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Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-16)Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective ... -
Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-07)Purpose - Previously reported associations of protein-rich foods with stroke subtypes have prompted interest in the assessment of individual amino acids. We examined the associations of dietary amino acids with risks of ischaemic and haemorrhagic stroke in the EPIC study.<p> <p>Methods - We analysed data from 356,142 participants from seven European countries. Dietary intakes of 19 individual ... -
Deep Learning Model for Predicting Immunotherapy Response in Advanced Non-Small Cell Lung Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-26)Importance - Only a small fraction of patients with advanced non−small cell lung cancer (NSCLC) respond to immune checkpoint inhibitor (ICI) treatment. For optimal personalized NSCLC care, it is imperative to identify patients who are most likely to benefit from immunotherapy.<p> <p>Objective - To develop a supervised deep learning−based ICI response prediction method; evaluate its performance ... -
Promising microRNAs in pre-diagnostic serum associated with lung cancer up to eight years before diagnosis: a HUNT study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-20)Introduction - Blood biomarkers for early detection of lung cancer (LC) are in demand. There are few studies of the full microRNome in serum of asymptomatic subjects that later develop LC. Here we searched for novel microRNA biomarkers in blood from non-cancer, ever-smokers populations up to eight years before diagnosis.<p> <p>Methods - Serum samples from 98,737 subjects from two prospective ... -
Factor structure of the HIV-SM LMIC self-management questionnaire for people living with HIV in low- and middle-income countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-21)Introduction Despite the need for reliable questionnaires to monitor self-management in chronic disease patients, such tools are lacking in developing countries. This study aims to pilot and assess the construct validity of the HIV-SM LMIC questionnaire.<p> <p>Method The validation of the HIV-SM LMIC questionnaire involved two cross-sectional studies in Ethiopia. The first round, for exploratory ... -
The HUNT lung-SNP model: genetic variants plus clinical variables improve lung cancer risk assessment over clinical models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-12)Purpose - The HUNT Lung Cancer Model (HUNT LCM) predicts individualized 6-year lung cancer (LC) risk among individuals who ever smoked cigarettes with high precision based on eight clinical variables. Can the performance be improved by adding genetic information?<p> <p>Methods - A polygenic model was developed in the prospective Norwegian HUNT2 study with clinical and genotype data of individuals ... -
Quality of registration of antenatal, intrapartum, and newborn information in the Georgian birth registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-24)Background The Georgian Birth Registry (GBR) is a comprehensive digital birth registry covering 99.8% of births nationwide. By law, registration in the GBR is mandatory, with data primarily transferred from medical records (MRs) by designated personnel at medical facilities. We aimed to assess the correspondence of the registration of selected variables between GBR and MRs.<p> <p>Methods We ... -
Suicidality and use of psychotropic medications in patients with schizophrenia: A prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-09)Background. The lifetime prevalence of suicide is around 5% in patients with schizophrenia. Non-adherence to antipsychotic medication is an important risk factor, but prospective studies investigating joint effects of antipsychotic drugs, antidepressants, and benzodiazepines on suicidality are scarce. We aimed to investigate how use and non-use of psychotropic medications are associated with suicidality ... -
“They were sort of in the room with me”: a qualitative study about callers’ experience of video streaming during medical emergency calls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-08)Background During the recent years, emergency services in several countries have integrated video streaming into medical emergency calls, and research on the topic has gained increased focus. Video streaming during medical emergency calls may change dispatcher’s perspective of the call and can be a helpful tool for supervising bystanders’ first aid. Little research exists, however, about the ... -
Proton therapy versus conventional radiotherapy for the treatment of cavernous sinus benign meningioma, a randomized controlled phase III study protocol (COG-PROTON-01)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-30)Background Proton therapy (PRT) is an innovative radiotherapeutic modality for the treatment of cancer with unique ballistic properties. The depth-dose distribution of a proton beam reduces exposure of healthy tissues to radiations, compared with photon-therapy (XRT). To date, only few indications for proton-therapy, like pediatric cancers, chordomas, or intra-ocular neoplasms, are reimbursed by ... -
“They were sort of in the room with me”: a qualitative study about callers’ experience of video streaming during medical emergency calls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-08)Background During the recent years, emergency services in several countries have integrated video streaming into medical emergency calls, and research on the topic has gained increased focus. Video streaming during medical emergency calls may change dispatcher’s perspective of the call and can be a helpful tool for supervising bystanders’ first aid. Little research exists, however, about the ... -
