Recent additions

  • Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage 

    Iakunchykova, Olena; Averina, Maria; Wilsgaard, Tom; Watkins, Hugh; Malyutina, Sofia; Ragino, Yulia; Keogh, Ruth; Kudryavtsev, Alexander V; Govorun, Vadim; Cook, Sarah Anne; Schirmer, Henrik; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-15)
    <p><i>Background - </i>Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk. <p><i>Methods - </i>We compared age-standardised mean levels of CVD ...
  • Physical activity and blood gene expression profiles: the Norwegian Women and Cancer (NOWAC) Post-genome cohort 

    Olsen, Karina Standahl; Lukic, Marko; Borch, Kristin Benjaminsen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-11)
    <i>Objectives</i> - The influence of physical activity (PA) on the immune system has emerged as a new field of research. Regular PA may promote an anti-inflammatory state in the body, thus contributing to the down-regulation of pro-inflammatory processes related to the onset and progression of multiple diseases. We aimed to assess whether overall PA levels were associated with differences in blood ...
  • MAPPinfo, mapping quality of health information: Study protocol for a validation study of an assessment instrument 

    Kasper, Jürgen; Lühnen, Julia; Hinneburg, Jana; Siebenhofer, Andrea; Posch, Nicole; Berger-Höger, Birte; Grafe, Alexander; Keppler, Jan; Steckelberg, Anke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)
    <i>Abstract</i> - Introduction Health information is a prerequisite of informed decision-making. Criteria for development, content and presentation have recently been published in a corresponding guideline. Within a systematic search, 27 relevant checklists were identified, none of them, however, complying with the guideline or providing reasonably operationalised measurement items. Therefore, a ...
  • Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis 

    Florholmen, Jon; Johnsen, Kay-Martin; Meyer, Renate; Olsen, Trine; Moe, Øystein Kittel; Tandberg, Petter; Gundersen, Mona Dixon; Kvamme, Jan-Magnus; Johnsen, Knut; Løitegård, Terje; Raschpichler, Gabriele; Vold, Cecilia; Sørbye, Sveinung; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-02)
    <i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis ...
  • Protein kinase C isozymes associated with relapse free survival in non-small cell lung cancer patients 

    Halvorsen, Ann Rita; Haugen, Mads Haugland; Øjlert, Åsa Kristina; Lund-Iversen, Marius; Jørgensen, Lars Hilmar; Solberg, Steinar; Mælandsmo, Gunhild Mari; Brustugun, Odd Terje; Helland, Åslaug (Journal article; Tidsskriftartikkel, 2020-11-25)
    <i>Introduction</i>: Protein expression is deregulated in cancer, and the proteomic changes observed in lung cancer may be a consequence of mutations in essential genes. The purpose of this study was to identify protein expression associated with prognosis in lung cancers stratified by smoking status, molecular subtypes, and EGFR-, TP53-, and KRAS-mutations.<p> <p><i>Methods</i>: We performed ...
  • Thromboelastometry for Assessing Risks of Free Flap Thrombosis in Patients Undergoing Microvascular Surgery 

    Vanags, Indulis; Stepanovs, Jevgenijs; Ozolina, Agnese; Mukans, Maksims; Bjertnaes, Lars J.; Mamaja, Biruta (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-23)
    <p>Introduction</i>: Coagulation assessment is often missing in microvascular surgery. We aimed at evaluating the predictive value of thromboelastometry for free flap thrombosis in microvascular surgery patients.<p> <p> <i>Materials and Methods</i>: We enrolled 103 adult patients with traumatic injuries scheduled for microvascular free flap surgery into a prospective observational study. Thirty-six ...
  • NADPH oxidase 2 mediates myocardial oxygen wasting in obesity 

    Hafstad, Anne Dragøy; Hansen, Synne Simonsen; Lund, Jim; Santos, Celio X.C.; Boardman, Neoma Tove; Shah, Ajay M.; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-19)
    Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO<sub>2</sub>) and impaired cardiac efficiency. Although the pathophysiology of this cardiomyopathy is multifactorial and complex, reactive oxygen species (ROS) may play an important role. One of the ...
  • Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution 

    Alakunle, Emmanuel; Moens, Ugo; Nchinda, Godwin; Okeke, Malachy Ifeanyi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-05)
    Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is a member of orthopoxvirus genus. The reemergence of MPXV in 2017 (at Bayelsa state) after 39 years of no reported case in Nigeria, and the export of travelers’ monkeypox (MPX) from Nigeria to other parts of the world, in 2018 and 2019, respectively, have raised concern that MPXV may have emerged to occupy the ecological and ...
  • Hearing in schoolchildren after neonatal exposure to a high-dose gentamicin regimen 

    Hemmingsen, Dagny; Mikalsen, Camilla; Rydland Hansen, Alexander; Fjalstad, Jon Widding; Stenklev, Niels Christian; Klingenberg, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)
    <p>OBJECTIVE: To assess the association between gentamicin exposure in the neonatal period and hearing in school age. <p>METHODS: This study included children exposed to a high-dose (6 mg/kg) gentamicin regimen as neonates (2004–2012), invited for follow-up at school age, and a healthy age-matched control group. We assessed hearing with pure tone audiometry including the extended high-frequency ...
  • Nurses experiences of ethical responsibility: A hermeneutic phenomenological design 

    Tøllefsen, Annette; Olsen, Aid; Clancy, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-04)
    There is a lack of studies on ethical responsibility in nursing. Nurses experience ethical responsibility in all settings where patients are exposed and vulnerable. The authors’ interest in public health and intensive care nursing provided a motivation to study these settings. The study aimed to explore how intensive care and public health nurses experience ethical responsibility. A qualitative ...
  • Optimized cutoff maternal age for adverse obstetrical outcomes: A multicenter retrospective cohort study in Urban China during 2011 to 2012 

