Det helsevitenskapelige fakultet

Recent additions

  • Clinical value of novel blood-based tau biomarkers in Creutzfeldt–Jakob disease 

    Bentivenga, Giuseppe Mario; Gonzalez-Ortiz, Fernando; Baiardi, Simone; Kirsebom, Bjørn-Eivind Seljelid; Mastrangelo, Andrea; Mammana, Angela; Capellari, Sabina; Fladby, Tormod; Zetterberg, Henrik; Blennow, Kaj; Parchi, Piero (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-06)
    BACKGROUND The diagnostic and prognostic performance of the novel fluid biomarkers brain-derived tau (BD-tau) and phospho-tau217 (p-tau217) in Creutzfeldt–Jakob disease (CJD) is not defined.<p> <p>METHODS We measured cerebrospinal fluid (CSF) and plasma BD-tau, p-tau217, p-tau181, total tau (t-tau), neurofilament light (NfL), and 14-3-3 in 100 CJD patients, 100 with non-prion rapidly progressive ...

  • Correlative Super-Resolution Imaging of Cellular Nanopores Facilitated by Transparent Polymer Waveguide Chips 

    Dutta, Surjendu Bikash; Schürstedt-Seher, Jasmin Celine; Engdahl, Anders Kokkvoll; Hübner, Wolfgang; Belle, Stefan; Szafranska, Karolina Joanna; McCourt, Peter Anthony; Hellmann, Ralf; Schüttpelz, Mark; Huser, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-25)
    Super-resolution optical microscopy (SRM) permits the visualization of subcellular structures of biological samples beyond the diffraction limit of light. To evaluate and utilize the specific strengths of each SRM technique a combined approach in the form of correlative super-resolution imaging is essential. Here, the correlative SRM imaging of the ultrastructure of rat liver sinusoidal endothelial ...

  • “But when I come home…”: How patients with chronic musculoskeletal pain account for their absent pain during naturally occurring clinical consultations 

    Andersen, Trine Cæcilie Bræstrup; Lian, Olaug S (Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-20)
    When patients’ embodied experiences cannot be conveyed to clinicians in real-time, the challenges of reaching a shared understanding between patient and clinician are enhanced. In this study, we explore how patients with chronic musculoskeletal pain manage the situation of knowing that they regularly experience pain, yet exhibit minimal signs of it during clinical consultations. Utilizing a multimethod, ...

  • The HUNT lung-SNP model: genetic variants plus clinical variables improve lung cancer risk assessment over clinical models 

    Nguyen, Olav Toai Duc; Røe, Oluf Dimitri; Ioannis, Fotopoulos; Nøst, Therese Haugdahl; Maria, Markaki; Vincenzo, Lagani; Ioannis, Tsamardinos (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-12)
    Purpose The HUNT Lung Cancer Model (HUNT LCM) predicts individualized 6-year lung cancer (LC) risk among individuals who ever smoked cigarettes with high precision based on eight clinical variables. Can the performance be improved by adding genetic information?<p> <p>Methods A polygenic model was developed in the prospective Norwegian HUNT2 study with clinical and genotype data of individuals ...

  • Promising microRNAs in pre-diagnostic serum associated with lung cancer up to eight years before diagnosis: a HUNT study 

    Nguyen, Olav Toai Duc; Røe, Oluf Dimitri; Nøst, Therese Haugdahl; Markaki, Maria; Lagani, Vincenzo; Fotopoulos, Ioannis; Mjelle, Robin; Sandanger, Torkjel Manning; Sætrom, Pål; Tsamardinos, Ioannis (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-20)
    Introduction Blood biomarkers for early detection of lung cancer (LC) are in demand. There are few studies of the full microRNome in serum of asymptomatic subjects that later develop LC. Here we searched for novel microRNA biomarkers in blood from non-cancer, ever-smokers populations up to eight years before diagnosis.<p> <p>Methods Serum samples from 98,737 subjects from two prospective ...

  • Families refusing assistance from the Norwegian child welfare Services- the importance of family characteristics, case processing and identified problems 

    Rustad, Kirsten Buck; Lauritzen, Camilla; Havnen, Karen J Skaale; Fossum, Sturla; Christiansen, Øivin; Vis, Svein Arild Myhra (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-24)
    The Norwegian Child Welfare Services provide support primarily based on family acceptance and cooperation. Previous studies have found that one out of four Norwegian child welfare investigations closed without intervention, are closed due to the family refusing assistance. The aim of this study was to investigate the characteristics of cases where families refuse assistance from the CWS, contributing ...

