Recent additions

  • Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses 

    Benedicto, Aitor; Herrero, Alba; Romayor, Irene; Marquez, Joana; Smedsrød, Bård; Olaso, Elvira; Arteta, Beatriz (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-11)
    The prometastatic stroma generated through tumor cells/host cells interaction is critical for metastatic growth. To elucidate the role of ICAM-1 on the crosstalk between tumor and primary liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs), implicated in tumor adhesion and angiogenesis, we performed <i>in vitro</i> cocultures and an <i>in vivo</i> model of liver metastasis ...
  • Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations 

    Albrecht, Wiebke; Kappenberg, Franziska; Brecklinghaus, Tim; Stoeber, Regina; Marchan, Rosemarie; Zhang, Mian; Ebbert, Kristina; Kirschner, Hendrik; Grinberg, Marianna; Leist, Marcel; Moritz, Wolfgang; Cadenas, Cristina; Ghallab, Ahmed; Reinders, Jörg; Vartak, Nachiket; van Thriel, Christoph; Golka, Klaus; Tolosa, Laia; Castell, José V.; Damm, Georg; Seehofer, Daniel; Lampen, Alfonso; Braeuning, Albert; Buhrke, Thorsten; Behr, Anne-Cathrin; Oberemm, Axel; Gu, Xiaolong; Kittana, Naim; van de Water, Bob; Kreiling, Reinhard; Fayyaz, Susann; van Aerts, Leon; Smedsrød, Bård; Ellinger-Ziegelbauer, Heidrun; Steger-Hartmann, Thomas; Gundert-Remy, Ursula; Zeigerer, Anja; Ullrich, Anett; Runge, Dieter; Lee, Serene M.L.; Schiergens, Tobias S.; Kuepfer, Lars; Aguayo-Orozco, Alejandro; Sachinidis, Agapios; Edlund, Karolina; Gardner, Iain; Rahnenführer, Jörg; Hengstler, Jan G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-27)
    Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or the determination of an acceptable daily intake (ADI). To overcome this limitation, an in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations. ...
  • Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs 

    Birgisdottir, Åsa Birna; Mouilleron, Stephane; Bhujabal, Zambarlal; Wirth, Martina; Sjøttem, Eva; Evjen, Gry; Zhang, Wenxin; Lee, Rebecca; O'Reilly, Nicola; Tooze, Sharon A; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-04)
    Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1). The latter contains PIK3C3/VPS34, PIK3R4/VPS15, BECN1/Beclin 1 ...
  • Impact of polyols on oral microbiome of Estonian schoolchildren 

    Štšepetova, Jelena; Truu, Jaak; Runnel, Riina; Nõmmela, Rita; Saag, Mare; Olak, Jaana; Nõlvak, Hiie; Preem, Jens-Konrad; Oopkaup, Kristjan; Krjutškov, Kaarel; Honkala, Eino; Honkala, Sisko; Mäkinen, Kauko; Mäkinen, Pirkko-Liisa; Vahlberg, Tero; Vermeiren, Joan; Bosscher, Douwina; de Cock, Peter; Mändar, Reet (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-18)
    <i>Background</i> - Oral microbiome has significant impact on both oral and general health. Polyols have been promoted as sugar substitutes in prevention of oral diseases. We aimed to reveal the effect of candies containing erythritol, xylitol or control (sorbitol) on salivary microbiome.<p><p> <i>Methods</i> - Ninety children (11.3 ± 0.6 years) consumed candies during 3 years. Microbial ...
  • Development and validation of circulating CA125 prediction models in postmenopausal women 

