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norskInstitutt for klinisk medisin
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Disparities in casemix, acute interventions, discharge destinations and mortality of patients with traumatic brain injury between Europe and India
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-11)Background - Traumatic brain injury (TBI) is a major global health problem that disproportionally affects low- and middle-income countries. The needs for patients with TBI therefore may differ between levels of national development. We aimed to describe differences in epidemiology and acute care provision of TBI between India and Europe.<p> <p>Methods - We used data from two prospective observational ... -
Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-17)Background - The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation in patients with TBI have not improved patient outcomes.<p> <p>Methods - Serum and plasma samples from two prospective, multi-centre observational studies of patients with TBI were used to discover ... -
Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injury
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-26)Background - Traumatic brain injury is conventionally categorised as mild, moderate, or severe on the Glasgow Coma Scale (GCS). Recently developed biomarkers can provide more objective and nuanced measures of the extent of brain injury.<p> <p>Methods - Exposure–response relationships were investigated in 2479 patients aged ≥16 enrolled in the Collaborative European NeuroTrauma Effectiveness ... -
Systolic Function in the Fontan Circulation Is Exercise, but Not Preload, Recruitable
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-15)Background - Fontan circulatory failure with impaired systolic function is well documented; however, its mechanisms are not fully understood. The aim of this study was to explore myocardial functional reserve in adolescent patients with Fontan circulation in response to exercise or acute preload increase.<p> <p>Methods - The study included 32 patients (median age, 16.7 years; range, 15.4–17.9 years; ... -
Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-27)Background - The Bari-SolidAct randomized controlled trial compared baricitinib with placebo in patients with severe COVID-19. A post hoc analysis revealed a higher incidence of serious adverse events (SAEs) among SARS-CoV-2-vaccinated participants who had received baricitinib. This sub-study aimed to investigate whether vaccination influences the safety profile of baricitinib in patients with severe ... -
Increased Herpes simplex virus 1, Toxoplasma gondii and Cytomegalovirus antibody concentrations in severe mental illness
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-18)Infections with Cytomegalovirus (CMV), Herpes simplex virus 1 (HSV1) and Toxoplasma gondii (TG) have been implicated in severe mental illness. All three pathogens have high seroprevalence in the human population, are neurotropic and establish a persistent infection. We hypothesized that exposed (seropositive) patients with severe mental illness would show higher immunoglobulin G (IgG) concentrations ... -
Surgery for intestinal injuries in very preterm infants: a Norwegian population-based study with a new approach to disease classification
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-18)Objective To evaluate population-based data on very preterm infants (<32 weeks gestation) operated for intestinal injuries, focusing on necrotising enterocolitis (NEC) and focal intestinal perforation (FIP).<p> <p>Design Nationwide, population-based registry cohort study. <p>Setting All 21 neonatal units in Norway. <p>Participants All very preterm infants born from 2014 through 2021 and ... -
Validity of dietary intake methods in cancer cachexia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024)Purpose of review: Accurate assessment of dietary intake, especially energy and protein intake, is crucial for optimizing nutritional care and outcomes in patients with cancer. Validation of dietary assessment methods is necessary to ensure accuracy, but the validity of these methods in patients with cancer, and especially in those with cancer cachexia, is uncertain. Validating nutritional intake ... -
High density of TCF1+ stem-like tumor-infiltrating lymphocytes is associated with favorable disease-specific survival in NSCLC
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-19)Introduction: Tumor-infiltrating lymphocytes are both prognostic and predictive biomarkers for immunotherapy response. However, less is known about the survival benefits of their subpopulations.<p> <p>Methods: Using machine learning models, we assessed the clinical association of the CD8+, PD1+, TCF1+ cel l subset by multiplex immunohistochemistry using tissue microarrays in 553 non-small cell ... -
Labor curves based on cervical dilatation over time and their accuracy and effectiveness: A systematic scoping review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-22)Objectives: This systematic scoping review was conducted to 1) identify and describe labor curves that illustrate cervical dilatation over time; 2) map any evidence for, as well as outcomes used to evaluate the accuracy and effectiveness of the curves; and 3) identify areas in research that require further investigation.<p><p> Methods: A three-step systematic literature search was conducted for ... -
