Recent additions

  • Radiosynthesis and biological investigation of a novel fluorine-18 labeled benzoimidazotriazine- based radioligand for the imaging of phosphodiesterase 2A with positron emission tomography 

    Ritawidya, Rien; Wenzel, Barbara; Teodoro, Rodrigo; Toussaint, Magali; Kranz, Mathias; Deuther-Conrad, Winnie; Dukić-Stefanović, Sladjana; Ludwig, Friedrich-Alexander; Scheunemann, Matthias; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-15)
    A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A (PDE2A) via positron emission tomography (PET) would be helpful for research on the physiology and disease-related changes in the expression of this enzyme in the brain. In this report, the radiosynthesis of a novel PDE2A radioligand and the subsequent biological evaluation were described. Our prospective compound ...
  • C-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes 

    Andersen, Thomas; Ueland, Thor; Ghukasyan Lakic, Tatevik; Åkerblom, Axel; Bertilsson, Maria; Aukrust, Pål; Michelsen, Annika E; James, Stefan K.; Becker, Richard C.; Storey, Robert F.; Wallentin, Lars; Siegbahn, Agneta; Kontny, Frederic (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
    <i>Objective:</i> - The chemokine CXCL16 (C-X-C motif ligand 16) is a scavenger receptor for OxLDL (oxidized low-density lipoproteins) and involved in inflammation at sites of atherosclerosis. This study aimed to investigate the association of CXCL16 with clinical outcome in patients with acute coronary syndrome.<p> <p><i>Approach and Results:</i> - Serial measurements of CXCL16 were performed ...
  • The influences of morphine or ketamine pre-treatment on hemodynamic, acid-base status, biochemical markers of brain damage and early survival in rats after asphyxial cardiac arrest 

    Kuklin, Vladimir; Akhatov, Nurlan; Kondratiev, Timofei; Konkayev, Aidos; Baigenzhin, Abai K.; Konkayeva, Maiya; Karibekov, Temirlan; Barlow, Nicholas; Tveita, Torkjel; Dahl, Vegard (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-20)
    <i>Background</i> - In different models of hypoxia, blockade of opioid or N-methyl-D-aspartate (NMDA) receptors shows cardio- and neuroprotective effects with a consequent increase in animal survival. The aim of the study was to investigate effects of pre-treatment with Morphine or Ketamine on hemodynamic, acid-base status, early survival, and biochemical markers of brain damage in a rat model of ...
  • Elevated cholesteryl ester transfer protein activity early in pregnancy predicts prediabetes 5 years later 

    Ueland, Thor; Roland, Marie Cecilie; Michelsen, Annika; Godang, Kristin; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Lekva, Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-29)
    <i>Context</i> - Cholesteryl ester transfer protein (CETP) regulates high-density lipoprotein (HDL) cholesterol levels and interaction between glucose, and HDL metabolism is central in the development of diabetes.<p> <p><i>Objective</i> - We hypothesized that CETP levels would be regulated in diabetic pregnancies. We tested the hypothesis by evaluating CETP activity measured multiple times during ...
  • School functioning and internalizing problems in young schoolchildren 

    Pedersen, Marit Løtveit; Holen, Solveig; Lydersen, Stian; Martinsen, Kristin Dagmar; Neumer, Simon-Peter; Adolfsen, Frode; Sund, Anne Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-23)
    <i>Background</i> - Symptoms of anxiety and depression are common mental health problems in children and are often referred to as internalizing symptoms. Youth with such symptoms are at greater risk for poor academic achievement, school non-completion, and future mental health problems, all of which, lead to public health consequences and costs to society. The aim of the current study was to ...
  • Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses 

    Benedicto, Aitor; Herrero, Alba; Romayor, Irene; Marquez, Joana; Smedsrød, Bård; Olaso, Elvira; Arteta, Beatriz (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-11)
    The prometastatic stroma generated through tumor cells/host cells interaction is critical for metastatic growth. To elucidate the role of ICAM-1 on the crosstalk between tumor and primary liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs), implicated in tumor adhesion and angiogenesis, we performed <i>in vitro</i> cocultures and an <i>in vivo</i> model of liver metastasis ...
  • Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations 

