Recent additions

  • Postprandial changes in gene expression of cholesterol influx and efflux mediators after intake of SFA compared to n-6 PUFA in subjects with and without familial hypercholesterolemia: secondary outcomes of a randomized controlled trial 

    Øyri, Linn Kristin Lie; Narverud, Ingunn; Bogsrud, Martin Prøven; Hansson, Patrik; Leder, Lena; Byfuglien, Marte Gjeitung; Veierød, Marit Bragelien; Thoresen, Magne; Ulven, Stine Marie; Holven, Kirsten Bjørklund (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-13)
    The long-term cholesterol-lowering effect of replacing intake of SFA with PUFA is well established, but has not been fully explained mechanistically. We examined the postprandial response of meals with different fat quality on expression of lipid genes in peripheral blood mononuclear cells (PBMC) in subjects with and without familial hypercholesterolaemia (FH). Thirteen subjects with FH (who had ...
  • The effect of white matter hyperintensities on regional brain volumes and white matter microstructure, a population-based study in HUNT 

    Vangberg, Torgil Riise; Eikenes, Live; Håberg, Asta K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-04)
    Even though age-related white matter hyperintensities (WMH) begin to emerge in middle age, their effect on brain micro- and macrostructure in this age group is not fully elucidated. We have examined how presence of WMH and load of WMH affect regional brain volumes and microstructure in a validated, representative general population sample of 873 individuals between 50 and 66 years. Presence of WMH ...
  • Effect of genetically low 25-hydroxyvitamin D on mortality risk: Mendelian randomization analysis in 3 large European cohorts 

    Aspelund, Thor; Grübler, Martin R.; Smith, Albert V.; Gudmundsson, Elias F.; Keppel, Martin; Cotch, Mary Frances; Harris, Tamara B.; Jorde, Rolf; Grimnes, Guri; Joakimsen, Ragnar Martin; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; März, Winfried; Kleber, Marcus E.; Tomaschitz, Andreas; Grove-Laugesen, Diana; Rejnmark, Lars; Swart, Karin M.A.; Brouwer, Ingeborg A.; Lips, Paul; van Schoor, Natasja M.; Sempos, Christopher T.; Durazo-Arvizu, Ramón A.; Škrabáková, Zuzana; Dowling, Kirsten G.; Cashman, Kevin D.; Kiely, Mairead; Pilz, Stefan; Gudnason, Vilmundur; Eiríksdóttir, Gudny (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-02)
    The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D ...
  • Pain-relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice 

    Hansson, Per; Jensen, Troels Staehelin; Kvarstein, Gunnvald; Strömberg, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-01)
    <p><i>Context - </i>Clinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. <p><i>Objective - </i>To determine whether treatment and re‐treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. <p><i>Methods - </i>Three ...
  • A novel scale-space approach for multinormality testing and the k-sample problem in the high dimension low sample size scenario 

    Hindberg, Kristian; Hannig, Jan; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
    Two classical multivariate statistical problems, testing of multivariate normality and the <i>k</i>-sample problem, are explored by a novel analysis on several resolutions simultaneously. The presented methods do not invert any estimated covariance matrix. Thereby, the methods work in the High Dimension Low Sample Size situation, i.e. when <i>n</i> ≤ <i>p</i>. The output, a significance map, is ...
  • Bipolar radiofrequency neurotomy for spinal pain - A promising technique but still some steps to go 

    Kvarstein, Gunnvald; Lundeland, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-02)
  • Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation 

    Berzaghi, Rodrigo; Akhtar, Muhammad Asad; Islam, Md Ashraful; Pedersen, Brede Dille; Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-17)
    The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ...
  • Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study 

    Småbrekke, Silje; Schirmer, Henrik; Melsom, Toralf; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
    <p><i>Background - </i>Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive ...
  • A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults 

    Bramness, Jørgen Gustav; von Soest, Tilmann (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)
    <p><i>Background - </i>A small number of studies have shown that the use of cannabis increases the risk of bronchial asthma. There is, however, a paucity of longitudinal studies which are able to control for known risk factors of bronchial asthma. <p><i>Methods - </i>Survey data from a population-based longitudinal study encompassing 2602 young adults followed for 13 years were coupled with individual ...
  • Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous 

    Nieder, Carsten; Guckenberger, Matthias; Gaspar, Laurie E.; Rusthoven, Chad G.; De Ruysscher, Dirk; Sahgal, Arjun; Nguyen, Timothy; Grosu, Anca L.; Mehta, Minesh P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-15)
    <p><i>Background - </i>Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over the last decade. It is not trivial to find the optimal balance of over- versus undertreatment in these patients. Several recent trials, including the randomized QUARTZ ...
  • A quality indicator set for use in rehabilitation team care of people with rheumatic and musculoskeletal diseases; development and pilot testing 

    Johansen, Inger; Klokkerud, Mari; Anke, Audny; Børke, Janne-Birgitte; Glott, Thomas; Hauglie, Uno; Høyem, Audhild; Klovning, Atle; Lande, Karin Anna; Larsen, Mona; Nordvik, Jan Egil; Wigers, Sigrid Hørven; Øyeflaten, Irene Larsen; Hagen, Kåre Birger; Kjeken, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-29)
    <p><i>Background - </i>Systems for monitoring effectiveness and quality of rehabilitation services across health care levels are needed. The purpose of this study was to develop and pilot test a quality indicator set for rehabilitation of rheumatic and musculoskeletal diseases. <p><i>Methods - </i>The set was developed according to the Rand/UCLA Appropriateness Method, which integrates evidence ...
  • Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study 

