Recent additions

  • The Master Study in Telemedicine and E-health at the University of Tromsø, Norway, 2005-2018 

    Wynn, Rolf; Ellingsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
    In this paper we describe the Master Study in Telemedicine and E-health at the University of Tromsø, Norway. The study enrolled its first students in 2005 and was closed in 2018. We describe and discuss the background of the programme, its development and accomplishments and why it was closed. Hopefully, this narrative will be of use to other programmes focusing on e-health.
  • Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer 

    Dawadi, Rangita; Malla, Nabin; Hegge, Beate; Wushur, Imin; Berg, Eli; Svineng, Gunbjørg; Sylte, Ingebrigt; Winberg, Jan-Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-12)
    Previous studies have shown that THP-1 cells produced an SDS-stable and reduction-sensitive complex between proMMP-9 and a chondroitin sulfate proteoglycan (CSPG) core protein. The complex could be reconstituted in vitro using purified serglycin (SG) and proMMP-9 and contained no inter-disulfide bridges. It was suggested that the complex involved both the FnII module and HPX domain of proMMP-9. The ...
  • Plan, recruit, retain: a framework for local healthcare organizations to achieve a stable remote rural workforce 

    Abelsen, Birgit; Strasser, Roger; Heaney, David; Berggren, Peter; Sigurðsson, Sigurður; Brandstorp, Helen; Wakegijig, Jennifer; Forsling, Niclas; Moody-Corbett, Penny; Akearok, Gwen Healey; Mason, Anne; Savage, Claire; Nicoll, Pam (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-03)
    <i>Background</i> - Recruiting and retaining a skilled health workforce is a common challenge for remote and rural communities worldwide, negatively impacting access to services, and in turn peoples’ health. The research literature highlights different factors facilitating or hindering recruitment and retention of healthcare workers to remote and rural areas; however, there are few practical tools ...
  • Serum PTH is not a good marker for defining a threshold for vitamin D deficiency 

    Jorde, Rolf; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-01)
    <i>Objective</i>: In addition to its skeletal effects, vitamin D may also be important for health in general. It is uncertain what level of serum 25-hydroxyvitamin D (25(OH)D), marker of vitamin D status, is sufficient for these effects. With decreasing serum 25(OH)D levels there is an increase in serum PTH. The point at which this occurs has been considered as a threshold for vitamin D sufficiency. ...
  • Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: the Nordic-Baltic Bifurcation Study IV 

    Kumsars, Indulis; Holm, Niels Ramsing; Niemelä, Matti; Erglis, Andrejs; Kervinen, Kari; Kervinen, Evald Høj; Maeng, Michael; Dombrovskis, Andis; Abraitis, Vytautas; Kibarskis, Aleksandras; Trovik, Thor; Latkovskis, Gustavs; Sondore, Dace; Narbute, Inga; Juhl Terkelsen, Christian; Eskola, Markko; Romppanen, Hannu; Laine, Mika; Jensen, Lisette Okkels; Pietila, Mikko; Gunnes, Pål; Hebsgaard, Lasse; Frobert, Ole; Calais, Fredrik; Hartikainen, Juha; Aarøe, Jens; Ravkilde, Jan; Engstrøm, Thomas; Steigen, Terje K.; Thuesen, Leif; Lassen, Jens F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-19)
    <i>Background</i> - It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation.<p> <p><i>Methods</i> ...
  • Behandlingsrater for ryggkirurgi i Norge og Helse Nord 2014-18 

    Ingebrigtsen, Tor; Balteskard, Lise; Guldhaugen, Kristel Ailin; Kloster, Roar; Uleberg, Bård Erling; Grotle, Margreth; Solberg, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-23)
    <i>BAKGRUNN</i> - Formålet med denne studien var å undersøke om behandlingstilbudet innen ryggkirurgi i Helse Nord er i henhold til den vedtatte funksjonsfordelingen mellom sykehusene i regionen, og om det er geografisk variasjon i tilbudet. Vi undersøkte derfor behandlingsrater i Norge og Helse Nord, samt egendekning i Helse Nord, og vurderte aktiviteten i regionen.<p> <p><i>MATERIALE OG METODE</i> ...
  • Clinical characterization of Helicobacter pylori infected patients 15 years after unsuccessful eradication 