    Albrecht, Wiebke; Kappenberg, Franziska; Brecklinghaus, Tim; Stoeber, Regina; Marchan, Rosemarie; Zhang, Mian; Ebbert, Kristina; Kirschner, Hendrik; Grinberg, Marianna; Leist, Marcel; Moritz, Wolfgang; Cadenas, Cristina; Ghallab, Ahmed; Reinders, Jörg; Vartak, Nachiket; van Thriel, Christoph; Golka, Klaus; Tolosa, Laia; Castell, José V.; Damm, Georg; Seehofer, Daniel; Lampen, Alfonso; Braeuning, Albert; Buhrke, Thorsten; Behr, Anne-Cathrin; Oberemm, Axel; Gu, Xiaolong; Kittana, Naim; van de Water, Bob; Kreiling, Reinhard; Fayyaz, Susann; van Aerts, Leon; Smedsrød, Bård; Ellinger-Ziegelbauer, Heidrun; Steger-Hartmann, Thomas; Gundert-Remy, Ursula; Zeigerer, Anja; Ullrich, Anett; Runge, Dieter; Lee, Serene M.L.; Schiergens, Tobias S.; Kuepfer, Lars; Aguayo-Orozco, Alejandro; Sachinidis, Agapios; Edlund, Karolina; Gardner, Iain; Rahnenführer, Jörg; Hengstler, Jan G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-27)
    Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or the determination of an acceptable daily intake (ADI). To overcome this limitation, an in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations. ...
  • Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs 

    Birgisdottir, Åsa Birna; Mouilleron, Stephane; Bhujabal, Zambarlal; Wirth, Martina; Sjøttem, Eva; Evjen, Gry; Zhang, Wenxin; Lee, Rebecca; O'Reilly, Nicola; Tooze, Sharon A; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-04)
    Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1). The latter contains PIK3C3/VPS34, PIK3R4/VPS15, BECN1/Beclin 1 ...
  • Impact of polyols on oral microbiome of Estonian schoolchildren 

    Štšepetova, Jelena; Truu, Jaak; Runnel, Riina; Nõmmela, Rita; Saag, Mare; Olak, Jaana; Nõlvak, Hiie; Preem, Jens-Konrad; Oopkaup, Kristjan; Krjutškov, Kaarel; Honkala, Eino; Honkala, Sisko; Mäkinen, Kauko; Mäkinen, Pirkko-Liisa; Vahlberg, Tero; Vermeiren, Joan; Bosscher, Douwina; de Cock, Peter; Mändar, Reet (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-18)
    <i>Background</i> - Oral microbiome has significant impact on both oral and general health. Polyols have been promoted as sugar substitutes in prevention of oral diseases. We aimed to reveal the effect of candies containing erythritol, xylitol or control (sorbitol) on salivary microbiome.<p><p> <i>Methods</i> - Ninety children (11.3 ± 0.6 years) consumed candies during 3 years. Microbial ...
  • Development and validation of circulating CA125 prediction models in postmenopausal women 

    Sasamoto, Naoko; Babic, Ana; Rosner, Bernard A.; Fortner, Renée T.; Vitonis, Allison F; Yamamoto, Hidemi; Fichorova, Raina N.; Titus, Linda J.; Tjønneland, Anne; Hansen, Louise; Kvaskoff, Marina; Fournier, Agnès; Mancini, Francesca Romana; Boeing, Heiner; Trichopoulou, Antonia; Peppa, Eleni; Karakatsani, Anna; Palli, Domenico; Grioni, Sara; Mattiello, Amalia; Tumino, Rosario; Fiano, Valentina; Onland-Moret, N. Charlotte; Weiderpass, Elisabete; Gram, Inger Torhild; Quirós, José Ramón; Lujan-Barroso, Leila; Sánchez, María-José; Colorado-Yohar, Sandra; Barricarte, Aurelio; Amiano, Pilar; Idahl, Annika; Lundin, Eva; Sartor, Hanna; Khaw, Kay-Tee; Key, Timothy J.; Muller, David; Riboli, Elio; Gunter, Marc; Dossus, Laure; Trabert, Britton; Wentzensen, Nicolas; Kaaks, Rudolf; Cramer, Daniel W.; Tworoger, Shelley S.; Terry, Kathryn L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-26)
    <i>Background</i> - Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.<p><p> <i>Methods</i> - We developed and validated ...
  • SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function 

