Recent additions

  • NADPH oxidase 2 mediates myocardial oxygen wasting in obesity 

    Hafstad, Anne Dragøy; Hansen, Synne Simonsen; Lund, Jim; Santos, Celio X.C.; Boardman, Neoma Tove; Shah, Ajay M.; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-19)
    Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO<sub>2</sub>) and impaired cardiac efficiency. Although the pathophysiology of this cardiomyopathy is multifactorial and complex, reactive oxygen species (ROS) may play an important role. One of the ...
  • Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution 

    Alakunle, Emmanuel; Moens, Ugo; Nchinda, Godwin; Okeke, Malachy Ifeanyi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-05)
    Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is a member of orthopoxvirus genus. The reemergence of MPXV in 2017 (at Bayelsa state) after 39 years of no reported case in Nigeria, and the export of travelers’ monkeypox (MPX) from Nigeria to other parts of the world, in 2018 and 2019, respectively, have raised concern that MPXV may have emerged to occupy the ecological and ...
  • Hearing in schoolchildren after neonatal exposure to a high-dose gentamicin regimen 

    Hemmingsen, Dagny; Mikalsen, Camilla; Rydland Hansen, Alexander; Fjalstad, Jon Widding; Stenklev, Niels Christian; Klingenberg, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)
    <p>OBJECTIVE: To assess the association between gentamicin exposure in the neonatal period and hearing in school age. <p>METHODS: This study included children exposed to a high-dose (6 mg/kg) gentamicin regimen as neonates (2004–2012), invited for follow-up at school age, and a healthy age-matched control group. We assessed hearing with pure tone audiometry including the extended high-frequency ...
  • Nurses experiences of ethical responsibility: A hermeneutic phenomenological design 

    Tøllefsen, Annette; Olsen, Aid; Clancy, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-04)
    There is a lack of studies on ethical responsibility in nursing. Nurses experience ethical responsibility in all settings where patients are exposed and vulnerable. The authors’ interest in public health and intensive care nursing provided a motivation to study these settings. The study aimed to explore how intensive care and public health nurses experience ethical responsibility. A qualitative ...
  • Optimized cutoff maternal age for adverse obstetrical outcomes: A multicenter retrospective cohort study in Urban China during 2011 to 2012 

    Zhang, Xiaolei; Liang, Huan; Zhao, Huan-Qiang; Wu, Su-Wen; Zhou, Qiongjie; Li, Xiao-Tian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-05)
    <p><i>Background: </i>China's two-child policy has led to a trend of aging in pregnancy which was associated with adverse outcomes. This study aimed to identify the clinically cutoff maternal age for adverse obstetric outcomes in China. <p><i>Methods: </i>This secondary analysis of a multicenter retrospective cohort study included data of childbearing women from 39 hospitals collected in urban China ...
  • Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs 

    Falavigna, Margherita; Brurok, Sunniva; Klitgaard, Mette; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-21)
    The prediction of the <i>in vivo</i> performance of self-nanoemulsifying drug delivery systems (SNEDDSs) is currently gaining increasing attention. Therefore, the need for reliable <i>in vitro</i> models able to assess the drug solubilization capacity of such formulations upon <i>in vitro</i> lipolysis, as well as to concomitantly evaluate <i>in vitro</i> drug permeation, has become ever so evident. ...
  • Data on RT-qPCR assay of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) from human uterine endometrial tissue and cancer cells of the uterine cervix 

    Smaglyukova, Natalia; Sletten, Elise Thoresen; Ørbo, Anne; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-25)
    A previous investigation showed that the endometrium normalized in women with endometrial hyperplasia after three months treatment with high dose levonorgestrel IUS (intrauterine system). The effect was maintained even if immunohistochemical analyses of the endometrium showed that nuclear progesterone receptors (nPRs) were completely downregulated. These observations indicated that some type of ...
  • Expression of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy 

    Sletten, Elise Thoresen; Smaglyukova, Natalia; Ørbo, Anne; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-29)
    The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely the last decades. In a previous clinical study of endometrial hyperplasia, we observed that the antiproliferative progestin effect persisted after ...
  • Betydning av tilbakemelding om avvikende FEV1-verdier i Tromsø 7 

