Recent additions

  • Rising Sun: Prioritized outcomes for suicide prevention in the Arctic 

    Collins, Pamela Y.; Delgado, Roberto A.; Apok, Charlene; Baez, Laura; Bjerregaard, Peter; Chatwood, Susan; Chipp, Cody; Crawford, Allison; Crosby, Alex; Dillard, Denise; Driscoll, David; Ericksen, Heidi; Hicks, Jack; Larsen, Christina Viskum Lytken; McKeon, Richard; Partapuoli, Per Jonas; Phillips, Anthony; Pringle, Beverly; Rasmus, Stacy; Sigurðardóttir, Sigrún; Silviken, Anne; Stoor, Jon Petter Anders; Sumarokov, Yury; Wexler, Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-24)
    The Arctic Council, a collaborative forum among governments and Arctic communities, has highlighted the problem of suicide and potential solutions. The mental health initiative during the United States chairmanship, Reducing the Incidence of Suicide in Indigenous Groups: Strengths United Through Networks (RISING SUN), used a Delphi methodology complemented by face-to-face stakeholder discussions to ...
  • Tumor lysis with LTX-401 creates anticancer immunity 

    Xie, Wei; Mondragon, Laura; Mauseth, Brynjar; Wang, Yan; Pol, Jonathan; Levesque, Sarah; Zhou, Heng; Yamazaki, Takahiro; Eksteen, Jacobus Johannes; Zitvogel, Laurence; Sveinbjørnsson, Baldur; Rekdal, Øystein; Kepp, Oliver; Kroemer, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-13)
    Local immunotherapies such as the intratumoral injection of oncolytic compounds aim at reinstating and enhancing systemic anticancer immune responses. LTX-315 is a first-in-class, clinically evaluated oncolytic peptide-based local immunotherapy that meets these criteria. Here, we show that LTX-401, yet another oncolytic compound designed for local immunotherapy, depicts a similar safety profile and ...
  • Continuing increased risk of second cancer in long-term testicular cancer survivors after treatment in the cisplatin era 

    Hellesnes, Ragnhild; Kvammen, Øivind; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-09)
    Using complete information on total treatment burden, this population‐based study aimed to investigate second cancer (SC) risk in testicular cancer survivors (TCS) treated in the cisplatin era. The Cancer Registry of Norway identified 5,625 1‐year TCS diagnosed 1980–2009. Standardized incidence ratios (SIRs) were calculated to evaluate the total and site‐specific incidence of SC compared to the ...
  • Isoflurane increases tolerance to renal ischemia reperfusion injury compared to propofol: An experimental study in pigs 

    Roaldsen, Marius Håke; Ciosek, Timothy Allan; Richardsen, Elin; Al-Saad, Samer; Patel, Hitendra R.H.; Aarsæther, Erling Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-09)
    <i>Purpose</i>: To compare two clinically relevant anesthetic agents, i.e., isoflurane versus propofol with respect to protection of the kidney in a porcine renal ischemia reperfusion model. <p> <p><i>Materials and Methods</i>: 14 hybrid pigs were randomized to anesthesia with either isoflurane or propofol prior to laparoscopic surgery. Following anesthesia, the left kidney hilum was clamped for ...
  • NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1 

    Shrestha, Birendra Kumar; Rasmussen, Mads Skytte; Abudu, Yakubu Princely; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Alemu, Endalkachew Ashenafi; Sjøttem, Eva; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-19)
    Human ATG8 family proteins (ATG8s) are active in all steps of the macroautophagy pathway, and their lipidation is essential for autophagosome formation. Lipidated ATG8s anchored to the outer surface of the phagophore serve as scaffolds for binding of other core autophagy proteins and various effector proteins involved in trafficking or fusion events, whereas those at the inner surface are needed for ...
  • Detection of tissue factor in platelets: why is it so troublesome? 

