Nye registreringer

  • Transforming growth factor beta (TGF‑β)in adolescent chronic fatigue syndrome 

    Wyller, Vegard Brunn; Ngyuen, Chinh Bkrong; Ludviksen, Judith Anita; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-04)
    <i>Background</i>: Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a recent meta-analysis of 38 articles found that of 77 diferent cytokines measured in plasma, transforming growth factor beta (TGF-β) was the only one that was elevated in patients ...
  • Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome 

    Thomas, Anub Mathew; Schjalm, Camilla; Nilsson, Per; Lindenskov, Paal Helge H.; Rørtveit, Runa; Solberg, Rønnaug; Saugstad, Ola Didrik; Berglund, Magnus M.; Strömberg, Patrik; Lau, Corinna; Espevik, Terje; Jansen, Johan Høgset; Castellheim, Albert; Mollnes, Tom Eirik; Barratt-Due, Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-27)
    <p><i>Background</i>: Meconium aspiration syndrome (MAS) is a severe lung condition affecting newborns and it can lead to a systemic inflammatory response. We previously documented complement activation and cytokine release in a piglet MAS model. Additionally, we showed ex vivo that meconium-induced inflammation was dependent on complement and Toll-like receptors.</p> <p><i>Objectives</i>: To ...
  • Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes 

    Wibroe, Peter Popp; Anselmo, Aaron C; Nilsson, Per; Sarode, Apoorva; Gupta, Vivek; Urbanics, Rudolf; Szebeni, Janos; Hunter, Alan Christy; Mitragotri, Samir; Mollnes, Tom Eirik; Moghimi, Seyed Moein (Journal article; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-04-10)
    Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are highly reproducible in pigs. Although the underlying mechanisms are poorly understood, roles for both the complement system and reactive macrophages have been implicated. Here, we show the dominance and importance of robust ...
  • Cerebral aneurysm morphology before and after rupture: nation-wide case series of 29 aneurysms 

    Skodvin, Torbjørn Øygard; Johnsen, Liv-Hege; Gjertsen, Øivind; Isaksen, Jørgen Gjernes; Sorteberg, Angelika (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-06)
    <p><i>Background and Purpose</i>: Using postrupture morphology to predict rupture risk of an intracranial aneurysm may be inaccurate because of possible morphological changes at or around the time of rupture. The present study aims at comparing morphology from angiograms obtained prior to and just after rupture and to evaluate whether postrupture morphology is an adequate surrogate for rupture ...
  • Normal magnetic resonance appearances of the temporomandibular joints in children and young adults aged 2–18 years 

    Angenete, Oskar W; Augdal, Thomas Angell; Jellestad, Stig; Rygg, Marite; Rosendahl, Karen (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-12)
    <p><i>Background</i>: Knowledge of normal appearances of the temporomandibular joint (TMJ) is paramount when assessing the joint for disease in juvenile idiopathic arthritis. Reliable features defining normal TMJs in children are limited.</p> <p><i>Objective</i>: To establish reliable normal standards for the TMJ at magnetic resonance imaging (MRI).</p> <p><i>Materials and methods</i>: We ...
  • Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study 

    Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål; Åsvold, Bjørn Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-06)
    <p><i>Background</i>: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals.</p> <p><i>Methods</i>: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control ...
  • Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke 

    Hald, Erin Mathiesen; Rinde, Ludvig Balteskard; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
    <p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ...
  • Prognostic Impact of the Tumor Marker CA 15-3 in Patients With Breast Cancer and Bone Metastases Treated With Palliative Radiotherapy 

    Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor; Mannsåker, Bård; Pawinski, Adam (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-25)
    <p><i>Background</i>: The aim of the study was to explore the prognostic impact of different abnormal blood tests and the tumor marker CA 15-3 as well as established parameters such as disease extent and receptor status in patients with bone metastases from breast cancer who received palliative radiotherapy in addition to contemporary systemic treatment.</p> <p><i>Methods</i>: This was a ...
  • Myocardial infarction and future risk of cancer in the general population—the Tromsø Study 

    Rinde, Ludvig Balteskard; Småbrekke, Birgit; Mathisen Hald, Erin; Brodin, Ellen Elisabeth; Njølstad, Inger; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Vik, Anders; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
    The association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, ...
  • Serum osteoprotegerin and renal function in the general population: The Tromsø Study 

    Vik, Anders; Brodin, Ellen Elisabeth; Mathiesen, Ellisiv B.; Brox, Jan; Jørgensen, Lone; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-03)
    <p><i>Background</i>: Serum osteoprotegerin (OPG) is elevated in patients with chronic kidney disease (CKD) and increases with decreasing renal function. However, there are limited data regarding the association between OPG and renal function in the general population. The aim of the present study was to explore the relation between serum OPG and renal function in subjects recruited from the general ...
  • Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines – Consequences for defining reference values in healthy humans 

    Hennø, Linda Torrissen; Storjord, Elin; Christiansen, Dorte; Bergseth, Grete; Ludviksen, Judith K; Fure, Hilde; Barene, Svein; Nielsen, Erik Waage; Mollnes, Tom Eirik; Brekke, Ole Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-06)
    Cytokines are potentially useful biomarkers of sepsis and other inflammatory conditions. Many cytokines can be released by leukocytes and platelets after sampling. The sampling and processing techniques are consequently critically important to measure the <i>in vivo</i> levels. We therefore examined the effects of four different anticoagulants, EDTA, citrate, lepirudin, heparin compared to serum, ...
  • An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistance 

