Recent additions

  • Establishment of an advanced flow cytometry protocol for analyzing immune cell subsets from lung cancer patients 

    Beyene, Sweet Yibio (Mastergradsoppgave; Master thesis, 2022-08-22)
    Lymphocytes are known for their role in tumor promotion and tumor suppression. T cell infiltration of the tumor microenvironment has been linked to a better prognosis and outcome in various malignancies. CD8+ T cells can eliminate cancer cells by causing them to lyse, while CD4+ T cells can be both tumor promoting and tumor suppressing. However, the prognostic impact of functional lymphocyte subtypes ...
  • The human polyomavirus KI: A study on cell permissivity, sub-cellular localization of VP1 and presence in cerebrospinal fluid and urine 

    Ludvigsen, Maria A. (Master thesis; Mastergradsoppgave, 2011-11-17)
    KI polyomavirus (KIPyV) is a relatively newly discovered human polyomavirus originally identified in respiratory tract samples. Little is known about the route of infection or transmission, and the pathogenic properties of this virus are virtually unknown. The life cycle of KIPyV has not been studied as a permissive cell system has not been identified so far. The bona fide sites of viral replication ...
  • Non-Invasive Methods for Detection of Genetic Abnormalities in Human Embryos Cell-Free DNA Secreted from Human Embryos as an Alternative to DNA from Cell Biopsies for Genetic Analyses 

    Finanger, Viktoria Emeline Swaty (Mastergradsoppgave; Master thesis, 2022-05-15)
    Chromosomal abnormalities are one of the main causes of implantation failure following embryo transfer in in vitro fertilization (IVF). Preimplantation genetic testing for aneuploidies (PGT-A) is time-consuming, expensive, and invasive. Non-invasive PGT-A (niPGT-A) is an alternative where secreted embryonic cell-free DNA (cfDNA) in spent culture medium (SCM) is investigated. This study aimed to ...
  • Evaluation of the performance of two prediction models, the IrisPlex and the novel EC12 model, for eye colour predictions in a Norwegian population. 

    Kjersem, Marianne (Mastergradsoppgave; Master thesis, 2020-06-12)
    Biological material obtained from a crime scene is used to generate DNA-profile by typing short tandem repeat (STR) markers. However, if the STR-profile do not match the DNA profile of suspects or from a crime DNA database, the investigation can go towards typing markers that can estimate externally visible characteristics (EVCs). EVCs can function as a “biological witness” and thus aid a police ...
  • Analysis of 30 Y-chromosomal STR markers in the Norwegian population 

    Støtvig, Ingrid (Mastergradsoppgave; Master thesis, 2019-05-15)
    Autosomal STR-analysis is the standard method of DNA-typing in casework. However, there are forensic sample types that may contain a large fraction of female DNA and a minimal fraction of male DNA. The male fraction may not be successfully amplified using autosomal STR-analysis because it “drowns” in the female fraction. However, the analysis of male-specific YSTR markers may circumvent this obstacle. ...
  • The prognostic significance of miR-17-5p and miR-20a-5p in prostate cancer 

    Ingebriktsen, Lise Martine (Mastergradsoppgave; Master thesis, 2019-05-15)
    Prostate cancer accounts for extensive mortality and is the second most frequent cancer type occurring in men, acknowledged as a severe health problem globally. In Norway, Prostate cancer is the most common form of cancer in men, and around 5.000 patients are diagnosed each year. Using in situ hybridization, we examined the in situ tissue distribution of miR-17-5p and miR-20a-5p in prostate cancer ...
  • Characterization of commensal enterococcal membrane vesicles and their cytotoxic effect on various host cells 

