Recent additions

  • Common social determinants for overweight and obesity, and dental caries among adolescents in Northern Norway: a cross-sectional study from the Tromsø Study Fit Futures cohort 

    Stangvaltaite-Mouhat, Lina; Furberg, Anne-Sofie; Drachev, Sergei Nikolaevich; Trovik, Tordis A (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-05)
    <i>Background</i> - Non-communicable general and oral health conditions share common risk factors. Studies investigating common social determinants as risk factors for overweight/obesity and dental caries among the same adolescents are scarce and inconclusive.<p><p> <i>Methods</i> - This cross-sectional study included data from 464 girls and 494 boys from the population-based Tromsø study Fit ...
  • A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment 

    Dragomir, Mihnea Paul; Moisoiu, Vlad; Manaila, Roxana; Pardini, Barbara; Knutsen, Erik; Anfossi, Simone; Amit, Moran; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-31)
    One of the limitations of cancer research has been the restricted focus on tumor cells and the omission of other non-malignant cells that are constitutive elements of this systemic disease. Current research is focused on the bidirectional communication between tumor cells and other components of the tumor microenvironment (TME), such as immune and endothelial cells, and nerves. A major success of ...
  • Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies 

    Tellez Gabriel, Marta; Knutsen, Erik; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
    Breast cancer is the most common cancer among women worldwide. Although the five-, ten- and fifteen-year survival rates are good for breast cancer patients diagnosed with early-stage disease, some cancers recur many years after completion of primary therapy. Tumor heterogeneity and clonal evolution may lead to distant metastasis and therapy resistance, which are the main causes of breast cancer-associated ...
  • The value of dynamic infrared thermography in pedicled thoracodorsal artery perforator flap surgery 

    Sjöberg, Thomas K.; Mercer, James; Weum, Sven; de Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
    <p><i>Background:</i> Dynamic infrared thermography (DIRT) is a noninvasive imaging technique that can provide indirect and real-time information on skin perfusion by measuring skin temperature. Although used in flap surgery, there are no reports on its value in procedures using a pedicled thoracodorsal artery perforator (TDAP) flap. The aim of this study was to assess the usefulness of DIRT in ...
  • Factors Engaging Users of Diabetes Social Media Channels on Facebook, Twitter, and Instagram: Observational Study 

    Gabarron, Elia; Larbi, Dillys; Dorronzoro, Enrique; Hasvold, Per Erlend; Wynn, Rolf; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-29)
    <p><i>Background:</i> Diabetes patient associations and diabetes-specific patient groups around the world are present on social media. Although active participation and engagement in these diabetes social media groups has been mostly linked to positive effects, very little is known about the content that is shared on these channels or the post features that engage their users the most. <p><i>Objective:</i> ...
  • Stroke-Specific Quality of Life one-year post-stroke in two Scandinavian country-regions with different organisation of rehabilitation services: a prospective study 

    Pedersen, Synne Garder; Friborg, Oddgeir; Heiberg, Guri Anita; Arntzen, Cathrine; Holm Stabel, Henriette; Thrane, Gyrd; Nielsen, Jørgen Feldbæk; Anke, Audny (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-01)
    <p><i>Purpose:</i> To compare stroke-specific health related quality of life in two country-regions with organisational differences in subacute rehabilitation services, and to reveal whether organisational factors or individual factors impact outcome. <p><i>Materials and methods:</i> A prospective multicentre study with one-year follow-up of 369 first-ever stroke survivors with ischaemic or ...
  • "We belong to nature": Communicating Mental Health in an Indigenous Context 

    Sørly, Rita; Mathisen, Vår; Kvernmo, Siv (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-23)
    The approach to standardized services in Norwegian mental health care is tailored to the needs of the majority population, focusing on diagnoses and overshadows an approach that understands, values and emphasizes Sámi storytelling and everyday life. This study aims to contribute knowledge regarding the promotion of user involvement in mental health care from the perspectives of Sámi mental health ...
  • Epipericardial Fat Necrosis: A Case Report and a Review of the Literature 

    Mortensen, Synnøve Gjelsten; Buchmann, Petr; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-16)
    Epipericardial fat necrosis (EFN), also known as pericardial or mediastinal fat necrosis, has until lately been considered an unusual cause of acute chest pain. Due to increased use of computed tomography (CT) and other imaging techniques, EFN is now believed to be an under-diagnosed cause of acute chest pain. We here present a patient with a short history of acute, left-sided pleuritic chest pain ...
  • Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage 

    Iakunchykova, Olena; Averina, Maria; Wilsgaard, Tom; Watkins, Hugh; Malyutina, Sofia; Ragino, Yulia; Keogh, Ruth; Kudryavtsev, Alexander V; Govorun, Vadim; Cook, Sarah Anne; Schirmer, Henrik; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-15)
    <p><i>Background - </i>Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk. <p><i>Methods - </i>We compared age-standardised mean levels of CVD ...
  • Physical activity and blood gene expression profiles: the Norwegian Women and Cancer (NOWAC) Post-genome cohort 

    Olsen, Karina Standahl; Lukic, Marko; Borch, Kristin Benjaminsen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-11)
    <i>Objectives</i> - The influence of physical activity (PA) on the immune system has emerged as a new field of research. Regular PA may promote an anti-inflammatory state in the body, thus contributing to the down-regulation of pro-inflammatory processes related to the onset and progression of multiple diseases. We aimed to assess whether overall PA levels were associated with differences in blood ...
  • MAPPinfo, mapping quality of health information: Study protocol for a validation study of an assessment instrument 

