Recent additions

  • Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls 

    Zebaze, Roger; Osima, Marit; Bui, Minh; Lukic, Marko; Wang, Xiaofang; Ghasem-Zadeh, Ali; Eriksen, Erik Fink; Vais, Angela; Shore-Lorenti, Catherine; Ebeling, Peter R.; Seeman, Ego; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-18)
    Advancing age is accompanied by a reduction in bone formation and remodeling imbalance, which produces microstructural deterioration. This may be partly caused by a diversion of mesenchymal cells towards adipocytes rather than osteoblast lineage cells. We hypothesized that microstructural deterioration would be associated with an increased marrow adiposity, and each of these traits would be independently ...
  • Kunnskapsoppsummering og klassifisering av tiltaket De Utrolige Årene Universalprogrammet (1. utg.) 

    Drozd, Filip; Hansen, Ketil Lenert (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-17)
    <i>BAKGRUNN</i> - Denne artikkelen er en kunnskapsoppsummering av effektene på De Utrolige Årenes universalprogram Oppmerksomme og utviklingsstøttende foreldre (DUÅ Universal) i Norden. DUÅ Universal er et universalforebyggende program som gis til foreldre, for å forebygge atferdsvansker og styrke sosial og emosjonell kompetanse hos barn i alderen 2 til 6 år. Regionalt kunnskapssenter for barn og ...
  • Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging 

    Fjellaksel, Richard; Moldes-Anaya, Angel; Vasskog, Terje; Oteiza, Ana; Martin-Armas, Maria Montserrat; Hjelstuen, Ole Kristian; Hansen, Jørn H; Riss, Patrick; Sundset, Rune (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
    The increased expression of gonadotropin releasing hormone receptor (GnRH‐R) in brain has been strongly linked to Alzheimer disease. Therefore, the development of radiolabeled imaging agents for GnRH‐R is relevant for early diagnosis of Alzheimer disease. We have recently disclosed the discovery of two promising compounds displaying nanomolar‐range affinity for the GnRH‐R. In the present study, a ...
  • Optimisation of high-resolution fluorescence microscopy of normal- and preeclamptic placentas 

    Knutsen, Kristine Marie Bakken (Master thesis; Mastergradsoppgave, 2019-08-14)
    Preeclampsia (PE) affects 3-5 % of pregnant women and may lead to maternal and/or fetal death. The main theory of PE is placental ischemia, leading to a dysfunctional placenta and clinical signs as hypertension and proteinuria in the mother. The primary aim of the thesis was to implement and optimise a method for high-resolution microscopy of placental cryo-sections. Secondary aims were to compare ...
  • The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery 

    Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-16)
    Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as drugs absorbed in the olfactory epithelium bypass the blood-brain barrier and reach the brain within minutes. However, the nasal mucosa properties (e.g., tonicity, pH) are not constant ...
  • Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor 

    Fjellaksel, Richard; Boomgaren, Marc; Sundset, Rune; Haraldsen, Ira Hebold; Hansen, Jørn H; Riss, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-14)
    In this communication, we report the synthesis and characterization of a library of small molecule antagonists of the human gonadotropin releasing hormone receptor based upon the 2-(4-<i>tert</i>-butylphenyl)-4-piperazinyl-benzimidazole scaffold <i>via</i> Cu-catalysed azide alkyne cycloaddition. Our main purpose was to find a more soluble compound based on the WAY207024 lead with nanomolar potency ...
  • Ambulatory vocal acoustics, temporal dynamics, and serious mental illness 

    Cohen, Alex S.; Fedechko, Taylor L.; Schwartz, Elana K.; Le, Thanh P.; Foltz, Peter W.; Bernstein, Jared; Cheng, Jian; Holmlund, Terje Bektesevic; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
    Acoustic analysis of vocal expression offers a potentially inexpensive, unobtrusive, and highly sensitive biobehavioral measure of serious mental illness (SMI)-related issues. Despite literature documenting its use for understanding SMI, prior studies have largely ignored that vocal expression is highly dynamic within individuals over time. We employed ambulatory vocal assessment from SMI outpatients ...
  • Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes 

    Wu, Iren Yeeling; Bala, Sonali; Skalko-Basnet, Natasa; Di Cagno, Massimiliano Pio (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-30)
    The aim of this work was to clarify the dynamics behind the influence of ionic strength on the changes in drug release from large unilamellar vesicles (LUVs). For this purpose, we have investigated the transport of two different model drugs (caffeine and hydrocortisone) formulated into liposomes through different types of barriers with different retention properties (regenerated cellulose and the ...
  • Reflective writing followed by dialogue improves supervision practices and cooperation in midwifery education 

    Thoresen, Anne- Lise; Norbye, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-17)
    Writing as a tool for learning and reflection is acknowledged as important in education. This article discusses how writing and subsequent dialogue can support midwife supervisors in enhancing their supervisory skills. The aim of this article is to discuss the significance of reflective journals as a tool for reflection, dialogue and cooperation in supervision practices in midwifery education. An ...
  • A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells 

    Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-01)
    Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections correlated with a poor prognosis. Furthermore, the results showed that NPNT is localized in extracellular vesicles derived from mouse breast cancer cells. In this study, we ...
  • Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition 