    Østerud, Bjarne; Bouchard, Beth A (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-30)
    Tissue factor (TF) is the most important trigger for the extrinsic coagulation pathway. TF, earlier denoted as thromboplastin, has always been a mystery since its discovery due to its abundant presence in most human tissues but not blood. The latter has been extensively studied in a vast quest for possible sources of blood-borne TF yielding many conflicting findings and confusing conclusions regarding ...
  • High levels of C-reactive protein are associated with an increased risk of ovarian cancer: Results from the Ovarian Cancer Cohort Consortium 

    Peres, Lauren C.; Mallen, Adrianne R.; Townsend, Mary K.; Poole, Elizabeth M.; Trabert, Britton; Allen, Naomi E.; Arslan, Alan A.; Dossus, Laure; Fortner, Renee T.; Gram, Inger T.; Hartge, Patricia; Idahl, Annika; Kaaks, Rudolf; Kvaskoff, Marina; Magliocco, Anthony M.; Merritt, Melissa A.; Quirós, Ramón; Tjonneland, Anne; Trichopoulou, Antonia; Tumino, Rosario; van Gils, Carla H.; Visvanathan, Kala; Wentzensen, Nicolas; Zeleniuch-Jacquotte, Anne; Tworoger, Shelley S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-28)
    Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient characteristics has not been adequately explored. In this study, we pooled data from ...
  • Sex-specific reference ranges of cerebroplacental and umbilicocerebral ratios: A longitudinal study 

    Acharya, Ganesh; Ebbing, Cathrine; Karlsen, Henriette Odland; Kiserud, Torvid; Rasmussen, Svein (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-10)
    <p><i>Objectives - </i>The ratio of middle cerebral artery (MCA) pulsatility index (PI) to umbilical artery (UA) PI, i.e. cerebro‐placental ratio (CPR), has been suggested as a measure of fetal “brain sparing” phenomenon reflecting redistribution of fetal cardiac output as a response to placental insufficiency. Observational studies have shown that low CPR values predict increased risk of adverse ...
  • LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects 

    Liao, Hsin-Wei; Garris, Christopher; Pfirschke, Christina; Rickelt, Steffen; Arlauckas, Sean; Siwicki, Marie; Kohler, Rainer; Weissleder, Ralph; Sundvold-Gjerstad, Vibeke; Sveinbjørnsson, Baldur; Rekdal, Øystein; Pittet, Mikael J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-14)
    LTX-315 is an oncolytic peptide that has antitumor efficacy in mice grafted with various tumor cell lines and is currently being tested in phase II clinical trials. Here we aimed to further evaluate LTX-315 in conditional genetic mouse models of cancer that typically resist current treatment options and to better understand the drug’s mode of action in vivo. We report LTX-315 mediates profound ...
  • Smoking and breast cancer risk by race/ethnicity and oestrogen and progesterone receptor status: the Multiethnic Cohort (MEC) study 

    Gram, Inger Torhild; Park, Song-Yi; Maskarinec, Gertraud; Wilkens, Lynne R; Haiman, Christopher A.; Le Marchand, Loïc (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-18)
    <i>Background</i> - The purpose of this study was to examine if the smoking-related higher breast cancer risk was similar for the five race/ethnicity groups in the Multiethnic Cohort (MEC) study and by oestrogen (ER) and progesterone (PR) receptor status.<p> <p><i>Methods</i> - From 1993 to 2013, we followed 67 313 women who were enrolled in the MEC study at 45–75 years of age. We identified ...
  • Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study 

    Sejrup, Joakim Knutsen; Børvik, Trond; Grimnes, Gro; Isaksen, Trond; Hindberg, Kristian; Hansen, John-Bjarne; Morelli, Vania Maris; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-16)
    Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients (<i>n</i> = 707) recruited from the ...
  • Amnioexchange for gastroschisis does not help, and may even harm 

    Bhide, Amarnath (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)
    This is a mini commentary on D Luton et al., pp. 1233–1241 in this issue. To view this article visit https://doi.org/10.1111/1471-0528.15804.
  • Initiation of systemic therapy during the last 30 days of life in patients with metastatic castration-resistant prostate cancer 

    Nieder, Carsten; Haukland, Ellinor Christin; Mannsåker, Bård; Pawinski, Adam; Yobuta, Rosalba; Norum, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
    <b>Background/Aim</b>: Compared to intravenous taxane chemotherapy, newer orally-available and/or less toxic agents for metastatic castration-resistant prostate cancer (MCRPC) may be associated with higher likelihood of starting treatment in patients with adverse prognostic features and limited life expectancy. To test this hypothesis, we analyzed the rates of treatment initiation during the last ...
  • Fetal and neonatal alloimmune thrombocytopenia - The Norwegian management model 