    Bhandari, Ishan (Mastergradsoppgave; Master thesis, 2020-05-14)
    Enterococcus are a group of bacteria growing on different environmental condition behaving as a commensal as well as opportunistic pathogen. Among the enterococci, Enterococcus faecium is recently emerged as a nosocomial multi-resistance pathogen especially in the severely ill and immunocompromised patients causing a wide range of diseases like endocarditis, bacteraemia and urinary tract infections. ...
  • Expression and characterization of recombinant murine integrin β3 modified to express the human platelet antigen-1a epitope 

    Rasmussen, Trude Victoria (Mastergradsoppgave; Master thesis, 2017-05-14)
    Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a condition where the mother produces alloantibodies against fetal platelets during pregnancy most commonly due to an incompatibility in the human platelet antigen (HPA)-1 system; a single amino acid polymorphism located on integrin β3 with two common variants, HPA-1a and HPA-1b. Antibody responses against HPA-1a can be formed in women who ...
  • Optimization of biomarkers for morphological analysis of healthy and preeclamptic term human placental tissue sections using advanced fluorescence microscopy methods 

    Nalliah, Maddhusja (Mastergradsoppgave; Master thesis, 2021-07-01)
    Preeclampsia (PE) is a pregnancy-related disorder affecting 5-8% of women worldwide (4% in Norway). It is believed that placental ischemia is the initial event in the development of PE and is characterized by placental insufficiency and clinical symptoms such as hypertension and proteinuria. In this project, we aimed to study suitable biomarkers for morphological analysis of human term placenta from ...
  • The Regulatory Relationship between E2F4 and MiRNA-363, and it’s Relevance to Oral Cancer 

    Assadi, Geed Alaa (Master thesis; Mastergradsoppgave, 2020-08-14)
    BACKGROUND Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer and persists a leading cause of cancer associated mortality and morbidity universally. Survival rate is still poor at less than 50% urging the need for biomarkers to allow better diagnosis, prognosis and therapeutic strategies. In this study we focus on E2F4, a repressor of cell cycle, and further propose ...
  • Optimization of the use of PrepFiler Express™ Forensic DNA extraction kit lysis buffer discard for mRNA profiling 

    Hamnevoll, Kari (Mastergradsoppgave; Master thesis, 2021-06-01)
    mRNA profiling for body fluid or tissue type identification is able to provide circumstantial information alongside DNA profiles from biological material found at a crime scene. To solve the challenge of material limitation in body fluid identification, studies have successfully developed mRNA profiles of RNA extracted from lysis buffer discard of DNA-extraction. It would be interesting to examine ...
  • High Palmitate Alters Glutathione Redox During Severe Oxidant Stress in the Heart; An Evaluation of Altered Glutathione Redox Environment on Cardiac Function and Mitochondrial Energetics. 

    Sepehrara, Ramin (Mastergradsoppgave; Master thesis, 2021-05-18)
    When the heart is under stress, e.g. ischemia-reperfusion (IR), it produces an enormous amount of reactive oxygen species (ROS). Glutathione, which is an endogenous antioxidant derived from the ‘nicotinamide adenine dinucleotide hydrogen’ (NADH) of the ‘tricarboxylic acid’ cycle, can fight against this oxidative stress to balance the redox environment, and convert the produced ROS to H2O. In this ...
  • A study on the interactions between perfluorosulfonic acids and P-glycoprotein 

    Voloshyna, Tetyana (Mastergradsoppgave; Master thesis, 2021-05-18)
    Perfluoroalkyl substances (PFAS) have received a great deal of attention due to the ubiquitous occurrence and persistence in the environment, resistance to degradation, and biological accumulation in wildlife and humans. PFAS are being detected around the globe, raising concerns regarding the toxicity and health risks to humans. Studies have shown that environmental toxicants, including PFAS, can ...
  • Investigation into the presence of CRISPR-Cas- and R-M systems in Klebsiella pneumoniae and correlation with antibiotic resistance, virulence and plasmids 

