Nye registreringer

  • Systematic review of clinical and patient-reported outcomes following oral rehabilitation on dental implants with a tapered compared to a non-tapered implant design 

    Jokstad, Asbjørn; Ganeles, Jeffrey (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-17)
    <p><i>Background</i>: Dental implants are available in different shapes.</p> <p><i>Aims</i>: This systematic review aims to address whether tapered compared to non‐tapered implants demonstrate similar clinical and patient‐reported outcomes. The review follows the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) format.</p> <p><i>Materials & Methods</i>: We searched ...
  • Drug permeability profiling using cell-free permeation tools: Overview and applications 

    Berben, Philippe; Bauer-Brandl, Annette; Brandl, Martin; Faller, Bernard; Flaten, Gøril Eide; Jacobsen, Ann-Cathrine; Brouwers, Joachim; Augustijns, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-13)
    Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are ...
  • The independent and joint associations of physical activity and body mass index with myocardial infarction: The Tromsø Study 

    Renninger, Marius; Løchen, Maja-Lisa; Ekelund, Ulf; Hopstock, Laila Arnesdatter; Jørgensen, Lone; Mathiesen, Ellisiv B.; Njølstad, Inger; Schirmer, Henrik; Wilsgaard, Tom; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-13)
    Physical activity and overweight are associated with myocardial infarction (MI). However, their joint association with MI remains unclear. Our objective was to examine the independent and joint association between leisuretime physical activity (LTPA), body mass index (BMI) and MI. This prospective cohort study included 16,572 men and women (47.5% women) aged 20–54 years who took part in the second ...
  • Levonorgestrel-releasing intrauterine system use is associated with a decreased risk of ovarian and endometrial cancer, without increased risk of breast cancer. Results from the NOWAC Study 

    Jareid, Mie; Thalabard, Jean-Christophe; Aarflot, Morten; Bøvelstad, Hege Marie; Lund, Eiliv; Braaten, Tonje (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-02)
    <p><i>Objective</i>: Women with ovarian cancer have poor survival rates, which have proven difficult to improve; therefore primary prevention is important. The levonorgestrel-releasing intrauterine system (LNG-IUS) prevents endometrial cancer, and recent studies suggested that it may also prevent ovarian cancer, but with a concurrent increased risk of breast cancer. We compared adjusted risks of ...
  • Dual-specificity MAP kinase phosphatases in health and disease 

    Seternes, Ole Morten; Kidger, Andrew M; Keyse, Stephen M (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-08)
    It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions ...
  • Novel in situ gel-forming solid dosage form (gfSDF) prepared by the simple syringe-based moulding: A screening study 

    Falavigna, Margherita; Skalko-Basnet, Natasa; Cavallari, Cristina; Pini, Andrea; Luppi, Barbara; Di Cagno, Massimiliano Pio (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-05)
    The aim of this study was to prepare and optimize a novel type of in situ gel-forming solid dosage form (gfSDF) to be used in the treatment of mucosal/skin ulcerations. For this purpose, a simple but reliable syringe-based hot melt/moulding method was employed. Chloramphenicol (antibiotic) and ibuprofen (anti-inflammatory) were chosen as model active pharmaceutical ingredients (APIs) to be loaded ...
  • Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction 

    Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Damås, Jan Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-29)
    <p><i>Aim</i>: To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI).</p> <p><i>Methods</i>: 117 patients with acute NSTEMI were randomised to an intravenous infusion of 280 mg tocilizumab or placebo prior to coronary angiography. Blood samples were obtained at baseline, at 6 consecutive ...
  • Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study 

    Lappegård, Jostein; Ellingsen, Trygve; Hindberg, Kristian; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Løchen, Maja-Lisa; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-10)
    Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high sensitivity CRP (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between ...
  • Nestin-expressing progenitor cells: function, identity and therapeutic implications 

    Bernal Mera, Aurora; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-14)
    The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with progenitor and/or regulatory functions in a number of additional tissues, remarkably bone marrow. This review presents the current knowledge on the role ...
  • Diabetes on Twitter: A Sentiment Analysis 

    Gabarron, Elia; Dorronzoro, Enrique; Rivera-Romero, Octavio; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-19)
    Background: <br>Contents published on social media have an impact on individuals and on their decision-making. Knowing the sentiment towards diabetes is fundamental to understanding the impact that such information could have on people affected with this health condition and their family members. The objective of this study is to analyze the sentiment expressed in messages on diabetes posted ...
  • Factors Associated with High Weight Gain and Obesity Duration: The Norwegian Women and Cancer (NOWAC) Study 

    da Silva, Marisa Eleonor; Weiderpass, Elisabete; Licaj, Idlir; Rylander, Charlotta (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-12)
    <i>Aim:</i> To identify factors associated with high weight gain and obesity duration in a representative sample of Norwegian women.<p> <p><i>Methods</i>: 66,618 Norwegian women aged 34–70 years at baseline were included in the analysis. Baseline and follow-up questionnaires completed in 1991–2011 provided information on height, weight as well as sociodemographic, lifestyle and reproductive ...
  • Kunnskapsoppsummering og klassifisering av tiltaket FRIENDS for life (behandling) 

