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  • Characterization of ATG8 Family Protein Binding to TRIM23 and TRIM31 

    Isaksen, Heidi (Master thesis; Mastergradsoppgave, 2018-05-15)
    Macroautophagy (hereafter called autophagy) is a process where proteins, organelles and intracellular micro-organisms are degraded by the lysosome. The autophagosome engulfs a part of the cytoplasm where the cargo is, and transports it to the endosomal-lysosomal system for degradation. Autophagy can also be selective, where cargos are recognized directly by the autophagy receptors or by other proteins ...
  • In vitro reconstitution of proMatrix Metalloproteinase-9/Chondroitin Sulfate Proteoglycan Complexes. Identification of motifs in proMMP-9 and the serglycin core protein involved in the complex formation. 

    Dawadi, Rangita (Master thesis; Mastergradsoppgave, 2014-05-15)
    Previously it has been shown that different monocytic leukemic cell lines such as THP-1, MonoMac and U-937 can produce proteolytic enzymes such as MMP-9 as well as various types of proteoglycans (PG). These proteins have been shown to be involved in homeostasis as well as in various diseases, such as cancer. When proMMP-9 was mixed with isolated PGs from these three cell lines or pure serglycin and ...
  • Hereditary breast and ovarian cancer. Diversity of genetic causes of HBOC in a Norwegian breast and ovarian cancer patient cohort, BRCA2 c.8331+2C>T - a Norwegian founder mutation 

    Skarsfjord, Siri Hermansen (Master thesis; Mastergradsoppgave, 2017-05-14)
    Hereditary breast and ovarian cancer (HBOC) causes 5-10 % of breast cancer cases and 25 % of ovarian cancer cases. About 24 % of HBOC are caused by deleterious variants in BRCA1 and BRCA2. Currently, more than 25 different genes have been associated with HBOC, including BRCA1 and BRCA2, many of which encode proteins participating in homologous recombination repair (HRR) and mismatch repair (MMR). ...
  • The oncoproteins gelsolin, periostin and thrombospondin are enriched in Merkel cell carcinoma exosomes, and their promoter activity is stimulated by Large T-antigen of Merkel cell polyomavirus 

    Furuholmen-Jenssen, Ida Sofie (Master thesis; Mastergradsoppgave, 2017-05-14)
    Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine form of skin cancer with high mortality rate and increasing incidence. Around 80 % of MCC tumours are positive for Merkel cell polyomavirus (MCPyV), the only polyomavirus known to induce cancer in humans. Continuous expression of the viral oncogenes LT-ag and st-ag is necessary for MCPyV positive MCC tumour cell survival, suggesting ...
  • Analysis of glomerular target structures for nephritic anti-dsDNA antibodies playing central roles in lupus nephritis 

    Tømmerås, Berit (Master thesis; Mastergradsoppgave, 2008-05)
    Systemic lupus erythematosus is an autoimmune disease characterized by the presence of autoantibodies towards nuclear antigens. Sub-populations of anti-dsDNA antibodies have the potential to bind in the kidney and thereby induce nephritis, but there is no definite distinction that separates non-pathogenic from pathogenic antibodies. There must be parameters that determine anti-dsDNA antibody binding, ...
  • Production and purification of recombinant C-terminal truncated pro-Matrix Metalloprotease-9 

    Rahman, Fatema (Master thesis; Mastergradsoppgave, 2016-06-21)
    MMP-9 consists of N-terminal signal peptide, a pro-domain, catalytic domain, a long flexible hinge region and C- terminal hemopexin domain. In the present study a truncated version of proMMP-9 which lacking hinge region and C-terminal hemopexin domain was produced. To do so Sf9 insect cells and the BaculoDirect Baculovirus expression system were used. Using site directed mutagenesis, single mutation ...
  • Effect of viral early proteins, mutations and IL-17F on the transcriptional activity of the Merkel cell polyomavirus promoter in different cell lines 