    Norum, Julie (Master thesis; Mastergradsoppgave, 2020-02-21)
    <p><i>Bakgrunn:</i> Spirometri er en anbefalt undersøkelse for å diagnostisere og undersøke for obstruktiv lungesykdom. Deltakerne i Tromsø 7 som måler en FEV1 < 70 % (grenseverdi på FEV1 < 65 % hos deltakere > 70 år) fikk et informasjonsskriv på spirometriposten med anbefaling å kontakte sin fastlege. Denne informasjonen kan være en stor fordel for deltakeren hvis det kan avdekke risiko for alvorlig ...
  • Lifestyle among long-term survivors of cancers in young adulthood 

    Bøhn, Synne-Kristin Hoffart; Lie, Hanne Cathrine; Reinertsen, Kristin Valborg; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen; Kiserud, Cecilie E.; Loge, Jon Håvard; Wisløff, Torbjørn; Thorsen, Lene (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-01)
    <i>Purpose</i> - To investigate lifestyle in a population-based sample of long-term (≥ 5 years since diagnosis) young adult cancer survivors (YACSs), and explore factors associated with not meeting the lifestyle guidelines for physical activity (PA), body mass index (BMI), and smoking. <p> <p><i>Methods</i> - YACSs (<i>n</i> = 3558) diagnosed with breast cancer (BC), colorectal cancer (CRC), ...
  • Use of group based trajectory modelling to identify groups based on trajectories obtained for overall number of antibiotics prescription to children age 0-3 years in Norway during year 2004 to 2017 

    Tanwar, Bhupender Singh (Master thesis; Mastergradsoppgave, 2020-12-01)
    Bacterial infection occur frequently in children. In 2015 more than 900,000 children below 5 years were killed due to respiratory tract infections (RTIs). Early life onset and prolonged use of antibiotics in children can leads to health complications later in life. Antibiotics prescribing in young children is affected by many factors and identifying these factors can provide an opportunity to develop ...
  • Employment status three years after percutaneous coronary intervention and predictors for being employed: A nationwide prospective cohort study 

    Olsen, Siv Jorunn Storli; Schirmer, Henrik; Wilsgaard, Tom; Bønaa, Kaare Harald; Hanssen, Tove Aminda (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-01)
    <i>Background</i> - Vocational support is recommended for patients in cardiac rehabilitation (CR), as returning to work is important in patients social readjusting after an acute coronary event. Information is lacking on whether CR leads to higher long-term employment after percutaneous coronary intervention (PCI).<p> <p><i>Aims</i> - The aims of this study were to determine employment status ...
  • Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease 

    Mercado, Nicolas; Colley, Thomas; Baker, Jonathan R.; Vuppussetty, Chaitanya; Kono, Yuta; Clarke, Colin; Tooze, Sharon A; Johansen, Terje; Barnes, Peter J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
    Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD, in which oxidative stress‐induced misfolded proteins accumulate into toxic aggregates dependent on the accumulation of the autophagic cargo receptor p62. Defective ...
  • DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma 

    Haider, Zahra; Landfors, Mattias; Golovleva, Irina; Erlanson, Martin; Schmiegelow, Kjeld; Flægstad, Trond; Kanerva, Jukka; Norén-Nyström, Ulrika; Hultdin, Magnus; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-28)
    Despite having common overlapping immunophenotypic and morphological features, T-cell lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) have distinct clinical manifestations, which may represent separate diseases. We investigated and compared the epigenetic and genetic landscape of adult and pediatric T-ALL (<i>n</i> = 77) and T-LBL (<i>n</i> = 15) patient samples by high-resolution genome-wide ...
  • mHealth: opportunities and challenges for diabetes intervention research 

