Recent additions

  • Chronic Pelvic Pain in women. Group based multimodal physical therapy 

    Nygaard, Ane Sigrid (Doctoral thesis; Doktorgradsavhandling, 2021-02-26)
    <p><i>Introduction - </i>The aims of this thesis were (1) to describe the characteristics of women with chronic pelvic pain (CPP) referred for physical therapy after evaluation at a tertiary hospital, (2) to compare group-based multimodal physical therapy (intervention group) with primary care physical therapy (comparator group), and (3) to explore if selected pre-treatment characteristics were ...
  • Group-based multimodal physical therapy in women with chronic pelvic pain: A randomized controlled trial 

    Nygaard, Ane Sigrid; Rydningen, Mona Birgitte; Stedenfeldt, Mona; Wojniusz, Slawomir; Larsen, Marthe; Lindsetmo, Rolv-Ole; Haugstad, Gro Killi; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-09)
    <p><i>Introduction - </i>Chronic pelvic pain in women is a complex condition, and physical therapy is recommended as part of a broader treatment approach. The objective of this study was to compare structured group‐based multimodal physical therapy in a hospital setting (intervention group) with primary‐care physical therapy (comparator group) for women with chronic pelvic pain. <p><i>Material and ...
  • «Nært, men på avstand» - En kvalitativ metasyntese om pasienters erfaring med fysioterapi via telerehabilitering 

    Kulseng, Andrea Wensberg; Gretland, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
    Bakgrunn: Rehabilitering er en sentral del av fysioterapitjenesten. Innføring av flere nasjonale handlingsplaner, der digitalisering står i fokus, kan tyde på at tradisjonell rehabilitering vil måtte endres og tilpasses. Telerehabilitering er en tilnærming som hevdes å kunne øke tilgjengelighet. Hensikten med denne studien var å undersøke pasienters erfaring med fysioterapi over avstand. Metode: ...
  • Vitamin D supplementation for prevention of type 2 diabetes mellitus: To D or Not to D? 

    Pittas, Anastassios G.; Jorde, Rolf; Kawahara, Tetsuya; Dawson-Hughes, Bess (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-26)
    <i>Context</i> - Over the last decade, vitamin D has emerged as a risk determinant for type 2 diabetes and vitamin D supplementation has been hypothesized as a potential intervention to lower diabetes risk. Recently, several trials have reported on the effect of vitamin D supplementation on diabetes prevention in people with prediabetes.<p> <p><i>Evidence Acquisition</i> - A comprehensive literature ...
  • Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival 

    Beretta, Matteo; Santos, Celio X.C.; Molenaar, Chris; Hafstad, Anne Dragøy; Miller, Chris CJ; Revazian, Aram; Betteridge, Kai; Schröder, Katrin; Streckfuß-Bömeke, Katrin; Doroshow, James H; Fleck, Roland A; Su, Tsung-Ping; Belousov, Vsevelod; Parsons, Maddy; Shah, Ajay M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-10)
    Cells subjected to environmental stresses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent triggering of the mitochondrial permeability transition (mPT), which is especially important in post‐mitotic cells such as cardiomyocytes and neurons. Here, we show that stress‐induced ...
  • Self-reported sleep quality with mandibular advancement device or continuous positive airway pressure: A randomized clinical trial on patients with mild and moderate obstructive sleep apnea 

    Berg, Lars Martin; Ankjell, Torun Karina Solheim; Trovik, Tordis A; Sjögren, Anders; Rikardsen, Oddveig G; Moen, Ketil; Sun, Yi-Qian; Bugten, Vegard (Journal article; Tidsskriftartikkel, 2020)
    <i>Study</i> - objectives To compare self-reported sleep quality, treatment compliance and respiratory event index (REI) after 4 months of treatment with mandibular advancement device (MAD) or continuous positive airway pressure (CPAP) in mild and moderate obstructive sleep apnea (OSA). <p> <p><i>Methods</i> - 104 patients with mild or moderate OSA were randomly allocated to MAD or CPAP treatment, ...
  • Deliberation Decreases the Likelihood of Expressing Dominant Responses 

    Martiny-Huenger, Torsten; Bieleke, Maik; Doerflinger, Johannes T.; Stephensen, Matthew; Gollwitzer, Peter M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-11)
    Deliberation is commonly assumed to be a central characteristic of humans’ higher cognitive functions, and the responses following deliberation are attributed to mechanisms that are qualitatively different from lower-level associative or affectively driven responses. In contrast to this perspective, the current article’s aim is to draw attention to potential issues with making inferences about ...
  • Challenges and Best Practices in Ethical Review of Human and Organizational Factors Studies in Health Technology: a Synthesis of Testimonies 

