birth as a discipline in the 19th century when chemical dyes were used to visualize structural features of bacterial cells for the first time. In this review article we will illustrate the evolving design of chemical probes in modern chemical biology and their diverse applications in bacterial imaging and phenotypic analysis. We will ...
  • Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival 

    Beretta, Matteo; Santos, Celio X.C.; Molenaar, Chris; Hafstad, Anne Dragøy; Miller, Chris CJ; Revazian, Aram; Betteridge, Kai; Schröder, Katrin; Streckfuß-Bömeke, Katrin; Doroshow, James H; Fleck, Roland A; Su, Tsung-Ping; Belousov, Vsevelod; Parsons, Maddy; Shah, Ajay M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-10)
    Cells subjected to environmental stresses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent triggering of the mitochondrial permeability transition (mPT), which is especially important in post‐mitotic cells such as cardiomyocytes and neurons. Here, we show that stress‐induced ...
  • The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell 

    Hunt, Nicholas J; Lockwood, Glen P; Kang, Sun; Pulpitel, Tamara; Clark, Ximonie; Mao, Hong; McCourt, Peter Anthony; Cooney, Greg; Wali, Jibran; Le Couteur, Frank; Le Couteur, David G; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-14)
    Age-related changes in the liver sinusoidal endothelium, particularly the reduction in fenestrations, contribute to insulin resistance in old age. Metformin impacts on the aging process and improves insulin resistance. Therefore, the effects of metformin on the liver sinusoidal endothelium were studied. Metformin increased fenestrations in liver sinusoidal endothelial cells isolated from both young ...
  • Olaparib monotherapy as primary treatment in unselected triple negative breast cancer 

    Eikesdal, Hans Petter; Yndestad, Synnøve; Elzawahry, Asmaa; Llop-Guevara, Alba; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Vagstad, Geirfinn; Venizelos, Andreas; Minsaas, Laura; Leirvaag, Beryl; Gudlaugsson, Einar; Vintermyr, Olav Karsten; Aase, Hildegunn Siv; Aas, Turid; Balmaña, Judith; Serra, Violeta; Janssen, Emiel; Knappskog, Stian; Lønning, Per Eystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-23)
    <p><i>Background - </i>The antitumor efficacy of PARP inhibitors (PARPi) for breast cancer patients harboring germline BRCA1/2 (gBRCA1/2) mutations is well established. While PARPi monotherapy was ineffective in patients with metastatic triple negative breast cancer (TNBC) wild type for BRCA1/2, we hypothesized that PARPi may be effective in primary TNBCs without previous chemotherapy exposure. < ...
  • Alternative vanHAX promoters and increased vanA-plasmid copy number resurrect silenced glycopeptide resistance in Enterococcus faecium 

    Wagner, Theresa; Janice, Jessin; Sivertsen, Audun; Sjögren, Ingegerd; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-26)
    <i>Background</i> - Vancomycin variable enterococci (VVE) are <i>van</i>-positive isolates with a susceptible phenotype that can convert to a resistant phenotype during vancomycin selection.<p> <p><i>Objectives</i> - To describe a vancomycin-susceptible <i>vanA</i>-PCR positive ST203 VVE <i>Enterococcus faecium</i> isolate (VVE<i>Swe</i>-S) from a liver transplantation patient in Sweden which ...
  • Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer 

    Dawadi, Rangita; Malla, Nabin; Hegge, Beate; Wushur, Imin; Berg, Eli; Svineng, Gunbjørg; Sylte, Ingebrigt; Winberg, Jan-Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-12)
    Previous studies have shown that THP-1 cells produced an SDS-stable and reduction-sensitive complex between proMMP-9 and a chondroitin sulfate proteoglycan (CSPG) core protein. The complex could be reconstituted in vitro using purified serglycin (SG) and proMMP-9 and contained no inter-disulfide bridges. It was suggested that the complex involved both the FnII module and HPX domain of proMMP-9. The ...
  • Shotgun-Metagenomics on Positive Blood Culture Bottles Inoculated With Prosthetic Joint Tissue: A Proof of Concept Study 

    Sanabria-Moreno, Adriana Maria; Hjerde, Erik; Johannessen, Mona; Sollid, Johanna U Ericson; Simonsen, Gunnar Skov; Hanssen, Anne Merethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-17)
    Clinical metagenomics is actively moving from research to clinical laboratories. It has the potential to change the microbial diagnosis of infectious diseases, especially when detection and identification of pathogens can be challenging, such as in prosthetic joint infection (PJI). The application of metagenomic sequencing to periprosthetic joint tissue (PJT) specimens is often challenged by low ...
  • Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila 

