Recent additions

  • Giant group I intron in a mitochondrial genome is removed by RNA back-splicing 

    Chi, Sylvia Ighem; Dahl, Mikael; Emblem, Åse; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)
    <p><i>Background - </i>The mitochondrial genomes of mushroom corals (Corallimorpharia) are remarkable for harboring two complex group I introns; ND5-717 and COI-884. How these autocatalytic RNA elements interfere with mitochondrial RNA processing is currently not known. Here, we report experimental support for unconventional processing events of ND5-717 containing RNA. <p><i>Results - </i>We obtained ...
  • Improved maximal strength is not associated with improvements in sprint time or jump height in high-level female football players: a clusterrendomized controlled trial 

    Pedersen, Sigurd; Heitmann, Kim Arne; Sagelv, Edvard Hamnvik; Johansen, Dag; Pettersen, Svein Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-17)
    <i>Background</i> - Maximal strength increments are reported to result in improvements in sprint speed and jump height in elite male football players. Although similar effects are expected in females, this is yet to be elucidated. The aim of this study was to examine the effect of maximal strength training on sprint speed and jump height in high-level female football players.<p> <p><i>Methods</i> ...
  • Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis 

    Fiorito, Giovanni; McCrory, Cathal; Robinson, Oliver; Carmeli, Cristian; Rosales, Carolina Ochoa; Zhang, Yan; Colicino, Elena; Dugué, Pierre-Antoine; Artaud, Fanny; McKay, Gareth J.; Jeong, Ayoung; Mishra, Pashupati P.; Nøst, Therese Haugdahl; Krogh, Vittorio; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Palli, Domenico; Matullo, Giuseppe; Guarrera, Simonetta; Gandini, Martina; Bochud, Murielle; Dermitzakis, Emmanouil; Muka, Taulant; Schwartz, Joel; Vokonas, Pantel S.; Just, Allan; Hodge, Allison M.; Giles, Graham G.; Southey, Melissa C.; Hurme, Mikko A.; Young, Ian; McKnight, Amy Jayne; Kunze, Sonja; Waldenberger, Melanie; Peters, Annette; Schwettmann, Lars; Lund, Eiliv; Baccarelli, Andrea; Milne, Roger L.; Kenny, Rose A.; Elbaz, Alexis; Brenner, Hermann; Kee, Frank; Voortman, Trudy; Probst-Hensch, Nicole; Lehtimäki, Terho; Elliot, Paul; Stringhini, Silvia; Vineis, Paolo; Polidoro, Silvia (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-14)
    <p>Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life. <p>We examined the ...
  • Bone matrix levels of Dickkopf and sclerostin are positively correlated with bone mass and strength in postmenopausal osteoporosis 

    Ueland, Thor; Stilgren, Lis; Bollerslev, Jens (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-03)
    Wnt signaling plays a pivotal role in maintaining bone mass. Secreted pathway modulators such as sclerostin (SOST) and Dickkopfs (DKKs) may influence bone mass inhibiting the canonical Wnt pathway. We evaluated whether bone protein content of secreted Wnt antagonists is related to age, bone mass, and strength in postmenopausal osteoporosis. We measured cortical and trabecular bone contents of SOST ...
  • Transkateter aorta ventil implantasjon. En retrospektiv kvalitetssikringsoppgave 

    Wilhelmsen, Håkon Wilhelm (Master thesis; Mastergradsoppgave, 2017-09-17)
    Bakgrunn: Aortastenose er en sykdom som har økt forekomst med økende alder, og alvorlig symptomgivende aortastenose har en dyster prognose. Uten behandling er median overlevelsestid 2 år dersom pasienten utvikler hjertesvikt. Tidligere ble denne pasientgruppen operert med åpen hjertekirurgi, men mange fikk ikke tilbud om behandling grunnet omfattende komorbiditet og høy-risiko. Dermed oppstod behovet ...
  • Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency 

    Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-01)
    Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients have non-infectious inflammatory and autoimmune complications, associated with systemic immune activation. Our aim was to explore if HDL, known to have anti-inflammatory properties, ...
  • Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways 

    Moens, Ugo; Macdonald, Andrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-12)
    Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the ...
  • Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus 

    Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Lekva, Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
    <i>Aims</i> - The risk of gestational diabetes mellitus (GDM) is increased in overweight and obese women potentially involving secreted mediators from adipose tissue. Our main aim was to evaluate if circulating adipokines and monocyte/macrophage markers were dysregulated in GDM and the influence body mass and indices of glucose metabolism had on this association. We further explored if early detection ...
  • In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding 

    Evenseth, Linn M.; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-04)
    Molting is an essential process in the life cycle of arthropods and is regulated by complex neuroendocrine pathways where activation of the ecdysone receptor (EcR) plays a major role. The EcR forms a non-covalent heterodimer with the ultraspiracle protein (USP) when activated by endogenous ecdysteroids, but can also be activated by several insecticides and other environmental chemicals. Environmental ...
  • Blinding is compromised for transcranial direct current stimulation at 1 mA for 20 min in young healthy adults 

