Recent additions

  • D-Dimer Measured at Diagnosis of Venous Thromboembolism is Associated with Risk of Major Bleeding 

    Johnsen, Håkon Sanbukt; Hindberg, Kristian; Bjøri, Esben; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-25)
    Identification of patients at risk of major bleeding is pivotal for optimal management of anticoagulant therapy in venous thromboembolism (VTE). Studies have suggested that D-dimer may predict major bleeding during anticoagulation; however, this is scarcely investigated in VTE patients. We aimed to investigate the role of D-dimer, measured at VTE diagnosis, as a predictive biomarker of major bleeding. ...
  • Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets 

    Mao, Hong; Diekmann, Robin; Liang, Hai; Cogger, Victoria Carroll; Le Couteur, David George; Lockwood, Glen P; Hunt, Nick; Schuttpelz, Mark; Huser, Thomas Rolf; Chen, Vivien; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-09)
    Single-molecule localization microscopy (SMLM) provides a powerful toolkit to specifically resolve intracellular structures on the nanometer scale, even approaching resolution classically reserved for electron microscopy (EM). Although instruments for SMLM are technically simple to implement, researchers tend to stick to commercial microscopes for SMLM implementations. Here we report the construction ...
  • Not engaged in education, employment or training (NEET) in an Arctic sociocultural context: the NAAHS cohort study 

    Bania, Elisabeth Valmyr; Eckhoff, Christian; Kvernmo, Siv (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-23)
    <p><i>Objectives - </i>The purpose of the study is to explore the prevalence and predictors of not engaged in education, employment or training (NEET) status in a multicultural young adult population in Northern Norway. <p><i>Design and setting - </i>The longitudinal design link a selfreported survey (2003–2005) with an objective registry linkage follow-up 8–10 years later. <p><i>Participants - ...
  • En in vitro-studie av antiviral effekt av cidofovirderivatet ODBG-CDV mot BK polyomavirus-replikasjon 

    Bjørkøy, Magnus Bjørgan (Master thesis; Mastergradsoppgave, 2017-09-18)
    Bakgrunn: Polyomavirus BK (BKPyV) infiserer omtrent 80% av befolkningen tidlig i livet og etablerer en livslang infeksjon. Viruset forårsaker sjeldent sykdom, men kan ved nyretransplantasjon reaktiveres og forårsake polyomavirusassosiert nefropati (PyVAN) med betydelig risiko for grafttap. Ingen effektive antivirale medikamenter mot BKPyV-infeksjoner finnes i dag. Cidofovir (CDV) har sporadisk blitt ...
  • Kvinners opplevelse av å føde langt hjemmefra 

    Ramberg, Ida Karoline Sand (Master thesis; Mastergradsoppgave, 2017-09-18)
    Fødetilbudet i Norge har vært gjennom en stor omveltning de siste tiårene der mange klinikker i distriktene har blitt stengt. Det er senere vist at det kan være trygt å drifte jordmorstyrte fødestuer i distriktene dersom det gjøres adekvat selektering av gravide ut fra risikofaktorer. På den måten kan kvinnen tilbys den beredskapen hun trenger. Er ikke den beredskapen tilgjengelig lokalt må hun reise ...
  • Defining compulsive exercise in eating disorders: acknowledging the exercise paradox and exercise obsessions 

    Bratland-Sanda, Solfrid; Mathisen, Therese Fostervold; Sundgot-Borgen, Jorunn; Rosenvinge, Jan H (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-04)
    Recently Dittmer et al. (JED 6:1–9, 2018). suggested a transdiagnostic definition and a clinical assessment for compulsive exercise in adolescents and adults with eating disorders. In this letter to the editor, we extend the transdiagnostic bridge to the DSM-5-criteria for obsessive-compulsive disorders and hence raise the issue of exercise obsession without compulsive exercise actions. We argue ...
  • The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006-2017 

