Recent additions

  • Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones 

    Clarelli, Fabrizio; Palmer, Adam; Singh, Bhupender; Storflor, Merete; Lauksund, Silje; Cohen, Ted; Abel, Sören; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-14)
    Antibiotic resistance is rising and we urgently need to gain a better quantitative understanding of how antibiotics act, which in turn would also speed up the development of new antibiotics. Here, we describe a computational model (COMBAT-COmputational Model of Bacterial Antibiotic Target-binding) that can quantitatively predict antibiotic dose-response relationships. Our goal is dual: We address a ...
  • A Survey on Cannabinoid Treatment of Pediatric Epilepsy Among Neuropediatricians in Scandinavia and Germany 

    Klingenberg, Claus; Mouslet, George; Hjalgrim, Helle; Gerstner, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-24)
    <i>Objectives</i>: There is an increasing interest in cannabinoid-based products for the treatment of refractory pediatric epilepsy. However, a licensed cannabidiol (CBD) product was first approved for use by the European regulatory authorities in 2019. We aimed to obtain knowledge about clinical experience and attitudes toward cannabinoid use for epilepsy treatment among neuropediatricians in ...
  • Are Parents Less Responsive to Young Children When They Are on Their Phones? A Systematic Naturalistic Observation Study 

    Vanden Abeele, Mariek M. P.; Abels, Monika; Hendrickson, Andrew T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-04)
    This study examined whether parents are less responsive to their young children (0–5) when they use a phone. We systematically observed 53 parent–child dyads in consultation bureau waiting rooms and playgrounds. Twenty-three parents used their phone at least once during the observation. Across the dyads, we observed parent and child behavior during a total of 1,038 ten-second intervals. Of these ...
  • Prediction of chronic heart failure and chronic obstructive pulmonary disease in a general population: the Tromsø study 

    Melbye, Hasse; Stylidis, Michael; Aviles Solis, Juan Carlos; Averina, Maria; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-07)
    <i>Aims</i> - Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are main causes of dyspnoea, and echocardiography and spirometry are essential investigations for these diagnoses. Our aim was to determine the prevalence of HF and COPD in a general population, also how the diseases may be identified, and to what extent their clinical characteristics differ.<br><br> <i>Methods and ...
  • Room tilt illusion and subclavian steal - A case report 

    Arntzen, Kathrine; Alstadhaug, Karl Bjørnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-08)
    <i>Background</i> - Room tilt illusion (RTI) is a rare symptom of higher vestibular dysfunction, consisting of a transient vertical rotation of the visual scene in the sagittal or coronal plane, most often 90<sup>o</sup> or 180<sup>o</sup>, without any alteration in shape, size and color of objects.<br><br> <i>Case presentation</i> - A 63-year-old woman with a history of hypertension and chronic ...
  • The Role of Emotions for 4 Athletes in Nordic Combined in Ski Jumping Competitions in World Cup 

    Moen, Frode; Vitsøe, Joar; Rasdal, Vegard; Myhre, Kenneth; Sandbakk, Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)
    This study looks at how emotions were associated with ski jumping competitions in world cup for four athletes representing the Norwegian national team in Nordic combined. The athletes documented their emotional experiences during competition rounds (trial-, and competition rounds) and non-competitive episodes (the period just after the competition round). The results in this study show that there ...
  • Shotgun-Metagenomics on Positive Blood Culture Bottles Inoculated With Prosthetic Joint Tissue: A Proof of Concept Study 

    Sanabria-Moreno, Adriana Maria; Hjerde, Erik; Johannessen, Mona; Sollid, Johanna U Ericson; Simonsen, Gunnar Skov; Hanssen, Anne Merethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-17)
    Clinical metagenomics is actively moving from research to clinical laboratories. It has the potential to change the microbial diagnosis of infectious diseases, especially when detection and identification of pathogens can be challenging, such as in prosthetic joint infection (PJI). The application of metagenomic sequencing to periprosthetic joint tissue (PJT) specimens is often challenged by low ...
  • Plasmid Interactions Can Improve Plasmid Persistence in Bacterial Populations 