    Sæle, Rannveig Grøm; Sagatun, Åse (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-28)
    <p><i>BAKGRUNN</i>: Denne artikkelen er en kunnskapsoppsummering av effektene av tiltaket FRIENDS for life, et behandlingsprogram for barn og ungdommer med angst. Tiltaket er tilrettelagt for grupper, men kan også brukes individuelt. FRIENDS har som mål å hjelpe barn og ungdommer med å utvikle ferdigheter og kunnskaper som gjør dem bedre rustet til å håndtere angstprovoserende situasjoner. I Norge ...
  • The role of NADPH oxidases in diabetic cardiomyopathy 

    Hansen, Synne Simonsen; Aasum, Ellen; Hafstad, Anne Dragøy (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)
    Systemic changes during diabetes such as high glucose, dyslipidemia, hormonal changes and low grade inflammation, are believed to induce structural and functional changes in the cardiomyocyte associated with the development of diabetic cardiomyopathy. One of the hallmarks of the diabetic heart is increased oxidative stress. NADPH-oxidases (NOXs) are important ROS-producing enzymes in the cardiomyocyte ...
  • Lower attendance rates in BreastScreen Norway among immigrants across all levels of socio-demographic factors: a population-based study 

    Le, Mary Thuy An; Hofvind, Solveig; Tsuruda, Kaitlyn; Braaten, Tonje; Bhargava, Sameer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-03)
    <i>Background:</i> Several studies have shown that immigrants attend mammographic screening less frequently than non-immigrants. Studies have also shown that attendance is influenced by socio-demographic factors. We aimed to describe the relationship between socio-demographic factors and first attendance among immigrant and non-immigrant women invited to BreastScreen Norway.<p> <p><i>Methods:</i> ...
  • Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif 

    Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-30)
    Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in an integrin‐dependent manner. Here, we used reverse‐phase protein array (RPPA) to analyze NPNT‐triggered intracellular signaling in the 66cl4 mouse breast cancer cell line. The results ...
  • Medication management in municipality based health care: a time and motion study of nurses 

    Holmqvist, Malin; Ekstedt, Mirjam; Walter, Scott R; Lehnbom, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-01)
    The objective of this observational time and motion study was to increase our understanding of how nurses in home healthcare currently distribute their work time with a focus on the medication management process. The research was conducted in four municipalities in the southern part of Sweden. Participants were nurses working in home healthcare. The study measured proportion of time, comparison ...
  • Three essays on measuring health-related quality of life: external and internal relationships of the EQ-5D-5L 

    Gamst-Klaussen, Thor (Doctoral thesis; Doktorgradsavhandling, 2019-01-18)
    The use of quality-adjusted life years (QALYs) as a commensurable health outcome measure has been encouraged by health authorities in many countries in order to aid decisions on healthcare priorities. A key methodological challenge is to estimate the weights used for valuing health-related quality of life, i.e. the “Q” in QALY, based on people’s preferences. Such generic preference-based measures ...
  • Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism 

    Høiland, Ina Isabella; Liang, Robin Amanda; Hindberg, Kristian; Latysheva, Nadezhda; Brekke, Ole-Lars; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-30)
    INTRODUCTION: Deep vein thrombosis (DVT) originates in the valvular sinuses of large veins in a local milieu characterized by stasis and severe hypoxia. This may induce complement- and coagulation activation, which potentially increases the risk of venous thromboembolism (VTE). The aim of the present study was to investigate whether the activity of the complement pathways, the level of mannose-binding ...
  • Coloring of the past via respondent’s current psychological state, mediation, and the association between childhood disadvantage and morbidity in adulthood 

    Sheikh, Mashhood Ahmed (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-31)
    <p><i>Objective</i>: Many researchers view retrospective reports with skepticism. Indeed, the observed association between retrospectively-reported childhood disadvantage (CD) and morbidity in adulthood has been criticized as an artefactual correlation driven by the psychological state of the respondent at the time of reporting (current psychological state). The aim of this study was to assess the ...
  • Involvement in research and development projects among community-working occupational therapists in Norway 

    Bonsaksen, Tore; Dolva, Anne-Stine; Hagby, Cathrine; Sveen, Unni; Horghagen, Sissel; Thyness, Else Merete; Arntzen, Cathrine (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-31)
    A cross-sectional descriptive survey was conducted (n = 561). Almost half of the participants took part in research and development projects. Being involved in research and development was associated with lower age, having further education, and higher levels of work experience. The current and prioritized research topics were reablement and assistive technology. The study implies that community-working ...

Vis mer