    Elstrøm, Petter; Astrup, Elisabeth; Hegstad, Kristin; Samuelsen, Ørjan; Enger, Hege; Kacelnik, Oliver (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-04)
    <p><i>Introduction - </i>Scandinavian countries have traditionally had a low prevalence of resistant organisms, but have in recent years experienced a change in their epidemiology. We aim to describe the epidemiology of carbapenemase-producing organisms (CPOs), vancomycin-resistant enterococci (VRE) and methicillin-resistant <i>S. aureus</i> (MRSA) in Norway, measure the importance of infections ...
  • "If you do not birget [manage] then you don't belong here": a qualitative focus group study on the cultural meanings of suicide among Indigenous Sámi in arctic Norway 

    Stoor, Jon Petter Anders; Berntsen, Gro; Hjelmeland, Heidi Marie; Silviken, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-24)
    Suicide is a major public health issue across the Arctic, especially among Indigenous Peoples. The aim of this study was to explore and describe cultural meanings of suicide among Sámi in Norway. Five open-ended focus group discussions (FGDs) were conducted with 22 Sámi (20) and non-Sámi (2) participants in South, Lule, Marka, coastal and North Sámi communities in Norway. FGDs were recorded, transcribed ...
  • Giant group I intron in a mitochondrial genome is removed by RNA back-splicing 

    Chi, Sylvia Ighem; Dahl, Mikael; Emblem, Åse; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)
    <p><i>Background - </i>The mitochondrial genomes of mushroom corals (Corallimorpharia) are remarkable for harboring two complex group I introns; ND5-717 and COI-884. How these autocatalytic RNA elements interfere with mitochondrial RNA processing is currently not known. Here, we report experimental support for unconventional processing events of ND5-717 containing RNA. <p><i>Results - </i>We obtained ...
  • Improved maximal strength is not associated with improvements in sprint time or jump height in high-level female football players: a clusterrendomized controlled trial 

    Pedersen, Sigurd; Heitmann, Kim Arne; Sagelv, Edvard Hamnvik; Johansen, Dag; Pettersen, Svein Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-17)
    <i>Background</i> - Maximal strength increments are reported to result in improvements in sprint speed and jump height in elite male football players. Although similar effects are expected in females, this is yet to be elucidated. The aim of this study was to examine the effect of maximal strength training on sprint speed and jump height in high-level female football players.<p> <p><i>Methods</i> ...
  • Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis 

    Fiorito, Giovanni; McCrory, Cathal; Robinson, Oliver; Carmeli, Cristian; Rosales, Carolina Ochoa; Zhang, Yan; Colicino, Elena; Dugué, Pierre-Antoine; Artaud, Fanny; McKay, Gareth J.; Jeong, Ayoung; Mishra, Pashupati P.; Nøst, Therese Haugdahl; Krogh, Vittorio; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Palli, Domenico; Matullo, Giuseppe; Guarrera, Simonetta; Gandini, Martina; Bochud, Murielle; Dermitzakis, Emmanouil; Muka, Taulant; Schwartz, Joel; Vokonas, Pantel S.; Just, Allan; Hodge, Allison M.; Giles, Graham G.; Southey, Melissa C.; Hurme, Mikko A.; Young, Ian; McKnight, Amy Jayne; Kunze, Sonja; Waldenberger, Melanie; Peters, Annette; Schwettmann, Lars; Lund, Eiliv; Baccarelli, Andrea; Milne, Roger L.; Kenny, Rose A.; Elbaz, Alexis; Brenner, Hermann; Kee, Frank; Voortman, Trudy; Probst-Hensch, Nicole; Lehtimäki, Terho; Elliot, Paul; Stringhini, Silvia; Vineis, Paolo; Polidoro, Silvia (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-14)
    <p>Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life. <p>We examined the ...
  • Bone matrix levels of Dickkopf and sclerostin are positively correlated with bone mass and strength in postmenopausal osteoporosis 

