Recent additions

  • Prognostic biomarkers for immunotherapy with ipilimumab in metastatic melanoma 

    Nyakas, Marta Sølvi; Aamdal, Elin; Jacobsen, Kari Dolven; Guren, Tormod Kyrre; Aamdal, Steinar; Hagene, Kirsten Thorin; Brunsvig, Paal Fr.; Yndestad, Arne; Halvorsen, Bente; Tasken, Kristin Austlid; Aukrust, Pål; Mælandsmo, Gunhild Mari; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-01)
    New therapies, including the anti‐cytotoxic T lymphocyte antigen (CTLA)‐4 antibody, ipilimumab, is approved for metastatic melanoma. Prognostic biomarkers need to be identified, because the treatment has serious side effects. Serum samples were obtained before and during treatment from 56 patients with metastatic or unresectable malignant melanoma, receiving treatment with ipilimumab in a national ...
  • Novel targets for delaying aging: The importance of the liver and advances in drug delivery 

    Hunt, Nicholas J; McCourt, Peter Anthony; Le Couteur, David George; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2018-09-21)
    Age-related changes in liver function have a significant impact on systemic aging and susceptibility to age-related diseases. Nutrient sensing pathways have emerged as important targets for the development of drugs that delay aging and the onset age-related diseases. This supports a central role for the hepatic regulation of metabolism in the association between nutrition and aging. Recently, a role ...
  • In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds 

    Evenseth, Linn; Warszycki, Dawid; Bojarski, Andrzej J; Gabrielsen, Mari; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-07)
    The GABA<sub>B</sub> receptor (GABA<sub>B</sub>-R) is a heterodimeric class C G protein-coupled receptor comprised of the GABA<sub>B1a/b</sub> and GABA<sub>B2</sub> subunits. The endogenous orthosteric agonist γ-amino-butyric acid (GABA) binds within the extracellular Venus flytrap (VFT) domain of the GABA<sub>B1a/b</sub> subunit. The receptor is associated with numerous neurological and ...
  • A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases 

    Flørenes, Vivi Ann; Flem-Karlsen, Karine; McFadden, Erin; Bergheim, Inger Riise; Nygaard, Vigdis; Nygård, Vegard Mokleiv; Farstad, Inger Nina; Øy, Geir Frode; Emilsen, Elisabeth; Fleten, Karianne Giller; Ree, Anne Hansen; Flatmark, Kjersti; Gullestad, Hans Petter; Hermann, Robert; Ryder, Truls; Wernhoff, Patrik; Mælandsmo, Gunhild Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-13)
    Although clinical management of melanoma has changed considerably in recent years, intrinsic treatment resistance remains a severe problem and strategies to design personal treatment regimens are highly warranted. We have applied a three-dimensional (3D) <i>ex vivo</i> drug efficacy assay, exposing disaggregated cells from 38 freshly harvested melanoma lymph node metastases and 21 patient derived ...
  • Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling 

    Fjelldal, Marthe Fredheim; Freyd, Thibaud; Evenseth, Linn; Sylte, Ingebrigt; Ring, Avi; Paulsen, Ragnhild Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-30)
    N‐methyl‐d‐aspartate receptors (NMDAR) are widely expressed in the brain. GluN2B subunit‐containing NMDARs has recently attracted significant attention as potential pharmacological targets, with emphasis on the functional properties of allosteric antagonists. We used primary cultures from chicken embryo forebrain (E10), expressing native GluN2B‐containing NMDA receptors as a novel model system. ...
  • MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer 

    Richardsen, Elin; Andersen, Sigve; Melbø-Jørgensen, Christian; Rakaee, Mehrdad; Ness, Nora; Al-Saad, Samer; Nordby, Yngve; Pedersen, Mona Irene; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-23)
    A large number of miRNAs influence key cellular processes involved in prostate tumorigenesis. Previous studies have demonstrated high expression of miRNAs in human prostate cancer (PC) tissues and cell lines. In previous microarray data, we found miR-141 to be upregulated and miR-145 to be downregulated in PC. In this large PC cohort (n = 535), we explored the prognostic role of miR-141 and miR-145 ...
  • Ocean acidification at a coastal CO2 vent induces expression of stress-related transcripts and transposable elements in the sea anemone Anemonia viridis 

