Recent additions

  • Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold 

    Alopaeus, Julia Fredrika; Hellfritzsch, Marie; Gutowski, Tobias; Scherließ, Regina; Almeida, Andreia F; Sarmento, Bruno; Skalko-Basnet, Natasa; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)
    From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without the need of swallowing, and improved patient safety. The aim of the presented work was to prepare a buccal film using a self-forming micellar drug solubiliser as the film matrix, combining it with a mucoadhesive polymer for an enhanced retention on the buccal mucosa. Specifically, ...
  • Identifying sequence variants contributing to hereditary breast and ovarian cancer in BRCA1 and BRCA2 negative breast and ovarian cancer patients 

    Jarhelle, Elisabeth; Stensland, Hilde Monica Frostad Riise; Hansen, Geir Åsmund Myge; Skarsfjord, Siri; Jonsrud, Christoffer; Ingebrigtsen, Monica; Strømsvik, Nina; Van Ghelue, Marijke (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-27)
    Families with breast and ovarian cancer are often tested for disease associated sequence variants in <i>BRCA1</i> and <i>BRCA2</i>. Pathogenic sequence variants (PVs) in these two genes are known to increase breast and ovarian cancer risks in females. However, in most families no PVs are detected in these two genes. Currently, several studies have identified other genes involved in hereditary breast ...
  • Association of use of the neonatal early-onset sepsis calculator with reduction in antibiotic therapy and safety: A systematic review and meta-analysis 

    Achten, Niek B.; Klingenberg, Claus; Benitz, William E.; Stocker, Martin; Schlapbach, Luregn J.; Giannoni, Eric; Bokelaar, Robin; Driessen, Gertjan J.A.; Brodin, Petter; Uthaya, Sabita; van Rossum, Annemarie M.C.; Plötz, Frans B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-03)
    <i>Importance</i> - The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on the effectiveness and safety of the EOS calculator is essential to inform clinicians considering implementation.<p> <p><i>Objective</i> - To assess the association between management of neonatal EOS ...
  • The effect of high-dose vitamin D3 supplementation on bone mineral density in subjects with prediabetes 

    Larsen, Anette Uhlving; Grimnes, G.; Jorde, R. (Master thesis; Mastergradsoppgave, 2019-10-30)
    Purpose: Type 2 diabetes mellitus is associated with increased fracture risk and recent studies show crosstalk between bone and glucose metabolism. Few studies have investigated the effect of vitamin D supplementation on bone without additional calcium. In the present study, we aimed to determine whether a high dose of vitamin D3 could improve bone mass density (BMD) in prediabetic subjects. Methods: ...
  • Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study 

    Småbrekke, Silje; Schirmer, Henrik; Melsom, Toralf; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Master thesis; Mastergradsoppgave, 2019-10-28)
    Background: Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive function in ...
  • Socio-economic inequalities in utilisation of physiotherapy and chiropractic treatment in Norway. A population based cross-sectional survey 

    Sørensen, Sigrid Hveding (Master thesis; Mastergradsoppgave, 2019-09-15)
    Background: In Norway, it is widely agreed that health services should be available for all, irrespective of place of residence, gender, income or socioeconomic status. It seems that the use of general practitioners is equally distributed, while the better-off are more likely to use specialist healthcare. There is limited knowledge of the equity of other aspects of health care, such as physiotherapy ...
  • The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model 

    Granslo, Hildegunn Norbakken; Aarag, Elizabeth; Esaiassen, Eirin; Christophersen, Lars; Jensen, Peter Østrup; Mollnes, Tom Eirik; Moser, Claus; Flægstad, Trond; Klingenberg, Claus; Cavanagh, Jorunn Pauline (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-27)
    The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host defence are important strategies in the search for novel antimicrobial drugs. We investigated the inflammatory response of the synthetic short antimicrobial peptide LTX21 in two ...
  • Factors influencing growth of children aged 12-24 months in the Tanga Region, Tanzania 

    Elverud, Ingvild Skålnes; Størdal, Ketil; Chiduo, Mercy Grace; Klingenberg, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-23)
    <i>Background</i> - The first 1000 days of life, from conception to the second birthday, offer a unique window of opportunity for optimal growth, critical for future health. The primary aim of this study was to analyze growth of children between 12 and 24 months age in Tanzanian children, and to explore possible predictors for growth.<p> <p><i>Methods</i> - Observational, cross-sectional study ...
  • Growth and neurodevelopment in very preterm infants receiving a high enteral volume-feeding regimen - a population-based cohort study 

    Klingenberg, Claus; Muraas, Fredrik Kragh; Isaksen, Catherine Elde; Nilsen, Tina; Torgersen, Marte; Melum-Hansen, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-06)
    <i>Aim</i>: The aim of this study is to evaluate a feeding regimen routinely providing >180 ml/kg/d fortified human milk to very preterm infants and impact on in-hospital growth, osteopenia, and neurodevelopment.<p> <p><i>Method</i>: Retrospective population-based descriptive study of infants <30-week gestation admitted within 24 h of birth and discharged during the 6-year period 2005–2010. ...
  • Multi-scale modeling of drug binding kinetics to predict drug efficacy 

    Clarelli, Fabrizio; Liang, Jingyi; Martinecz, Antal; Heiland, Ines; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-25)
    Optimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration). Mathematical models are frequently used to infer drug concentrations over time based on infrequent sampling and/or in inaccessible body compartments. Models are ...
  • How can task shifting put patient safety at risk? A qualitative study of experiences among general practitioners in Norway 

