Recent additions

  • Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: a case report 

    Jebsen, Nina Louise; Apelseth, Torunn Oveland; Haugland, Hans Kristian; Rekdal, Øystein; Patel, Hamina; Gjertsen, Bjørn Tore; Jøssang, Dag Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-10)
    <p><i>Background - </i>Desmoid tumors are intermediary malignant, fibrous lesions occurring in various soft tissues. Surgical treatment is relentlessly challenging because of the propensity for local aggressive behavior and high risk of recurrence. Consequently, a wide range of oncological drugs and radiation therapy are being used; however, outcomes are unpredictable. We investigated whether local ...
  • Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 

    Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
    <p><i>Introduction - </i>Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currently undergoing clinical trials in several human malignancies, including triple-negative breast cancer ...
  • Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model 

    Camilio, Ketil Andre; Wang, Meng-Yu; Mauseth, Brynjar; Waagene, Stein; Kvalheim, Gunnar; Rekdal, Øystein; Sveinbjørnsson, Baldur; Mælandsmo, Gunhild M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
    <i>Background</i> - Immunochemotherapy, the combined use of immunotherapy and chemotherapy, has demonstrated great promise in several cancers. LTX-315 is an oncolytic peptide with potent immunomodulatory properties designed for the local treatment of solid tumors. By inducing rapid immunogenic cell death through the release of danger-associated molecular pattern molecules (DAMPs), LTX-315 is capable ...
  • p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance 

    Flem-Karlsen, Karine; Tekle, Christina; Øyjord, Tove Ragnhild; Flørenes, Vivi Ann; Mælandsmo, Gunhild Mari; Fodstad, Øystein; Nunes-Xavier, Caroline Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-09)
    Immunoregulatory protein B7-H3 is involved in the oncogenic and metastatic potential of cancer cells, as well as in drug resistance. Resistance to conventional chemotherapy is an important aspect of melanoma treatment, and a better understanding of how B7-H3 enhances drug resistance may lead to the development of more effective therapies. We investigated the <i>in vitro</i> and <i>in vivo</i> ...
  • Circulating tumor cell-derived pre-clinical models for personalized medicine 

    Tellez Gabriel, Marta; Cochonneau, Denis; Jubelin, Camille; Heymann, Marie-Françoise; Heymann, Dominique (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-24)
    The main cause of death from cancer is associated with the development of metastases, resulting from the inability of current therapies to cure patients at metastatic stages. Generating preclinical models to better characterize the evolution of the disease is thus of utmost importance, in order to implement effective new cancer biomarkers and therapies. Circulating Tumor Cells (CTCs) are good ...
  • Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche 

    Cuminetti, Vincent; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-18)
    Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differentiation of BM mesenchymal stromal cells, but they seem to be a heterogeneous population with distinct metabolisms, lipid compositions, secretory properties and ...
  • Chlamydia pecorum associated with an outbreak of infectious keratoconjunctivitis in semi-domesticated reindeer in Sweden 

    Sanchez Romano, Javier; Leijon, Mikael; Hagström, Åsa; Jinnerot, Tomas; Rockström, Urlika; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-05)
    Infectious keratoconjunctivitis (IKC), the most common ocular disease in ruminants worldwide, has affected semi-domesticated Eurasian reindeer (<i>Rangifer tarandus tarandus</i>) for over 100 years, both as individual cases and in outbreaks affecting tens to hundreds of animals. Recurrent IKC outbreaks have been affecting a semi-domesticated reindeer herd in Östra Kikkejaure (Norrbotten county, ...
  • 3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice 

    Boardman, Neoma Tove; Rossvoll, Line; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-02)
    Physical activity is an efficient strategy to delay development of obesity and insulin resistance, and thus the progression of obesity/diabetes-related cardiomyopathy. In support of this, experimental studies using animal models of obesity show that chronic exercise prevents the development of obesity-induced cardiac dysfunction (cardiomyopathy). Whether exercise also improves the tolerance to ...
  • The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS 

    Hoem, Gry; Larsen, Kenneth Bowitz; Øvervatn, Aud Karin; Brech, Andreas; Lamark, Trond; Sjøttem, Eva; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-28)
    Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a CGG-repeat expansion in the 5′ UTR of the FMR1 gene on the X-chromosome. Both elevated levels of the expanded FMR1 mRNA and aberrant expression of a polyglycine protein (FMRpolyG) from the CGG-repeat region are hypothesized to trigger the pathogenesis of FXTAS. While increased expression of FMRpolyG leads ...
  • Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer 

    Richardsen, Elin; Andersen, Sigve; Al-Saad, Samer; Rakaee, Mehrdad; Nordby, Yngve; Pedersen, Mona Irene; Ness, Nora; Ingebriktsen, Lise; Fassina, Ambrogio; Tasken, Kristin Austlid; Millls, Ian; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-23)
    Prostate cancer (PC) is a highly heterogenous disease and one of the leading causes of mortality in developed countries. Recently, studies have shown that expression of immune checkpoint proteins are directly or indirectly repressed by microRNAs (miRs) in many types of cancers. The great advantages of using miRs based therapy is the capacity of these short transcripts to target multiple molecules ...
  • Prognostic Value of Macrophage Phenotypes in Resectable Non–Small Cell Lung Cancer Assessed by Multiplex Immunohistochemistry 