    Gama, João Alves; Zilhão, Rita; Dionisio, Francisco (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-31)
    It is difficult to understand plasmid maintenance in the absence of selection and theoretical models predict the conditions for plasmid persistence to be limited. Plasmid-associated fitness costs decrease bacterial competitivity, while imperfect partition allows the emergence of plasmid-free cells during cell division. Although plasmid conjugative transfer allows mobility into plasmid-free cells, ...
  • Model Gender Interacts With Expressed Emotion to Enhance Startle: Angry Male and Happy Female Faces Produce the Greatest Potentiation 

    Åsli, Ole; Øvervoll, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-09)
    Several studies have implied gender differences in startle reaction to emotional facial expressions. However, few studies have been designed to investigate the difference between responding to emotional female vs. male faces, nor gender differences in responses. The present experiment investigated startle EMG responses to a startle probe while viewing pictures of neutral, happy, angry, fearful, and ...
  • Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study 

    Jorde, Rolf; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-02)
    <i>Background</i> - There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined.<p> <p><i>Method</i> - In the seventh survey of the Tromsø study, serum 25(OH)D and parathyroid hormone were measured, and questionnaires ...
  • Biocompatibility in low-density lipoprotein apheresis and plasma separation 

    Hardersen, Randolf Inge (Doctoral thesis; Doktorgradsavhandling, 2021-02-12)
    <p><i>Introduction:</i> Low-density lipoprotein (LDL) apheresis is used for the removal of LDL in selected patients and is also used for other medical indications. This thesis aimed to systematically study how different LDL apheresis systems affected the immune system in a biocompatibility perspective under in vivo and ex vivo conditions. <p><i>Methods:</i> Whole blood adsorption, dextran sulfate ...
  • Sudden caffeine withdrawal triggers migraine—A randomized controlled trial 

    Alstadhaug, Karl Bjørnar; Ofte, Hilde Karen; Müller, Kai Ivar; Andreou, Anna P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-10)
    <i>Objective</i>: Assessing the effects of caffeine withdrawal on migraine.<p> <p><i>Background</i>: The effects of caffeine withdrawal on migraineurs are at large unknown.<p> <p><i>Methods</i>: This was a randomized, double-blind, crossover study (NCT03022838), designed to enroll 80 adults with episodic migraine and a daily consumption of 300–800 mg caffeine. Participants substituted their ...
  • Genetic risk-factors for anxiety in healthy individuals: polymorphisms in genes important for the HPA axis 

    Lindholm, Heléne; Morrison, India; Krettek, Alexandra; Malm, Dan; Novembre, Giovanni; Handlin, Linda (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-21)
    <i>Background</i> - Two important aspects for the development of anxiety disorders are genetic predisposition and alterations in the hypothalamic-pituitary-adrenal (HPA) axis. In order to identify genetic risk-factors for anxiety, the aim of this exploratory study was to investigate possible relationships between genetic polymorphisms in genes important for the regulation and activity of the HPA ...
  • Have medical students’ attitudes towards clinical communication skills changed over a 12- year period? A comparative long-term study 

    Gude, Tore; Tyssen, Reidar; Anvik, Tor; Grimstad, Hilde; Holen, Are; Baerheim, Anders; Vaglum, Per Jørgen Wiggen; Løvseth, Lise T (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-10)
    <i>Background</i> - Attitudes towards learning clinical communication skills at the end of medical school are likely to reflect the students’ training and motivation for the continued development of their skills as doctors. Students from two Norwegian medical schools, one with a traditional, and the other with an integrated curriculum, were approached in 2003 and 2015; with regard to changes in ...
  • Web-based exercise versus supervised exercise for decreasing visceral adipose tissue in older adults with central obesity: A randomized controlled trial 

