Recent additions

  • Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study 

    Hald, Erin Mathiesen; Løchen, Maja-Lisa; Lappegård, Jostein; Ellingsen, Trygve; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-28)
    <i>Introduction</i>- Red cell distribution width (RDW) is associated with cardiovascular diseases, including atrial fibrillation (AF) and venous thromboembolism (VTE). Whether RDW is a risk marker for thromboembolic events in AF patients is scarcely known. We aimed to assess the association between RDW and the risk of AF, and AF-related VTE and ischemic stroke, in a population-based cohort.<p> ...
  • Quantifying the contribution of established risk factors to cardiovascular mortality differences between Russia and Norway 

    Trias-Llimós, Sergi; Pennells, Lisa; Tverdal, Aage; Kudryavtsev, Alexander V; Malyutina, Sofia; Hopstock, Laila Arnesdatter; Iakunchykova, Olena; Nikitin, Yuri; Magnus, Per; Kaptoge, Stephen; Di Angelantonio, Emanuele; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-27)
    Surprisingly few attempts have been made to quantify the simultaneous contribution of well-established risk factors to CVD mortality differences between countries. We aimed to develop and critically appraise an approach to doing so, applying it to the substantial CVD mortality gap between Russia and Norway using survey data in three cities and mortality risks from the Emerging Risk Factor Collaboration. ...
  • High spatially sensitive quantitative phase imaging assisted with deep neural network for classification of human spermatozoa under stressed condition 

    Butola, Ankit; Popova, Daria; Prasad, Dilip K.; Ahmad, Azeem; Habib, Anowarul; Tinguely, Jean-Claude; Basnet, Purusotam; Acharya, Ganesh; Paramasivam, Senthilkumaran; Mehta, Dalip Singh; Ahluwalia, Balpreet Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-04)
    Sperm cell motility and morphology observed under the bright field microscopy are the only criteria for selecting a particular sperm cell during Intracytoplasmic Sperm Injection (ICSI) procedure of Assisted Reproductive Technology (ART). Several factors such as oxidative stress, cryopreservation, heat, smoking and alcohol consumption, are negatively associated with the quality of sperm cell and ...
  • Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription 

    Shrestha, Anup; Bruckmüller, Henrike; Kildalsen, Hanne; Kaur, Gurjit; Gaestel, Matthias; Ljones Wetting, Hilde; Mikkola, Ingvild; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
    Steroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several common cancers including breast, colorectal and lung tumors. Phosphorylation is an important regulatory event controlling the activities of SRC-3. Serine 857 ...
  • Mangfoldsperspektiver i forskning på vold i nære relasjoner 

    Bredal, Anja; Eggebø, Helga; Eriksen, Astrid (Chapter; Bokkapittel, 2020-06-10)
    Most research on domestic violence has focused on violence against women in a gender perspective. However, there has been an increasing understanding of the importance of other social dimensions in order to understand the nature and impact of the violence. The aim of this chapter is to explore the current status of research on domestic violence in a diversity perspective. We argue that dimensions like ...
  • Post-stroke health-related quality of life at 3 and 12 months and predictors of change in a Danish and Arctic Norwegian Region 

    Heiberg, Guri Anita; Friborg, Oddgeir; Pedersen, Synne Garder; Thrane, Gyrd; Stabell, Henriette Holm; Nielsen, Jørgen Feldbæk; Anke, Audny (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-30)
    Objectives: To investigate changes in health-related quality of life between 3- and 12-months post-stroke in a north Norwegian and a Danish region that organize their rehabilitation services differently, and to identify clinically relevant predictors of change. Design: Prospective multicentre cohort study. Subjects: In total, 304 patients with first-ever stroke (male sex 59%, mean age 68.7 years) ...
  • Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models 

    Castaneda Zegarra, Sergio Miguel; Fernandez Berrocal, Marion Silvana; Tkachev, Max; Yao, Rouan; Esnardo Upfold, Nikki Lyn; Oksenych, Valentyn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-12)
    Non‐homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double‐strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J recombination to increase the repertoire of B and T cell receptors. DSBs are also generated during the class switch recombination (CSR) process in mature B lymphocytes, providing ...
  • Time trends in the effects of mindfulness-based cognitive therapy for depression: A meta-analysis 