    Nestegard, Oddmund; Johnsen, Kay-Martin; Sørbye, Sveinung; Halvorsen, Fred-Arne; Tønnessen, Tor; Paulssen, Eyvind Jakob; Melby, Kjetil K.; Goll, Rasmus; Florholmen, Jon (Journal article; Tidsskriftartikkel, 2020-09-23)
    <i>Background and aims</i> - Patients that have failed therapy for Helicobacter pylori (H. pylori) infection are incompletely characterized. The aim of this study was to characterize a H. pylori treatment resistant cohort compared to the cohorts of newly diagnosed, earlier eradicated and non-infected.<p> <p><i>Material and methods</i> - Patients were selected from routine referrals to the Endoscopy ...
  • Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones 

    Clarelli, Fabrizio; Palmer, Adam; Singh, Bhupender; Storflor, Merete; Lauksund, Silje; Cohen, Ted; Abel, Sören; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-14)
    Antibiotic resistance is rising and we urgently need to gain a better quantitative understanding of how antibiotics act, which in turn would also speed up the development of new antibiotics. Here, we describe a computational model (COMBAT-COmputational Model of Bacterial Antibiotic Target-binding) that can quantitatively predict antibiotic dose-response relationships. Our goal is dual: We address a ...
  • A Survey on Cannabinoid Treatment of Pediatric Epilepsy Among Neuropediatricians in Scandinavia and Germany 

    Klingenberg, Claus; Mouslet, George; Hjalgrim, Helle; Gerstner, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-24)
    <i>Objectives</i>: There is an increasing interest in cannabinoid-based products for the treatment of refractory pediatric epilepsy. However, a licensed cannabidiol (CBD) product was first approved for use by the European regulatory authorities in 2019. We aimed to obtain knowledge about clinical experience and attitudes toward cannabinoid use for epilepsy treatment among neuropediatricians in ...
  • Are Parents Less Responsive to Young Children When They Are on Their Phones? A Systematic Naturalistic Observation Study 

    Vanden Abeele, Mariek M. P.; Abels, Monika; Hendrickson, Andrew T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-04)
    This study examined whether parents are less responsive to their young children (0–5) when they use a phone. We systematically observed 53 parent–child dyads in consultation bureau waiting rooms and playgrounds. Twenty-three parents used their phone at least once during the observation. Across the dyads, we observed parent and child behavior during a total of 1,038 ten-second intervals. Of these ...
  • Prediction of chronic heart failure and chronic obstructive pulmonary disease in a general population: the Tromsø study 

    Melbye, Hasse; Stylidis, Michael; Aviles Solis, Juan Carlos; Averina, Maria; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-07)
    <i>Aims</i> - Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are main causes of dyspnoea, and echocardiography and spirometry are essential investigations for these diagnoses. Our aim was to determine the prevalence of HF and COPD in a general population, also how the diseases may be identified, and to what extent their clinical characteristics differ.<br><br> <i>Methods and ...
  • Room tilt illusion and subclavian steal - A case report 

    Arntzen, Kathrine; Alstadhaug, Karl Bjørnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-08)
    <i>Background</i> - Room tilt illusion (RTI) is a rare symptom of higher vestibular dysfunction, consisting of a transient vertical rotation of the visual scene in the sagittal or coronal plane, most often 90<sup>o</sup> or 180<sup>o</sup>, without any alteration in shape, size and color of objects.<br><br> <i>Case presentation</i> - A 63-year-old woman with a history of hypertension and chronic ...
  • The Role of Emotions for 4 Athletes in Nordic Combined in Ski Jumping Competitions in World Cup 