    Turi, Zsolt; Csifcsak, Gabor; Boayue, Nya Mehnwolo; Aslaksen, Per M; Antal, Andrea; Paulus, Walter; Groot, Josephine; Hawkins, Guy E.; Opitz, Alexander; Thielscher, Axel; Mittner, Matthias (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-19)
    Transcranial direct current stimulation (tDCS) is a non‐invasive brain stimulation method that is frequently used to study cortical excitability changes and their impact on cognitive functions in humans. While most stimulators are capable of operating in double‐blind mode, the amount of discomfort experienced during tDCS may break blinding. Therefore, specifically designed sham stimulation protocols ...
  • In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol 

    Larose, Tricia L; Sætrom, Pål; Martinussen, Marit; Skogseth, Haakon; Sandanger, Torkjel M; Scélo, Ghislaine; McHale, Cliona M; Jacobsen, Geir Wenberg; Smith, Martyn T (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-05)
    <i>Background</i>: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD).<p> <p><i>Methods/design</i>: This pilot study includes pregnant women at high risk (smoking at ...
  • Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14 

    Skjeflo, Espen Waage; Christiansen, Dorte; Landsem, Anne; Stenvik, Jørgen; Woodruff, T. M.; Espevik, Terje; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-15)
    <i>Background</i> - Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-negative and Gram-positive bacteria in human whole blood.<p> <p><i>Methods</i> - Lepirudin-anticoagulated blood was incubated with live or dead <i>E. coli</i> or <i>S. aureus</i> at 37 °C for 120 min ...
  • Research involving older persons with dementia; ethical considerations 

    Drageset, Ingrid Marie Saga (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-04)
    In a research project where ten persons with dementia and their close families participated, the researcher explored how older people suffering from dementia could live meaningful lives. The aim of this article is to discuss some ethical considerations when persons with dementia are included in research, and to emphasize how to ensure their integrity and dignity. The qualitative research project ...
  • Plasma levels of mannose-binding lectin and future risk of venous thromboembolism 

    Liang, Robin Amanda; Høiland, Ina Isabella; Ueland, Thor; Aukrust, Pål; Snir, Omri; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Garred, Peter; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-20)
    <i>Background</i> - Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose‐binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular ...
  • Empati hos medisinstudenter - en kartleggingsoversikt 

    Fladset, Linn Mari (Master thesis; Mastergradsoppgave, 2019-08-20)
    Bakgrunn: Empati hos medisinstudenter er et populært tema innenfor medisinsk etikk, undervisning og sosiologi. Det spørres om empatien beholdes over terskelen til ferdigutdannede leger, og hvis ikke, i hvilken grad og om empati påvirkes. Hensikten med denne oppgaven var å se nærmere på forskningen omkring empati fra det siste tiåret, og sammenfatte resultater med ulike funn og ulike aspekter. Metode: ...
  • Behandling av ekstrauterint svangerskap ved Universitetssykehuset Nord-Norge i perioden 2006-2016. En kvalitetssikringsstudie 

    Hansen, Mari (Master thesis; Mastergradsoppgave, 2019-08-19)
    Bakgrunn: Ekstrauterin graviditet (ex.u.) påvises i økende tilfeller før symptomdebut og gir mulighet for tidlig og ikke-operativ behandling. Formålet med prosjektet er å utprøve behandlingspraksis ved Universitetssykehuset Nord-Norge (UNN) Tromsø mot nasjonale standarder for å avdekke avvik og forbedringsmuligheter. Utprøvingen gjøres ved å studere tidligere pasientforløp og kartlegge utfall i form ...
  • Skaderegisteret ved UNN Narvik. En enkel kvalitetsvurdering av anonymiserte data for perioden 2004-1017 

    Ravlo, Celina (Master thesis; Mastergradsoppgave, 2019-08-14)
    Denne masteroppgaven med tittelen ‘Skaderegisteret ved UNN Narvik - En enkel kvalitetsvurdering av anonymiserte data for perioden 2004-2017’’ ble godkjent av Helsefakultetet i oktober 2017. Hensikten er å beskrive, rekode og korrigere Skaderegisteret ved UNN Narvik, samt vurdere muligheten for å anvende dette materialet for videre analyse og evaluering. Dette for å få større innsikt i og kunnskap ...
  • Allmennlegens tiltro til egne akuttmedisinske ferdigheter. En spørreundersøkelse blant norske fastleger 

    Holte-Ambjørnsen, Øivind Kjønsvik (Master thesis; Mastergradsoppgave, 2017-09-12)
    Bakgrunn: Akuttmedisinforskriften og Nasjonal traumeplan stiller krav til legevaktlegens kompetanse. Det foreligger et behov for økt kunnskap om legevaktlegens tiltro til eget akuttmedisinske ferdighetsnivå. Metode: Samtlige norske fastleger (n=4883) ble invitert til å delta i en nettbasert spørreundersøkelse. For 12 spesifiserte ferdigheter ble legene bedt om å angi tiltro til egen evne på en ...
  • Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study 

    Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Lapid, Maria; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-26)
    Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to ...
  • Health Professionals' Experience with Patients Accessing Their Electronic Health Records: Results from an Online Survey 

    Johansen, Monika Alise; Kummervold, Per Egil; Sørensen, Tove; Zanaboni, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
    The aim of this study was to investigate hospital professionals’ experience and attitude with patients accessing their own electronic health records. The study was conducted one year after service establishment. Data was collected through an online survey. In total, 457 replies were received. The results revealed a quarter of the administrative staff received feedback from patients or relatives ...

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