    Sasamoto, Naoko; Babic, Ana; Rosner, Bernard A.; Fortner, Renée T.; Vitonis, Allison F; Yamamoto, Hidemi; Fichorova, Raina N.; Titus, Linda J.; Tjønneland, Anne; Hansen, Louise; Kvaskoff, Marina; Fournier, Agnès; Mancini, Francesca Romana; Boeing, Heiner; Trichopoulou, Antonia; Peppa, Eleni; Karakatsani, Anna; Palli, Domenico; Grioni, Sara; Mattiello, Amalia; Tumino, Rosario; Fiano, Valentina; Onland-Moret, N. Charlotte; Weiderpass, Elisabete; Gram, Inger Torhild; Quirós, José Ramón; Lujan-Barroso, Leila; Sánchez, María-José; Colorado-Yohar, Sandra; Barricarte, Aurelio; Amiano, Pilar; Idahl, Annika; Lundin, Eva; Sartor, Hanna; Khaw, Kay-Tee; Key, Timothy J.; Muller, David; Riboli, Elio; Gunter, Marc; Dossus, Laure; Trabert, Britton; Wentzensen, Nicolas; Kaaks, Rudolf; Cramer, Daniel W.; Tworoger, Shelley S.; Terry, Kathryn L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-26)
    <i>Background</i> - Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.<p><p> <i>Methods</i> - We developed and validated ...
  • Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium 

    Brunner, Fabian J.; Waldeyer, Christoph; Ojeda, Francisco; Salomaa, Veikko; Kee, Frank; Sans, Susana; Thorand, Barbara; Giampaoli, Simona; Brambilla, Paolo; Tunstall-Pedoe, Hugh; Moitry, Marie; Iacoviello, Licia; Veronesi, Giovanni; Grassi, Guido; Mathiesen, Ellisiv B.; Söderberg, Stefan; Linneberg, Allan; Brenner, Hermann; Amouyel, Philippe; Ferrières, Jean; Tamosiunas, Abdonas; Nikitin, Yuriy P.; Drygas, Wojciech; Melander, Olle; Jöckel, Karl-Heinz; Leistner, David M.; Shaw, Jonathan E.; Panagiotakos, Demosthenes B.; Simons, Leon A.; Kavousi, Maryam; Vasan, Ramachandran S.; Dullaart, Robin P.F.; Wannamethee, S. Goya; Risérus, Ulf; Shea, Steven; de Lemos, James A.; Omland, Torbjørn; Kuulasmaa, Kari; Landmesser, Ulf; Blankenberg, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
    <i>Background</i> - The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream non-HDL cholesterol concentrations. We also created an easy-to-use tool to estimate the long-term ...
  • Continuous hemodynamic monitoring in an intact rat model of simulated diving 

    Gaustad, Svein Erik; Kondratyev, Timofey; Eftedal, Ingrid; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-13)
    Cardiovascular risk is elevated in divers, but detailed information of cardiac function during diving is missing. The aim of this study was to apply an intact rat model with continuous monitoring of cardiac left ventricular (LV) function in a simulated diving experiment. Thirteen rats were inserted with a LV pressure–volume catheter and a pressure transducer in the femoral artery to measure hemodynamic ...
  • Role of CALCOCO1 in scaling down endoplasmic reticulum and Golgi by autophagy 

    Nthiga, Thaddaeus Mutugi (Doctoral thesis; Doktorgradsavhandling, 2020-02-20)
    Endoplasmic reticulum (ER) and Golgi apparatus are key organelles in the synthesis, modification and trafficking of proteins in eukaryotic cells. In response to stress stimuli such as nutrients deprivation, accumulation of misfolded proteins or exposure to chemicals, the ER increases in size through increased synthesis of its components to counteract the stress. Similarly, Golgi response to stress ...
  • Symposium on "parental education" at the ICCH17 

    Ingemann, Christine; Kvernmo, Siv; Møller, Helle; Moffitt, Pertice; Tagalik, Shirley; Kuhn, Rikke L; Nilsen, Siv Eirin; Rich, Rebecca; Larsen, Christina Viskum Lytken (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-22)
    This symposium report provides a brief overview of the six programmes and studies on parental education and maternal health services within the circumpolar region presented in the symposium “parental education” at the 17th International Congress of Circumpolar Health in Copenhagen, Denmark, August 2018.
  • Increased risk of fatal paediatric injuries in rural Northern Norway 

    Holter, June Alette; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
    <i>Background</i> - Finnmark, Northern Norway, had a mortality rate for paediatric injury in 1998‐2007 that was more than twice the national average. We investigated whether this rate had decreased in 2008‐2015 after improvements in emergency care. We also compared the mortality rate to rates of non‐fatal injury and trauma team activation both regionally and in Norway.<p> <p><i>Methods</i> - The ...
  • Pulmonary manifestations and progression of lung disease in juvenile-onset mixed connective tissue disease 