    Urbarova, Ilona; Forêt, Sylvain; Dahl, Mikael Per; Emblem, Åse E.; Milazzo, Marco; Hall-Spencer, Jason M.; Johansen, Steinar Daae (Journal article; Peer reviewed, 2019-05-08)
    Ocean acidification threatens to disrupt interactions between organisms throughout marine ecosystems. The diversity of reef-building organisms decreases as seawater CO2 increases along natural gradients, yet soft-bodied animals, such as sea anemones, are often resilient. We sequenced the polyA-enriched transcriptome of adult sea anemone Anemonia viridis and its dinoflagellate symbiont sampled along ...
  • The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response 

    Lellahi, Seyed Mohammad; Rosenlund, Ingrid Arctander; Hedberg, Annica; Kiær, Liv Torill; Mikkola, Ingvild; Knutsen, Erik; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-10)
    The long noncoding RNA (lncRNA) <i>NEAT1</i> (nuclear enriched abundant transcript 1) is the architectural component of nuclear paraspeckles, and it has recently gained considerable attention as it is abnormally expressed in pathological conditions such as cancer and neurodegenerative diseases. <i>NEAT1</i> and paraspeckle formation are increased in cells upon exposure to a variety of environmental ...
  • Screening for hepatitis C in a general adult population in a low-prevalence area: the Tromsø study 

    Kileng, Hege; Gutteberg, Tore Jarl; Goll, Rasmus; Paulssen, Eyvind Jakob (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)
    <i>Background - </i>Chronic hepatitis C virus (HCV) infection can progress to cirrhosis and end-stage liver disease in a substantial proportion of patients. The infection is frequently asymptomatic, leaving many infected individuals unaware of the diagnosis until complications occur. This advocates the screening of healthy individuals. The aim of this study was to estimate the prevalence of HCV ...
  • Modulation of dendritic cells phenotype and functions by irradiated and non-irradiated lung cancer fibroblasts. An in vitro study. 

    Tornaas, Stian (Master thesis; Mastergradsoppgave, 2019-05-15)
    Stromal cells in the tumor microenvironment (TME) interacts with cancer cells and affect their behavior in diverse manners. In this study, we investigated in vitro the mechanisms by which non-irradiated and irradiated cancer-associated fibroblasts (CAFs) isolated from patients with non-small cell lung carcinoma (NSCLC) affected the phenotype and function of monocyte-derived dendritic cells (Mo-DCs) ...
  • Exploring the in vitro expansion of CD4 T cells. For improved culturing of CD4 T cells linked to FNAIT 

    Hofsten, Susannah von (Master thesis; Mastergradsoppgave, 2018-05-15)
    Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare disease that may cause serious bleedings in the fetus or neonate of a woman who has developed antibodies against the fetus’ platelets. Development of FNAIT has been linked to the presence of platelet reactive CD4 T cells that help B cells to develop into antibody producing plasma cells. To be able to conduct research on such T cells, ...
  • Identification of protein interaction candidates for the GOLD domain of FYCO1 

    Furulund, Betty Martine Normann (Master thesis; Mastergradsoppgave, 2016-05-27)
    Autophagy is an evolutionary conserved degradative pathway, where damaged or surplus cytosolic components are sequestered into double membrane vesicles, autophagosomes, which become degraded through the lysosomal system. The autophagy is a dynamic process, which is depended of transport of autophagosomes along microtubule, to become degraded by lysosomes. One of the proteins involved in this transport ...
  • Forensic DNA genotyping by means of next generation sequencing. Analysis of Autosomal STRs of a Norwegian population sample using the ForenSeq FGx system 

    Buadu, Sandra (Master thesis; Mastergradsoppgave, 2018-05-15)
    Population databases containing allele frequencies of the genetic markers used for DNA-profiling are necessary for forensic geneticist to be able to perform statistical calculations on the statistical weight of DNA-evidence. However, allele frequencies differ from population to population, it is therefore important to establish population databases for specific graphical areas or population groups. ...
  • The Immunostimulatory Potential of Mesenchymal Stem Cells for formation of Tertiary Lymphoid Structures in Lupus Nephritis 

