Recent additions

  • The role of mitochondrial reactive oxygen species, NO and H2S in ischaemia/reperfusion injury and cardioprotection 

    Andreadou, Ioanna; Schulz, Rainer; Papapetropoulos, Andreas; Turan, Belma; Ytrehus, Kirsti; Ferdinandy, Peter; Daiber, Andreas; Di Lisa, Fabio (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-08)
    Redox signalling in mitochondria plays an important role in myocardial ischaemia/reperfusion (I/R) injury and in cardioprotection. Reactive oxygen and nitrogen species (ROS/RNS) modify cellular structures and functions by means of covalent changes in proteins including among others S‐nitros(yl)ation by nitric oxide (NO) and its derivatives, and S‐sulphydration by hydrogen sulphide (H<sub>2</sub>S). ...
  • Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania 

    Pedersen, Torunn Annie; Tellevik, Marit Gjerde; Kommedal, Øyvind; Lindemann, Paul Christoffer; Moyo, Sabrina John; Janice, Jessin; Blomberg, Bjørn; Samuelsen, Ørjan; Langeland, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
    Increased knowledge about the role of horizontal gene transfer is key to improve our understanding of the spread of antimicrobial resistance (AMR) in human populations. We therefore studied the dissemination of the <i>bla</i><sub>CTX-M-15</sub> extended-spectrum-β-lactamase (ESBL) gene in <i>Klebsiella pneumoniae</i> isolates obtained from stool samples from hospitalized children and healthy controls ...
  • The Metabolome and Lipidome of Ulcerative Colitis 

    Diab, Joseph (Doctoral thesis; Doktorgradsavhandling, 2020-10-09)
    The two major forms of Inflammatory bowel disease (IBD), Ulcerative Colitis (UC) and Crohn’s Disease (CD), are characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host-microbe interaction. This overwhelming complexity makes IBD ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient ...
  • Finding ways to carry on : stories of vulnerability in chronic illness 

    Synnes, Oddgeir; Orøy, Aud Jorun; Råheim, Målfrid; Bachmann, Liv; Ekra, Else Mari Ruberg; Gjengedal, Eva; Høie, Magnhild; Jørgensen, Else; Michaelsen, Ragnhild Karen Astad; Sundal, Hildegunn; Vatne, Solfrid; Lykkeslet, Else (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-20)
    <i>Purpose</i>: In this study, we explore the lived experiences of chronic illness in four groups of patients; children with asthma, adolescents with diabetes, young adults with depression, and adult patients with chronic, obstructive pulmonary disease (COPD). Persons living with chronic illness are often designated as vulnerable. This study builds on the assumption that being vulnerable belongs to ...
  • A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naïve and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression 

    Diab, Joseph; Al-Mahdi, Rania; Gouveia, Sandra; Hansen, Terkel; Jensen, Einar; Goll, Rasmus; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-22)
    <p><i>Background</i> - The bioactive metabolites of omega 3 and omega 6 polyunsaturated fatty acids (ω-3 and ω-6) are known as oxylipins and endocannabinoids (eCBs). These lipid metabolites are involved in prompting and resolving the inflammatory response that leads to the onset of inflammatory bowel disease (IBD). This study aims to quantify these bioactive lipids in the colonic mucosa and to ...
  • Patient experiences with digital health solutions. A systematic review 

    Leonardsen, Ann-Chatrin Linqvist; Hardeland, Camilla; Helgesen, Ann Karin; Grøndahl, Vigdis Abrahamsen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-24)
    <i>Background</i> - Healthcare services are facing extensive challenges due to the increased proportion of elderly persons and persons with chronic disease. Technology enabled care (TEC) is a collective term for telecare, telehealth, telemedicine, mobile (m)-, digital- and electronic (e) health services. TEC is increasingly seen as a solution to many of the challenges facing the health sector. Patient ...
  • Description of health-related rehabilitation service provision and delivery in randomized controlled trials: A topic review 

    Andelic, Nada; Lu, Juan; Gutenbrunner, Christoph; Nugraha, Boya; Gormley, Mirinda; Søberg, Helene; Sveen, Unni; Anke, Audny; Kirkevold, Marit; Røe, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-18)
    Objective: To determine how health-related rehabilitation services have been described in recently pub-lished randomized clinical trials, using the International Classification System for Service Organization in Health-Related Rehabilitation (ICSO-R 2.0) as a framework.<p><p> Methods: Medline was searched for English--language randomized clinical trials (RCTs) published between 1 January 2018 and ...
  • Psychosis and Psychotic-Like Symptoms Affect Cognitive Abilities but Not Motivation in a Foraging Task 

    ten Velden Hegelstad, Wenche; Kreis, Isabel Viola; Tjelmeland, Håkon; Pfuhl, Gerit (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-31)
    <i>Background and Objective</i>: Goal-directed behavior is a central feature of human functioning. It requires goal appraisal and implicit cost-benefit analyses, i.e., how much effort to invest in the pursuit of a certain goal, against its value and a confidence judgment regarding the chance of attainment. Persons with severe mental illness such as psychosis often struggle with reaching goals. ...
  • Perceptions of Family Caregivers of Home-Dwelling Persons with Dementia regarding Access to Information and Involvement in Decisions 

