Recent additions

  • Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance 

    Jacobsen, Henrik Børsting; Stubhaug, Audun; Schirmer, Henrik; Landrø, Nils Inge; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Nielsen, Christopher Sivert (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
    <p><i>Background - </i>Effects from cognitive performance on pain tolerance have been documented, however, sample sizes are small and confounders often overlooked. We aimed to establish that performance on neuropsychological tests was associated with pain tolerance, controlling for salient confounders. <p><i>Methods - </i>This was a cross‐sectional study nested within the Tromsø‐6 survey. ...
  • Impact of Chronic Obstructive Respiratory Disease (COPD), respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism (VTE) and VTE-related mortality in a general population 

    Børvik, Trond (Doctoral thesis; Doktorgradsavhandling, 2019-11-01)
    <p>Venous thromboembolism (VTE) is a collective term for pulmonary embolism (PE) and deep vein thrombosis (DVT). Chronic Obstructive Pulmonary Disease (COPD) is described as a moderate risk factor for VTE, but the association has so far been scarcely examined. The aims of this thesis were to I) investigate the impact of COPD on the risk of incident VTE and the risk of mortality in COPD-patients with ...
  • Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway: the Tromsø study 

    Olsøy, Irene Beate; Henriksen, Stian; Weissbach, Fabian H.; Larsen, Marthe; Borgen, Karoline; Abravanel, Florence; Kamar, Nassim; Paulssen, Eyvind Jakob; Hirsch, Hans H.; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-22)
    Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in many parts of the world but only a few cases have been diagnosed in Norway. To investigate the HEV exposure rate in a presumed low-risk area, we have conducted a population-based study of anti-HEV IgG seroprevalence in Northern Norway. A total of 1800 serum samples from 900 women and 900 men, age 40–79 years, were randomly selected ...
  • Mandatory medication indications in electronic systems – the prescriber perspective 

    Baysari, Melissa; Del Gigante, Jessica; Moran, Maria; Lehnbom, Elin; Day, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
    As hospitals transition from paper to electronic medication charts, an opportunity exists to ‘nudge’ prescribers to document medication indications by making this data-entry field mandatory. The aim of this study was to explore hospital doctors’ perceptions of mandatory documentation of indications in an electronic medication management (EMM) system. Ten junior doctors took part in brief semi-structured ...
  • A meta-analysis of constraint-induced movement therapy after stroke 

    Thrane, Gyrd; Friborg, Oddgeir; Anke, Audny; Indredavik, Bent (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-02)
    <p><i>Objective - </i>To evaluate the effect of constraint-induced movement therapy in adult stroke patients and to examine the impact of time since stroke and various treatment modalities. <p><i>Data sources - </i>PubMed, EMBASE, Cochrane and PEDro trial registers were searched for clinical trials published before November 2012. <p><i>Study selection - </i>Randomized or quasi-randomized controlled ...
  • Transcriptional profiling of ulcerative colitis in remission 

    Fenton, Christopher Graham; Taman, Hagar; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel, 2019-01-25)
    <p><i>Background - </i>This study addresses whether existing transcriptional profiles can improve and support the current definition of UC in remission apart from the today existing endoscopic, histological and laboratory scoring systems. <p><i>Methods - </i>Mucosal biopsies from treatment-naïve UC patients (<i>n</i> = 14), healthy controls (<i>n</i> = 16), and UC patients in remission (<i>n</i> = ...
  • Changes in conventional cardiovascular risk factors and the estimated 10-year risk of acute myocardial infarction or cerebral stroke in Sami and non-Sami populations in two population-based cross-sectional surveys: The SAMINOR Study 

    Siri, Susanna Ragnhild; Eliassen, Bent Martin; Jacobsen, Bjarne K.; Melhus, Marita; Broderstad, Ann Ragnhild; Michalsen, Vilde Lehne; Braaten, Tonje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-19)
    <p><i>Objective - </i>To describe changes in cardiovascular risk factors and in the estimated 10-year risk of acute myocardial infarction (AMI) or cerebral stroke (CS) between SAMINOR 1 (2003–2004) and SAMINOR 2 (2012–2014), and explore if these changes differed between Sami and non-Sami. <p><i>Design - </i>Two cross-sectional surveys. <p><i>Setting - </i>Inhabitants of rural Northern Norway. < ...
  • Increasing propensity to mind‐wander by transcranial direct current stimulation? A registered report 

