Recent additions

  • Olaparib monotherapy as primary treatment in unselected triple negative breast cancer 

    Eikesdal, Hans Petter; Yndestad, Synnøve; Elzawahry, Asmaa; Llop-Guevara, Alba; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Vagstad, Geirfinn; Venizelos, Andreas; Minsaas, Laura; Leirvaag, Beryl; Gudlaugsson, Einar; Vintermyr, Olav Karsten; Aase, Hildegunn Siv; Aas, Turid; Balmaña, Judith; Serra, Violeta; Janssen, Emiel; Knappskog, Stian; Lønning, Per Eystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-23)
    <p><i>Background - </i>The antitumor efficacy of PARP inhibitors (PARPi) for breast cancer patients harboring germline BRCA1/2 (gBRCA1/2) mutations is well established. While PARPi monotherapy was ineffective in patients with metastatic triple negative breast cancer (TNBC) wild type for BRCA1/2, we hypothesized that PARPi may be effective in primary TNBCs without previous chemotherapy exposure. < ...
  • Surgery for herniated lumbar disc in private vs public hospitals: A pragmatic comparative effectiveness study 

    Madsbu, Mattis Aleksander; Salvesen, Øyvind; Carlsen, Sven Magnus; Westin, Steinar; Onarheim, Kristian; Nygaard, Øystein Petter; Solberg, Tore; Gulati, Sasha (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-04)
    <p><i>Background - </i>There is limited evidence on the comparative performance of private and public healthcare. Our aim was to compare outcomes following surgery for lumbar disc herniation (LDH) in private versus public hospitals. <p><i>Methods - </i>Data were obtained from the Norwegian registry for spine surgery. Primary outcome was change in Oswestry disability index (ODI) 1 year after surgery. ...
  • Surgery for Extraforaminal Lumbar Disc Herniation: A Single Center Comparative Observational Study 

    Polak, Samuel B.; Madsbu, Mattis Aleksander; Vangen-Lønne, Vetle; Salvesen, Øyvind; Nygaard, Øystein Petter; Solberg, Tore; Vleggeert-Lankamp, Carmen L. A. M.; Gulati, Sasha (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-13)
    <p><i>Background - </i>Surgery on extraforaminal lumbar disc herniation (ELDH) is a commonly performed procedure. Operating on this type of herniation is known to come with more difficulties than on the frequently seen paramedian lumbar disc herniation (PLDH). However, no comparative data are available on the effectiveness and safety of this operation. We sought out to compare clinical outcomes at ...
  • Disparities amidst plenty: a health portrait of Indigenous peoples in circumpolar regions 

    Young, T. Kue; Broderstad, Ann Ragnhild; Sumarokov, Yury; Bjerregaard, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-30)
    This paper describes the extent and variation in health disparities between Indigenous and non-Indigenous people within Alaska, Greenland and the northern regions of Canada, Russia and the Nordic countries. We accessed official health statistics and reviewed research studies. We selected a few indicators of health status, health determinants and health care to demonstrate the health disparities that ...
  • Selection or drift: The population biology underlying transposon insertion sequencing experiments 

    Mahmutovic, Anel; Abel zur Wiesch, Pia; Abel, Sören (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-25)
    <p>Transposon insertion sequencing methods such as Tn-seq revolutionized microbiology by allowing the identification of genomic loci that are critical for viability in a specific environment on a genome-wide scale. While powerful, transposon insertion sequencing suffers from limited reproducibility when different analysis methods are compared. From the perspective of population biology, this may be ...
  • All non-adherence is equal, but is some more equal than others? TB in the digital era 

    Stagg, Helen; Flook, Mary; Martinecz, Antal; Kielmann, Karina; Abel zur Wiesch, Pia; Karat, Aaron; Lipman, Marc; Sloan, Derek; Walker, Elizabeth; Fielding, Katherine L (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-02)
    Adherence to treatment for tuberculosis (TB) has been a concern for many decades, resulting in the World Health Organization's recommendation of the direct observation of treatment in the 1990s. Recent advances in digital adherence technologies (DATs) have renewed discussion on how to best address nonadherence, as well as offering important information on dose-by-dose adherence patterns and their ...
  • Can accelerated transcranial direct current stimulation improve memory functions? An experimental, placebo-controlled study 