Deep learning-based classification of breast cancer molecular subtypes from H&E whole-slide images
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-17)Classifying breast cancer molecular subtypes is crucial for tailoring treatment strategies. While immunohistochemistry (IHC) and gene expression profiling are standard methods for molecular subtyping, IHC can be subjective, and gene profiling is costly and not widely accessible in many regions. Previous approaches have highlighted the potential application of deep learning models on hematoxylin ... -
The governance of the SAMINOR Study and integration of the CARE principles
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-13)The SAMINOR Study represents a unique data collection on health and diseases among the multiethnic population – including the Sámi population in Norway – making it a case study for discussing Sámi research data governance in a health context. This article describes how Sámi interests and needs in the SAMINOR Study are governed by two steps of a research application review process consisting of the ... -
Longitudinal cholesterol trends across socioeconomic groups in Norway: the influence of lipid-lowering drugs in the population-based Tromsø Study 1994–2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-26)Objectives There is limited evidence regarding the impact of lipid-lowering drugs (LLDs) on the socioeconomic gradient in a longitudinal perspective. The study investigates the longitudinal socioeconomic gradient in total cholesterol levels and whether this is affected by the use of LLDs.<p> <p>Design Population-based cohort study. <p>Setting Sample from adult inhabitants of Tromsø municipality, ... -
Combined prediagnostic lifestyle factors and survival of breast, colorectal and lung cancer in the Norwegian Women and Cancer (NOWAC) study: a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-27)Background With improvements in cancer treatment and early detection, the number of people living with cancer is increasing.<p> <p>Objective This study aimed to investigate the association between combined prediagnostic lifestyle factors, assessed by a Healthy Lifestyle Index (HLI) score, and mortality among women diagnosed with breast cancer (BC), colorectal cancer (CRC) and lung cancer ... -
Alcohol and cause-specific mortality in Russia: the Know Your Heart Study 2015–23
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-12)Background - Alcohol-related mortality in Russia exceeds the world average and presents a critical public health concern. This study assesses the impact of alcohol consumption levels on mortality and investigates mortality predictors among Russians, including people treated for alcohol-related diagnoses (narcology patients).<p> <p>Methods - We examined 2629 men and women aged 35–69 years who ... -
Prescription of benzodiazepines and antidepressants among Sami and non-Sami — How childhood violence shapes prescription patterns: the SAMINOR 2 questionnaire survey and the Norwegian prescription database
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-07)Background - Medication for mental health problems represents a significant proportion of overall medication use and the prescription of psychotropic medicine has increased in many western countries over the last decades. Childhood violence (CV) is strongly associated with mental health problems, which in turn may increase the likelihood of being prescribed psychotropic medication. However, the ... -
Work-leave rotation among general practitioners in Norwegian municipalities
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-19)Bakgrunn - Flere kommuner har innført rotasjonsordning (nordsjøturnus) for allmennleger, der legene gjennom året veksler mellom arbeidsperioder og friperioder. Vi har undersøkt utbredelsen av, årsaker til, innhold i og erfaringer med denne arbeidsformen.<p> <p>Materiale og metode - Vi har gjennomført en flerkasusstudie med data fra Statistisk sentralbyrå, fastlegeregisteret, kommunale dokumenter, ... -
Menopausal hormone therapy and incidence, mortality, and survival of breast cancer subtypes: a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-04)Background Menopausal hormone therapy (MHT) is associated with an increased risk of postmenopausal breast cancer, predominantly the luminal A-like subtype. The impact of MHT on deaths from breast cancer subtypes is less understood. This study aimed to explore associations between MHT use and the incidence, mortality, and survival of intrinsic-like breast cancer subtypes.<p> <p>Methods Data from ... -
Social isolation and loneliness and their association with all-cause mortality. A population-based longitudinal study in Norway: The Tromsø Study 1994–2023
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-20)Objectives - Loneliness and social isolation are associated with increased mortality, but few studies have assessed this association over long time in young adults.<p> <p>Methods - The study sample comprised 9061 women and 8735 men aged 25 to 69 years who participated in the Tromsø4 survey (1994–95, baseline) of the Tromsø Study, Norway. A subset of the study sample also attended the Tromsø5 ...
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