    Malterud, Kirsti; Aamland, Aase; Fosse, Anette (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)
    <i>Objective</i>: To describe experiences among general practitioners (GPs) in Norway regarding horizontal task shifting experiences associated with adverse events that potentially put patient safety at risk.<p> <p><i>Design and contributors</i>: We conducted a qualitative study with data from a retrospective convenience sample of consecutive, already posted comments in a restricted Facebook group ...
  • The Maternal and Paternal Effects on Clinically and Surgically Defined Osteoarthritis 

    Weldingh, Eirik; Johnsen, Marianne Bakke; Hagen, Kåre Birger; Østerås, Nina; Risberg, May Arna; Natvig, Bård; Christensen, Barbara Therese Slatkovsky; Fenstad, Anne Marie; Furnes, Ove; Nordsletten, Lars; Magnusson, Karin (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-25)
    <i>Objective</i> - It is currently unknown whether osteoarthritis (OA) is inherited mainly from the mother, father, or both. This study was undertaken to explore the effect of maternal and paternal factors on hip, knee, and hand OA in offspring.<p> <p><i>Methods</i> - Participants from the Musculoskeletal Pain in Ullensaker Study (MUST) (69% female; mean ± SD age 64 ± 9 years) and a Norwegian ...
  • Group-based, individualized exercises can provide perceived bodily changes and strengthen aspects of self in individuals with MS: a qualitative interview study 

    Arntzen, Ellen Christin; Øberg, Gunn Kristin; Gallagher, Shaun; Normann, Britt (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-26)
    <i>Background</i>: Group-based physiotherapy is effective for individuals with MS; nevertheless individualization within groups is questioned and little is known regarding individuals´ experiences with individualization in small groups.<p> <p><i>Objective</i>: We aimed to explore the short- and long-term experiences of individuals with MS participating in a 6-week, group-based, individualized ...
  • Exposures and Health Effects of Bioaerosols in Seafood Processing Workers - a Position Statement 

    Bonlokke, Jakob; Bang, Berit; Aasmoe, Lisbeth; Rahman, Anas M. Abdel; Syron, Laura N.; Andersson, Eva; Dahlman-Høglund, Anna; Lopata, Andreas L.; Jeebhay, Mohamed Fareed (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-27)
    Occupational hazards exist in the processing of seafood both in land-based facilities as well as on board vessels. Recent findings on occupational injury and respiratory health risks among seafood processing workers were presented and discussed at the IFISH5 conference. Particular emphasis was put on the challenges that im/migrant workers encounter, the greater risks onboard factory vessels, especially ...
  • Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls 

    Zebaze, Roger; Osima, Marit; Bui, Minh; Lukic, Marko; Wang, Xiaofang; Ghasem-Zadeh, Ali; Eriksen, Erik Fink; Vais, Angela; Shore-Lorenti, Catherine; Ebeling, Peter R.; Seeman, Ego; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-18)
    Advancing age is accompanied by a reduction in bone formation and remodeling imbalance, which produces microstructural deterioration. This may be partly caused by a diversion of mesenchymal cells towards adipocytes rather than osteoblast lineage cells. We hypothesized that microstructural deterioration would be associated with an increased marrow adiposity, and each of these traits would be independently ...
  • Kunnskapsoppsummering og klassifisering av tiltaket De Utrolige Årene Universalprogrammet (1. utg.) 

    Drozd, Filip; Hansen, Ketil Lenert (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-17)
    <i>BAKGRUNN</i> - Denne artikkelen er en kunnskapsoppsummering av effektene på De Utrolige Årenes universalprogram Oppmerksomme og utviklingsstøttende foreldre (DUÅ Universal) i Norden. DUÅ Universal er et universalforebyggende program som gis til foreldre, for å forebygge atferdsvansker og styrke sosial og emosjonell kompetanse hos barn i alderen 2 til 6 år. Regionalt kunnskapssenter for barn og ...
  • Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging 

    Fjellaksel, Richard; Moldes-Anaya, Angel; Vasskog, Terje; Oteiza, Ana; Martin-Armas, Maria Montserrat; Hjelstuen, Ole Kristian; Hansen, Jørn H; Riss, Patrick; Sundset, Rune (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
    The increased expression of gonadotropin releasing hormone receptor (GnRH‐R) in brain has been strongly linked to Alzheimer disease. Therefore, the development of radiolabeled imaging agents for GnRH‐R is relevant for early diagnosis of Alzheimer disease. We have recently disclosed the discovery of two promising compounds displaying nanomolar‐range affinity for the GnRH‐R. In the present study, a ...
  • Optimisation of high-resolution fluorescence microscopy of normal- and preeclamptic placentas 

    Knutsen, Kristine Marie Bakken (Master thesis; Mastergradsoppgave, 2019-08-14)
    Preeclampsia (PE) affects 3-5 % of pregnant women and may lead to maternal and/or fetal death. The main theory of PE is placental ischemia, leading to a dysfunctional placenta and clinical signs as hypertension and proteinuria in the mother. The primary aim of the thesis was to implement and optimise a method for high-resolution microscopy of placental cryo-sections. Secondary aims were to compare ...
  • The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery 

    Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-16)
    Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as drugs absorbed in the olfactory epithelium bypass the blood-brain barrier and reach the brain within minutes. However, the nasal mucosa properties (e.g., tonicity, pH) are not constant ...
  • Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor 

    Fjellaksel, Richard; Boomgaren, Marc; Sundset, Rune; Haraldsen, Ira Hebold; Hansen, Jørn H; Riss, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-14)
    In this communication, we report the synthesis and characterization of a library of small molecule antagonists of the human gonadotropin releasing hormone receptor based upon the 2-(4-<i>tert</i>-butylphenyl)-4-piperazinyl-benzimidazole scaffold <i>via</i> Cu-catalysed azide alkyne cycloaddition. Our main purpose was to find a more soluble compound based on the WAY207024 lead with nanomolar potency ...

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