    Ballin, Marcel; Hult, Andreas; Björk, Sabine; Lundberg, Emmy; Nordström, Peter; Nordström, Anna Hava (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-12)
    <i>Background</i> - Visceral adipose tissue (VAT) is a strong risk factor for cardiovascular disease and increases with age. While supervised exercise (SE) may be an effective approach, web-based exercise (WE) have other advantages such as being more readily accessible. Therefore, we evaluated the effects of WE on VAT, body composition and cardiometabolic risk markers in centrally obese older adults ...
  • Adverse effects in homeopathy. A systematic review and meta-analysis of observational studies 

    Stub, Trine; Kristoffersen, Agnete Egilsdatter; Overvåg, Grete; Jong, Miek; Musial, Frauke; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-28)
    <p><i>Background - </i>Almost all health care interventions have the potential to be associated with risk to patient safety. Different terminologies are used to define treatment induced risk to patient safety and a common definition is the term adverse effect. Beyond the concept of adverse effect and specific to homeopathy is the concept of homeopathic aggravation. Homeopathic aggravation describes ...
  • Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila 

    Jacomin, Anne-Claire; Petridi, Stavroula; Di Monaco, Marisa; Bhujabal, Zambarlal; Jain, Ashish; Mulakkal, Nitha C.; Palara, Anthimi; Powell, Emma L.; Chung, Bonita; Zampronio, Cleidiane; Jones, Alexandra; Cameron, Alexander; Johansen, Terje; Nezis, Ioannis P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-26)
    Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3. Despite growing evidence that LC3 is enriched in the nucleus, its nuclear role is poorly understood. Here, we show that <i>Drosophila</i> Atg8a protein, homologous to mammalian LC3, interacts with the transcription factor Sequoia in a LIR motif-dependent ...
  • Help-seeking behavior in Norwegian adolescents: the role of bullying and cyberbullying victimization in a cross-sectional study 

    Kaiser, Sabine; Kyrrestad, Henriette; Fossum, Sturla (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-30)
    <i>Background:</i> Help-seeking is considered a constructive coping style. However, the threshold at which many adolescents seek help is relatively high, and the outcomes are not necessarily always positive.<p> <p><i>Objective:</i> The main aim of this study was to examine if bullying and cyberbullying victimization predicted help-seeking behavior among< Norwegian adolescents.<p> <p><i>Method:</i> ...
  • Structural Analysis of Merkel Cell Polyomavirus (MCPyV) Viral Capsid Protein (VP1) in HIV-1 Infected Individuals 

    Prezioso, Carla; Bianchi, Martina; Obregon, Francisco; Ciotti, Marco; Sarmati, Loredana; Andreoni, Massimo; Palamara, Anna Teresa; Pascarella, Stefano; Moens, Ugo; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-27)
    Merkel cell polyomavirus (MCPyV) viral protein 1 (VP1) is the capsid protein that mediates virus attachment to host cell receptors and is the major immune target. Given the limited data on MCPyV VP1 mutations, the VP1 genetic variability was examined in 100 plasma and 100 urine samples from 100 HIV+ individuals. Sequencing of VP1 DNA in 17 urine and 17 plasma specimens, simultaneously MCPyV DNA ...
  • Staphylococcus borealis sp. nov., isolated from human skin and blood 

    Pain, Maria; Wolden, Runa; Jaén-Luchoro, Daniel; Salvà-Serra, Francisco; Iglesias, Beatriz Piñeiro; Karlsson, Roger; Klingenberg, Claus; Cavanagh, Jorunn Pauline (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-13)
    When analysing a large cohort of <i>Staphylococcus haemolyticus</i>, using whole-genome sequencing, five human isolates (four from the skin and one from a blood culture) with aberrant phenotypic and genotypic traits were identified. They were phenotypically similar with yellow colonies, nearly identical 16S rRNA gene sequences and initially speciated as <i>S. haemolyticus</i> based on 16S rRNA gene ...

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