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Learning to play to learn in pediatric physical therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-06)Introduction: Play is a way for children to develop and learn about themselves in conjunction with the world. Using play as part of pediatric physical therapy is broadly recommended. This study investigates this integration of play and seeks to answer the research question: How do pediatric physical therapists (PPT) understand and manage embedding play in pediatric physical therapy with children ... -
Female sex hormones and subtypes of breast cancer
(Doctoral thesis; Doktorgradsavhandling, 2025-02-20)Bakgrunn: Det er gode holdepunkter for at kvinnelige kjønnshormoner har en avgjørende rolle i utviklingen av brystkreft. Subtyper av brystkreft utgjør distinkte sykdomsentiteter og har ulik etiologi, risikofaktorer og prognoser. Disse subtypene er ofte klassifisert som luminal A-lignende, luminal B-lignende, HER2-positiv og trippel-negativ brystkreft (TNBC) basert på immunhistokjemisk undersøkelse. ... -
The association between animal protein, plant protein, and their substitution with bladder cancer risk: a pooled analysis of 10 cohort studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-24)Purpose - Although total dietary protein intake has been associated with bladder cancer (BC) risk, the effect of the origin (plant or animal) and the substitutions remain to be understood. This study aimed to investigate the effect of total dietary protein, animal-based protein, plant-based protein, and their substitutions with each other on the risk of BC using a pooled analysis of 10 cohort ... -
Cortisol and C-reactive protein (CRP) regulation in severe mental disorders
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-25)Background - People with schizophrenia (SZ) and bipolar disorder (BD) show abnormalities in the biological stress system and low-grade inflammation. However, whether the hypothalamic-pituitary-adrenal (HPA) axis-immune regulation is disrupted in SZ and BD, is yet to be determined.<p> <p>Methods - Cortisol and C-reactive protein (CRP) were measured in blood samples collected at or before 10 am in ... -
Long Covid: a global health issue - a prospective, cohort study set in four continents
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-21)Introduction - A proportion of people develop Long Covid after acute COVID-19, but with most studies concentrated in high-income countries (HICs), the global burden is largely unknown. Our study aims to characterise long-term COVID-19 sequelae in populations globally and compare the prevalence of reported symptoms in HICs and low-income and middle-income countries (LMICs).<p> <p>Methods - A ... -
MRI in musculoskeletal inflammatory disease in children, with a focus on technique, standardisation and findings
(Doctoral thesis; Doktorgradsavhandling, 2025-02-07)Inflammatory musculoskeletal (MSK) diseases are common among children and adolescents, with early diagnosis and treatment crucial for long-term outcomes. Magnetic resonance imaging (MRI) has become a key tool in guiding treatment due to the challenges of clinical assessment of disease activity. However, there is a lack of validated, child-specific MRI tools for monitoring these diseases. This ... -
Bridging borders: Global insights and challenges in internationalising higher education using a decade-long case study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-02)The manuscript examines a decade of internationalisation efforts at the Department of Health and Care Sciences at UiT The Arctic University of Norway. Employing a mixed-methods approach, it analyses student mobility, research collaborations, and international partnerships, offering strategic recommendations to enhance global educational practices. The findings provide valuable insights into international ... -
Interactive Governance of Fisheries and Aquaculture: Transdisciplinary Challenges and Stakeholder Involvement in Coastal Zone Management
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-28)This paper examines the interactions between fisheries and aquaculture in Northern Norway, with a particular focus on environmental impacts and governance frameworks. The increasing overlap between aquaculture facilities and critical fisheries, such as cod spawning grounds, has raised concerns regarding habitat degradation and ecosystem sustainability. This study evaluates stakeholder perspectives ... -
Patient cohorts of interest in resuscitation science - Aligning Cardiac Arrest Registry Outputs with Stakeholder Needs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-21)Cardiac arrest registries can benchmark, enhance quality of care and provide data for research. Key stakeholders from Emergency Medical Communication Centre (EMCC), Emergency Medical Services (EMS), In-Hospital Care Providers (IHCP) and Recovery and Rehabilitation Providers (RRP) have different perspectives, and registry results and patient cohorts should be tailored to facilitate benchmarking, ... -
Repeat traumatic brain injury exacerbates acute thalamic hyperconnectivity in humans
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-28)Repeated mild traumatic brain injury is of growing interest regarding public and sporting safety and is thought to have greater adverse or cumulative neurological effects when compared with single injury. While epidemiological links between repeated traumatic brain injury and outcome have been investigated in humans, exploration of its mechanistic substrates has been largely undertaken in animal ... -