    Rakaee, Mehrdad; Busund, Lill-Tove; Jamaly, Simin; Paulsen, Erna-Elise; Richardsen, Elin; Andersen, Sigve; Al-Saad, Samer; Bremnes, Roy M.; Dønnem, Tom; Kilvær, Thomas Karsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-10)
    Macrophages are important inflammatory cells that regulate innate and adaptive immunity in cancer. Tumor-associated macrophages (TAMs) are thought to differentiate into two main phenotypes: proinflammatory M1 and protumorigenic M2. Currently, the prognostic impact of TAMs and their M1 and M2 phenotypes is unclear in non–small cell cancer (NSCLC). The present study was set up to evaluate an approach ...
  • The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma 

    Mauseth, Brynjar; Camilio, Ketil Andre; Shi, Jihua; Hammarström, Clara Louise; Rekdal, Øystein; Sveinbjørnsson, Baldur; Line, Pål Dag (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-21)
    LTX-401 is a novel oncolytic compound designed for the local treatment of solid tumors. In the present study, we have examined the applicability and efficacy of LTX-401 in a rat model JM1 hepatocellular carcinoma, with particular interest in its ability to induce antitumor immunity. LTX-401 induces necrotic cell death followed by the release of immunogenic cell death mediators such as high-mobility ...
  • Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms 

    Olsvik, Pål Asgeir; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Yadetie, Fekadu; Sanden, Monica; Kristensen, Torstein (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
    Screening has revealed that modern-day feeds used in Atlantic salmon aquaculture might contain trace amounts of agricultural pesticides. To reach slaughter size, salmon are produced in open net pens in the sea. Uneaten feed pellets and undigested feces deposited beneath the net pens represent a source of contamination for marine organisms. To examine the impacts of long-term and continuous dietary ...
  • Post-test adverse psychological effects and coping mechanisms amongst HIV self-tested individuals living in couples in urban Blantyre, Malawi 

    Kumwenda, Moses Kelly; Corbett, Elizabeth Lucy; Choko, Augustine Talumba; Chikovore, Jeremiah; Kaswaswa, Kruger; Mwapasa, Mphatso; Sambakunsi, Rodrick; Gutteberg, Tore Jarl; Gordon, Stephen; Munthali, Alister; Desmond, Nicola (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-12)
    <i>Introduction</i> - Mandatory face-to-face counselling is necessary during HIV testing but difficult to implement within the context of HIV self-testing. We investigated adverse psychological effects and coping mechanisms following HIV-positive and HIV-discordant test results amongst self-tested individuals living in couples in urban Blantyre, Malawi.<p> <p><i>Methods</i> - Qualitative data ...
  • Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets 

    Mao, Hong; Diekmann, Robin; Liang, Hai; Cogger, Victoria Carroll; Le Couteur, David George; Lockwood, Glen P; Hunt, Nick; Schuttpelz, Mark; Huser, Thomas Rolf; Chen, Vivien; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-09)
    Single-molecule localization microscopy (SMLM) provides a powerful toolkit to specifically resolve intracellular structures on the nanometer scale, even approaching resolution classically reserved for electron microscopy (EM). Although instruments for SMLM are technically simple to implement, researchers tend to stick to commercial microscopes for SMLM implementations. Here we report the construction ...
  • The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006-2017 

    Elstrøm, Petter; Astrup, Elisabeth; Hegstad, Kristin; Samuelsen, Ørjan; Enger, Hege; Kacelnik, Oliver (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-04)
    <p><i>Introduction - </i>Scandinavian countries have traditionally had a low prevalence of resistant organisms, but have in recent years experienced a change in their epidemiology. We aim to describe the epidemiology of carbapenemase-producing organisms (CPOs), vancomycin-resistant enterococci (VRE) and methicillin-resistant <i>S. aureus</i> (MRSA) in Norway, measure the importance of infections ...
  • Giant group I intron in a mitochondrial genome is removed by RNA back-splicing 

    Chi, Sylvia Ighem; Dahl, Mikael; Emblem, Åse; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)
    <p><i>Background - </i>The mitochondrial genomes of mushroom corals (Corallimorpharia) are remarkable for harboring two complex group I introns; ND5-717 and COI-884. How these autocatalytic RNA elements interfere with mitochondrial RNA processing is currently not known. Here, we report experimental support for unconventional processing events of ND5-717 containing RNA. <p><i>Results - </i>We obtained ...
  • Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways 

    Moens, Ugo; Macdonald, Andrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-12)
    Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the ...
  • In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding 

    Evenseth, Linn M.; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-04)
    Molting is an essential process in the life cycle of arthropods and is regulated by complex neuroendocrine pathways where activation of the ecdysone receptor (EcR) plays a major role. The EcR forms a non-covalent heterodimer with the ultraspiracle protein (USP) when activated by endogenous ecdysteroids, but can also be activated by several insecticides and other environmental chemicals. Environmental ...
  • Culturing periprosthetic tissue in BacT/Alert® Virtuo blood culture system leads to improved and faster detection of prosthetic joint infections 

    Sanabria-Moreno, Adriana Maria; Røkeberg, Merethe E.O.; Johannessen, Mona; Sollid, Johanna U Ericson; Simonsen, Gunnar Skov; Hanssen, Anne Merethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-10)
    <i>Background</i> - Blood culture bottles (BCBs) provide a semiautomated method for culturing periprosthetic tissue specimens. A study evaluating BCBs for culturing clinical samples other than body fluids is needed before implementation into clinical practice. Our objective was to evaluate use of the BacT/Alert® Virtuo blood culture system for culturing periprosthetic tissue specimens. <p> ...

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