    Zhang, Xiaolei; Liang, Huan; Zhao, Huan-Qiang; Wu, Su-Wen; Zhou, Qiongjie; Li, Xiao-Tian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-05)
    <p><i>Background: </i>China's two-child policy has led to a trend of aging in pregnancy which was associated with adverse outcomes. This study aimed to identify the clinically cutoff maternal age for adverse obstetric outcomes in China. <p><i>Methods: </i>This secondary analysis of a multicenter retrospective cohort study included data of childbearing women from 39 hospitals collected in urban China ...
  • Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs 

    Falavigna, Margherita; Brurok, Sunniva; Klitgaard, Mette; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-21)
    The prediction of the <i>in vivo</i> performance of self-nanoemulsifying drug delivery systems (SNEDDSs) is currently gaining increasing attention. Therefore, the need for reliable <i>in vitro</i> models able to assess the drug solubilization capacity of such formulations upon <i>in vitro</i> lipolysis, as well as to concomitantly evaluate <i>in vitro</i> drug permeation, has become ever so evident. ...
  • Data on RT-qPCR assay of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) from human uterine endometrial tissue and cancer cells of the uterine cervix 

    Smaglyukova, Natalia; Sletten, Elise Thoresen; Ørbo, Anne; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-25)
    A previous investigation showed that the endometrium normalized in women with endometrial hyperplasia after three months treatment with high dose levonorgestrel IUS (intrauterine system). The effect was maintained even if immunohistochemical analyses of the endometrium showed that nuclear progesterone receptors (nPRs) were completely downregulated. These observations indicated that some type of ...
  • Expression of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy 

    Sletten, Elise Thoresen; Smaglyukova, Natalia; Ørbo, Anne; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-29)
    The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely the last decades. In a previous clinical study of endometrial hyperplasia, we observed that the antiproliferative progestin effect persisted after ...
  • Betydning av tilbakemelding om avvikende FEV1-verdier i Tromsø 7 

    Norum, Julie (Master thesis; Mastergradsoppgave, 2020-02-21)
    <p><i>Bakgrunn:</i> Spirometri er en anbefalt undersøkelse for å diagnostisere og undersøke for obstruktiv lungesykdom. Deltakerne i Tromsø 7 som måler en FEV1 < 70 % (grenseverdi på FEV1 < 65 % hos deltakere > 70 år) fikk et informasjonsskriv på spirometriposten med anbefaling å kontakte sin fastlege. Denne informasjonen kan være en stor fordel for deltakeren hvis det kan avdekke risiko for alvorlig ...
  • Lifestyle among long-term survivors of cancers in young adulthood 

    Bøhn, Synne-Kristin Hoffart; Lie, Hanne Cathrine; Reinertsen, Kristin Valborg; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen; Kiserud, Cecilie E.; Loge, Jon Håvard; Wisløff, Torbjørn; Thorsen, Lene (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-01)
    <i>Purpose</i> - To investigate lifestyle in a population-based sample of long-term (≥ 5 years since diagnosis) young adult cancer survivors (YACSs), and explore factors associated with not meeting the lifestyle guidelines for physical activity (PA), body mass index (BMI), and smoking. <p> <p><i>Methods</i> - YACSs (<i>n</i> = 3558) diagnosed with breast cancer (BC), colorectal cancer (CRC), ...
  • Use of group based trajectory modelling to identify groups based on trajectories obtained for overall number of antibiotics prescription to children age 0-3 years in Norway during year 2004 to 2017 

    Tanwar, Bhupender Singh (Master thesis; Mastergradsoppgave, 2020-12-01)
    Bacterial infection occur frequently in children. In 2015 more than 900,000 children below 5 years were killed due to respiratory tract infections (RTIs). Early life onset and prolonged use of antibiotics in children can leads to health complications later in life. Antibiotics prescribing in young children is affected by many factors and identifying these factors can provide an opportunity to develop ...
  • Employment status three years after percutaneous coronary intervention and predictors for being employed: A nationwide prospective cohort study 

    Olsen, Siv Jorunn Storli; Schirmer, Henrik; Wilsgaard, Tom; Bønaa, Kaare Harald; Hanssen, Tove Aminda (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-01)
    <i>Background</i> - Vocational support is recommended for patients in cardiac rehabilitation (CR), as returning to work is important in patients social readjusting after an acute coronary event. Information is lacking on whether CR leads to higher long-term employment after percutaneous coronary intervention (PCI).<p> <p><i>Aims</i> - The aims of this study were to determine employment status ...
  • Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease 

    Mercado, Nicolas; Colley, Thomas; Baker, Jonathan R.; Vuppussetty, Chaitanya; Kono, Yuta; Clarke, Colin; Tooze, Sharon A; Johansen, Terje; Barnes, Peter J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
    Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD, in which oxidative stress‐induced misfolded proteins accumulate into toxic aggregates dependent on the accumulation of the autophagic cargo receptor p62. Defective ...
  • DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma 

    Haider, Zahra; Landfors, Mattias; Golovleva, Irina; Erlanson, Martin; Schmiegelow, Kjeld; Flægstad, Trond; Kanerva, Jukka; Norén-Nyström, Ulrika; Hultdin, Magnus; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-28)
    Despite having common overlapping immunophenotypic and morphological features, T-cell lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) have distinct clinical manifestations, which may represent separate diseases. We investigated and compared the epigenetic and genetic landscape of adult and pediatric T-ALL (<i>n</i> = 77) and T-LBL (<i>n</i> = 15) patient samples by high-resolution genome-wide ...

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