    Jacomin, Anne-Claire; Petridi, Stavroula; Di Monaco, Marisa; Bhujabal, Zambarlal; Jain, Ashish; Mulakkal, Nitha C.; Palara, Anthimi; Powell, Emma L.; Chung, Bonita; Zampronio, Cleidiane; Jones, Alexandra; Cameron, Alexander; Johansen, Terje; Nezis, Ioannis P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-26)
    Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3. Despite growing evidence that LC3 is enriched in the nucleus, its nuclear role is poorly understood. Here, we show that <i>Drosophila</i> Atg8a protein, homologous to mammalian LC3, interacts with the transcription factor Sequoia in a LIR motif-dependent ...
  • Structural Analysis of Merkel Cell Polyomavirus (MCPyV) Viral Capsid Protein (VP1) in HIV-1 Infected Individuals 

    Prezioso, Carla; Bianchi, Martina; Obregon, Francisco; Ciotti, Marco; Sarmati, Loredana; Andreoni, Massimo; Palamara, Anna Teresa; Pascarella, Stefano; Moens, Ugo; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-27)
    Merkel cell polyomavirus (MCPyV) viral protein 1 (VP1) is the capsid protein that mediates virus attachment to host cell receptors and is the major immune target. Given the limited data on MCPyV VP1 mutations, the VP1 genetic variability was examined in 100 plasma and 100 urine samples from 100 HIV+ individuals. Sequencing of VP1 DNA in 17 urine and 17 plasma specimens, simultaneously MCPyV DNA ...
  • Resistance to ventricular fibrillation predicted by the QRS/QTc - ratio in an intact rat model of hypothermia/rewarming 

    Dietrichs, Erik Sveberg; Selli, Anders Lund; Kondratiev, Timofei; McGlynn, Karen; Smith, Godfrey L; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-04)
    Accidental hypothermia is associated with increased risk for arrhythmias. QRS/QTc is proposed as an ECG-marker, where decreasing values predict hypothermia-induced ventricular arrhythmias. If reliable it should also predict nonappearance of arrhythmias, observed in species like rat that regularly tolerate prolonged hypothermia.<p> <p>A rat model designed for studying cardiovascular function during ...
  • Strategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopenia 

    Kjær, Mette; Geisen, Christof; Akkøk, Cigdem Ahaein; Wikman, Agneta; Sachs, Ulrich; Bussel, James B.; Nielsen, Kaspar; Walles, Katarina; Curtis, Brian R.; Vidarsson, Gestur; Järås, Kerstin; Skogen, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-31)
    Anti-HPA-1a-antibodies are the main cause of fetal and neonatal alloimmune thrombocytopenia (FNAIT) which may result in intracranial hemorrhage (ICH) and death among fetuses and newborns. Advances in understanding the pathogenesis of FNAIT and proof of concept for prophylaxis to prevent immunization suggest that development of hyperimmune anti-HPA-1a IgG aimed at preventing immunization against ...
  • Antibiotic sensitivity screening of Klebsiella spp. and Raoultella spp. isolated from marine bivalve molluscs reveal presence of CTX-M-producing K. pneumoniae 

    Håkonsholm, Fredrik; Hetland, Marit A.K.; Svanevik, Cecilie Smith; Sundsfjord, Arnfinn; Lunestad, Bjørn Tore; Marathe, Nachiket (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-30)
    <i>Klebsiella</i> spp. are a major cause of both nosocomial and community acquired infections, with <i>K. pneumoniae</i> being responsible for most human infections. Although <i>Klebsiella</i> spp. are present in a variety of environments, their distribution in the sea and the associated antibiotic resistance is largely unknown. In order to examine prevalence of <i>K. pneumoniae</i> and related ...
  • Modulation of Plasma Membrane Composition and Microdomain Organization Impairs Heat Shock Protein Expression in B16-F10 Mouse Melanoma Cells 

    Crul, Tim; Csoboz, Balint; Gombos, Imre; Marton, Annamaria; Peter, Maria; Balogh, Gabor; Vizler, Csaba; Szente, Lajos; Vigh, Laszlo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-12)
    The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes in its microdomain organization. PM microdomains such as lipid rafts, dynamic nanoscale assemblies enriched in cholesterol and sphingomyelin, and ...

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