How well can the fetal heart rate baseline be assessed by intrapartum intermittent auscultation? An interrater reliability and agreement study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-20)Background: We aimed to examine the inter-reliability and agreement among midwives when assessing the fetal heart rate (FHR) using the handheld Doppler. The primary aim was to measure the reliability and agreement of FHR baseline (baseline) as beats per minute (bpm). The secondary aims were to measure fluctuations from the baseline, defined as increases and decreases, and classifications ... -
Incidence and genetic risk of juvenile idiopathic arthritis in Norway by latitude
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-21)Objective: We aimed to investigate the incidence of juvenile idiopathic arthritis (JIA) in the three geographic regions of Norway and whether potential regional incidence differences are explained by environmental or genetic factors across regions. <p><p>Methods: We conducted a register-based cohort study including all Norwegian children born from 2004 to 2019, with follow-up throughout 2020. The ... -
Geografiske forskjeller i trombolysebehandling ved akutt hjerneinfarkt
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-16)Bakgrunn - Trombolysebehandling tidligst mulig etter symptomstart påvirker behandlingsresultatet ved akutt hjerneinfarkt. Målet med studien var å kartlegge om avstanden fra sykehus påvirker trombolysetilbudet ved akutt hjerneinfarkt ved Universitetssykehuset Nord-Norge Tromsø.<p> <p>Materiale og metode - I denne prospektive kvalitetsstudien inkluderte vi 231 pasienter innlagt med akutt hjerneinfarkt ... -
Transcranial direct current stimulation (tDCS) enhances cognitive function in schizophrenia: A randomized double-blind sham-controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-02)This study aimed to examine the cognitive effects of tDCS and the subjective cognitive improvement perceived by patients with schizophrenia. A total of 173 outpatients diagnosed with schizophrenia were recruited for this double-blind, randomized, placebo-controlled trial. Two different stimulation modes were applied: 2 mA 20 minutes active tDCS and sham tDCS. Ten daily sessions over 10 consecutive ... -
Characteristics That Predict Psoriatic Arthritis by the Classification Criteria for Psoriatic Arthritis in Patients With Juvenile Idiopathic Arthritis 18 Years After Disease Onset
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-10)Objective. The purposes of this study were to assess the clinical characteristics of patients with juvenile idiopathic arthritis (JIA) who fulfill the ClASsification criteria for Psoriatic ARthritis (CASPAR) 18 years after disease onset in a population-based setting and to identify features likely to predict psoriatic arthritis (PsA).<p> <p>Methods. Patients with JIA from defined geographic regions ... -
A hands-free carotid Doppler can identify spontaneous circulation without interrupting cardiopulmonary resuscitation: an animal study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-27)Background Identifying spontaneous circulation during cardiopulmonary resuscitation (CPR) is challenging. Current methods, which involve intermittent and time-consuming pulse checks, necessitate pauses in chest compressions. This issue is problematic in both in-hospital cardiac arrest and out-of-hospital cardiac arrest situations, where resources for identifying circulation during CPR may be limited. ... -
What is it all about? An explorative study of patients’ experiences with medication free treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-02)Background As a response to the political decision by the Norwegian Ministry of Health and Care Services to establish some kind of“medication free treatment” for patients with severe mental illness throughout the country, a 6-bed ward unit dedicated to offer such treatment was in 2017 established in Tromsø, Norway by the North Norway Health Care Region. The aim of the present study was to explore ... -
The annual trend of suicide rates from 2010 to 2021 in patients with cannabis use disorder – a national registry study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-28)Purpose - The temporal trend of suicide in patients with cannabis use disorder (CUD) is important to investigate, considering the recent increases in THC concentration in cannabis products. This study describes the annual suicide rates in patients with CUD from 2010 to 2021. To investigate if any change in suicide rate was specific to CUD, we compared these suicide rates with corresponding data for ... -
Development of brain metastases in patients managed with non-curative thoracic radiotherapy for stage II/III non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-27)Background - This retrospective study analyzed the incidence of subsequent brain metastases after palliative radiotherapy or chemoradiation in patients with stage II/III non-small cell lung cancer (NSCLC). Risk factors for brain metastases development and survival after diagnosis were evaluated.<p> <p>Methods - Different baseline parameters including but not limited to age, stage and target volume ... -
P314 TNF gene activation used as criterion to discontinue biologic therapy – A patient series introducing the NovaPrime TNF kit
(Conference object; Konferansebidrag, 2021-05-27)<p><i>Background - </i>Severe inflammatory bowel disease can be successfully treated with biologic drugs such as anti-TNF. However, there is no consensus on if and how to stop treatment. Our group has earlier shown that normalization of TNF gene expression may be a beneficial prognostic factor when attempting to discontinue biologic therapy. We here present data from a series of patients in endoscopic ...
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