    Lin, Crystal; Travis, Ruth C.; Appleby, Paul N.; Tipper, Sarah; Weiderpass, Elisabete; Chang-Claude, Jenny; Gram, Inger Torhild; Kaaks, Rudolf; Kiemeney, Lambertus A.; Ljungberg, Börje; Tumino, Rosario; Tjønneland, Anne; Roswall, Nina; Overvad, Kim; Boutron-Ruault, Marie-Christine; Manciniveri, Francesca Romana; Severi, Gianluca; Trichopoulou, Antonia; Masala, Giovanna; Sacerdote, Carlotta; Agnoli, Claudia; Panico, Salvatore; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Salamanca-Fernández, Elena; Chirlaque, Maria-Dolores; Ardanaz, Eva; Dorronsoro, Miren; Menéndez, Virginia; Luján-Barroso, Leila; Liedberg, Fredrik; Freisling, Heinz; Gunter, Marc; Aune, Dagfinn; Cross, Amanda J.; Riboli, Elio; Key, Timothy J.; Perez-Cornago, Aurora (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-04)
    Previous <i>in vitro</i> and case–control studies have found an association between the insulin‐like growth factor (IGF)‐axis and bladder cancer risk. Circulating concentrations of IGF‐I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre‐diagnostic circulating IGF‐I concentrations and bladder cancer has never been studied ...
  • Smoking and other determinants of bone turnover 

    Jorde, Rolf; Stunes, Astrid Kamilla; Kubiak, Julia Magdalena; Grimnes, Guri; Thorsby, Per Medbøe; Syversen, Unni (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-25)
    The balance between bone resorption and formation may be assessed by measurement of bone turnover markers (BTMs), like carboxyl-terminal cross-linked telopeptide of type 1 collagen (CTX-1) and procollagen type 1 amino-terminal propeptide (P1NP). Smoking has been shown to influence bone turnover and to reduce bone mass density (BMD), the exact mechanism for this is, however, not settled. In this ...
  • Academic detailing as a method of continuing medical education 

    Dyrkorn, Roar; Langaas, Harald Chr.; Giverhaug, Trude; Espnes, Ketil Arne; Rowett, Debra; Spigset, Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
    <i>Introduction</i>: Academic detailing is an interactive educational outreach to prescribers to present unbiased, non-commercial, evidence-based information, mostly about medications, with the goal of improving patient care. Academic detailing in Norway is an approach for providing continuing medical education to general practitioners (GPs). The basis of academic detailing is a one-to-one discussion ...
  • Development and evaluation of gonadotropin releasing hormone antagonists as SPECT radiotracers 

    Fjellaksel, Richard (Doctoral thesis; Doktorgradsavhandling, 2018-05-24)
    The overall aim of the thesis was to evaluate the potential of gonadotropin releasing hormone receptor (GnRH-R) antagonists as radiotracers for the early detection and understanding of Alzheimer`s disease (AD). The molecular imaging field is a symbiosis between organic chemistry, radiochemistry, in vitro biology, as well as preclinical- and clinical trials, therefore an evaluation should involve all ...
  • Station of the fetal head at complete cervical dilation impacts duration of second stage of labor 

    Ludvigsen, Elisabeth; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-31)
    <i>Objective</i> - To examine the association between station of the fetal head at complete cervical dilation and duration of second stage of labor, as well as prolonged second stage of labor, without and with the use of analgesia (EA).<p> <p><i>Study design</i> - We conducted a population-based retrospective cohort study of 3311 women with a singleton pregnancy, gestational age ≥ 37<sup>0</sup> ...
  • What is currently the best investigational approach to the patient with sudden-onset severe headache? 

    Sjulstad, Ane Skaare; Alstadhaug, Karl Bjørnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-11)
    <i>Presentation of Case</i> – Ane Skaare Sjulstad, MD, Adult Neurology Resident, Nordland Hospital, Bodø, Norway A 48‐year‐old man with no previous medical history suddenly experienced severe intense retro‐bulbar pain of pulsating character on the right side, and was seen in the emergency department 7 hours later. He was then alert and oriented, but in excruciating pain. There was no neck stiffness ...
  • Young immigrants in Norway: The role of national and ethnic identity in immigrants’ integration 

    Martiny, Sarah E.; Froehlich, Laura; Soltanpanah, Jilwan; Haugen, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-08)
    The present work investigates the endorsement, antecedents, relationships, and consequences of young immigrants’ social identities in Norway. Despite increasing numbers of refugees and immigrants entering Norway in recent years, little is known about the relationship between immigrants’ different social identities and their feeling of integration into Norwegian society. The main goal of the present ...
  • The role of adrenoceptors in the central nervous system in male and female rat sexual behavior 

    Snoeren, Eelke (Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2014-09-10)
    Three different phases can be distinguished in rats’ sexual cycle, the introductory (precopulatory), the copulatory and the executive (ejaculatory) phases. In this review, a new analysis of existing pharmacological data is made, both in male and female rats, in which the different aspects of sexual behavior are taken into account. An effort is made to distinguish pharmacological effects on sexual ...
  • Hjemmedødens lovlighet 

    Wackers, Ger (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-20)
    <i>Den døendes rom</i> er kanskje et av de mest private rommene vi kjenner til; hjemme sannsynligvis i enda større grad enn i sykehus eller sykehjem. Også det som skjer innenfor det private territoriet av den døendes rom hjemme, skal være innenfor lovens rammer. En <i>post hoc</i> vurdering av et dødsfalls lovlighet, gjennom en dødsattest, er ikke tilstrekkelig. Hjemmedødens lovlighet må også sikres ...
  • Four months vitamin D supplementation to vitamin D insufficient individuals does not improve muscular strength: A randomized controlled trial 

    Grimnes, Guri; Kubiak, Julia Magdalena; Jorde, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-16)
    <i>Main objective</i> - The inconsistent results on the effects of vitamin D on muscle strength reported by intervention trials may partly be explained by inclusion of vitamin D sufficient individuals. The main objective was to study whether vitamin D supplementation will improve muscle strength in men and women with low serum vitamin D status, as measured by 25-hydroxyvitamin D (25(OH)D) at ...

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