    Kasper, Jürgen; Lühnen, Julia; Hinneburg, Jana; Siebenhofer, Andrea; Posch, Nicole; Berger-Höger, Birte; Grafe, Alexander; Keppler, Jan; Steckelberg, Anke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)
    <i>Abstract</i> - Introduction Health information is a prerequisite of informed decision-making. Criteria for development, content and presentation have recently been published in a corresponding guideline. Within a systematic search, 27 relevant checklists were identified, none of them, however, complying with the guideline or providing reasonably operationalised measurement items. Therefore, a ...
  • Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis 

    Florholmen, Jon; Johnsen, Kay-Martin; Meyer, Renate; Olsen, Trine; Moe, Øystein Kittel; Tandberg, Petter; Gundersen, Mona Dixon; Kvamme, Jan-Magnus; Johnsen, Knut; Løitegård, Terje; Raschpichler, Gabriele; Vold, Cecilia; Sørbye, Sveinung; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-02)
    <i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis ...
  • Protein kinase C isozymes associated with relapse free survival in non-small cell lung cancer patients 

    Halvorsen, Ann Rita; Haugen, Mads Haugland; Øjlert, Åsa Kristina; Lund-Iversen, Marius; Jørgensen, Lars Hilmar; Solberg, Steinar; Mælandsmo, Gunhild Mari; Brustugun, Odd Terje; Helland, Åslaug (Journal article; Tidsskriftartikkel, 2020-11-25)
    <i>Introduction</i>: Protein expression is deregulated in cancer, and the proteomic changes observed in lung cancer may be a consequence of mutations in essential genes. The purpose of this study was to identify protein expression associated with prognosis in lung cancers stratified by smoking status, molecular subtypes, and EGFR-, TP53-, and KRAS-mutations.<p> <p><i>Methods</i>: We performed ...
  • Thromboelastometry for Assessing Risks of Free Flap Thrombosis in Patients Undergoing Microvascular Surgery 

    Vanags, Indulis; Stepanovs, Jevgenijs; Ozolina, Agnese; Mukans, Maksims; Bjertnaes, Lars J.; Mamaja, Biruta (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-23)
    <p>Introduction</i>: Coagulation assessment is often missing in microvascular surgery. We aimed at evaluating the predictive value of thromboelastometry for free flap thrombosis in microvascular surgery patients.<p> <p> <i>Materials and Methods</i>: We enrolled 103 adult patients with traumatic injuries scheduled for microvascular free flap surgery into a prospective observational study. Thirty-six ...
  • NADPH oxidase 2 mediates myocardial oxygen wasting in obesity 

    Hafstad, Anne Dragøy; Hansen, Synne Simonsen; Lund, Jim; Santos, Celio X.C.; Boardman, Neoma Tove; Shah, Ajay M.; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-19)
    Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO<sub>2</sub>) and impaired cardiac efficiency. Although the pathophysiology of this cardiomyopathy is multifactorial and complex, reactive oxygen species (ROS) may play an important role. One of the ...
  • Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution 

    Alakunle, Emmanuel; Moens, Ugo; Nchinda, Godwin; Okeke, Malachy Ifeanyi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-05)
    Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is a member of orthopoxvirus genus. The reemergence of MPXV in 2017 (at Bayelsa state) after 39 years of no reported case in Nigeria, and the export of travelers’ monkeypox (MPX) from Nigeria to other parts of the world, in 2018 and 2019, respectively, have raised concern that MPXV may have emerged to occupy the ecological and ...
  • Hearing in schoolchildren after neonatal exposure to a high-dose gentamicin regimen 

    Hemmingsen, Dagny; Mikalsen, Camilla; Rydland Hansen, Alexander; Fjalstad, Jon Widding; Stenklev, Niels Christian; Klingenberg, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)
    <p>OBJECTIVE: To assess the association between gentamicin exposure in the neonatal period and hearing in school age. <p>METHODS: This study included children exposed to a high-dose (6 mg/kg) gentamicin regimen as neonates (2004–2012), invited for follow-up at school age, and a healthy age-matched control group. We assessed hearing with pure tone audiometry including the extended high-frequency ...
  • Nurses experiences of ethical responsibility: A hermeneutic phenomenological design 

    Tøllefsen, Annette; Olsen, Aid; Clancy, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-04)
    There is a lack of studies on ethical responsibility in nursing. Nurses experience ethical responsibility in all settings where patients are exposed and vulnerable. The authors’ interest in public health and intensive care nursing provided a motivation to study these settings. The study aimed to explore how intensive care and public health nurses experience ethical responsibility. A qualitative ...
  • Optimized cutoff maternal age for adverse obstetrical outcomes: A multicenter retrospective cohort study in Urban China during 2011 to 2012 

    Zhang, Xiaolei; Liang, Huan; Zhao, Huan-Qiang; Wu, Su-Wen; Zhou, Qiongjie; Li, Xiao-Tian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-05)
    <p><i>Background: </i>China's two-child policy has led to a trend of aging in pregnancy which was associated with adverse outcomes. This study aimed to identify the clinically cutoff maternal age for adverse obstetric outcomes in China. <p><i>Methods: </i>This secondary analysis of a multicenter retrospective cohort study included data of childbearing women from 39 hospitals collected in urban China ...
  • Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs 

    Falavigna, Margherita; Brurok, Sunniva; Klitgaard, Mette; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-21)
    The prediction of the <i>in vivo</i> performance of self-nanoemulsifying drug delivery systems (SNEDDSs) is currently gaining increasing attention. Therefore, the need for reliable <i>in vitro</i> models able to assess the drug solubilization capacity of such formulations upon <i>in vitro</i> lipolysis, as well as to concomitantly evaluate <i>in vitro</i> drug permeation, has become ever so evident. ...

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