    Schwob, Aurélien; Teruel, Elodie; Dubuisson, Louise; Lormières, Florence; Verlhac, Pauline; Abudu, Yakubu Princely; Gauthier, Janelle; Naoumenko, Marie; Cloarec-Ung, Fanny-Meï; Faure, Mathias; Johansen, Terje; Dutartre, Hélène; Mahieux, Renaud; Journo, Chloé (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)
    The NF-κB pathway is constitutively activated in adult T cell leukemia, an aggressive malignancy caused by Human T Leukemia Virus type 1 (HTLV-1). The viral oncoprotein Tax triggers this constitutive activation by interacting with the ubiquitin-rich IKK complex. We previously demonstrated that Optineurin and TAX1BP1, two members of the ubiquitin-binding, Sequestosome-1 (SQSTM-1/p62)-like selective ...
  • Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study 

    Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-21)
    In this controlled before-after study based on data from the Norwegian Prescription Database, we examine whether starting off-label use of Low Dose Naltrexone (LDN) is followed by changes in the consumption of psychotropic medicines including antiepileptics. Patients that collected LDN for the first time in 2013 (N = 11247) were included and stratified into three groups based on LDN exposure. We ...
  • Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium 

    Brunner, Fabian J.; Waldeyer, Christoph; Ojeda, Francisco; Salomaa, Veikko; Kee, Frank; Sans, Susana; Thorand, Barbara; Giampaoli, Simona; Brambilla, Paolo; Tunstall-Pedoe, Hugh; Moitry, Marie; Iacoviello, Licia; Veronesi, Giovanni; Grassi, Guido; Mathiesen, Ellisiv B.; Söderberg, Stefan; Linneberg, Allan; Brenner, Hermann; Amouyel, Philippe; Ferrières, Jean; Tamosiunas, Abdonas; Nikitin, Yuriy P.; Drygas, Wojciech; Melander, Olle; Jöckel, Karl-Heinz; Leistner, David M.; Shaw, Jonathan E.; Panagiotakos, Demosthenes B.; Simons, Leon A.; Kavousi, Maryam; Vasan, Ramachandran S.; Dullaart, Robin P.F.; Wannamethee, S. Goya; Risérus, Ulf; Shea, Steven; de Lemos, James A.; Omland, Torbjørn; Kuulasmaa, Kari; Landmesser, Ulf; Blankenberg, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
    <i>Background</i> - The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream non-HDL cholesterol concentrations. We also created an easy-to-use tool to estimate the long-term ...
  • Continuous hemodynamic monitoring in an intact rat model of simulated diving 

    Gaustad, Svein Erik; Kondratyev, Timofey; Eftedal, Ingrid; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-13)
    Cardiovascular risk is elevated in divers, but detailed information of cardiac function during diving is missing. The aim of this study was to apply an intact rat model with continuous monitoring of cardiac left ventricular (LV) function in a simulated diving experiment. Thirteen rats were inserted with a LV pressure–volume catheter and a pressure transducer in the femoral artery to measure hemodynamic ...
  • Role of CALCOCO1 in scaling down endoplasmic reticulum and Golgi by autophagy 

    Nthiga, Thaddaeus Mutugi (Doctoral thesis; Doktorgradsavhandling, 2020-02-20)
    Endoplasmic reticulum (ER) and Golgi apparatus are key organelles in the synthesis, modification and trafficking of proteins in eukaryotic cells. In response to stress stimuli such as nutrients deprivation, accumulation of misfolded proteins or exposure to chemicals, the ER increases in size through increased synthesis of its components to counteract the stress. Similarly, Golgi response to stress ...
  • Symposium on "parental education" at the ICCH17 