  • Informasjonskilder og litteratursøk i sjekklistebasert tiltaksarbeid og anvendt atferdsanalyse: Rutiner, vaner og KBP 

    Titlestad, Kristine Berg; Finden, Eireen; Løkke, Jon Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024)
    Kunnskapsbasert praksis (KBP) kan sikre at anvendt atferdsanalyse og miljøterapi er forankret i brukerkunnskap, forskningsbasert kunnskap og erfaringsbasert kunnskap. Det innebærer å reflektere sammen med mottakeren om behov og ønsker, og kritisk undersøke kunnskapsstatus før tiltak planlegges og evalueres. Artikkelen diskuterer hvordan KBP kan integreres i sjekklistebasert tiltaksarbeid for å fremme ...

  • Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects 

    Rienstra, Michiel; Tzeis, Stylianos; Bunting, Karina V.; Caso, Valeria; Crijns, Harry J. G M.; De Potter, Tom J. R.; Sanders, Prashanthan; Svennberg, Emma; Casado-Arroyo, Ruben; Dwight, Jeremy; Guasti, Luigina; Hanke, Thorsten; Jaarsma, Tiny; Lettino, Maddalena; Løchen, Maja-Lisa; Lumbers, R Thomas; Maesen, Bart; Mølgaard, Inge; Rosano, Giuseppe M. C.; Schnabel, Renate B.; Suwalski, Piotr; Tamargo, Juan; Tica, Otilia; Traykov, Vassil; Kotecha, Dipak; Van Gelder, Isabelle C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-24)
    Atrial fibrillation (AF) remains the most common cardiac arrhythmia worldwide and is associated with significant morbidity and mortality. The European Society of Cardiology (ESC)/European Association for Cardio-Thoracic Surgery (EACTS) have recently released the 2024 guidelines for the management of AF. This review highlights 10 novel aspects of the ESC/EACTS 2024 Guidelines. The AF-CARE framework ...

  • Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort 

    Huybrechts, Inge; Jacobs, Inarie; Biessy, Carine; Aglago, Elom K.; Jenab, Mazda; Claeys, Liesel; Zavadil, Jiri; Casagrande, Corinne; Nicolas, Genevieve; Scelo, Ghislaine; Altieri, Andrea; Fervers, Beatrice; Oswald, Isabelle P.; Vignard, Julien; Chimera, Bernadette; de Magistris, Maria Santucci; Masala, Giovanna; Palli, Domenico; Padroni, Lisa; Castilla, Jesús; Jiménez-Zabala, Ana; Frenoy, Pauline; Mancini, Francesca Romana; Ren, Xuan; Sonestedt, Emily; Vineis, Paolo; Heath, Alicia; Werner, Mårten; Molina-Montes, Esther; Dahm, Christina C.; Langmann, Fie; Huerta, José María; Brustad, Magritt; Skeie, Guri; Schulze, Matthias B.; Agudo, Antonio; Sieri, Sabina; Korenjak, Michael; Gunter, Marc J.; De Saeger, Sarah; De Boevre, Marthe (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-16)
    Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective ...

  • Aging in (a meaningful) place – appropriateness and feasibility of Outdoor Reablement in a rural Arctic setting 

    Eliassen, Marianne; Hartviksen, Trude Anita; Holm, Solrun Gjertine; Sørensen, Bodil Anita; Zingmark, Magnus (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-18)
    Background As populations age in the Western world, interventions aiming for‘aging in place’, such as reablement, have gained prominence. Reablement programs have focused on enabling older people to maintain independence in their home environment. However, while a growing body of research points to the considerable benefts of engaging in outdoor environments, reablement rarely addresses outdoor ...

  • Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries 

    Tammy Y N, Tong; Clarke, Robert; Schmidt, Julie A; Huybrechts, Inge; Noor, Urwah; Forouhi, Nita G.; Imamura, Fumiaki; Travis, Ruth C.; Weiderpass, Elisabete; Aleksandrova, Krasimira; Dahm, Christina C.; van der Schouw, Y T; Overvad, Kim; Kyro, Cecilie; Tjønneland, Anne; Kaaks, Rudolf; Katzke, Verena; Schiborn, Catarina; Schulze, M B; Mayen-Chacon, A L; Masala, Giovanna; Sieri, Sabina; de Magistris, M S; Tumino, Rosario; Sacerdote, Carlotta; Boer, J M A; Verschuren, W M M; Brustad, Magritt; Nøst, Therese Haugdahl; Crous-Bou, Marta; Petrova, Dafina; Amiano, Pilar; Huerta, J M; Moreno-Iribas, Conchi; Engström, Gunnar; Melander, Olle; Johansson, Kristina; Lindvall, Kristina; Aglago, Elom K.; Heath, Alicia K; Butterworth, Adam S; Danesh, John; Key, Timothy J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-07)
    Purpose - Previously reported associations of protein-rich foods with stroke subtypes have prompted interest in the assessment of individual amino acids. We examined the associations of dietary amino acids with risks of ischaemic and haemorrhagic stroke in the EPIC study.<p> <p>Methods - We analysed data from 356,142 participants from seven European countries. Dietary intakes of 19 individual ...

  • Deep Learning Model for Predicting Immunotherapy Response in Advanced Non-Small Cell Lung Cancer 

    Rakaee, Mehrdad; Tafavvoghi, Masoud; Ricciuti, Biagio; V Alessi, Joao; Cortellini, Alessio; Nibid, Lorenzo; Perrone, Giuseppe; Adib, Elio; A M Fulgenzi, Claudia; Di Federico, Alessandro; jabar, falah; Hashemi, Sayed; Houda, Ilias; Richardsen, Elin; Busund, Lill-Tove Rasmussen; Dønnem, Tom; Bahce, Idris; J Pinato, David; Helland, Åslaug; M. Sholl, Lynette; M Awad, Mark; J Kwiatkowski, David (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-26)
    Importance - Only a small fraction of patients with advanced non−small cell lung cancer (NSCLC) respond to immune checkpoint inhibitor (ICI) treatment. For optimal personalized NSCLC care, it is imperative to identify patients who are most likely to benefit from immunotherapy.<p> <p>Objective - To develop a supervised deep learning−based ICI response prediction method; evaluate its performance ...

  • Promising microRNAs in pre-diagnostic serum associated with lung cancer up to eight years before diagnosis: a HUNT study 

    Fotopoulos, Ioannis; Nguyen, Olav Toai Duc; Nøst, Therese Haugdahl; Markaki, Maria; Lagani, Vincenzo; Mjelle, Robin; Sandanger, Torkjel Manning; Sætrom, Pål; Tsamardinos, Ioannis; Røe, Oluf Dimitri (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-20)
    Introduction - Blood biomarkers for early detection of lung cancer (LC) are in demand. There are few studies of the full microRNome in serum of asymptomatic subjects that later develop LC. Here we searched for novel microRNA biomarkers in blood from non-cancer, ever-smokers populations up to eight years before diagnosis.<p> <p>Methods - Serum samples from 98,737 subjects from two prospective ...

  • Factor structure of the HIV-SM LMIC self-management questionnaire for people living with HIV in low- and middle-income countries 

    Dadi, Tegene Legese; Medhin, Girmay; Spigt, Marcus (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-21)
    Introduction Despite the need for reliable questionnaires to monitor self-management in chronic disease patients, such tools are lacking in developing countries. This study aims to pilot and assess the construct validity of the HIV-SM LMIC questionnaire.<p> <p>Method The validation of the HIV-SM LMIC questionnaire involved two cross-sectional studies in Ethiopia. The first round, for exploratory ...

  • The HUNT lung-SNP model: genetic variants plus clinical variables improve lung cancer risk assessment over clinical models 

    Nguyen, Olav Toai Duc; Ioannis, Fotopoulos; Nøst, Therese Haugdahl; Maria, Markaki; Vincenzo, Lagani; Ioannis, Tsamardinos; Oluf Dimitri, Røe (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-12)
    Purpose - The HUNT Lung Cancer Model (HUNT LCM) predicts individualized 6-year lung cancer (LC) risk among individuals who ever smoked cigarettes with high precision based on eight clinical variables. Can the performance be improved by adding genetic information?<p> <p>Methods - A polygenic model was developed in the prospective Norwegian HUNT2 study with clinical and genotype data of individuals ...

  • Quality of registration of antenatal, intrapartum, and newborn information in the Georgian birth registry 

    Rylander, Karin Charlotta Maria; Manjavidze, Tinatin; Nedberg, Ingvild Hersoug; Kerselidze, Maia; Anda, Erik Eik (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-24)
    Background The Georgian Birth Registry (GBR) is a comprehensive digital birth registry covering 99.8% of births nationwide. By law, registration in the GBR is mandatory, with data primarily transferred from medical records (MRs) by designated personnel at medical facilities. We aimed to assess the correspondence of the registration of selected variables between GBR and MRs.<p> <p>Methods We ...

