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Reply: How do we avoid polarization of interdisciplinary research on cancer diagnosis?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-30)First, we would like to take the opportunity to thank Andersen and colleagues for their thorough reading of our paper. We appreciate and welcome a critical dialogue that helps furthering an understanding of early cancer diagnostics. <p> <p>However, our paper is a critical comment on the epidemiological reasoning that early diagnosis equals better outcomes, using anthropological and social science ... -
Healthcare seeking for people diagnosed with severe mental illness: Sensations, symptoms and diagnostic work
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-27)For people with mental and somatic illnesses, the interpretive process of attending to a multitude of bodily sensations and recognising them as potential symptoms represents daily and ‘chronic homework’. Based on 16 months of ethnographic fieldwork in Denmark, this study explores diagnostic work and healthcare seeking among people with severe mental and somatic illnesses. As multiple studies have ... -
Rethinking the logic of early diagnosis in cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-26)To reduce morbidity and mortality of cancer, more countries have implemented strategies to detect cancer, based on the logic of ‘the sooner the better’. Time is thereby an essential component in how cancer research, policies, and prevention are practiced today. Where the logic of early diagnosis benefits some, the logic also produces harms. In this article, we use a cross-disciplinary case-study ... -
Erstatning av rødt og bearbeidet kjøtt med mager eller fet fisk og risiko for kolorektal kreft
(Mastergradsoppgave; Master thesis, 2024-05-15)Kolorektal kreft er den nest vanligste kreftformen i Norge, der norske kvinner er blant de med høyest insidens globalt. Samtidig er inntaket av rødt og bearbeidet kjøtt en kjent risikofaktor for kolorektal kreft, som derfor anbefales av de offentlige kostrådene å reduseres. Ved reduksjon vil det være naturlig å substituere med alternative proteinkilder, hvor fet eller mager fisk er anbefalt å innta ... -
Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-02)Co-observation of a gene variant with a pathogenic variant in another gene that explains the disease presentation has been designated as evidence against pathogenicity for commonly used variant classification guidelines. Multiple variant curation expert panels have specified, from consensus opinion, that this evidence type is not applicable for the classification of breast cancer predisposition gene ... -
Blood-based DNA methylation markers for lung cancer prediction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-30)Objective - Screening high-risk individuals with low-dose CT reduces mortality from lung cancer, but many lung cancers occur in individuals who are not eligible for screening. Risk biomarkers may be useful to refine risk models and improve screening eligibility criteria. We evaluated if blood-based DNA methylation markers can improve a traditional lung cancer prediction model.<p> <p>Methods and ... -
Converging perspectives on the processes exacerbating adolescent obesity: An integrative systems approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-22)Adolescent obesity is a complex public health challenge with steadily increasing and variable prevalence among countries. This paper synthesises the driving feedback mechanisms of adolescent obesity studied in the CO-CREATE project, furthering our understanding of the complexity of this issue. Using systems thinking principles and causal loop diagramming, we integrated the following knowledge and ... -
Degree of food processing and breast cancer risk: a prospective study in 9 European countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-09)Recent epidemiological studies have suggested a positive association between ultra-processed food consumption and breast cancer risk, although some studies also reported no association. Furthermore, the evidence regarding the associations between intake of food with lower degrees of processing and breast cancer risk is limited. Thus, we investigated the associations between dietary intake by ... -
The association between animal protein, plant protein, and their substitution with bladder cancer risk: a pooled analysis of 10 cohort studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-24)Purpose - Although total dietary protein intake has been associated with bladder cancer (BC) risk, the effect of the origin (plant or animal) and the substitutions remain to be understood. This study aimed to investigate the effect of total dietary protein, animal-based protein, plant-based protein, and their substitutions with each other on the risk of BC using a pooled analysis of 10 cohort ... -
“But when I come home…”: How patients with chronic musculoskeletal pain account for their absent pain during naturally occurring clinical consultations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-20)When patients’ embodied experiences cannot be conveyed to clinicians in real-time, the challenges of reaching a shared understanding between patient and clinician are enhanced. In this study, we explore how patients with chronic musculoskeletal pain manage the situation of knowing that they regularly experience pain, yet exhibit minimal signs of it during clinical consultations. Utilizing a multimethod, ... -
