Recent additions

  • The effect of white matter hyperintensities on regional brain volumes and white matter microstructure, a population-based study in HUNT 

    Vangberg, Torgil Riise; Eikenes, Live; Håberg, Asta K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-04)
    Even though age-related white matter hyperintensities (WMH) begin to emerge in middle age, their effect on brain micro- and macrostructure in this age group is not fully elucidated. We have examined how presence of WMH and load of WMH affect regional brain volumes and microstructure in a validated, representative general population sample of 873 individuals between 50 and 66 years. Presence of WMH ...
  • Identifying decisions in optometry: A validation study of the decision identification and classification taxonomy for use in medicine (DICTUM) in optometric consultations 

    Sundling, Vibeke; Stene, Hege Anita; Eide, Hilde; Ofstad, Eirik Hugaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-18)
    <i>Objective</i> - The aim of this study was to assess the validity and reliability of the Decision Identification and Classification Taxonomy for Use in Medicine (DICTUM) applied to optometry, to compare decisions in medical and optometric consultations, and to describe decisions in optometry. <p> <p><i>Methods</i> - The study had a cross-sectional design. Data was collected from January to ...
  • Effect of genetically low 25-hydroxyvitamin D on mortality risk: Mendelian randomization analysis in 3 large European cohorts 

    Aspelund, Thor; Grübler, Martin R.; Smith, Albert V.; Gudmundsson, Elias F.; Keppel, Martin; Cotch, Mary Frances; Harris, Tamara B.; Jorde, Rolf; Grimnes, Guri; Joakimsen, Ragnar Martin; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; März, Winfried; Kleber, Marcus E.; Tomaschitz, Andreas; Grove-Laugesen, Diana; Rejnmark, Lars; Swart, Karin M.A.; Brouwer, Ingeborg A.; Lips, Paul; van Schoor, Natasja M.; Sempos, Christopher T.; Durazo-Arvizu, Ramón A.; Škrabáková, Zuzana; Dowling, Kirsten G.; Cashman, Kevin D.; Kiely, Mairead; Pilz, Stefan; Gudnason, Vilmundur; Eiríksdóttir, Gudny (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-02)
    The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D ...
  • Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model 

    Camilio, Ketil Andre; Wang, Meng-Yu; Mauseth, Brynjar; Waagene, Stein; Kvalheim, Gunnar; Rekdal, Øystein; Sveinbjørnsson, Baldur; Mælandsmo, Gunhild M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
    <i>Background</i> - Immunochemotherapy, the combined use of immunotherapy and chemotherapy, has demonstrated great promise in several cancers. LTX-315 is an oncolytic peptide with potent immunomodulatory properties designed for the local treatment of solid tumors. By inducing rapid immunogenic cell death through the release of danger-associated molecular pattern molecules (DAMPs), LTX-315 is capable ...
  • Pain-relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice 

    Hansson, Per; Jensen, Troels Staehelin; Kvarstein, Gunnvald; Strömberg, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-01)
    <p><i>Context - </i>Clinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. <p><i>Objective - </i>To determine whether treatment and re‐treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. <p><i>Methods - </i>Three ...
  • A novel scale-space approach for multinormality testing and the k-sample problem in the high dimension low sample size scenario 

    Hindberg, Kristian; Hannig, Jan; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
    Two classical multivariate statistical problems, testing of multivariate normality and the <i>k</i>-sample problem, are explored by a novel analysis on several resolutions simultaneously. The presented methods do not invert any estimated covariance matrix. Thereby, the methods work in the High Dimension Low Sample Size situation, i.e. when <i>n</i> ≤ <i>p</i>. The output, a significance map, is ...
  • Kartlegging av prosedyrer for oppdekking av instrumentbord ved kirurgiske inngrep 

    Igesund, Unni; Rasmussen, Guri; Overvåg, Grete; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel, 2019)
  • Bipolar radiofrequency neurotomy for spinal pain - A promising technique but still some steps to go 

    Kvarstein, Gunnvald; Lundeland, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-02)
  • p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance 

    Flem-Karlsen, Karine; Tekle, Christina; Øyjord, Tove Ragnhild; Flørenes, Vivi Ann; Mælandsmo, Gunhild Mari; Fodstad, Øystein; Nunes-Xavier, Caroline Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-09)
    Immunoregulatory protein B7-H3 is involved in the oncogenic and metastatic potential of cancer cells, as well as in drug resistance. Resistance to conventional chemotherapy is an important aspect of melanoma treatment, and a better understanding of how B7-H3 enhances drug resistance may lead to the development of more effective therapies. We investigated the <i>in vitro</i> and <i>in vivo</i> ...
  • Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation 