    Bystad, Martin; Storø, Benedicte Haug; Gundersen, Nina; Larsen Wiik, Ida Karine; Nordvang, Lene; Grønli, Ole; Rasmussen, Ingrid Daae; Aslaksen, Per M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-01)
    The aim of this study was to investigate whether transcranial Direct Current Stimulation (tDCS) could improve verbal memory functions in healthy old and younger participants. We hypothesized that active tDCS led to significantly improved memory function, compared to placebo tDCS. Forty healthy participants (20 old and 20 younger participants) were included in the study. We applied a novel stimulation ...
  • Group mentorship for undergraduate medical students—a systematic review 

    Skjevik, Elise; Boudreau, J. Donald; Ringberg, Unni; Schei, Edvin; Stenfors, Terese; Kvernenes, Monika; Ofstad, Eirik Hugaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-20)
    <p><i>Introduction - </i>Mentoring has become a prevalent educational strategy in medical education, with various aims. Published reviews of mentoring report very little on group-based mentorship programs. The aim of this systematic review was to identify group-based mentorship programs for undergraduate medical students and describe their aims, structures, contents and program evaluations. Based ...
  • Alternative vanHAX promoters and increased vanA-plasmid copy number resurrect silenced glycopeptide resistance in Enterococcus faecium 

    Wagner, Theresa; Janice, Jessin; Sivertsen, Audun; Sjögren, Ingegerd; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-26)
    <i>Background</i> - Vancomycin variable enterococci (VVE) are <i>van</i>-positive isolates with a susceptible phenotype that can convert to a resistant phenotype during vancomycin selection.<p> <p><i>Objectives</i> - To describe a vancomycin-susceptible <i>vanA</i>-PCR positive ST203 VVE <i>Enterococcus faecium</i> isolate (VVE<i>Swe</i>-S) from a liver transplantation patient in Sweden which ...
  • Factors Associated with Cesarean Section among Primiparous Women in Georgia: A Registry-based Study 

    Nedberg, Ingvild Hersoug; Rylander, Charlotta; Skjeldestad, Finn Egil; Blix, Ellen; Ugulava, Tamar; Anda, Erik Eik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-21)
    Cesarean section rates remain high in Georgia. As a cesarean section in the first pregnancy generally lead to a cesarean section in subsequent pregnancies, primiparous women should be targeted for prevention strategies. The aim of the study was to assess factors associated with cesarean section among primiparous women. The study comprised 17,065 primiparous women with singleton, cephalic deliveries ...
  • Factors associated with exclusive breastfeeding at hospital discharge: a study using data from the Georgian Birth Registry 

    Sigstad, Marie; Nedberg, Ingvild Hersoug; Anda, Erik Eik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-13)
    <p><i>Background - </i>The World Health Organization recommends exclusive breastfeeding for six months, defined as no other solids or liquids besides breast milk and essential vitamins or medicines. Data about exclusive breastfeeding are limited in Georgia, and the information that exist are provided by national surveys, that present inconsistent numbers. Georgia has recently established a national ...
  • Red Cell Distribution Width and Risk of Atrial Fibrillation and Subsequent Thromboembolism: The Tromsø Study 

    Hald, Erin Mathiesen; Løchen, Maja-Lisa; Lappegård, Jostein; Ellingsen, Trygve; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-28)
    <i>Introduction</i>- Red cell distribution width (RDW) is associated with cardiovascular diseases, including atrial fibrillation (AF) and venous thromboembolism (VTE). Whether RDW is a risk marker for thromboembolic events in AF patients is scarcely known. We aimed to assess the association between RDW and the risk of AF, and AF-related VTE and ischemic stroke, in a population-based cohort.<p> ...
  • Quantifying the contribution of established risk factors to cardiovascular mortality differences between Russia and Norway 