The HUNT lung-SNP model: genetic variants plus clinical variables improve lung cancer risk assessment over clinical models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-12)Purpose The HUNT Lung Cancer Model (HUNT LCM) predicts individualized 6-year lung cancer (LC) risk among individuals who ever smoked cigarettes with high precision based on eight clinical variables. Can the performance be improved by adding genetic information?<p> <p>Methods A polygenic model was developed in the prospective Norwegian HUNT2 study with clinical and genotype data of individuals ... -
Promising microRNAs in pre-diagnostic serum associated with lung cancer up to eight years before diagnosis: a HUNT study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-20)Introduction Blood biomarkers for early detection of lung cancer (LC) are in demand. There are few studies of the full microRNome in serum of asymptomatic subjects that later develop LC. Here we searched for novel microRNA biomarkers in blood from non-cancer, ever-smokers populations up to eight years before diagnosis.<p> <p>Methods Serum samples from 98,737 subjects from two prospective ... -
Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-16)Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective ... -
Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-07)Purpose - Previously reported associations of protein-rich foods with stroke subtypes have prompted interest in the assessment of individual amino acids. We examined the associations of dietary amino acids with risks of ischaemic and haemorrhagic stroke in the EPIC study.<p> <p>Methods - We analysed data from 356,142 participants from seven European countries. Dietary intakes of 19 individual ... -
Deep Learning Model for Predicting Immunotherapy Response in Advanced Non-Small Cell Lung Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-26)Importance - Only a small fraction of patients with advanced non−small cell lung cancer (NSCLC) respond to immune checkpoint inhibitor (ICI) treatment. For optimal personalized NSCLC care, it is imperative to identify patients who are most likely to benefit from immunotherapy.<p> <p>Objective - To develop a supervised deep learning−based ICI response prediction method; evaluate its performance ... -
Promising microRNAs in pre-diagnostic serum associated with lung cancer up to eight years before diagnosis: a HUNT study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-20)Introduction - Blood biomarkers for early detection of lung cancer (LC) are in demand. There are few studies of the full microRNome in serum of asymptomatic subjects that later develop LC. Here we searched for novel microRNA biomarkers in blood from non-cancer, ever-smokers populations up to eight years before diagnosis.<p> <p>Methods - Serum samples from 98,737 subjects from two prospective ... -
Factor structure of the HIV-SM LMIC self-management questionnaire for people living with HIV in low- and middle-income countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-21)Introduction Despite the need for reliable questionnaires to monitor self-management in chronic disease patients, such tools are lacking in developing countries. This study aims to pilot and assess the construct validity of the HIV-SM LMIC questionnaire.<p> <p>Method The validation of the HIV-SM LMIC questionnaire involved two cross-sectional studies in Ethiopia. The first round, for exploratory ... -
The HUNT lung-SNP model: genetic variants plus clinical variables improve lung cancer risk assessment over clinical models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-12)Purpose - The HUNT Lung Cancer Model (HUNT LCM) predicts individualized 6-year lung cancer (LC) risk among individuals who ever smoked cigarettes with high precision based on eight clinical variables. Can the performance be improved by adding genetic information?<p> <p>Methods - A polygenic model was developed in the prospective Norwegian HUNT2 study with clinical and genotype data of individuals ... -
Quality of registration of antenatal, intrapartum, and newborn information in the Georgian birth registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-24)Background The Georgian Birth Registry (GBR) is a comprehensive digital birth registry covering 99.8% of births nationwide. By law, registration in the GBR is mandatory, with data primarily transferred from medical records (MRs) by designated personnel at medical facilities. We aimed to assess the correspondence of the registration of selected variables between GBR and MRs.<p> <p>Methods We ... -
A Difference Has Been Made...
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-12)A few months ago, a letter to the editor was submitted by Dr. Axel Wiebrecht, a highly respected expert in Chinese Herbal Therapy, particularly known for his emphasis on safety. Dr. Wiebrecht is also actively involved as a reviewer for Complementary Medicine Research (CMR). According to CMR's guidelines for authors “Letters may explore subjects related to matters discussed in the journal, providing ...
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