  • A Difference Has Been Made... 

    Musial, Frauke (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-12)
    A few months ago, a letter to the editor was submitted by Dr. Axel Wiebrecht, a highly respected expert in Chinese Herbal Therapy, particularly known for his emphasis on safety. Dr. Wiebrecht is also actively involved as a reviewer for Complementary Medicine Research (CMR). According to CMR's guidelines for authors “Letters may explore subjects related to matters discussed in the journal, providing ...

  • Disparities in casemix, acute interventions, discharge destinations and mortality of patients with traumatic brain injury between Europe and India 

    Gupta, Deepak; Singh, Ranjit D.; Vreeburg, Rick Jg; van Dijck, Jeroen T.J.M.; Boogert, Hugo den; Sharma, Kaveri; Praneeth, Kokkula; Clarke, David B.; Lecky, Fiona E.; Maas, Andrew IR; Sinha, Virendra Deo; Ruiter, Godard Cw de; Peul, Wilco C.; Van Essen, Thomas A.; Åkerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Antoni, Anna; Audibert, Gérard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzó, Pál; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo; Carbonara, Marco; Cavallo, Simona; Chevallard, Giorgio; Chieregato, Arturo; Citerio, Giuseppe; Clusmann, Hans; Coburn, Mark; Coles, Jonathan; Cooper, Jamie D.; Correia, Marta; Čović, Amra; Curry, Nicola; Czeiter, Endre; Czosnyka, Marek; Fizelier, Claire Dahyot; Dark, Paul; Dawes, Helen; De Keyser, Véronique; Degos, Vincent; Corte, Francesco Della; Depreitere, Bart; Đilvesi, Đula; K Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-11)
    Background - Traumatic brain injury (TBI) is a major global health problem that disproportionally affects low- and middle-income countries. The needs for patients with TBI therefore may differ between levels of national development. We aimed to describe differences in epidemiology and acute care provision of TBI between India and Europe.<p> <p>Methods - We used data from two prospective observational ...

  • Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury 

    Samanta, Romit J; Chiollaz, Anne-Cécile; Needham, Edward; Yue, John K; Helmy, Adel; Zanier, Elisa R.; Wang, Kevin K W; Kobeissy, Firas; Posti, Jussi P.; Summers, Charlotte; Manley, Geoffrey T; Maas, Andrew IR; Tenovuo, Olli; Sanchez, Jean-Charles; Menon, David K; Badjatia, Neeraj; Diaz-Arrastia, Ramon; Duhaime, Ann-Christine; Feeser, V Ramana; Gopinath, Shankar; Grandhi, Ramesh; Ha, Ruchira J; Keene, Dirk; Madden, Christopher; McCrea, Michael; Merchant, Randall; Ngwenya, Laura B; Rodgers, Richard B; Schnyer, David; Taylor, Sabrina R.; Zafonte, Ross; Ackerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Audibert, Gérard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Beer, Ronny; Bellander, Bo-Michael; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Beqiri, Erta; Blaabjerg, Morten; Lund, Stine Borgen; Brorsson, Camilla; Buki, Andras; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Helseth, Eirik; K Frisvold, Shirin; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Sandrød, Oddrun; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-17)
    Background - The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation in patients with TBI have not improved patient outcomes.<p> <p>Methods - Serum and plasma samples from two prospective, multi-centre observational studies of patients with TBI were used to discover ...

  • Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injury 

    Wilson, Lindsay; Newcombe, Virginia FJ; Whitehouse, Daniel P; Mondello, Stefania; Maas, Andrew I. R.; Menon, David K.; Ackerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Antoni, Anna; Audibert, Gérard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzó, Pál; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Büki, András; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Carbayo Lozano, Guillermo; Carbonara, Marco; Castaño-León, Ana M.; Cavallo, Simona; Chevallard, Giorgio; Chieregato, Arturo; Citerio, Guiseppe; Clusmann, Hans; Coburn, Mark Steven; K Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-26)
    Background - Traumatic brain injury is conventionally categorised as mild, moderate, or severe on the Glasgow Coma Scale (GCS). Recently developed biomarkers can provide more objective and nuanced measures of the extent of brain injury.<p> <p>Methods - Exposure–response relationships were investigated in 2479 patients aged ≥16 enrolled in the Collaborative European NeuroTrauma Effectiveness ...

View more