    Boayue, Nya Mehnwolo; Csifcsak, Gabor; Aslaksen, Per M; Turi, Zsolt; Antal, Andrea; Groot, Josephine Maria; Hawkins, Guy E.; Forstmann, Birte U.; Opitz, Alexander; Thielscher, Axel; Mittner, Matthias (Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2019-01-24)
    Transcranial direct current stimulation (tDCS) has been proposed to be able to modulate different cognitive functions. However, recent meta‐analyses conclude that its efficacy is still in question. Recently, an increase in subjects’ propensity to mind‐wander has been reported as a consequence of anodal stimulation of the left dorsolateral prefrontal cortex (Axelrod et al., Proceedings of the National ...
  • Clinical Presentation of Gastroesophageal Reflux Disease: A Prospective Study on Symptom Diversity and Modification of Questionnaire Application 

    Broderik, Ryan; Fuchs, Karl-Hermann; Breithaupt, Wolfram; Varga, Gabor; Schulz, Thomas; Babic, Benjamin; Lee, Arielle; Musial, Frauke; Horgan, Santiago (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-12)
    <p><i>Introduction - </i>Symptoms occurring in gastroesophageal reflux disease (GERD) such as heartburn, regurgitation, thoracic pain, epigastric pain, respiratory symptoms, and others can show a broad overlap with symptoms from other foregut disorders. The goal of this study is the accurate assessment of symptom presentation in GERD. <p><i>Methods - </i>Patients with foregut symptoms were ...
  • Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 

    GBD 2017, DALYs and HALE Collaborators; Kyu, Hmwe Hmwe; Bjørge, Tone; Eggen, Anne Elise; Htet, Aung Soe; Kisa, Adnan; Knudsen, Ann Kristin Skrindo; Øverland, Simon Nygaard; Skirbekk, Vegard Fykse; Sulo, Gerhard; Steiner, Timothy J.; Stovner, Lars Jacob; Weiderpass, Elisabete; Winkler, Andrea Sylvia; Murray, Christopher J.L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-08)
    <p><i>Background - </i>How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected ...
  • Lekens plass i barnefysioterapi 

    Håkstad, Ragnhild B. (Journal article; Tidsskriftartikkel, 2018)
  • Mild Effect of Nalmefene on Alcoholic Cue-Induced Response Invigoration in Alcohol Use Disorder Without Accompanying Changes in Electrophysiological Signatures of Early Visual Processing and Executive Control 

    Gál, Bernadett Ildikó; Kilencz, Tunde; Albert, Anita; Demeter, Ildikó; Hegedűs, Klára Mária; Janka, Zoltán; Csifcsak, Gabor; Álmos, Péter Zoltán (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
    Nalmefene is approved for as-needed pharmacological treatment in alcohol use disorder (AUD) by the European Medicines Agency. While the cellular effects of nalmefene have been thoroughly investigated, data are very limited on how this agent influences neural signals associated with inhibitory control and the visual analysis of environmental cues. This double-blind crossover study assessed the ...
  • Rural general practice patients’ coping with hazards and harm: an interview study 

    Harbitz, Martin Bruusgaard; Brandstorp, Helen; Gaski, Margrete (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-18)
    <i>Objective</i>: The aim of this study is to identify and analyse rural general practice patients’ experiences of hazards and harm that comprise adverse events, and their strategies for coping with them.<p> <p><i>Design</i>: Interview study using systematic text condensation and coping strategy theory in an abductive analysis process.<p> <p><i>Setting</i>: Nine rural general practice clinics ...
  • Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis 

    Gundersen, Mona D.; Goll, Rasmus; Fenton, Christopher Graham; Anderssen, Endre; Sørbye, Sveinung Wergeland; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
    <i>OBJECTIVES</i>: A healed intestinal mucosa is the aim of therapy in acute ulcerative colitis (UC). Disruption of mucosal wound healing may lead to severe complications including intestinal fibrosis. This study examined mucosal gene expression in the healing process of acute UC with a special focus on known mediators of fibrosis.<p> <p><i>METHODS</i>: Endoscopic biopsies from patients with ...
  • Differences and similarities between users of traditional healing and other CAM modalities in the seventh survey of the Tromsø Study 

    Kristoffersen, Agnete Egilsdatter; Broderstad, Ann Ragnhild; Musial, Frauke; Stub, Trine (Conference object; Konferansebidrag, 2019-05)
  • Leisure time and occupational physical activity, resting heart rate, and mortality in the Arctic region of Norway: The Finnmark Study 