    Abdulsalam, Ibrahim Afolabi (Master thesis; Mastergradsoppgave, 2016-05-23)
    Merkel cell polyomavirus (MCPyV) is common in the human population with a seropositivity of approximately 60%. The virus is chronically shed from healthy skin, but the genuine host cell remains unknown and a permissive cell culture system is lacking. The viral genome is in an episomal state in cells where MCPyV has been found. The virus is not harmful in healthy individuals, but it is involved in ...
  • An investigation of Intercellular Adhesion Molecule-1 (ICAM-1) in Breast Cncer 

    Elston, Bryan George Vincent (Master thesis; Mastergradsoppgave, 2016-05-18)
    Intercellular Adhesion Molecule-1 (ICAM-1, CD54), a cell surface glycoprotein that functions as an integrin, has a well-established role in leukocyte migration during inflammation. Recent studies have indicated a role for this protein in cancer development. In this study three breast cancer cell lines were stimulated with a variety of cytokines. The breast cancer cell lines (MCF7, SK-BR-3 and ...
  • Oncolytic Activity and Mechanisms of Action by a small β2,2-amino acid derivative LTX-401 

    Mauseth, Brynjar (Master thesis; Mastergradsoppgave, 2015-05-11)
    Antimicrobial peptides are part of the innate immune defence of many organisms and represent a novel class of therapeutics due to their broad-spectrum activities, including cytotoxic activity against cancer cells. It has recently been reported that small antimicrobial β2,2-amino acid derivatives (Mw<500), such as LTX-401, possess potent anticancer activity against Ramos human Burkitt’s lymphoma ...
  • A study of possible genetic causes of inherited breast and ovarian cancer in a Norwegian cancer population 

    Jarhelle, Elisabeth (Master thesis; Mastergradsoppgave, 2013-05-15)
    Homologous recombination repair (HRR) is an important repair mechanism, and mutations disrupting the function of this machinery might contribute to cancer formation. Several proteins interact in this mechanism, and the two best known are BRCA1 and BRCA2. Mutations in their corresponding genes BRCA1 and BRCA2 are found in 40% of hereditary breast and ovarian cancer cases. However, there are still ...
  • Identification, isolation and characterisation of scavenging endothelial cells in placenta 

    Mjølsnes, Nina (Master thesis; Mastergradsoppgave, 2014-05-15)
    Haemopoiesis occurs in the BM, where haemopoietic stem cells (HSC) reside in a three-dimensional “niche” and give rise to the millions of circulating blood cells required everyday of life. The precise regulation of this immense task occurs by interaction of HSC with other BM cells and extracellular matrix molecules. In addition, the BM vasculature has also now been identified as a key HSC regulator. ...
  • Role of the mannose receptor in tumor associated macrophages. Studies in a mouse melanoma model 

    Rønningen, Iselin (Master thesis; Mastergradsoppgave, 2014-04-15)
    Tumor-associated macrophages (TAMs) play an important role in cancer-related inflammation. TAMs develop M2 polarization which may support tumor growth. Mannose receptor (MR) expression is a hallmark for this cell-subpopulation, and the MR has recently been suggested to be involved in TAM polarization. The aim of the study was to investigate the role of MR in TAM polarization and tumor development ...
  • Cyclic nucleotide dependent ATPase activity in inside out vesicles from human erythrocytes 

    Rafiq, Sarah (Master thesis; Mastergradsoppgave, 2015-01-27)
    The transport of cyclic nucleotides out of the cell is energy requiring, dependent on ATP- hydrolysis. The ability to stimulate this ATPase is a hallmark of substrates for ABC-transporters e.g. ABCC5, ABCC4. It is believed that ABCC5 transporter has selective high affinity for cGMP. Previous studies support the idea that ABCC5 contribute to cGMP transport by human erythrocytes. Human erythrocyte ...
  • The effect of sub-lethal concentration of ciprofloxacin on the transfer of multidrug resistance plasmids, fitness costs on the host and the stability of the newly acquired plasmids 