    Hjemsæter, Arne Jan; Bramness, Jørgen Gustav; Drake, Robert; Monsbakken, Bent Berntsen; Saltyte Benth, Jurate; Landheim, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
    <p><i>Background - </i>This study investigated cause of death, mortality rates and explored if baseline characteristics were associated with risk of death in patients with alcohol use disorder alone or poly-substance use disorders. <p><i>Methods - </i>This was a prospective, longitudinal study of patients followed for 19 years after entering specialized treatment for substance use disorders. At ...
  • Outcome of 881 total hip arthroplasties in 747 patients 21 years or younger: data from the Nordic Arthroplasty Register Association (NARA) 1995-2016 

    Halvorsen, Vera Baasland; Fenstad, Anne Marie; Engesæter, Lars B.; Nordsletten, Lars; Overgaard, Søren; Pedersen, Alma B.; Kärrholm, Johan; MOHADDES, MAZIAR; Eskelinen, Antti; Mäkelä, Keijo T.; Röhrl, Stephan Maximillian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-15)
    <p><i>Background and purpose — </i>The literature is scarce on the outcome of the youngest patients with total hip arthroplasties (THAs). We analyzed register data, revision risk, and related factors in patients 21 years or younger with THAs in the Nordic Arthroplasty Register Association (NARA). <p><i>Patients and methods — </i>We included all THA patients 21 years or younger reported during 1995 ...
  • Predictors of early mortality after transcatheter aortic valve implantation 

    Kjønås, Didrik; Dahle, Gry; Schirmer, Henrik; Malm, Siri; Eidet, Jo; Aaberge, Lars; Steigen, Terje; Aakhus, Svend; Busund, Rolf; Rösner, Assami (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-23)
    <p><i>Objectives - </i>To investigate whether preoperative echocardiographic evaluation of ventricular function, especially right ventricular systolic and diastolic parameters including speckle-tracking analysis, could aid in the prediction of 30-day mortality after transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis. <p><i>Methods - </i>This is a prospective observational ...
  • Relationship between level of CPR training, self-reported skills, and actual manikin test performance—an observational study 

    Lund-Kordahl, Inger; Mathiassen, Maria; Melau, Jørgen; Olasveengen, Theresa M.; Sunde, Kjetil; Fredriksen, Knut (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-10)
    <p><i>Background - </i>Quality of bystander cardiopulmonary resuscitation (CPR) skills may influence out of hospital cardiac arrest (OHCA) outcomes. We analyzed how the level of CPR training related to indicators of good CPR quality and also the relationship between self-reported skills and actual CPR performance. <p><i>Methods - </i>Two hundred thirty-seven persons trained in standardized BLS ...
  • Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure 

    Stubnova, Viera; Os, Ingrid; Høieggen, Aud; Solbu, Marit Dahl; Grundtvig, Morten; Westheim, Arne; Atar, Dan; Waldum-Grevbo, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-05)
    <p><i>Background - </i>Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. The purpose of the study was to investigate if SUA was an independent predictor of 5-year all-cause mortality in a propensity score matched cohort of chronic heart failure ...
  • Associations Between the Use of eHealth and Out-of-Hours Services in People With Type 1 Diabetes: Cross-Sectional Study 

    Hansen, Anne Helen; Claudi, Tor; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-21)
    <p><i>Background - </i>Despite the increasing prevalence of diabetes and the increasing use of eHealth, little is known about the association between provider-based health services and eHealth among people with diabetes. This is the second study in a project exploring the associations between the use of eHealth and the use of provider-based health services. <p><i>Objective - </i>The objective of ...
  • Novel GTF2I-PDGFRB and IKZF1-TYW1 fusions in pediatric leukemia with normal karyotype 

    Panagopoulos, Ioannis; Brunetti, Marta; Stoltenberg, Margrethe; Strandabø, Rønnaug; Staurseth, Julie; Andersen, Kristin; Kostolomov, Ilya; Hveem, Tarjei Sveinsgjerd; Lorenz, Susanne; Nystad, Tove Anita; Flægstad, Trond; Micci, Francesca; Heim, Sverre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-29)
    <i>Background</i> - Many cases of acute lymphoblastic leukemia (ALL) carry visible acquired chromosomal changes of pathogenetic, diagnostic, and prognostic importance. Nevertheless, from one-fourth to half of newly diagnosed ALL patients have no visible chromosomal changes detectable by G-banding analysis at diagnosis. The introduction of powerful molecular methodologies has shown that many ...
  • Patients' experiences of remote communication after pacemaker implant: The NORDLAND study 

    Catalán-Matamoros, Daniel; Lopez-Villegas, Antonio; Lappegård, Knut Tore; Lopez-Liria, Remedios (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-20)
    <i>Background</i> - The concept of ‘patient experience’ has become central to how to improve healthcare. Remote communication with patients is today a frequent practice in healthcare services, showing similar outcomes to standard outpatient care while enabling cost reduction in both formal and informal care. The purpose of this study was to analyse the experiences of people with telemonitoring ...
  • D-Dimer Measured at Diagnosis of Venous Thromboembolism is Associated with Risk of Major Bleeding 

    Johnsen, Håkon Sanbukt; Hindberg, Kristian; Bjøri, Esben; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-25)
    Identification of patients at risk of major bleeding is pivotal for optimal management of anticoagulant therapy in venous thromboembolism (VTE). Studies have suggested that D-dimer may predict major bleeding during anticoagulation; however, this is scarcely investigated in VTE patients. We aimed to investigate the role of D-dimer, measured at VTE diagnosis, as a predictive biomarker of major bleeding. ...

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