European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-19)Introduction: This second part of the S2k guidelines is an update of the 2015 S1 European guidelines.<p> <p>Objective: These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS). <p>Methods: The chapters have been selected after a Delphi procedure among ... -
Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI): an observational cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-08)Background - Even patients with normal computed tomography (CT) head imaging may experience persistent symptoms for months to years after mild traumatic brain injury (mTBI). There is currently no good way to predict recovery and triage patients who may benefit from early follow-up and targeted intervention. We aimed to assess if existing prognostic models can be improved by serum biomarkers or ... -
The temporal copulatory patterns of female rat sexual behavior
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-17)Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and enhancing the physiological conditions needed for successful fertilization. So far, traditional research on female sexual behavior has relied on a limited set of ... -
The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-18)Increasing infertility rates represent a growing medical challenge in modern societies resulting from a complex interplay of sociocultural trends, lifestyle factors, exposure to environmental toxins, and underlying health problems. Women's fertility is particularly vulnerable to these shifts. The obesogenic lifestyle not only accelerates weight gain, but also disrupts ovulation driving the ... -
One-Year Insights into the GLOBOSTAD Multinational Prospective Observational Study of Patients Receiving Dupilumab for Atopic Dermatitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-02)Introduction Currently, limited data are available on long-term use of dupilumab to treat atopic dermatitis (AD) in a multinational real-world setting. The aim of this analysis was to report the interim 1-year data for patients with AD enrolled in the GLOBOSTAD registry, including treatment patterns, dupilumab effectiveness and safety, and healthcare burden.<p> <p>Methods GLOBOSTAD is an ongoing, ... -
Clinical value of novel blood-based tau biomarkers in Creutzfeldt–Jakob disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-06)BACKGROUND The diagnostic and prognostic performance of the novel fluid biomarkers brain-derived tau (BD-tau) and phospho-tau217 (p-tau217) in Creutzfeldt–Jakob disease (CJD) is not defined.<p> <p>METHODS We measured cerebrospinal fluid (CSF) and plasma BD-tau, p-tau217, p-tau181, total tau (t-tau), neurofilament light (NfL), and 14-3-3 in 100 CJD patients, 100 with non-prion rapidly progressive ... -
Correlative Super-Resolution Imaging of Cellular Nanopores Facilitated by Transparent Polymer Waveguide Chips
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-25)Super-resolution optical microscopy (SRM) permits the visualization of subcellular structures of biological samples beyond the diffraction limit of light. To evaluate and utilize the specific strengths of each SRM technique a combined approach in the form of correlative super-resolution imaging is essential. Here, the correlative SRM imaging of the ultrastructure of rat liver sinusoidal endothelial ... -
“But when I come home…”: How patients with chronic musculoskeletal pain account for their absent pain during naturally occurring clinical consultations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-20)When patients’ embodied experiences cannot be conveyed to clinicians in real-time, the challenges of reaching a shared understanding between patient and clinician are enhanced. In this study, we explore how patients with chronic musculoskeletal pain manage the situation of knowing that they regularly experience pain, yet exhibit minimal signs of it during clinical consultations. Utilizing a multimethod, ... -
The HUNT lung-SNP model: genetic variants plus clinical variables improve lung cancer risk assessment over clinical models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-12)Purpose The HUNT Lung Cancer Model (HUNT LCM) predicts individualized 6-year lung cancer (LC) risk among individuals who ever smoked cigarettes with high precision based on eight clinical variables. Can the performance be improved by adding genetic information?<p> <p>Methods A polygenic model was developed in the prospective Norwegian HUNT2 study with clinical and genotype data of individuals ... -
Promising microRNAs in pre-diagnostic serum associated with lung cancer up to eight years before diagnosis: a HUNT study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-20)Introduction Blood biomarkers for early detection of lung cancer (LC) are in demand. There are few studies of the full microRNome in serum of asymptomatic subjects that later develop LC. Here we searched for novel microRNA biomarkers in blood from non-cancer, ever-smokers populations up to eight years before diagnosis.<p> <p>Methods Serum samples from 98,737 subjects from two prospective ...
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