    Hetlevik, Siri Opsahl; Flatø, Berit; Aaløkken, Trond Mogens; Samersaw-Lund, May Brit; Reiseter, Silje; Mynarek, Georg; Nordal, Ellen Berit; Rygg, Marite; Lilleby, Vibke (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-01)
    <i>Objective</i> - To assess the occurrence and extent of interstitial lung disease (ILD) in patients with juvenile mixed connective tissue disease (JMCTD), compare pulmonary function in patients and matched controls, study associations between ILD and disease-related variables, and examine progression of pulmonary manifestations over time.<p> <p><i>Methods</i> - A cohort of 52 patients with JMCTD ...
  • Timing of HPV16-E6 antibody seroconversion before OPSCC: Findings from the HPVC3 consortium 

    Kreimer, Aimée R.; Ferreiro-Iglesias, Aida; Nygård, Mari; Bender, Noemi; Schroeder, Lea; Hildesheim, Alan; Robbins, Hilary A.; Pawlita, Michael; Langseth, Hilde; Schlecht, Nicolas F.; Tinker, Lesley Fels; Agalliu, Ilir; Smoller, Sylvia W.; Ness-Jensen, Eivind; Hveem, Kristian; D'Souza, Gypsyamber; Visvanathan, Kala; May, Betty; Ursin, Giske; Weiderpass, Elisabete; Giles, Graham G.; Milne, Roger L.; Cai, Qiuyin; Blot, William J.; Zheng, Wei; Weinstein, Stephanie J.; Albanes, Demetrius; Brenner, Nicole; Hoffman-Bolton, Judith; Kaaks, Rudolf; Barricarte, Aurelio; Tjønneland, Anne; Sacerdote, Carlotta; Trichopoulou, Antonia; Vermeulen, Roel C.H.; Huang, Wen-Yi; Freedman, Neal D.; Brennan, Paul J.; Waterboer, Tim; Johansson, Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-06)
    <i>Background</i> - Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis in the majority of HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), but the timing of seroconversion is unknown.<p> <p><i>Patients and methods</i> - We formed the HPV Cancer Cohort Consortium which comprises nine population cohorts from Europe, North America and ...
  • Vitamin D status in a multi-ethnic population of northern Norway: The SAMINOR 2 Clinical Survey 

    Petrenya, Natalia; Lamberg-Allardt, Christel; Melhus, Marita; Broderstad, Ann Ragnhild; Brustad, Magritt (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-15)
    <i>Objective</i> - To investigate serum 25-hydroxyvitamin D (S-25(OH)D) concentration in a multi-ethnic population of northern Norway and determine predictors of S-25(OH)D, including Sami ethnicity.<p> <p><i>Design</i> - Cross-sectional data from the second survey of the Population-based Study on Health and Living Conditions in Regions with Sami and Norwegian Populations (the SAMINOR 2 Clinical ...
  • No ethnic disparities in nutritional adequacy between the Indigenous Sami and the non-Sami population living in rural Northern Norway—the SAMINOR 2 Clinical Survey 

    Petrenya, Natalia; Skeie, Guri; Melhus, Marita; Brustad, Magritt (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-28)
    The diet of the Indigenous Sami people has become more Westernized. The lack of population-based data on nutrient intake and nutritional adequacy, in combination with a high prevalence of obesity/metabolic syndrome among Sami, was the rationale behind the present study. We hypothesized that differences in nutrient intake between Sami and non-Sami populations may still exist but that these differences ...
  • Urban–Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study 

    Solbakken, Siri Marie; Magnus, Jeanette H.; Meyer, Haakon E; Dahl, Cecilie; Stigum, Hein; Søgaard, Anne-Johanne; Holvik, Kristin; Tell, Grethe S.; Emaus, Nina; Forsmo, Siri; Gjesdal, Clara Gram; Schei, Berit; Vestergaard, Peter; Omsland, Tone Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-09)
    Higher hip fracture incidence in urban than in rural areas has been demonstrated, but urban–rural differences in posthip fracture mortality have been less investigated, and the results are disparate. Hence, the aims of the present register‐based cohort study were to examine possible urban–rural differences in short‐ and long‐term mortality in Norwegian hip fracture patients and their potential ...
  • Telemedicine in Resource-Limited Settings to Optimize Care for Multidrug-Resistant Tuberculosis 

