Recent additions

  • Experience-based learning: Junior medical students’ reflections on end-of-life care 

    Wilson, Hamish; Warmington, Sally; Johansen, May-Lill (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-20)
    <i>Context</i> - Experience‐based learning may contribute to confidence, competence and professional identity; early experiences may be particularly formative. This study explored how pre‐clinical students make sense of their participation in the provision of end‐of‐life care within community settings.<p> <p><i>Methods</i> - We performed dialogic narrative analysis on essays written by junior ...
  • Biochemical characterization of Matrix Metalloproteinase-9 Binding interactions with two small non-peptide inhibitors and the proteoglycan serglycin & Processing of serglycin 

    Dawadi, Rangita (Doctoral thesis; Doktorgradsavhandling, 2020-04-17)
    The present work has a focus on biochemical characterization of the human matrix metalloproteinase-9. First part of the investigation focuses on the enzymes ability to form a complex with the small proteoglycan serglycin. Here the focus was on which amino acids and regions in both proMMP-9 and serglycin are important for the complex formation. For that, recombinant full-length proMMP-9 and various ...
  • Fruktene av "Lindring i nord" – nært samarbeid i en langstrakt landsdel 

    Ervik, Bente; Nordøy, Tone; Andersen, Sigve (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
    <i>Mer enn 20 år tilbake, hadde vi en ung mann med alvorlig kreftsykdom og spredning til høyre lår. Han hadde forsøkt mange behandlinger med kun kortvarig effekt. Sykdommen ga han en rekke plager som smerter, gang- vansker og store ulcerasjoner som var en ekstra utfordring pleiemessig. <p> Pasienten var gift, han var småbarnsfar og egentlig fra et annet sted i landet, men bodde nå på finnmarkskysten, ...
  • The effect of faecal microbiota transplantation in irritabel bowel syndrom. A double blind, randomized placebo controlled single centre study 

    Johnsen, Peter Holger (Doctoral thesis; Doktorgradsavhandling, 2020-04-17)
    Irritable bowel syndrome (IBS) is common disorder of the lower gastro intestinal tract associated with a poor quality of life. Revealing the interplay between the microbiota and the host has lead to a better understanding of IBS. A disturbance in the bidirectional communication in the microbiota-gut-brain axis is suggested to be involved in the pathophysiology of IBS. The microbiota in this context ...
  • Applying speech technologies to assess verbal memory in patients with serious mental illness 

    Holmlund, Terje Bektesevic; Chandler, Chelsea; Foltz, Peter W.; Cohen, Alex S.; Cheng, Jian; Bernstein, Jared C.; Rosenfeld, Elizabeth P.; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-11)
    Verbal memory deficits are some of the most profound neurocognitive deficits associated with schizophrenia and serious mental illness in general. As yet, their measurement in clinical settings is limited to traditional tests that allow for limited administrations and require substantial resources to deploy and score. Therefore, we developed a digital ambulatory verbal memory test with automated ...
  • Visibility of nursing in policy documents related to health care priorities 

    Tønnessen, Siri; Christiansen, Karin; Hjaltadottir, Ingibjörg; Leino-Kilpi, Helena; Scott, Philomena Anne; Suhonen, Riita; Öhlén, Joakim; Halvorsen, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-09)
    <i>Aim</i> - To explore the visibility of nursing in policy documents concerning health care priorities in the Nordic countries.<p><p> <i>Background</i> - Nurses at all levels in health care organisations set priorities on a daily basis. Such prioritization entails allocation of scarce public resources with implications for patients, nurses and society. Although prioritization in health care ...
  • When Bodies Speak and Words Act - poetry, psychosomatic illness and the lost art of medicine 

    Goldbeck-Wood, Sandy (Doctoral thesis; Doktorgradsavhandling, 2020-04-16)
    This is a discussion of what poetry has to do with medicine. It is about the psychological necessity and communicative purpose of art, with poetry as an example. It is about what poetry demands of the poet - humility, undogmatic diligence, resilience in the face of complexity, and the ability to think and feel at the same time. It is about a vital service poetry performs for poet and public which ...
  • Rising rural body-mass index is the main driver of the global obesity epidemic in adults 