    Hovd, Aud-Malin Karlsson (Master thesis; Mastergradsoppgave, 2017-05-15)
    Formation of tertiary lymphoid structures (TLS) occurs in tissues targeted by chronic inflammatory processes, such as infection and autoimmunity. In systemic lupus erythematosus (SLE), TLS have been observed in the kidneys of lupus-prone mice and in kidney biopsies of SLE patients with Lupus Nephritis (LN). Here the role of tissue-specific mesenchymal stem cells (MSCs) as lymphoid tissue organizer ...
  • The population structure of human carriage and clinical isolates of ESBL-producing Escherichia coli and Klebsiella pneumoniae in Norway 

    Andreassen, Lotte (Master thesis; Mastergradsoppgave, 2017-05-15)
    The increasing emergence of antimicrobial resistant bacteria worldwide is recognised as a severe threat to public health on a global scale. Without effective antimicrobial agents to treat bacterial infections, modern medicine will be set back several decades and deaths caused by bacterial infections will increase. The most widely used class of antimicrobials, is -lactams, and the increase in resistance ...
  • Computational study of SERT using new X-ray crystal structures and initial experimental verification of potential GABAB receptor compounds 

    Godtliebsen, Gustav (Master thesis; Mastergradsoppgave, 2018-05-15)
    Depression is currently one of the leading causes worldwide of suicide and disability, the most common treatment is antidepressants. Most antidepressants work by increasing the monoamine levels in the central nervous system by inhibition of the reuptake of monoamines into the presynaptic neuron, and thereby ensure accumulation of the monoamines in the synaptic cleft. The main target for most ...
  • O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes 

    Barkovskaya, Anna; Seip, Kotryna; Hilmarsdòttir, Bylgja; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas; Itkonen, Harri (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-05)
    Post-translational modifcation of intracellular proteins with a single N-acetylglucosamine sugar (O-GlcNAcylation) regulates signaling, proliferation, metabolism and protein stability. In breast cancer, expression of the enzyme that catalyzes O-GlcNAcylation – O-GlcNAc-transferase (OGT), and the extent of protein O-GlcNAcylation, are upregulated in tumor tissue, and correlate with cancer progression. ...
  • Discordance, Disclosure and Normative Gender Roles: Barriers to Couple Testing Within a Community-Level HIV Self-Testing Intervention in Urban Blantyre, Malawi 

    Kumwenda, Moses Kelly; Corbett, Elizabeth Lucy; Chikovore, Jeremiah; Phiri, Mackwellings; Mwale, Daniel; Choko, Augustine Talumba; Nliwasa, Marriot; Sambakunsi, Rodrick; Taegtmeyer, Miriam; Gutteberg, Tore Jarl; Munthali, Alister; Desmond, Nicola (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-06)
    A community-based HIV self-testing study in Blantyre, Malawi demonstrated that not all individuals living in couples tested with their partner. We describe factors dissuading individuals in couples from self-testing with their partner. Data were drawn from qualitative study exploring consequences of HIV self-testing within couples. In-depth interviews were conducted with 33 individuals living in ...
  • Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: towards a common nomenclature 

    Bender, Jennifer; Cattoir, Vincent; Hegstad, Kristin; Sadowy, Eva; Coque, Teresa M.; Westh, Henrik; Hammerum, Anette M.; Schaffer, Kirsten; Burns, Karen; Murchan, Stephen; Novais, Carla; Freitas, Ana R.; Peixe, Luísa; Del Grosso, Maria; Pantosti, Annalisa; Werner, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-02)
    Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and ...
  • Risk perception, beliefs about medicines and medical adherence among pregnant and breastfeeding women with migraine: findings from a cross-sectional study in Norway 

    Amundsen, Siri; Øvrebø, Torunn Gudmestad; Amble, Netta Marie Skretteberg; Poole, Anne Christine; Nordeng, Hedvig Marie Egeland (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-27)
    <i>Objectives</i>: To examine risk perception, beliefs about migraine medications and medical adherence among pregnant and breastfeeding women with migraine.<p> <p><i>Design and setting</i>: Cross-sectional study conducted in Norway from October 2013 to February 2014. Data were collected via an anonymous, electronic questionnaire.<p> <p><i>Participants</i>: Women with migraine, either ...

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