    Ueland, Thor; Stilgren, Lis; Bollerslev, Jens (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-03)
    Wnt signaling plays a pivotal role in maintaining bone mass. Secreted pathway modulators such as sclerostin (SOST) and Dickkopfs (DKKs) may influence bone mass inhibiting the canonical Wnt pathway. We evaluated whether bone protein content of secreted Wnt antagonists is related to age, bone mass, and strength in postmenopausal osteoporosis. We measured cortical and trabecular bone contents of SOST ...
  • Transkateter aorta ventil implantasjon. En retrospektiv kvalitetssikringsoppgave 

    Wilhelmsen, Håkon Wilhelm (Master thesis; Mastergradsoppgave, 2017-09-17)
    Bakgrunn: Aortastenose er en sykdom som har økt forekomst med økende alder, og alvorlig symptomgivende aortastenose har en dyster prognose. Uten behandling er median overlevelsestid 2 år dersom pasienten utvikler hjertesvikt. Tidligere ble denne pasientgruppen operert med åpen hjertekirurgi, men mange fikk ikke tilbud om behandling grunnet omfattende komorbiditet og høy-risiko. Dermed oppstod behovet ...
  • Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency 

    Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-01)
    Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients have non-infectious inflammatory and autoimmune complications, associated with systemic immune activation. Our aim was to explore if HDL, known to have anti-inflammatory properties, ...
  • Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways 

    Moens, Ugo; Macdonald, Andrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-12)
    Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the ...
  • Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus 

    Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Lekva, Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
    <i>Aims</i> - The risk of gestational diabetes mellitus (GDM) is increased in overweight and obese women potentially involving secreted mediators from adipose tissue. Our main aim was to evaluate if circulating adipokines and monocyte/macrophage markers were dysregulated in GDM and the influence body mass and indices of glucose metabolism had on this association. We further explored if early detection ...
  • In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding 

    Evenseth, Linn M.; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-04)
    Molting is an essential process in the life cycle of arthropods and is regulated by complex neuroendocrine pathways where activation of the ecdysone receptor (EcR) plays a major role. The EcR forms a non-covalent heterodimer with the ultraspiracle protein (USP) when activated by endogenous ecdysteroids, but can also be activated by several insecticides and other environmental chemicals. Environmental ...
  • Blinding is compromised for transcranial direct current stimulation at 1 mA for 20 min in young healthy adults 

    Turi, Zsolt; Csifcsak, Gabor; Boayue, Nya Mehnwolo; Aslaksen, Per M; Antal, Andrea; Paulus, Walter; Groot, Josephine; Hawkins, Guy E.; Opitz, Alexander; Thielscher, Axel; Mittner, Matthias (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-19)
    Transcranial direct current stimulation (tDCS) is a non‐invasive brain stimulation method that is frequently used to study cortical excitability changes and their impact on cognitive functions in humans. While most stimulators are capable of operating in double‐blind mode, the amount of discomfort experienced during tDCS may break blinding. Therefore, specifically designed sham stimulation protocols ...
  • In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol 

    Larose, Tricia L; Sætrom, Pål; Martinussen, Marit; Skogseth, Haakon; Sandanger, Torkjel M; Scélo, Ghislaine; McHale, Cliona M; Jacobsen, Geir Wenberg; Smith, Martyn T (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-05)
    <i>Background</i>: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD).<p> <p><i>Methods/design</i>: This pilot study includes pregnant women at high risk (smoking at ...
  • Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14 

    Skjeflo, Espen Waage; Christiansen, Dorte; Landsem, Anne; Stenvik, Jørgen; Woodruff, T. M.; Espevik, Terje; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-15)
    <i>Background</i> - Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-negative and Gram-positive bacteria in human whole blood.<p> <p><i>Methods</i> - Lepirudin-anticoagulated blood was incubated with live or dead <i>E. coli</i> or <i>S. aureus</i> at 37 °C for 120 min ...

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