    Thimm, Jens; Johnsen, Tom Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-21)
    Recent studies suggest that the effects of cognitive therapies for depression show systematic changes over time. A meta‐analysis was conducted to explore the temporal development of the effect of mindfulness‐based cognitive therapy (MBCT) for current depression in studies that used the Beck Depression Inventory (BDI) or the Hamilton Depression Rating Scale (HDRS) as outcome measures. A systematic ...
  • Cyberbullying status and mental health in Norwegian adolescents 

    Kaiser, Sabine; Kyrrestad, Henriette; Fossum, Sturla (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-26)
    The aim of the present study was to examine how the cyberbullying status (not involved, cyber‐victim only, cyberbully only, cyber‐victim and bully) is related to the mental health of the adolescents when controlled for traditional bullying experience. We also examined the potential moderator sex on the relationship between cyberbullying status and mental health. Univariate analyses of variance were ...
  • Information concerning ICU patients’ families in the handover— The clinicians’ «game of whispers»: A qualitative study 

    Nygaard, Anne Mette; Haugdahl, Hege Selnes; Brinchmann, Berit Støre; Lind, Ranveig (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-16)
    <i>Aims and objectives</i> - To explore how information concerning ICU patients´ families is included in the ICU clinicians’ daily handover.<p> <p><i>Background</i> - Handover refers to the transfer of information and care responsibility between clinicians. An effective and precise handover are of great importance to ensure quality of care. Although improvements in handovers have received increasing ...
  • The necessity and possibilities of playfulness in narrative care with older adults 

    Blix, Bodil Hansen; Berendonk, Charlotte; Clandinin, D. Jean; Caine, Vera (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-13)
    For us, narrative care is grounded in pragmatist philosophy and focused on experience. Narrative care is not merely about acknowledging or listening to people's experiences, but draws attention to practical consequences. We conceptualize care itself as an intrinsically narrative endeavour. In this article, we build on Lugones' understanding of playfulness, particularly to her call to remain attentive ...
  • A ‘near‐life experience’: lived experiences of spirituality from the perspective of people who have been subject to inpatient psychiatric care 

    Koslander, Tiburtius; Rönning, Sonia; Magnusson, Sofia; Wiklund Gustin, Lena (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-24)
    <i>Aims</i>: To describe lived experiences of spirituality from the perspective of people who have been subject to inpatient psychiatric care and to interpret these experiences from an understanding of health as dialectical.<p> <p><i>Methods</i>: After approval from a regional ethical board,eleven participants were recruited from two organisations for people with mental health problems. Participants ...
  • The Master Study in Telemedicine and E-health at the University of Tromsø, Norway, 2005-2018 

    Wynn, Rolf; Ellingsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
    In this paper we describe the Master Study in Telemedicine and E-health at the University of Tromsø, Norway. The study enrolled its first students in 2005 and was closed in 2018. We describe and discuss the background of the programme, its development and accomplishments and why it was closed. Hopefully, this narrative will be of use to other programmes focusing on e-health.
  • Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer 

    Dawadi, Rangita; Malla, Nabin; Hegge, Beate; Wushur, Imin; Berg, Eli; Svineng, Gunbjørg; Sylte, Ingebrigt; Winberg, Jan-Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-12)
    Previous studies have shown that THP-1 cells produced an SDS-stable and reduction-sensitive complex between proMMP-9 and a chondroitin sulfate proteoglycan (CSPG) core protein. The complex could be reconstituted in vitro using purified serglycin (SG) and proMMP-9 and contained no inter-disulfide bridges. It was suggested that the complex involved both the FnII module and HPX domain of proMMP-9. The ...
  • Plan, recruit, retain: a framework for local healthcare organizations to achieve a stable remote rural workforce 