    Bradway, Meghan (Doctoral thesis; Doktorgradsavhandling, 2021-03-12)
    <p><i>Background:</i> Traditionally, health intervention evaluations provide long-term evidence of efficacy and safety via validated protocols, following a positivist paradigm, or approach, to research. However, modern mobile health (mHealth) technologies develop too quickly and outside of medical regulation, making it challenging for health research to keep pace. <p><i>Objective:</i> This thesis ...
  • Assessing communication during remote follow-up of users with pacemakers in Norway: The Nordland study, a randomized trial 

    Catalán-Matamoros, Daniel; Lopez-Villegas, Antonio; Lappegård, Knut Tore; Lopez-Liria, Remedios (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-21)
    As effective communication is a key ingredient for the provision of quality healthcare services, this study aimed to explore the communication experiences in the remote monitoring of older adults with a pacemaker. The study was based on a non-masked randomized observational design. The Healthcare Communication Questionnaire and in-depth interviews were conducted for data collection. A total of 49 ...
  • From Differential Stains to Next Generation Physiology: Chemical Probes to Visualize Bacterial Cell Structure and Physiology 

    Hira, Jonathan; Uddin, Md Jalal; Haugland, Marius Myreng; Lentz, Christian Stephan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-26)
    Chemical probes have been instrumental in microbiology since its birth as a discipline in the 19th century when chemical dyes were used to visualize structural features of bacterial cells for the first time. In this review article we will illustrate the evolving design of chemical probes in modern chemical biology and their diverse applications in bacterial imaging and phenotypic analysis. We will ...
  • Live lectures and videos do not differ in relation to learning outcomes of dental ergonomics 

    Leinonen, Jukka; Laitala, Marja-Liisa; Pirttilahti, Julia; Niskanen, Leena; Pesonen, Paula; Anttonen, Vuokko (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-15)
    <p><i>Objectives - </i>This study aimed to compare the knowledge attained by third‐year dental students in physical ergonomics altering live lectures and videos in teaching. The second aim was to investigate implementation of the theoretical knowledge on ergonomics into practice. <p><i>Material and methods - </i>Forty‐five students divided into two groups attended a live lecture (45 min) or viewed ...
  • Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019 

    Ludden, Catherine; Lötsch, Felix; Alm, Erik; Kumar, Narender; Johansson, Karin; Albiger, Barbara; Huang, Te-Din; Denis, Olivier; Hammerum, Anette M.; Hasman, Henrik; Jalava, Jari; Räisänen, Kati; Dortet, Laurent; Jousset, Agnès B.; Gatermann, Sören; Haller, Sebastian; Cormican, Martin; Brennan, Wendy; Grosso, Maria Del; Monaco, Monica; Schouls, Leo; Samuelsen, Ørjan; Pirš, Mateja; Cerar, Tjaša; Oteo-Iglesias, Jésus; Pérez-Vázquez, Maria; Sjöström, Karin; Edquist, Petra; Hopkins, Katie L.; Struelens, Marc J.; Palm, Daniel; Monnet, Dominique L.; Kohlenberg, Anke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-21)
    An alert regarding an outbreak of carbapenem-resistant <i>Klebsiella pneumoniae</i> carrying <i>bla</i> <sub>NDM-1</sub> and <i>bla</i> <sub>OXA-48</sub> carbapenemase-encoding genes was sent by Germany to European Union (EU)/European Economic Area (EEA) countries in October 2019. Since only limited whole genome sequencing (WGS) data on <i>bla</i> <sub>NDM-1-</sub> and <i>bla</i> <sub>OXA-48</sub>-positive ...
  • Hvordan kan universitetet ivareta sitt samfunnsoppdrag: med eksempler fra sykepleierutdanningen i Finnmark 

    Eriksen, Liss Trine (Doctoral thesis; Doktorgradsavhandling, 2021-03-12)
    Avhandlingen består av seks artikler basert på studier fra sykepleierutdanning i Finnmark, og belyser ulike aspekter ved sykepleierutdanningens samfunnsoppdrag. Hensikten med artiklene er å bidra til økt kunnskap om urfolksperspektiv, utfordringer som stabilisering og rekruttering av sykepleiere til distriktene, samhandling mellom primær- og spesialisthelsetjeneste, samt pedagogiske tilnærminger ...

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