    Peute, Linda W.; Lichtner, Valentina; Baysari, Melissa T.; Hägglund, Maria; Homco, Juell; Jansen-Kosterink, Stephanie; Jauregui, Ignacio; Kaipio, Johanna; Kuziemsky, Craig E.; Lehnbom, Elin; Leite, Francisca; Lesselroth, Blake; Luna, Daniel; Otero, Carlos; Pedersen, Rune; Pelayo, Sylvia; Santos, Raquel; Silva, Nuno-André; Tyllinen, Mari; Van Velsen, Lex; Zheng, Wu Yi; Jaspers, Monique; Marcilly, Romaric (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-17)
    <i>Objective</i>: Human and Organizational Factors (HOF) studies in health technology involve human beings and thus require Institutional Review Board (IRB) approval. Yet HOF studies have specific constraints and methods that may not fit standard regulations and IRB practices. Gaining IRB approval may pose difficulties for HOF researchers. This paper aims to provide a first overview of HOF study ...
  • Digitally quantified CD8+ cells: the best candidate marker for an immune cell score in non-small cell lung cancer? 

    Paulsen, Erna-Elise; Andersen, Sigve; Rakaee, Mehrdad; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)
    The TNM classification is well established as a state-of-the-art prognostic and treatment-decision-making tool for non-small cell lung cancer (NSCLC) patients. However, incorporation of biological data may hone the TNM system. This article focuses on choosing and incorporating subsets of tissue-infiltrating lymphocyte (TIL), detected by specific immunohistochemistry and automatically quantified by ...
  • Association between diabetes and periodontitis: A cross sectional study based on findings from Tromsø 7 study 

    Alex, Silvi (Master thesis; Mastergradsoppgave, 2020-11-30)
    The 2017 reports published by Diabetesforbundet Norway showed an estimated 378 000 people living with diabetes (28 000 with Type 1 and 350 000 with Type 2). Mealey et al. (2006) showed that diabetes increases the risk for periodontitis, influenced by inflammatory processes. The formation of inflammatory molecules (e.g. Advanced glycation end products) leads to gingival attachment loss, periodontal ...
  • The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell 

    Hunt, Nicholas J; Lockwood, Glen P; Kang, Sun; Pulpitel, Tamara; Clark, Ximonie; Mao, Hong; McCourt, Peter Anthony; Cooney, Greg; Wali, Jibran; Le Couteur, Frank; Le Couteur, David G; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-14)
    Age-related changes in the liver sinusoidal endothelium, particularly the reduction in fenestrations, contribute to insulin resistance in old age. Metformin impacts on the aging process and improves insulin resistance. Therefore, the effects of metformin on the liver sinusoidal endothelium were studied. Metformin increased fenestrations in liver sinusoidal endothelial cells isolated from both young ...
  • Effects of gonadectomy and dihydrotestosterone on neuronal plasticity in motivation and reward related brain regions in the male rat 

    Huijgens, Patty; Snoeren, Eelke; Meisel, Robert; Mermelstein, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-06)
    Gonadal hormones affect neuronal morphology to ultimately regulate behaviour. In female rats, oestradiol mediates spine plasticity in hypothalamic and limbic brain structures, contributing to long‐lasting effects on motivated behaviour. Parallel effects of androgens in male rats have not been extensively studied. Here, we investigated the effect of both castration and androgen replacement on spine ...
  • Brukermedvirkning i samiske områder. Praktisering av urfolkskunnskap innen psykisk helsevern 

    Mathisen, Vår; Sørly, Rita (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-23)
    Brukermedvirkning er et ideal for norske myndigheter og helsevesen, og en rettighet for personer som benytter seg av tjenester, også innen psykisk helsevern. Et relevant spørsmål er om brukermedvirkning representerer en majoritetsforståelse for brukerorienterte tjenestetilbud, og om en slik forståelse direkte kan overføres til arbeid med samisk befolkning. Hensikten med vår studie er å få økt ...
  • Detection of mobile genetic elements associated with antibiotic resistance in Salmonella enterica using a newly developed web tool: MobileElementFinder 