    Bixby, Honor; Bentham, James; Zhou, Bin; Di Cesare, Mariachiara; Paciorek, Christopher J.; Bennett, James E.; Taddei, Cristina; Stevens, Gretchen A.; Rodriguez-Martinez, Andrea; Carrillo-Larco, Rodrigo M.; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ekelund, Ulf; Kolle, Elin; Steene-Johannessen, Jostein; Tarp, Jakob; Ariansen, Inger; Biehl, Anna Månsson; Graff-Iversen, Sidsel; Meisfjord, Jørgen Rajan; Bjertness, Espen; Bjertness, Marius Bergsmark; Meyer, Haakon E; Haugsgjerd, Teresa Risan; Tell, Grethe S.; Janszky, Imre; Krokstad, Steinar; Laugsand, Lars Erik; Sen, Abhijit; Vatten, Lars Johan; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Khang, Young-Ho; Soric, Maroje; Gregg, Edward W.; Miranda, J. Jaime; Bhutta, Zulfiqar A.; Savin, Stefan; Sophiea, Marisa K.; Iurilli, Maria L. C.; Solomon, Bethlehem D.; Cowan, Melanie J.; Riley, Leanne M.; Danaei, Goodarz; Bovet, Pascal; Chirita-Emandi, Adela; Hambleton, Ian R; Hayes, Alison J; Ikeda, Nayu; Kengne, Andre P; Laxmaiah, Avula (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-08)
    Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, ...
  • Incidence of gynecological fistula and its surgical treatment: A national registry-based study 

    Børseth, Katrine Trovik Flaatten; Acharya, Ganesh; Kiserud, Torvid; Trovik, Jone (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-19)
    <i>Introduction</i> - Gynecological fistula (affecting female genital organs) leads to involuntary loss of urine or feces. In industrialized societies, fistulas occur mostly as complications of surgery, radiation therapy or inflammatory bowel disease. We sought to determine the incidence of gynecological fistula and type of surgical treatment provided in Norway.<p><p> <i>Material and methods</i> ...
  • Rising Sun: Prioritized outcomes for suicide prevention in the Arctic 

    Collins, Pamela Y.; Delgado, Roberto A.; Apok, Charlene; Baez, Laura; Bjerregaard, Peter; Chatwood, Susan; Chipp, Cody; Crawford, Allison; Crosby, Alex; Dillard, Denise; Driscoll, David; Ericksen, Heidi; Hicks, Jack; Larsen, Christina Viskum Lytken; McKeon, Richard; Partapuoli, Per Jonas; Phillips, Anthony; Pringle, Beverly; Rasmus, Stacy; Sigurðardóttir, Sigrún; Silviken, Anne; Stoor, Jon Petter Anders; Sumarokov, Yury; Wexler, Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-24)
    The Arctic Council, a collaborative forum among governments and Arctic communities, has highlighted the problem of suicide and potential solutions. The mental health initiative during the United States chairmanship, Reducing the Incidence of Suicide in Indigenous Groups: Strengths United Through Networks (RISING SUN), used a Delphi methodology complemented by face-to-face stakeholder discussions to ...
  • Tumor lysis with LTX-401 creates anticancer immunity 

    Xie, Wei; Mondragon, Laura; Mauseth, Brynjar; Wang, Yan; Pol, Jonathan; Levesque, Sarah; Zhou, Heng; Yamazaki, Takahiro; Eksteen, Jacobus Johannes; Zitvogel, Laurence; Sveinbjørnsson, Baldur; Rekdal, Øystein; Kepp, Oliver; Kroemer, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-13)
    Local immunotherapies such as the intratumoral injection of oncolytic compounds aim at reinstating and enhancing systemic anticancer immune responses. LTX-315 is a first-in-class, clinically evaluated oncolytic peptide-based local immunotherapy that meets these criteria. Here, we show that LTX-401, yet another oncolytic compound designed for local immunotherapy, depicts a similar safety profile and ...
  • Continuing increased risk of second cancer in long-term testicular cancer survivors after treatment in the cisplatin era 

    Hellesnes, Ragnhild; Kvammen, Øivind; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-09)
    Using complete information on total treatment burden, this population‐based study aimed to investigate second cancer (SC) risk in testicular cancer survivors (TCS) treated in the cisplatin era. The Cancer Registry of Norway identified 5,625 1‐year TCS diagnosed 1980–2009. Standardized incidence ratios (SIRs) were calculated to evaluate the total and site‐specific incidence of SC compared to the ...
  • Isoflurane increases tolerance to renal ischemia reperfusion injury compared to propofol: An experimental study in pigs 

    Roaldsen, Marius Håke; Ciosek, Timothy Allan; Richardsen, Elin; Al-Saad, Samer; Patel, Hitendra R.H.; Aarsæther, Erling Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-09)
    <i>Purpose</i>: To compare two clinically relevant anesthetic agents, i.e., isoflurane versus propofol with respect to protection of the kidney in a porcine renal ischemia reperfusion model. <p> <p><i>Materials and Methods</i>: 14 hybrid pigs were randomized to anesthesia with either isoflurane or propofol prior to laparoscopic surgery. Following anesthesia, the left kidney hilum was clamped for ...
  • NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1 