    Berzaghi, Rodrigo; Akhtar, Muhammad Asad; Islam, Md Ashraful; Pedersen, Brede Dille; Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-17)
    The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ...
  • Exploring why and how encounters with the Norwegian health-care system can be considered culturally unsafe by North Sami-speaking patients and relatives: A qualitative study based on 11 interviews 

    Mehus, Grete; Bongo, Berit Andersdatter; Engnes, Janne Isaksen; Moffitt, Pertice (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
    <p><i>Background - </i>Citizens of Norway have free and equal access to healthcare. Nurses are expected to be culturally sensitive and have cultural knowledge in encounters with patients. Culturally safe care is considered both a process and an outcome, evaluated by whether the patients feel safe, empowered and cared for, or not. All patients request equal access to quality care in Norway, also Sami ...
  • Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study 

    Småbrekke, Silje; Schirmer, Henrik; Melsom, Toralf; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
    <p><i>Background - </i>Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive ...
  • Circulating tumor cell-derived pre-clinical models for personalized medicine 

    Tellez Gabriel, Marta; Cochonneau, Denis; Jubelin, Camille; Heymann, Marie-Françoise; Heymann, Dominique (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-24)
    The main cause of death from cancer is associated with the development of metastases, resulting from the inability of current therapies to cure patients at metastatic stages. Generating preclinical models to better characterize the evolution of the disease is thus of utmost importance, in order to implement effective new cancer biomarkers and therapies. Circulating Tumor Cells (CTCs) are good ...
  • Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche 

    Cuminetti, Vincent; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-18)
    Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differentiation of BM mesenchymal stromal cells, but they seem to be a heterogeneous population with distinct metabolisms, lipid compositions, secretory properties and ...
  • Chlamydia pecorum associated with an outbreak of infectious keratoconjunctivitis in semi-domesticated reindeer in Sweden 

    Sanchez Romano, Javier; Leijon, Mikael; Hagström, Åsa; Jinnerot, Tomas; Rockström, Urlika; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-05)
    Infectious keratoconjunctivitis (IKC), the most common ocular disease in ruminants worldwide, has affected semi-domesticated Eurasian reindeer (<i>Rangifer tarandus tarandus</i>) for over 100 years, both as individual cases and in outbreaks affecting tens to hundreds of animals. Recurrent IKC outbreaks have been affecting a semi-domesticated reindeer herd in Östra Kikkejaure (Norrbotten county, ...
  • Ambiguity and professional accountability in physiotherapy practice. Acquired brain injury rehabilitation across health care levels 

    Irgens, Eirik Lind (Doctoral thesis; Doktorgradsavhandling, 2019-09-10)
    At the time of this study, the Norwegian health care system was in the middle of the implementation of the Coordination reform, initiated in 2012 due to insufficient coordination and an increase in health care service expenditure. Earlier hospital discharge and increased municipal responsibilities for rehabilitation following acquired brain injuries (ABI) challenge the traditional rehabilitation ...
  • Blame it on the weather? The association between pain in fibromyalgia, relative humidity, temperature and barometric pressure 

    Fagerlund, Asbjørn Johansen; Iversen, Maria; Ekeland, Andrea; Moen, Connie Malén; Aslaksen, Per M (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-10)
    Self-reported pain levels in patients with fibromyalgia may change according to weather conditions. Previous studies suggest that low barometric pressure (BMP) is significantly related to increased pain, but that the contribution of changes in BMP has limited clinical relevance. The present study examined whether BMP influenced variability in perceived stress, and if stress levels moderated or ...
  • The Impact of the “Semente” Program on the Family-Focused Practice of Mental Health Professionals in Portugal 

    Doesum, Karin van; Maia, Teresa M; Pereira, Catarina; Loureiro, Monica; Marau, Joana; Toscano, Lurdes; Lauritzen, Camilla; Reedtz, Charlotte (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-07)
    <p><i>Background - </i>Children of parents with mental illness (COPMI) are a high-risk group. There is a strong association between parents’ psychiatric disorders and the incidence of psychopathology in their children. These children need to be identified and supported by mental health workers early, and hence, clinical practice in adult mental health services needs to change from a focus on individual ...
  • Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study 

    Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-14)
    In recent years, low dose naltrexone (LDN) has been used as an off-label therapy for several chronic diseases. Results from small laboratory and clinical studies indicate some beneficial effects of LDN in autoimmune diseases, but clinical research on LDN in rheumatic disease is limited. Using a pharmacoepidemiological approach, we wanted to test the hypothesis that starting LDN leads to reduced ...
  • A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults 

    Bramness, Jørgen Gustav; von Soest, Tilmann (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)
    <p><i>Background - </i>A small number of studies have shown that the use of cannabis increases the risk of bronchial asthma. There is, however, a paucity of longitudinal studies which are able to control for known risk factors of bronchial asthma. <p><i>Methods - </i>Survey data from a population-based longitudinal study encompassing 2602 young adults followed for 13 years were coupled with individual ...

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