    Henriksen, Nils Oddbjørn; Moholt, Jill-Marit; Blix, Bodil Hansen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)
    This cross-sectional study explored factors affecting information about available health services, content of services provided, and involvement in decisions regarding services as perceived by the family caregivers of home-dwelling persons with dementia in Northern Norway. Altogether, 788 family caregivers were invited to participate in a survey, with a response rate of 54.6% (n = 430). The respondents ...
  • Spatial distribution of malignant transformation in patients with low-grade glioma 

    Jakola, Asgeir S; Bouget, David Nicolas Jean-Marie; Reinertsen, Ingerid; Skjulsvik, Anne Jarstein; Sagberg, Lisa Millgård; Bø, Hans Kristian; Gulati, Sasha; Sjåvik, Kristin; Solheim, Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)
    <i>Background</i> - Malignant transformation represents the natural evolution of diffuse low-grade gliomas (LGG). This is a catastrophic event, causing neurocognitive symptoms, intensified treatment and premature death. However, little is known concerning the spatial distribution of malignant transformation in patients with LGG.<p><p> <i>Materials and methods</i> - Patients histopathological ...
  • Individual Variation in Adaptive Immune Responses and Risk of Hip Fracture-A NOREPOS Population-Based Cohort Study 

    Dahl, Jesper; Holvik, Kristin; Heldal, Einar; Grimnes, Guri; Hoff, Mari; Finnes, Trine; Apalset, Ellen Margrete; Meyer, Haakon E (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-22)
    Immune‐mediated bone loss significantly impacts fracture risk in patients with autoimmune disease, but to what extent individual variations in immune responses affect fracture risk on a population level is unknown. To examine how immune responses relate to risk of hip fracture, we looked at the individual variation in a post‐vaccination skin test response that involves some of the immune pathways ...
  • C1-inhibitor. Betydning i sykdom og terapi -Et narrativt litteraturstudium belyst med publikasjoner av T.E Mollnes, E.W. Nielsen og medarbeidere ved immunologisk forskningslaboratorium Nordlandssykehuset Bodø 

    Evjenth, Marie Hansen (Master thesis; Mastergradsoppgave, 2017-09-18)
    Formålet med denne oppgaven er todelt. Hoveddelen av oppgaven er et narrativt litteraturstudium med mål å få en bred og god forståelse for hvilken struktur og funksjon C1-inhibitor har, hvilken effekt proteinet har i de ulike kaskadesystemene i kroppen hvor proteinet inngår som en regulator, samt hvilken rolle proteinet spiller i patogenesen ved hereditært angioødem, alt dette belyst med publikasjoner ...
  • CORE-OM as a routine outcome measure for adolescents with emotional disorders: factor structure and psychometric properties 

    Lorentzen, Veronica; Handegård, Bjørn Helge; Moen, Connie Malén; Solem, Kenth; Lillevoll, Kjersti; Skre, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-20)
    <i>Background</i> - Instruments for monitoring the clinical status of adolescents with emotional problems are needed. The Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) according to theory measures problems/symptoms, well-being, functioning and risk. Documentation of whether the theoretical factor structure for CORE-OM is applicable for adolescents is lacking.<p><p> <i>Methods</i> ...
  • Chlorhexidine compounds in cosmetic products Risk assessment of antimicrobial and antibiotic resistance development in microorganisms 

    Lunestad, Bjørn Tore; Møretrø, Trond; Hegstad, Kristin; Langsrud, Solveig; Scheie, Anne Aamdal; Kapperud, Georg; Lassen, Jørgen Fr; Nygård, Karin Maria; Robertson, Lucy; Nesbakken, Truls; Olsvik, Ørjan; Tranulis, Michael A.; Tryland, Morten; Rimstad, Espen (Research report; Forskningsrapport, 2010-04-15)
    Chlorhexidine and its salts are reported as being used in cosmetics as an active ingredient to give the desired effect or as a preservative in concentrations of up to 0.3 %. Such products include mouthwashes, hair dying and bleaching formulations, shampoos, anti hair “aging” products and exfoliants, body lotions, eye creams, face cleansers, sun cream, after-sun lotions, ...
  • Helse- og miljørisikovurdering genmodifisert mais MON 87460 fra Monsanto (EFSA/GMO/NL/2009/70) 