    Huang, G. Khai Lin; Pawape, Gibson; Taune, Magdalene; Hiasihri, Stenard; Ustero, Pilar; O'Brien, Daniel P.; du Cros, Philipp; Graham, Steve; Wootton, Richard; Majumdar, Suman S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-13)
    The emergence and spread of multidrug-resistant tuberculosis (MDR-TB) poses a major threat to the global targets for TB control. In recent years, an evolving science and evidence base for MDR-TB has led to much needed changes in international guidelines promoting the use of newer TB drugs and regimens for MDR-TB, however, there remains a significant implementation gap. Due to the complexity of ...
  • Comparative Genomic Analysis of Staphylococcus haemolyticus Reveals Key to Hospital Adaptation and Pathogenicity 

    Pain, Maria; Hjerde, Erik; Klingenberg, Claus; Cavanagh, Jorunn Pauline (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-10)
    <i>Staphylococcus haemolyticus</i> is a skin commensal gaining increased attention as an emerging pathogen of nosocomial infections. However, knowledge about the transition from a commensal to an invasive lifestyle remains sparse and there is a paucity of studies comparing pathogenicity traits between commensal and clinical isolates. In this study, we used a pan-genomic approach to identify factors ...
  • Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue 

    Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane; Richardsen, Elin; Bertilsson, Helena; Heeren, Ron M.A.; Bathen, Tone Frost; Karst, Uwe; Giskeødegård, Guro F.; Tessem, May-Britt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-16)
    Levels of zinc, along with its mechanistically related metabolites citrate and aspartate, are widely reported as reduced in prostate cancer compared to healthy tissue and are therefore pointed out as potential cancer biomarkers. Previously, it has only been possible to analyze zinc and metabolites by separate detection methods. Through matrix-assisted laser desorption/ionization mass spectrometry ...
  • Use of aspirin, other nonsteroidal anti-inflammatory drugs and acetaminophen and risk of endometrial cancer: The Epidemiology of Endometrial Cancer Consortium 

    Webb, Penelope M.; Na, Renhua; Weiderpass, Elisabete; Adami, Hans Olov; Anderson, Katie E.; Bertrand, Kimberly A.; Botteri, Edoardo; Brasky, Theodore M.; Brinton, Louise Annette; Chen, Chu; Doherty, Jennifer Anne; Lu, Lingeng; Mccann, Susan E.; Moysich, Kirsten Barbara; Olson, Sara H.; Petruzella, Stacey; Palmer, Jaqy R.; Prizment, Anna E.; Schairer, Catherine; Setiawan, Veronica Wendy; Spurdle, Amanda B.; Trabert, Britton L.; Wentzensen, Nicolas A.; Wilkens, Lynne Ross; Yang, Hannah P.; Yu, Herbert; Risch, Harvey A.; Jordan, Susan J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-06)
    <i>Background</i> - Regular use of aspirin has been associated with a reduced risk of cancer at several sites but the data for endometrial cancer are conflicting. Evidence regarding use of other analgesics is limited.<p><p> <i>Patients and methods</i> - We pooled individual-level data from seven cohort and five case–control studies participating in the Epidemiology of Endometrial Cancer ...
  • Electrosurgery and temperature increase in tissue with a passive metal implant 

    Martinsen, Tormod; Pettersen, Fred-Johan; Kalvøy, Håvard; Tronstad, Christian; Kvarstein, Gunnvald; Bakken, André; Høgetveit, Jan Olav; Martinsen, Ørjan Grøttem; Grimnes, Sverre; Frich, Lars Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-12)
    <i>Importance</i>: During monopolar electrosurgery in patients, current paths can be influenced by metal implants, which can cause unintentional tissue heating in proximity to implants. Guidelines concerning electrosurgery and active implants such as pacemakers or implantable cardioverter defibrillators have been published, but most describe interference between electrosurgery and the active implant ...

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