    Shrestha, Birendra Kumar; Rasmussen, Mads Skytte; Abudu, Yakubu Princely; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Alemu, Endalkachew Ashenafi; Sjøttem, Eva; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-19)
    Human ATG8 family proteins (ATG8s) are active in all steps of the macroautophagy pathway, and their lipidation is essential for autophagosome formation. Lipidated ATG8s anchored to the outer surface of the phagophore serve as scaffolds for binding of other core autophagy proteins and various effector proteins involved in trafficking or fusion events, whereas those at the inner surface are needed for ...
  • Detection of tissue factor in platelets: why is it so troublesome? 

    Østerud, Bjarne; Bouchard, Beth A (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-30)
    Tissue factor (TF) is the most important trigger for the extrinsic coagulation pathway. TF, earlier denoted as thromboplastin, has always been a mystery since its discovery due to its abundant presence in most human tissues but not blood. The latter has been extensively studied in a vast quest for possible sources of blood-borne TF yielding many conflicting findings and confusing conclusions regarding ...
  • High levels of C-reactive protein are associated with an increased risk of ovarian cancer: Results from the Ovarian Cancer Cohort Consortium 

    Peres, Lauren C.; Mallen, Adrianne R.; Townsend, Mary K.; Poole, Elizabeth M.; Trabert, Britton; Allen, Naomi E.; Arslan, Alan A.; Dossus, Laure; Fortner, Renee T.; Gram, Inger T.; Hartge, Patricia; Idahl, Annika; Kaaks, Rudolf; Kvaskoff, Marina; Magliocco, Anthony M.; Merritt, Melissa A.; Quirós, Ramón; Tjonneland, Anne; Trichopoulou, Antonia; Tumino, Rosario; van Gils, Carla H.; Visvanathan, Kala; Wentzensen, Nicolas; Zeleniuch-Jacquotte, Anne; Tworoger, Shelley S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-28)
    Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient characteristics has not been adequately explored. In this study, we pooled data from ...
  • Sex-specific reference ranges of cerebroplacental and umbilicocerebral ratios: A longitudinal study 

    Acharya, Ganesh; Ebbing, Cathrine; Karlsen, Henriette Odland; Kiserud, Torvid; Rasmussen, Svein (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-10)
    <p><i>Objectives - </i>The ratio of middle cerebral artery (MCA) pulsatility index (PI) to umbilical artery (UA) PI, i.e. cerebro‐placental ratio (CPR), has been suggested as a measure of fetal “brain sparing” phenomenon reflecting redistribution of fetal cardiac output as a response to placental insufficiency. Observational studies have shown that low CPR values predict increased risk of adverse ...
  • LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects 

    Liao, Hsin-Wei; Garris, Christopher; Pfirschke, Christina; Rickelt, Steffen; Arlauckas, Sean; Siwicki, Marie; Kohler, Rainer; Weissleder, Ralph; Sundvold-Gjerstad, Vibeke; Sveinbjørnsson, Baldur; Rekdal, Øystein; Pittet, Mikael J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-14)
    LTX-315 is an oncolytic peptide that has antitumor efficacy in mice grafted with various tumor cell lines and is currently being tested in phase II clinical trials. Here we aimed to further evaluate LTX-315 in conditional genetic mouse models of cancer that typically resist current treatment options and to better understand the drug’s mode of action in vivo. We report LTX-315 mediates profound ...
  • Smoking and breast cancer risk by race/ethnicity and oestrogen and progesterone receptor status: the Multiethnic Cohort (MEC) study 

    Gram, Inger Torhild; Park, Song-Yi; Maskarinec, Gertraud; Wilkens, Lynne R; Haiman, Christopher A.; Le Marchand, Loïc (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-18)
    <i>Background</i> - The purpose of this study was to examine if the smoking-related higher breast cancer risk was similar for the five race/ethnicity groups in the Multiethnic Cohort (MEC) study and by oestrogen (ER) and progesterone (PR) receptor status.<p> <p><i>Methods</i> - From 1993 to 2013, we followed 67 313 women who were enrolled in the MEC study at 45–75 years of age. We identified ...
  • Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study 

    Sejrup, Joakim Knutsen; Børvik, Trond; Grimnes, Gro; Isaksen, Trond; Hindberg, Kristian; Hansen, John-Bjarne; Morelli, Vania Maris; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-16)
    Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients (<i>n</i> = 707) recruited from the ...

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