    Sorteberg, Hilde-Gunn Opsahl; Bøhn, Thomas; Finne, Merethe Aasmo; Holck, Askild Lorentz; Klungland, Helge; Meadow, Richard; Mikalsen, Arne; Myhr, Anne Ingeborg; Nerland, Audun Helge; Nes, Ingolf; Nielsen, Kaare Magne; Stabbetorp, Odd Egil; Thrane, Vibeke; Vikse, Rose (Research report; Forskningsrapport, 2010-05-04)
    Helse- og miljørisikovurderingen av den maislinjen MON 87460 (EFSA/GMO/NL/2009/70) fra Monsanto er utført av Faggruppe for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet (VKM). Mattilsynet og Direktoratet for naturforvalting (DN) ber Vitenskapskomiteen for mattrygghet om å vurdere den genmodifiserte maislinjen MON 87460 til import og prosessering, og til bruk ...
  • Assessment of benefits and risks of probiotics in baby foods Bifidobacterium lactis Bb12. 

    Halvorsen, Ragnhild; Narvhus, Judith; Lassen, Jørgen Fr; Midtvedt, Tore; Rugtveit, Jarle; Yazdankhah, Siamak Pour; Andersen, Lene Frost; Frølich, Wenche; Frøyland, Livar; Haugen, Margaretha; Høiby, Anne; Kapperud, Georg; Lunestad, Bjørn Tore; Meltzer, Helle Margrete; Nesbakken, Truls; Nygård, Karin Maria; Robertson, Lucy; Olsvik, Ørjan; Paulsen, Jan Erik; Tranulis, Michael A.; Tryland, Morten; Rimstad, Espen (Research report; Forskningsrapport, 2010-05-14)
    The Norwegian Scientific Committee for Food Safety (VKM) has appointed an ad hoc-group of experts to answer a request from the Norwegian Food Safety Authority regarding benefit and risk assessment of B. lactis Bb12 in baby foods focusing on the age groups 4-6 months, 6-12 months and 1-3 years. This assessment is based on the literature provided by the notifier as well as that found by a MEDLINE search.
  • Markedstest av reinkalvkjøtt i det norske restaurantsegmentet 

    Heide, Morten; Utsi, Tove Aagnes; Østli, Jens (Research report; Forskningsrapport, 2009-04)
    Rapporten omfatter resultatene fra en markedstest der 30 norske kjøkkensjefer har prøvd både reinkalvkjøtt og kjøtt fra voksen rein (simle). Målsettingen med undersøkelsen var å undersøke om en introduksjon av reinkalvkjøtt som eget produkt i det norske restaurantsegmentet kan bidra til økt differensiering og verdiskapning på reinkjøtt. Resultatene viser at kjøkkensjefene synes at reinkalvkjøtt ...
  • Kroppsvekt, vektøkning og kreftrisiko hos kvinner 

    da Silva, Marisa Eleonor (Conference object; Konferansebidrag, 2018-11-17)
  • Pasientvolum og behandlingskvalitet ved behandling av karotisstenose 

    Norderhaug, Inger Natvig; Krogstad, Unni; Jensen, Jan Odgard; Thürmer, Hanne (Research report; Forskningsrapport, 2009-06)
    Kunnskapssenteret fikk i april 2008 forespørsel fra Helse Sør-Øst RHF om å oppda-tere Kunnskapssenterets rapport fra 2007 om pasientvolum og behandlingskvalitet ved hjerte- og karsykdommer. Dette notatet er utført som et hasteoppdrag, med oppdatering av kapitlet om behandling ved forsnevring av halspulsåren (karotisste-nose). Oppdragsgiver var særlig interessert i om det var kommet ny litteratur ...
  • Prognostic indicators of survival for patients with oral cavity squamous cell carcinoma in Norway. Outcomes in a retrospective, multicenter cohort, with special focus on oral tongue squamous cell carcinoma, 2005-2009 

    Bjerkli, Inger-Heidi (Doctoral thesis; Doktorgradsavhandling, 2020-10-08)
    Oral cavity cancer (OCC) is the most frequent of head and neck cancers, most being squamous cell carcinomas (SCC). Within the oral cavity, the oral tongue is the most common site of cancer. These cancers are very aggressive, with poor survival. The treatment decision is based upon classifications of tumor (T), lymph node (N), and metastasis (M), although tumors with the same classification may act ...

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