    Tiller, Heidi; Ahlen, Maria Therese; Akkøk, Cigdem Ahaein; Husebekk, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-31)
    In Norway, the management strategy for fetal and neonatal alloimmune thrombocytopenia (FNAIT) has for more than two decades differed from most other countries. The focus of this paper is to describe and discuss the Norwegian FNAIT management program. We recommend antenatal IVIg to women who previously have had a child with FNAIT-induced ICH, and usually not to HPA-1a alloimmunized pregnant women ...
  • Measuring the effects of sharing mHealth data during diabetes consultations: a mixed-method study protocol 

    Bradway, Meghan; Giordanengo, Alain; Joakimsen, Ragnar Martin; Hansen, Anne Helen; Grøttland, Astrid; Hartvigsen, Gunnar; Randine, Pietro; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-10)
    <i>Background</i>: There is rising demand for health care’s limited resources. Mobile health (mHealth) could be a solution, especially for those with chronic illnesses such as diabetes. mHealth can increases patients’ options to self-manage their health, improving their health knowledge, engagement, and capacity to contribute to their own care decisions. However, there are few solutions for sharing ...
  • Psychiatric Risk Assessment from the Clinician´s Perspective: Lessons for the Future 

    Cohen, Alex S.; Fedechko, Taylor L.; Schwartz, Elana K.; Le, Thanh P.; Foltz, Peter W.; Bernstein, Jared; Cheng, Jian; Rosenfeld, Elizabeth; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)
    Accurate prediction of risk-states in Serious Mental Illnesses (SMIs) is critical for reducing their massive societal burden. Risk-state assessments are notably inaccurate. Recent innovations, including widely available and inexpensive mobile technologies for ambulatory “biobehavioral” data, can reshape risk assessment. To help understand and accelerate clinician involvement, we surveyed 90 ...
  • Murine models for studying treatment, prevention and pathogenesis of FNAIT 

    Rasmussen, Trude Victoria; Ahlen, Maria Therese (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-31)
    Maternal alloimmunization to paternally inherited antigens on fetal/neonatal platelets can cause fetal/neonatal alloimmune thrombocytopenia (FNAIT) after antibody-mediated removal of platelets from the fetal circulation. The complications vary from mild bleeding symptoms to severe intracranial hemorrhage and subsequent neurological impairment or death. Studies on <i>in vivo</i> mechanisms are ...
  • Second re-irradiation: A delicate balance between safety and efficacy 

    Nieder, Carsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-08)
    Except for straightforward palliative indications such as painful bone metastases, re-irradiation is often characterized by a narrow therapeutic window and the potential for decreased efficacy and increased toxicity, especially if the cumulative total dose from both courses is high. Second re-irradiations tend to pose even bigger challenges and are thus offered in a restrictive manner to highly ...
  • C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations 

    Butler, Christopher C; Gillespie, David; White, Patrick; Bates, Janine; lowe, rachel; Thomas-Jones, Emma; Wootton, Mandy; Hood, Kerenza; Phillips, Rhiannon; Melbye, Hasse; Llor, Carl; Cals, Jochen W L; Naik, Gurudutt; Kirby, Nigel; Gal, Micaela; Riga, Evgenia; Francis, Nick A (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-11)
    <i>BACKGROUND</i> - Point-of-care testing of C-reactive protein (CRP) may be a way to reduce unnecessary use of antibiotics without harming patients who have acute exacerbations of chronic obstructive pulmonary disease (COPD).<p><p> <i>METHODS</i> - We performed a multicenter, open-label, randomized, controlled trial involving patients with a diagnosis of COPD in their primary care clinical ...
  • Simuleringsbasert teamtrening virker 

    Brattebø, Guttorm; Ersdal, Hege Langli; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-09)
    Trening av tverrprofesjonelle team med bruk av simulering brukes særlig ved forberedelse til akuttmedisinske situasjoner. Det foreligger nå god dokumentasjon for at slik trening har betydning for pasientene. 27. mars 1977 skjedde verdens hittil verste flykatastrofe, der 583 personer omkom på Tenerife etter at to jumbojeter kolliderte på flyplassen i tett tåke. Granskningen etter katastrofen ...

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