    Moen, Frode; Vitsøe, Joar; Rasdal, Vegard; Myhre, Kenneth; Sandbakk, Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)
    This study looks at how emotions were associated with ski jumping competitions in world cup for four athletes representing the Norwegian national team in Nordic combined. The athletes documented their emotional experiences during competition rounds (trial-, and competition rounds) and non-competitive episodes (the period just after the competition round). The results in this study show that there ...
  • Shotgun-Metagenomics on Positive Blood Culture Bottles Inoculated With Prosthetic Joint Tissue: A Proof of Concept Study 

    Sanabria-Moreno, Adriana Maria; Hjerde, Erik; Johannessen, Mona; Sollid, Johanna U Ericson; Simonsen, Gunnar Skov; Hanssen, Anne Merethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-17)
    Clinical metagenomics is actively moving from research to clinical laboratories. It has the potential to change the microbial diagnosis of infectious diseases, especially when detection and identification of pathogens can be challenging, such as in prosthetic joint infection (PJI). The application of metagenomic sequencing to periprosthetic joint tissue (PJT) specimens is often challenged by low ...
  • Plasmid Interactions Can Improve Plasmid Persistence in Bacterial Populations 

    Gama, João Alves; Zilhão, Rita; Dionisio, Francisco (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-31)
    It is difficult to understand plasmid maintenance in the absence of selection and theoretical models predict the conditions for plasmid persistence to be limited. Plasmid-associated fitness costs decrease bacterial competitivity, while imperfect partition allows the emergence of plasmid-free cells during cell division. Although plasmid conjugative transfer allows mobility into plasmid-free cells, ...
  • Model Gender Interacts With Expressed Emotion to Enhance Startle: Angry Male and Happy Female Faces Produce the Greatest Potentiation 

    Åsli, Ole; Øvervoll, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-09)
    Several studies have implied gender differences in startle reaction to emotional facial expressions. However, few studies have been designed to investigate the difference between responding to emotional female vs. male faces, nor gender differences in responses. The present experiment investigated startle EMG responses to a startle probe while viewing pictures of neutral, happy, angry, fearful, and ...
  • Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study 

    Jorde, Rolf; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-02)
    <i>Background</i> - There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined.<p> <p><i>Method</i> - In the seventh survey of the Tromsø study, serum 25(OH)D and parathyroid hormone were measured, and questionnaires ...
  • Biocompatibility in low-density lipoprotein apheresis and plasma separation 

    Hardersen, Randolf Inge (Doctoral thesis; Doktorgradsavhandling, 2021-02-12)
    <p><i>Introduction:</i> Low-density lipoprotein (LDL) apheresis is used for the removal of LDL in selected patients and is also used for other medical indications. This thesis aimed to systematically study how different LDL apheresis systems affected the immune system in a biocompatibility perspective under in vivo and ex vivo conditions. <p><i>Methods:</i> Whole blood adsorption, dextran sulfate ...
  • Sudden caffeine withdrawal triggers migraine—A randomized controlled trial 

    Alstadhaug, Karl Bjørnar; Ofte, Hilde Karen; Müller, Kai Ivar; Andreou, Anna P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-10)
    <i>Objective</i>: Assessing the effects of caffeine withdrawal on migraine.<p> <p><i>Background</i>: The effects of caffeine withdrawal on migraineurs are at large unknown.<p> <p><i>Methods</i>: This was a randomized, double-blind, crossover study (NCT03022838), designed to enroll 80 adults with episodic migraine and a daily consumption of 300–800 mg caffeine. Participants substituted their ...
  • Genetic risk-factors for anxiety in healthy individuals: polymorphisms in genes important for the HPA axis 

    Lindholm, Heléne; Morrison, India; Krettek, Alexandra; Malm, Dan; Novembre, Giovanni; Handlin, Linda (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-21)
    <i>Background</i> - Two important aspects for the development of anxiety disorders are genetic predisposition and alterations in the hypothalamic-pituitary-adrenal (HPA) axis. In order to identify genetic risk-factors for anxiety, the aim of this exploratory study was to investigate possible relationships between genetic polymorphisms in genes important for the regulation and activity of the HPA ...

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