    Nilsen, Miriam Kristine (Master thesis; Mastergradsoppgave, 2020-06-05)
    The aims were to perform a bioinformatic-statistical analysis of CRISPR-Cas- and R-M systems in a diverse whole genome sequenced K. pneumoniae population, and their correlations to virulence score and AMR -/ plasmid content. The strains (n=999) consisted of Norwegian fecal carrier (n=484) and clinical (NORM; ESBL and non-ESBL producing) (n=414), and national-international clinical ST307 strains ...
  • ATAD3 proteins in autophagy. Do ATAD3 proteins have a direct role in regulating autophagy 

    Taboko, Nelsy Efundem (Master thesis; Mastergradsoppgave, 2020-05-22)
    ATPase Family AAA Domain -containing protein 3 (ATAD3) is a nuclear-encoded mitochondrial transmembrane protein encompassing three isoforms; ATAD3A, ATAD3B and ATAD3C. ATAD3 is involved in several cellular process and available data predict that ATAD3A and ATAD3B proteins may have potential roles in regulating autophagy and mitophagy. Preliminary data from our research group identified interactions ...
  • A study of TRIM32 self-ubiquitination 

    Khan, Waqas (Master thesis; Mastergradsoppgave, 2020-05-15)
    TRIMs (tripartite motif proteins) constitute a family of ubiquitin E3 ligases that are involved in a variety of cellular processes including autophagy and carcinogenesis. TRIM32 contains an N-terminal RING finger domain, B-box region, a coiled-coil domain and six NHL repeats in the C-terminal region, which are involved in protein dimerization and substrate recognitions. Various mutations in the NHL ...
  • Exploration of rabbit integrin β3 as a possible immune-tolerizing agent to prevent foetal and neonatal alloimmune thrombocytopenia. 

    van Ligtenberg, Lennart Maximilian (Mastergradsoppgave; Master thesis, 2020-08-07)
    Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease caused by the production of antibodies by the mother to the platelets of the foetus. The alloimmune response is caused by a P33L substitution in the Human Platelet Antigen-1a (HPA-1a) in a homo- or heterozygous HPA-1a foetus, in a homozygous HPA-1b+ mother. Maternal antibodies are produced by activated HPA-1a specific T-cells able ...
  • Molecular interaction studies of initial electrostatic attraction between trypsin and the human PAR-2 receptor 

    Kristoffersen, Tonje Håtveit (Master thesis; Mastergradsoppgave, 2020-01-16)
    Workers in livestock and fish cultivation are at increased risk of occupational airway damage caused by proteases. Proteases, such as trypsin, activate PAR-2 which in turn triggers an inflammatory response, potentially causing airway damage over time. There has been some speculation that PAR-2 receptors easier attract trypsin form species where this enzyme has a more negative electrostatic charge. ...
  • Regulation of urokinase receptor (uPAR) cleavage by cancer associated fibroblasts (CAFs) in oral cancer 

    Kitaw, Manyahilishal Etana (Master thesis; Mastergradsoppgave, 2019-05-15)
    Oral squamous cell carcinoma (OSCC) is one of the frequently diagnosed type of oral cancers and is a leading cause of cancer associated mortality and morbidity worldwide. Cancer associated fibroblasts (CAFs) are activated fibroblasts that are found in association with cancer cells. CAFs are the most abundant stromal cells in the tumor microenvironment (TME). In the TME, cell interactions mediated ...
  • Identifying Staphylococcus haemolyticus surface proteins. Development of a novel method for detection of bacterial surface proteins expressed during colonisation of human keratinocytes 

    Wolden, Runa (Master thesis; Mastergradsoppgave, 2018-05-15)
    The aim was to develop a method for identification of expressed surface proteins of Staphylococcus haemolyticus when colonising human keratinocytes. S. haemolyticus and HaCaT cells were grown together and separated with FACS prior to surface protein shaving using the LPI™FlowCell technology (Nanoxis Consulting AB). TMT-tags were used to investigate up- and downregulation of proteins comparing S. ...

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