    Abelsen, Birgit; Strasser, Roger; Heaney, David; Berggren, Peter; Sigurðsson, Sigurður; Brandstorp, Helen; Wakegijig, Jennifer; Forsling, Niclas; Moody-Corbett, Penny; Akearok, Gwen Healey; Mason, Anne; Savage, Claire; Nicoll, Pam (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-03)
    <i>Background</i> - Recruiting and retaining a skilled health workforce is a common challenge for remote and rural communities worldwide, negatively impacting access to services, and in turn peoples’ health. The research literature highlights different factors facilitating or hindering recruitment and retention of healthcare workers to remote and rural areas; however, there are few practical tools ...
  • Serum PTH is not a good marker for defining a threshold for vitamin D deficiency 

    Jorde, Rolf; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-01)
    <i>Objective</i>: In addition to its skeletal effects, vitamin D may also be important for health in general. It is uncertain what level of serum 25-hydroxyvitamin D (25(OH)D), marker of vitamin D status, is sufficient for these effects. With decreasing serum 25(OH)D levels there is an increase in serum PTH. The point at which this occurs has been considered as a threshold for vitamin D sufficiency. ...
  • Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: the Nordic-Baltic Bifurcation Study IV 

    Kumsars, Indulis; Holm, Niels Ramsing; Niemelä, Matti; Erglis, Andrejs; Kervinen, Kari; Kervinen, Evald Høj; Maeng, Michael; Dombrovskis, Andis; Abraitis, Vytautas; Kibarskis, Aleksandras; Trovik, Thor; Latkovskis, Gustavs; Sondore, Dace; Narbute, Inga; Juhl Terkelsen, Christian; Eskola, Markko; Romppanen, Hannu; Laine, Mika; Jensen, Lisette Okkels; Pietila, Mikko; Gunnes, Pål; Hebsgaard, Lasse; Frobert, Ole; Calais, Fredrik; Hartikainen, Juha; Aarøe, Jens; Ravkilde, Jan; Engstrøm, Thomas; Steigen, Terje K.; Thuesen, Leif; Lassen, Jens F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-19)
    <i>Background</i> - It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation.<p> <p><i>Methods</i> ...
  • Behandlingsrater for ryggkirurgi i Norge og Helse Nord 2014-18 

    Ingebrigtsen, Tor; Balteskard, Lise; Guldhaugen, Kristel Ailin; Kloster, Roar; Uleberg, Bård Erling; Grotle, Margreth; Solberg, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-23)
    <i>BAKGRUNN</i> - Formålet med denne studien var å undersøke om behandlingstilbudet innen ryggkirurgi i Helse Nord er i henhold til den vedtatte funksjonsfordelingen mellom sykehusene i regionen, og om det er geografisk variasjon i tilbudet. Vi undersøkte derfor behandlingsrater i Norge og Helse Nord, samt egendekning i Helse Nord, og vurderte aktiviteten i regionen.<p> <p><i>MATERIALE OG METODE</i> ...
  • Clinical characterization of Helicobacter pylori infected patients 15 years after unsuccessful eradication 

    Nestegard, Oddmund; Johnsen, Kay-Martin; Sørbye, Sveinung; Halvorsen, Fred-Arne; Tønnessen, Tor; Paulssen, Eyvind Jakob; Melby, Kjetil K.; Goll, Rasmus; Florholmen, Jon (Journal article; Tidsskriftartikkel, 2020-09-23)
    <i>Background and aims</i> - Patients that have failed therapy for Helicobacter pylori (H. pylori) infection are incompletely characterized. The aim of this study was to characterize a H. pylori treatment resistant cohort compared to the cohorts of newly diagnosed, earlier eradicated and non-infected.<p> <p><i>Material and methods</i> - Patients were selected from routine referrals to the Endoscopy ...
  • Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones 

    Clarelli, Fabrizio; Palmer, Adam; Singh, Bhupender; Storflor, Merete; Lauksund, Silje; Cohen, Ted; Abel, Sören; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-14)
    Antibiotic resistance is rising and we urgently need to gain a better quantitative understanding of how antibiotics act, which in turn would also speed up the development of new antibiotics. Here, we describe a computational model (COMBAT-COmputational Model of Bacterial Antibiotic Target-binding) that can quantitatively predict antibiotic dose-response relationships. Our goal is dual: We address a ...

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