    Fjellaksel, Richard; Dugalic, Damir; Demissie, Taye Beyene; Riss, Patrick; Hjelstuen, Ole Kristian; Sundset, Rune; Hansen, Jørn H (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-28)
    Herein, we report a straightforward sequential acylation‐Finkelstein approach to achieve iodination of amine containing bioactives. The utility was demonstrated by successful radiolabelling with <sup>123</sup>I in high radiochemical yield. Moreover, microwave‐assisted Finkelstein reaction can be employed to enhance conversion and reaction rates to obtain the desired iodides. The method is of interest ...
  • The interplay between global standards and local practice in nursing 

    Meum, Torbjørg; Ellingsen, Gunnar; Monteiro, Eric; Wangensteen, Gro; Igesund, Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-05-17)
    <p><i>Purpose</i>: The paper assesses the extent, form, and transformation of global nursing classifications (NANDA) in a nursing practice during a period of 5 years.</p> <p><i>Method</i>: A longitudinal case study was used to trace implementation, adoption and use of nursing classifications as an integral part of an electronic nursing module. A mixed method of data collection was used, including ...
  • A randomized trial of telemedicine efficacy and safety for nonacute headaches 

    Müller, Kai Ivar; Alstadhaug, Karl Bjørnar; Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-11)
    <p><i>Objective</i>: To evaluate long-term treatment efficacy and safety of one-time telemedicine consultations for nonacute headaches.</p> <p><i>Methods</i>: We randomized, allocated, and consulted nonacute headache patients via telemedicine (n = 200) or in a traditional manner (n = 202) in a noninferiority trial. Efficacy endpoints, assessed by questionnaires at 3 and 12 months, included change ...
  • Criteria for failure and worsening after surgery for lumbar disc herniation: a multicenter observational study based on data from the Norwegian Registry for Spine Surgery 

    Werner, David A. T.; Grotle, Margreth; Gulati, Sasha; Austevoll, Ivar M.; Lønne, Greger; Nygaard, Øystein P.; Solberg, Tore K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-14)
    PURPOSE: In clinical decision-making, it is crucial to discuss the probability of adverse outcomes with the patient. A large proportion of the outcomes are difficult to classify as either failure or success. Consequently, cutoff values in patient-reported outcome measures (PROMs) for "failure" and "worsening" are likely to be different from those of "non-success". The aim of this study was to identify ...
  • Long-term dropout from school and work and mental health in young adults in Norway: A qualitative interview-based study 

    Ramsdal, Gro Hilde; Bergvik, Svein; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-02)
    School dropout is related to difficult life trajectories in Western society. Developing effective preventive interventions is urgent. Nevertheless, few studies have interviewed unemployed young adults in the aftermath of school dropout to understand their experiences with influential factors. We interviewed seven former students two to five years after they had dropped out and seven same-aged students ...
  • More histologic and ultrastructural degenerative signs in the subscapularis tendon and the joint capsule in male patients with shoulder impingement 

    Farfaras, Stefanos; Ejerhed, Lars Erik; Hallström, Erling; Hultenby, Kjell; Meknas, Khaled; Movin, Tomas; Papdogiannakis, Nikos; Kartus, Jüri Toomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)
    <p><i>Purpose</i>: The purpose of the present study was to analyze biopsy samples from the subscapularis tendon and from the joint capsule from male patients with shoulder impingement syndrome (SAIS) and compare them with samples from male patients with post-traumatic recurrent shoulder instability. The hypothesis of the study was that patients with SAIS would have more histologic and ultrastructural ...
  • Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement 

    Hauge, Karoline Kråkmo; Dahle, Gry; Bendz, Bjørn; Halvorsen, Per Steinar; Abdelnoor, Michael; Mollnes, Tom Eirik; Fosse, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-12)
    <i>Objectives</i>. The inflammatory response to on-pump cardiac surgery is well known. Systemic inflammatory response syndrome after transcatheter valve implantation (TAVI) has been reported. The objective of this study was to study the inflammatory response during TAVI, and compare with the response during surgical aortic valve replacement. <i>Methods</i>. Eighteen patients undergoing transcatheter ...
  • First-aid training in school: amount, content and hindrances 

    Bakke, Håkon Kvåle; Bakke, Harald Kvåle; Bjørlo Schwebs, Runa (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-17)
    <p><i>Background</i>: To increase knowledge and competence about first aid in the population, first‐aid instruction is included in primary and secondary school curricula. This study aimed to establish how much time is spent on first‐aid training, which first‐aid measures are taught, and which factors prevent teachers from providing the quantity and quality of first‐aid training that they wish to ...
  • CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases 

    Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rakaee, Mehrdad; Richardsen, Elin; Hald, Sigurd; Andersen, Sigve; Busund, Lill-Tove; Bremnes, Roy M.; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-13)
    The immune checkpoint receptor CTLA-4 plays a crucial part in negatively regulating T cell activation and maintaining self-tolerance. It is frequently overexpressed in a variety of malignancies, yet its prognostic impact in non-small cell lung cancer (NSCLC) remains unclear. We constructed tissue microarrays from tumor tissue samples and evaluated the immunohistochemical expression of CTLA-4 in 536 ...

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