    Johansson, Markus H; Bortolaia, Valeria; Tansirichaiya, Supathep; Aarestrup, Frank M.; Roberts, Adam P.; Petersen, Thomas Nordahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-03)
    <i>Objectives</i> - Antimicrobial resistance (AMR) in clinically relevant bacteria is a growing threat to public health globally. In these bacteria, antimicrobial resistance genes are often associated with mobile genetic elements (MGEs), which promote their mobility, enabling them to rapidly spread throughout a bacterial community.<p> <i>Methods</i> - The tool MobileElementFinder was developed ...
  • GP decisions to participate in emergencies: a randomised vignette study 

    Hjortdahl, Magnus; Gyrd-Hansen, Dorte; Halvorsen, Peder Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)
    <i>Background</i> - GPs use their judgement on whether to participate in emergencies; however, little is known about how GPs make their decisions on emergency participation.<p> <p><i>Aim</i> - To test whether GPs' participation in emergencies is associated with cause of symptoms, distance to the patient, other patients waiting, and out-of-hours (OOH) clinic characteristics.<p> <p><i>Design & ...
  • Genetic dominance governs the evolution and spread of mobile genetic elements in bacteria 

    Rodríguez-Beltrán, Jerónimo; Sørum, Vidar; Toll-Riera, Macarena; de la Vega, Carmen; Peña-Miller, Rafael; San Millán, Álvaro (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-22)
    Mobile genetic elements (MGEs), such as plasmids, promote bacterial evolution through horizontal gene transfer (HGT). However, the rules governing the repertoire of traits encoded on MGEs remain unclear. In this study, we uncovered the central role of genetic dominance shaping genetic cargo in MGEs, using antibiotic resistance as a model system. MGEs are typically present in more than one copy per ...
  • Olaparib monotherapy as primary treatment in unselected triple negative breast cancer 

    Eikesdal, Hans Petter; Yndestad, Synnøve; Elzawahry, Asmaa; Llop-Guevara, Alba; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Vagstad, Geirfinn; Venizelos, Andreas; Minsaas, Laura; Leirvaag, Beryl; Gudlaugsson, Einar; Vintermyr, Olav Karsten; Aase, Hildegunn Siv; Aas, Turid; Balmaña, Judith; Serra, Violeta; Janssen, Emiel; Knappskog, Stian; Lønning, Per Eystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-23)
    <p><i>Background - </i>The antitumor efficacy of PARP inhibitors (PARPi) for breast cancer patients harboring germline BRCA1/2 (gBRCA1/2) mutations is well established. While PARPi monotherapy was ineffective in patients with metastatic triple negative breast cancer (TNBC) wild type for BRCA1/2, we hypothesized that PARPi may be effective in primary TNBCs without previous chemotherapy exposure. < ...
  • Surgery for herniated lumbar disc in private vs public hospitals: A pragmatic comparative effectiveness study 

    Madsbu, Mattis Aleksander; Salvesen, Øyvind; Carlsen, Sven Magnus; Westin, Steinar; Onarheim, Kristian; Nygaard, Øystein Petter; Solberg, Tore; Gulati, Sasha (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-04)
    <p><i>Background - </i>There is limited evidence on the comparative performance of private and public healthcare. Our aim was to compare outcomes following surgery for lumbar disc herniation (LDH) in private versus public hospitals. <p><i>Methods - </i>Data were obtained from the Norwegian registry for spine surgery. Primary outcome was change in Oswestry disability index (ODI) 1 year after surgery. ...
  • Surgery for Extraforaminal Lumbar Disc Herniation: A Single Center Comparative Observational Study 

    Polak, Samuel B.; Madsbu, Mattis Aleksander; Vangen-Lønne, Vetle; Salvesen, Øyvind; Nygaard, Øystein Petter; Solberg, Tore; Vleggeert-Lankamp, Carmen L. A. M.; Gulati, Sasha (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-13)
    <p><i>Background - </i>Surgery on extraforaminal lumbar disc herniation (ELDH) is a commonly performed procedure. Operating on this type of herniation is known to come with more difficulties than on the frequently seen paramedian lumbar disc herniation (PLDH). However, no comparative data are available on the effectiveness and safety of this operation. We sought out to compare clinical outcomes at ...
  • Disparities amidst plenty: a health portrait of Indigenous peoples in circumpolar regions 

    Young, T. Kue; Broderstad, Ann Ragnhild; Sumarokov, Yury; Bjerregaard, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-30)
    This paper describes the extent and variation in health disparities between Indigenous and non-Indigenous people within Alaska, Greenland and the northern regions of Canada, Russia and the Nordic countries. We accessed official health statistics and reviewed research studies. We selected a few indicators of health status, health determinants and health care to demonstrate the health disparities that ...

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