    Hermansen, Rune Hermann; Jacobsen, Bjarne K.; Løchen, Maja-Lisa; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-20)
    <p><i>Aims - </i>This study examined the association of leisure time physical activity, occupational physical activity, and resting heart rate with all-cause and cardiovascular disease mortality in Sami and non-Sami populations. <p><i>Study design - </i>This was a longitudinal, observational population-based study. <p><i>Methods - </i>The Finnmark 3 study cohort was examined in 1987–1988 and ...
  • Mapping of Nuclear Export Signals and domains mediating aggregation of NBR1 

    Næss, Morten Svendsen (Master thesis; Mastergradsoppgave, 2017-11-02)
    Autophagy is a conserved catabolic pathway for the lysosomal degradation of cytoplasmic components. Autophagy can be both selective and unselective. Selective autophagy receptor proteins are involved in mediating the degradation of specific substrates. Among these receptors we find the evolutionary related proteins p62 and NBR1, which are both involved in autophagic degradation of different ubiquitinated ...
  • Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia 

    McMaster, Mary L.; Berndt, Sonja I.; Zhang, Jianqing; Slager, Susan L.; Li, Shengchao Alfred; Vajdic, Claire M.; Smedby, Karin E.; Yan, Huihuang; Birmann, Brenda M.; Brown, Elizabeth E.; Smith, Alex; Kleinstern, Geffen; Fansler, Mervin M.; Mayr, Christine; Zhu, Bin; Chung, Charles C.; Park, Ju-Hyun; Burdette, Laurie; Hicks, Belynda D.; Hutchinson, Amy; Teras, Lauren R.; Adami, Hans Olov; Bracci, Paige M.; McKay, James; Monnereau, Alain; Link, Brian K.; Vermeulen, Roel C.H.; Ansell, Stephen M.; Maria, Ann; Diver, W. Ryan; Melbye, Mads; Ojesina, Akinyemi I.; Kraft, Peter; Boffetta, Paolo; Clavel, Jacqueline; Giovannucci, Edward; Besson, Caroline M.; Canzian, Federico; Travis, Ruth C.; Vineis, Paolo; Weiderpass, Elisabete; Montalvan, Rebecca; Wang, Zhaoming; Yeager, Meredith; Becker, Nikolaus; Benavente, Yolanda; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; Nieters, Alexandra; de Sanjose, Silvia; Staines, Anthony; Conde, Lucia; Riby, Jacques; Glimelius, Bengt; Hjalgrim, Henrik; Pradhan, Nisha; Feldman, Andrew L.; Novak, Anne J.; Lawrence, Charles; Bassig, Bryan A.; Lan, Qing; Zheng, Tongzhang; North, Kari E.; Tinker, Lesley F.; Cozen, Wendy; Severson, Richard K.; Hofmann, Jonathan N.; Zhang, Yawei; Jackson, Rebecca D.; Morton, Lindsay M.; Purdue, Mark P.; Chatterjee, Nilanjan; Offit, Kenneth; Cerhan, James R.; Chanock, Stephen J.; Rothman, Nathaniel; Vijai, Joseph; Goldin, Lynn R.; Skibola, Christine F.; Caporaso, Neil E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-10)
    Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40–31.03, P = 1.36 × 10<s ...
  • Acupuncture for the Treatment of Pain – A Mega-Placebo? 

    Musial, Frauke (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-17)
    Several control conditions, such as penetrating sham acupuncture and non-penetrating placebo needles, have been used in clinical trials on acupuncture effects in chronic pain syndromes. All these control conditions are surprisingly effective with regard to their analgesic properties. These findings have fostered a discussion as to whether acupuncture is merely a placebo. Meta-analyses on the clinical ...
  • EEG-based effective connectivity distinguishes between unresponsive states with and without report of conscious experience and correlates with brain complexity 

    Bremnes, Thomas René; Juel, B.E.; Gosseries, O.; Rosanova, M.; Boly, M.; Laureys, S.; Larsson, P.G.; Massimini, M.; Storm, Johan Frederik (Master thesis; Mastergradsoppgave, 2017-11-01)
    Objective methods for distinguishing conscious from unconscious states in humans are of key importance for clinical evaluation of general anesthesia and patients with disorders or consciousness. Here, we test the generalizability of a DTF-based algorithm - a measure of effective connectivity - as an objective measure of conscious experience during anesthesia and correlate it with a well-tested index ...

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