    Ingemann, Christine; Kvernmo, Siv; Møller, Helle; Moffitt, Pertice; Tagalik, Shirley; Kuhn, Rikke L; Nilsen, Siv Eirin; Rich, Rebecca; Larsen, Christina Viskum Lytken (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-22)
    This symposium report provides a brief overview of the six programmes and studies on parental education and maternal health services within the circumpolar region presented in the symposium “parental education” at the 17th International Congress of Circumpolar Health in Copenhagen, Denmark, August 2018.
  • Increased risk of fatal paediatric injuries in rural Northern Norway 

    Holter, June Alette; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
    <i>Background</i> - Finnmark, Northern Norway, had a mortality rate for paediatric injury in 1998‐2007 that was more than twice the national average. We investigated whether this rate had decreased in 2008‐2015 after improvements in emergency care. We also compared the mortality rate to rates of non‐fatal injury and trauma team activation both regionally and in Norway.<p> <p><i>Methods</i> - The ...
  • Pulmonary manifestations and progression of lung disease in juvenile-onset mixed connective tissue disease 

    Hetlevik, Siri Opsahl; Flatø, Berit; Aaløkken, Trond Mogens; Samersaw-Lund, May Brit; Reiseter, Silje; Mynarek, Georg; Nordal, Ellen Berit; Rygg, Marite; Lilleby, Vibke (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-01)
    <i>Objective</i> - To assess the occurrence and extent of interstitial lung disease (ILD) in patients with juvenile mixed connective tissue disease (JMCTD), compare pulmonary function in patients and matched controls, study associations between ILD and disease-related variables, and examine progression of pulmonary manifestations over time.<p> <p><i>Methods</i> - A cohort of 52 patients with JMCTD ...
  • Timing of HPV16-E6 antibody seroconversion before OPSCC: Findings from the HPVC3 consortium 

    Kreimer, Aimée R.; Ferreiro-Iglesias, Aida; Nygård, Mari; Bender, Noemi; Schroeder, Lea; Hildesheim, Alan; Robbins, Hilary A.; Pawlita, Michael; Langseth, Hilde; Schlecht, Nicolas F.; Tinker, Lesley Fels; Agalliu, Ilir; Smoller, Sylvia W.; Ness-Jensen, Eivind; Hveem, Kristian; D'Souza, Gypsyamber; Visvanathan, Kala; May, Betty; Ursin, Giske; Weiderpass, Elisabete; Giles, Graham G.; Milne, Roger L.; Cai, Qiuyin; Blot, William J.; Zheng, Wei; Weinstein, Stephanie J.; Albanes, Demetrius; Brenner, Nicole; Hoffman-Bolton, Judith; Kaaks, Rudolf; Barricarte, Aurelio; Tjønneland, Anne; Sacerdote, Carlotta; Trichopoulou, Antonia; Vermeulen, Roel C.H.; Huang, Wen-Yi; Freedman, Neal D.; Brennan, Paul J.; Waterboer, Tim; Johansson, Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-06)
    <i>Background</i> - Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis in the majority of HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), but the timing of seroconversion is unknown.<p> <p><i>Patients and methods</i> - We formed the HPV Cancer Cohort Consortium which comprises nine population cohorts from Europe, North America and ...
  • Vitamin D status in a multi-ethnic population of northern Norway: The SAMINOR 2 Clinical Survey 

    Petrenya, Natalia; Lamberg-Allardt, Christel; Melhus, Marita; Broderstad, Ann Ragnhild; Brustad, Magritt (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-15)
    <i>Objective</i> - To investigate serum 25-hydroxyvitamin D (S-25(OH)D) concentration in a multi-ethnic population of northern Norway and determine predictors of S-25(OH)D, including Sami ethnicity.<p> <p><i>Design</i> - Cross-sectional data from the second survey of the Population-based Study on Health and Living Conditions in Regions with Sami and Norwegian Populations (the SAMINOR 2 Clinical ...

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