Recent additions

  • Biomarkers of major bleeding after incident venous thromboembolism 

    Johnsen, Håkon Sandbukt (Doctoral thesis; Doktorgradsavhandling, 2021-03-23)
    Major bleeding (MB) events are feared and potentially fatal complications of anticoagulant treatment in patients with venous thromboembolism (VTE). Even though several clinical risk factors are associated with MB risk, the predictive power of currently available risk assessment models remain limited for VTE. The aim of this thesis was to identify biomarkers of MB risk during the first year after an ...
  • The relation of gender role attitudes with depression and generalised anxiety disorder in two Russian cities 

    Jaehn, Phillip; Bobrova, Natalia; Saburova, Lyudmila; Kudryavtsev, Alexander V; Malyutina, Sofia; Cook, Sarah Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-08)
    <i>Background</i> - Reported traditional gender role attitudes (GRAs) have been related to worse mental health in western countries. This study examined the link of GRAs with symptoms of depression and generalised anxiety disorder (GAD) in two Russian cities.<br><br> <i>Methods</i> - We used interview data from the cross-sectional Know Your Heart Study conducted among 5099 adults aged 35-69 in ...
  • Å lede eksperter inn i nye arbeidsmåter. Lederatferd ved implementering av primærhelseteam på fastlegekontor 

    Gaski, Margrete; Abelsen, Birgit (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-15)
    Ledelse ved norske fastlegekontor er lite utforsket; fastleger deler ofte på ledelsesfunksjoner, og hver fastlege er i stor grad sin egen leder. Helsemyndighetene i Norge og andre land ønsker tverrfaglige team rundt utvalgte pasientgrupper, men mange fastleger er skeptiske. Artikkelen utforsker lederatferd når fastlegekontor skal utvikles fra en samling solopraksiser under samme tak til å bli ...
  • Liposomal delivery of antibiotic loaded nucleic acid nanogels with enhanced drug loading and synergistic anti-inflammatory activity against S. aureus intracellular infections 

    Obuobi, Sybil Akua Okyerewa; Julin, Kjersti; Fredheim, Elizabeth G. Aarag; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-07)
    The persistence of <i>Staphylococcus aureus</i> has been accredited to its ability to escape immune response via host cell invasion. Despite the efficacy of many antibiotics against <i>S. aureus</i>, the high extracellular concentrations of conventional antibiotics required for bactericidal activity is limited by their low cellular accumulation and poor intracellular retention. While nanocarriers ...
  • Sars-CoV-2 hos barn og ungdom i Norge: Påvist smitte, sykehusinnleggelser og underliggende tilstander 

    Størdal, Ketil; Bakken, Inger Johanne Landsjøåsen; Greve-Isdahl, Margrethe; Klingenberg, Claus; Helland, Eyvind; Nystad, Wenche; Hjellvik, Vidar; Gulseth, Hanne Løvdal (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-24)
    BAKGRUNN - Barn og unge har lavere risiko for sykdom forårsaket av sars-CoV-2. Vi beskriver forekomsten av påvist smitte og innleggelser hos barn og unge under 20 år i Norge, og spesifikt blant dem med underliggende tilstander.<p> <p>MATERIALE OG METODE - Helsedirektoratet har i samarbeid med Folkehelseinstituttet etablert et datauttrekk for å overvåke koronavirusutbruddet. Data fra ...
  • FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs 

    Dragomir, Mihnea Paul; Manyam, Ganiraju C; Ott, Leonie Florence; Berland, Léa; Knutsen, Erik; Ivan, Cristina; Lipovich, Leonard; Broom, Bradley M.; Calin, George A (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-23)
    Non-coding RNAs (ncRNAs) are essential players in many cellular processes, from normal development to oncogenic transformation. Initially, ncRNAs were defined as transcripts that lacked an open reading frame (ORF). However, multiple lines of evidence suggest that certain ncRNAs encode small peptides of less than 100 amino acids. The sequences encoding these peptides are known as small open reading ...
  • I don’t want to think about it: A qualitative study of children’s and parents’ experiences with regular needle injections at home 

    Sørensen, Kari; Skirbekk, Helge; Kvarstein, Gunnvald; Wøien, Hilde (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-22)
    <i>Background</i> - Overall outcomes of pediatric rheumatic diseases (RD) have improved due to treatment with biologic agents and methotrexate. For many children, this treatment often entails regular needle injections. Pain and fear of needle injections are common in childhood, but how children and parents handle long-term needle injections at home has not been fully explored. This study aimed to ...
  • A biomarker approach to explain high cardiovascular disease burden in Russia: insights from population-based studies in Russia and Norway 

    Iakunchykova, Olena (Doctoral thesis; Doktorgradsavhandling, 2021-03-25)
    Although the problem of cardiovascular disease (CVD) in Russia has been the subject of attention for decades, a definitive and comprehensive explanation of why the CVD burden there is so high and generally greater than in many other countries has still not been found. In this thesis, I have attempted to advance research on these issues by examining the role of blood lipids, heart damage biomarkers ...
  • Common social determinants for overweight and obesity, and dental caries among adolescents in Northern Norway: a cross-sectional study from the Tromsø Study Fit Futures cohort 

    Stangvaltaite-Mouhat, Lina; Furberg, Anne-Sofie; Drachev, Sergei Nikolaevich; Trovik, Tordis A (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-05)
    <i>Background</i> - Non-communicable general and oral health conditions share common risk factors. Studies investigating common social determinants as risk factors for overweight/obesity and dental caries among the same adolescents are scarce and inconclusive.<p><p> <i>Methods</i> - This cross-sectional study included data from 464 girls and 494 boys from the population-based Tromsø study Fit ...
  • A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment 