    Mwansa, Besa James (Master thesis; Mastergradsoppgave, 2014-09-30)
    The increase in reported cases of antimicrobial resistance has raised a lot of concerns in the public health community. This has prompted efforts aimed at finding out factors that have been contributing to this situation. In Gram-negative bacteria plasmids have been singled out as the most important vehicles behind the spread of antimicrobial resistance. Some plasmids can harbour several resistance ...
  • A molecular genetic study investigating the role of maternal and placental laeverin gene mutation and fetal whole genome copy number variations in the pathophysiology of preeclampsia 

    Olsen, Hanne Listau (Master thesis; Mastergradsoppgave, 2011-11-29)
    Summary Preeclampsia is a clinical syndrome affecting only pregnant women and is defined as new onset of hypertension and proteinuria after 20 weeks of gestation. Approximately, 2-7 % of all pregnant women in the developed world are affected by this condition and it is a major cause of maternal and fetal morbidity and mortality. Despite intensive research the pathophysiology of preeclampsia is not ...
  • Intracellular gelatinolytic activity in mouse tissues 

    Solli, Ann Iren (Master thesis; Mastergradsoppgave, 2011-09-12)
    Matrix metalloproteinases have traditionally been thought to act only extracellulary. However, increasing evidence has revealed intracellular localization as well as several alternative substrates and novel biological roles for these proteinases. The aims of this master thesis were to map intracellular localization of MMP-2 and MMP-9 in different tissues from mouse, determine if detected enzymes ...
  • The effect of oral uptake of nicotine on skin blood perfusion of the face and hands in snus users as determined by thermography. 

    Høiland, Ina Isabella (Master thesis; Mastergradsoppgave, 2014-05-15)
    In recent years the number of people using cigarettes in Norway has significantly declined, with intake of nicotine being replaced by smokeless tobacco (ST) products such as snus placed in the oral cavity. While health risks from smoking cigarettes are well known little is known about health risks of using ST. The main aim of this thesis was to compare the effects of oral use of snus with nicotine ...
  • The role of MMP-2 and MMP-14 in cell migration and invasion 

    Okoli, Ndidiamaka Chinelo (Master thesis; Mastergradsoppgave, 2014-02-03)
    Cancer is becoming a global epidemic in recent times and can affect different organs in the body and even more worrying is that they do not have a common cause. Several factors have been implicated in the onset and spread of cancers, one of which are the metalloproteinases (MMPs). The MMPs utilize the same strategy they employ in normal physiological processes in pathology, thus creating a dilemma ...
  • A study of the protein kinase MK5's effect on melanoma cell proliferation 

    Dumitriu, Gianina Aurica (Master thesis; Mastergradsoppgave, 2012-09-14)
    The mitogen-activated protein kinases (MAPKs) play a crucial role in cellular processes such as proliferation, differentiation, apoptosis, metabolism and motility. Both conventional and atypical MAPKs can phosphorylate other proteins referred to as MAPK- activated protein kinases (MAPKAPK) such as MK5 or p38-regulated /activated protein kinase. Mutations in the MK5 gene have been detected in lung, ...
  • Development of an assay for determining PDE5 enzyme activity and for screening of potential inhibitors of the PDE5 enzyme in cancer cells 

    Granaas, Magnus Løkke (Master thesis; Mastergradsoppgave, 2013-05-15)
    PDE5 is a member of the superfamily of phosphodiesterases, and it is identified as the main mechanism for breakdown of cGMP in mammals. Sildenafil is a well-known inhibitor of the PDE5 enzyme and it is also shown that sildenafil inhibits the ABCC5 transporter pump. ABCC5 is a member of the superfamily of ABC-transporters, and identified as an important transporter for mediating the cellular efflux ...

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