    Trias-Llimós, Sergi; Pennells, Lisa; Tverdal, Aage; Kudryavtsev, Alexander V; Malyutina, Sofia; Hopstock, Laila Arnesdatter; Iakunchykova, Olena; Nikitin, Yuri; Magnus, Per; Kaptoge, Stephen; Di Angelantonio, Emanuele; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-27)
    Surprisingly few attempts have been made to quantify the simultaneous contribution of well-established risk factors to CVD mortality differences between countries. We aimed to develop and critically appraise an approach to doing so, applying it to the substantial CVD mortality gap between Russia and Norway using survey data in three cities and mortality risks from the Emerging Risk Factor Collaboration. ...
  • High spatially sensitive quantitative phase imaging assisted with deep neural network for classification of human spermatozoa under stressed condition 

    Butola, Ankit; Popova, Daria; Prasad, Dilip K.; Ahmad, Azeem; Habib, Anowarul; Tinguely, Jean-Claude; Basnet, Purusotam; Acharya, Ganesh; Paramasivam, Senthilkumaran; Mehta, Dalip Singh; Ahluwalia, Balpreet Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-04)
    Sperm cell motility and morphology observed under the bright field microscopy are the only criteria for selecting a particular sperm cell during Intracytoplasmic Sperm Injection (ICSI) procedure of Assisted Reproductive Technology (ART). Several factors such as oxidative stress, cryopreservation, heat, smoking and alcohol consumption, are negatively associated with the quality of sperm cell and ...
  • Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription 

    Shrestha, Anup; Bruckmüller, Henrike; Kildalsen, Hanne; Kaur, Gurjit; Gaestel, Matthias; Ljones Wetting, Hilde; Mikkola, Ingvild; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
    Steroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several common cancers including breast, colorectal and lung tumors. Phosphorylation is an important regulatory event controlling the activities of SRC-3. Serine 857 ...
  • Mangfoldsperspektiver i forskning på vold i nære relasjoner 

    Bredal, Anja; Eggebø, Helga; Eriksen, Astrid (Chapter; Bokkapittel, 2020-06-10)
    Most research on domestic violence has focused on violence against women in a gender perspective. However, there has been an increasing understanding of the importance of other social dimensions in order to understand the nature and impact of the violence. The aim of this chapter is to explore the current status of research on domestic violence in a diversity perspective. We argue that dimensions like ...
  • Post-stroke health-related quality of life at 3 and 12 months and predictors of change in a Danish and Arctic Norwegian Region 

    Heiberg, Guri Anita; Friborg, Oddgeir; Pedersen, Synne Garder; Thrane, Gyrd; Stabell, Henriette Holm; Nielsen, Jørgen Feldbæk; Anke, Audny (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-30)
    Objectives: To investigate changes in health-related quality of life between 3- and 12-months post-stroke in a north Norwegian and a Danish region that organize their rehabilitation services differently, and to identify clinically relevant predictors of change. Design: Prospective multicentre cohort study. Subjects: In total, 304 patients with first-ever stroke (male sex 59%, mean age 68.7 years) ...
  • Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models 

    Castaneda Zegarra, Sergio Miguel; Fernandez Berrocal, Marion Silvana; Tkachev, Max; Yao, Rouan; Esnardo Upfold, Nikki Lyn; Oksenych, Valentyn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-12)
    Non‐homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double‐strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J recombination to increase the repertoire of B and T cell receptors. DSBs are also generated during the class switch recombination (CSR) process in mature B lymphocytes, providing ...
  • Time trends in the effects of mindfulness-based cognitive therapy for depression: A meta-analysis 

    Thimm, Jens; Johnsen, Tom Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-21)
    Recent studies suggest that the effects of cognitive therapies for depression show systematic changes over time. A meta‐analysis was conducted to explore the temporal development of the effect of mindfulness‐based cognitive therapy (MBCT) for current depression in studies that used the Beck Depression Inventory (BDI) or the Hamilton Depression Rating Scale (HDRS) as outcome measures. A systematic ...
  • Cyberbullying status and mental health in Norwegian adolescents 

    Kaiser, Sabine; Kyrrestad, Henriette; Fossum, Sturla (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-26)
    The aim of the present study was to examine how the cyberbullying status (not involved, cyber‐victim only, cyberbully only, cyber‐victim and bully) is related to the mental health of the adolescents when controlled for traditional bullying experience. We also examined the potential moderator sex on the relationship between cyberbullying status and mental health. Univariate analyses of variance were ...

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