    Dragomir, Mihnea Paul; Moisoiu, Vlad; Manaila, Roxana; Pardini, Barbara; Knutsen, Erik; Anfossi, Simone; Amit, Moran; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-31)
    One of the limitations of cancer research has been the restricted focus on tumor cells and the omission of other non-malignant cells that are constitutive elements of this systemic disease. Current research is focused on the bidirectional communication between tumor cells and other components of the tumor microenvironment (TME), such as immune and endothelial cells, and nerves. A major success of ...
  • Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies 

    Tellez Gabriel, Marta; Knutsen, Erik; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
    Breast cancer is the most common cancer among women worldwide. Although the five-, ten- and fifteen-year survival rates are good for breast cancer patients diagnosed with early-stage disease, some cancers recur many years after completion of primary therapy. Tumor heterogeneity and clonal evolution may lead to distant metastasis and therapy resistance, which are the main causes of breast cancer-associated ...
  • The value of dynamic infrared thermography in pedicled thoracodorsal artery perforator flap surgery 

    Sjöberg, Thomas K.; Mercer, James; Weum, Sven; de Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
    <p><i>Background:</i> Dynamic infrared thermography (DIRT) is a noninvasive imaging technique that can provide indirect and real-time information on skin perfusion by measuring skin temperature. Although used in flap surgery, there are no reports on its value in procedures using a pedicled thoracodorsal artery perforator (TDAP) flap. The aim of this study was to assess the usefulness of DIRT in ...
  • Factors Engaging Users of Diabetes Social Media Channels on Facebook, Twitter, and Instagram: Observational Study 

    Gabarron, Elia; Larbi, Dillys; Dorronzoro, Enrique; Hasvold, Per Erlend; Wynn, Rolf; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-29)
    <p><i>Background:</i> Diabetes patient associations and diabetes-specific patient groups around the world are present on social media. Although active participation and engagement in these diabetes social media groups has been mostly linked to positive effects, very little is known about the content that is shared on these channels or the post features that engage their users the most. <p><i>Objective:</i> ...
  • Stroke-Specific Quality of Life one-year post-stroke in two Scandinavian country-regions with different organisation of rehabilitation services: a prospective study 

    Pedersen, Synne Garder; Friborg, Oddgeir; Heiberg, Guri Anita; Arntzen, Cathrine; Holm Stabel, Henriette; Thrane, Gyrd; Nielsen, Jørgen Feldbæk; Anke, Audny (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-01)
    <p><i>Purpose:</i> To compare stroke-specific health related quality of life in two country-regions with organisational differences in subacute rehabilitation services, and to reveal whether organisational factors or individual factors impact outcome. <p><i>Materials and methods:</i> A prospective multicentre study with one-year follow-up of 369 first-ever stroke survivors with ischaemic or ...
  • "We belong to nature": Communicating Mental Health in an Indigenous Context 

    Sørly, Rita; Mathisen, Vår; Kvernmo, Siv (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-23)
    The approach to standardized services in Norwegian mental health care is tailored to the needs of the majority population, focusing on diagnoses and overshadows an approach that understands, values and emphasizes Sámi storytelling and everyday life. This study aims to contribute knowledge regarding the promotion of user involvement in mental health care from the perspectives of Sámi mental health ...
  • Epipericardial Fat Necrosis: A Case Report and a Review of the Literature 

    Mortensen, Synnøve Gjelsten; Buchmann, Petr; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-16)
    Epipericardial fat necrosis (EFN), also known as pericardial or mediastinal fat necrosis, has until lately been considered an unusual cause of acute chest pain. Due to increased use of computed tomography (CT) and other imaging techniques, EFN is now believed to be an under-diagnosed cause of acute chest pain. We here present a patient with a short history of acute, left-sided pleuritic chest pain ...
  • Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage 

    Iakunchykova, Olena; Averina, Maria; Wilsgaard, Tom; Watkins, Hugh; Malyutina, Sofia; Ragino, Yulia; Keogh, Ruth; Kudryavtsev, Alexander V; Govorun, Vadim; Cook, Sarah Anne; Schirmer, Henrik; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-15)
    <p><i>Background - </i>Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk. <p><i>Methods - </i>We compared age-standardised mean levels of CVD ...
  • Physical activity and blood gene expression profiles: the Norwegian Women and Cancer (NOWAC) Post-genome cohort 

    Olsen, Karina Standahl; Lukic, Marko; Borch, Kristin Benjaminsen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-11)
    <i>Objectives</i> - The influence of physical activity (PA) on the immune system has emerged as a new field of research. Regular PA may promote an anti-inflammatory state in the body, thus contributing to the down-regulation of pro-inflammatory processes related to the onset and progression of multiple diseases. We aimed to assess whether overall PA levels were associated with differences in blood ...
  • MAPPinfo, mapping quality of health information: Study protocol for a validation study of an assessment instrument 

    Kasper, Jürgen; Lühnen, Julia; Hinneburg, Jana; Siebenhofer, Andrea; Posch, Nicole; Berger-Höger, Birte; Grafe, Alexander; Keppler, Jan; Steckelberg, Anke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)
    <i>Abstract</i> - Introduction Health information is a prerequisite of informed decision-making. Criteria for development, content and presentation have recently been published in a corresponding guideline. Within a systematic search, 27 relevant checklists were identified, none of them, however, complying with the guideline or providing reasonably operationalised measurement items. Therefore, a ...
  • Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis 

    Florholmen, Jon; Johnsen, Kay-Martin; Meyer, Renate; Olsen, Trine; Moe, Øystein Kittel; Tandberg, Petter; Gundersen, Mona Dixon; Kvamme, Jan-Magnus; Johnsen, Knut; Løitegård, Terje; Raschpichler, Gabriele; Vold, Cecilia; Sørbye, Sveinung; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-02)
    <i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis ...

View more