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norskArtikler, rapporter og annet (klinisk medisin)
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Immunological signatures from irradiated cancer-associated fibroblasts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-06)Introduction: Cancer-associated fibroblasts (CAFs) are abundant and influential elements of the tumor microenvironment (TME), giving support to tumor development in multiple ways. Among other mechanisms, CAFs are important regulators of immunological processes occurring in tumors. However, CAF-mediated tumor immunomodulation in the context of radiotherapy remains poorly understood. In this study, ... -
Neonatal Ultrasound and Radiographic Markers of Hip Dysplasia in Young Adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-19)OBJECTIVES - To examine radiologic outcomes at skeletal maturity of sonographically normal, immature, mildly, and severely dysplastic newborn hips.<p> <p>METHODS - During 1988 to 1990, 11 925 newborns were enrolled in a randomized controlled trial examining screening strategies for developmental hip dysplasia. In total, 4469 were invited to clinical and radiologic follow-up 18 years later, of ... -
General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-29)Background - Adiposity can be measured using BMI (which is based on weight and height) as well as indices of abdominal adiposity. We examined the association between BMI and waist-to-height ratio (WHtR) within and across populations of different world regions and quantified how well these two metrics discriminate between people with and without hypertension.<p> <p>Methods - We used data from ... -
Exploring Interaction between Genetically Predicted Body Mass Index and Serum 25-Hydroxyvitamin D Levels on the Odds for Psoriasis in UK Biobank and the HUNT Study: A Factorial Mendelian Randomization Study
(Journal article; Tidsskriftartikkel, 2025-12-03)Mendelian randomisation (MR) studies show that higher body mass index (BMI) and lower 25-hydroxyvitamin D (25[OH]D) increase psoriasis risk. The combined effect of these factors has not been explored using factorial MR. Using cross-sectional data from UK Biobank (UKB, n=398 404) and the Trøndelag Health Study (HUNT, n=86 648), we calculated polygenic risk scores for BMI and 25(OH)D to estimate odds ... -
Sensorineural hearing impairment among preterm children: a Norwegian population-based study
(Journal article; Tidsskriftartikkel, 2024-06-05)<p><i>Objective</i> To investigate the risk for sensorineural hearing impairment (SNHI) in preterm infants, and to what extent the risk is attributed to perinatal morbidities and therapies. <p><i>Design</i> Population-based cohort study using data from several nationwide registries. <p><i>Setting</i> Norwegian birth cohort 1999–2014, with data on SNHI until 2019. <p><i>Participants</i> 60 023 ... -
Evaluating the efficacy of endotracheal and intranasal epinephrine administration in severely asphyxic bradycardic newborn lambs: a randomised preclinical study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-04)Objective - Intravenous epinephrine administration is preferred during neonatal resuscitation, but may not always be rapidly administered due to lack of equipment or trained staff. We aimed to compare the time to return of spontaneous circulation (ROSC) and post-ROSC haemodynamics between intravenous, endotracheal (ET) and intranasal (IN) epinephrine in severely asphyxic, bradycardic newborn ... -
Deep learning-assisted two-dimensional transperineal ultrasound for analyzing bladder neck motion in women with stress urinary incontinence
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-07-18)Background - No universally recognized transperineal ultrasound parameters are available for evaluating stress urinary incontinence. The information captured by commonly used perineal ultrasound parameters is limited and insufficient for a comprehensive assessment of stress urinary incontinence. Although bladder neck motion plays a major role in stress urinary incontinence, objective and visual ... -
Exploring surgical infection prediction: A comparative study of established risk indexes and a novel model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-05)Background - Surgical site infections are a major health problem that deteriorates the patients’ health and increases health care costs. A reliable method to identify patients with modifiable risk of surgical site infection is necessary to reduce the incidence of them but data are limited. Hence the objective is to assess the predictive validity of a logistic regression model compared to risk indexes ... -
The Plasma Proteome and Risk of Future Venous Thromboembolism—Results from the HUNT Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-18)Background - This study aimed to identify novel plasma proteins associated with first-lifetime venous thromboembolism (VTE) and molecular pathways involved in VTE pathogenesis.<p> <p>Methods - A case–cohort comprising incident VTE cases (n = 294) and a randomly sampled age- and sex-weighted subcohort (n = 1,066) was derived from the Trøndelag Health Study (HUNT3, n = 50,800). Blood samples were ... -
Association of Psychological Problems for Which Help Was Sought With Physical Illness
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-10)Introduction - Persons with mental disorders are at increased risk for physical illness. Individuals who seek help for psychological problems might benefit from timely support and interventional approaches. This study aimed to explore the associations between psychological problems for which help was sought and physical illness.<p> <p>Methods - The 7th survey of the Tromsø Study, which included ... -
Pain prevalence rates and the mediating role of negative affect in adults referred to personality disorder treatment: A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-29)Personality disorders (PDs) are prevalent among individuals with chronic pain, but less is known about the prevalence of pain in the PD population. This study therefore sought to explore the prevalence of current or everyday pain among individuals referred to outpatient PD treatment, and further explore the mediating role of negative affect in the relationship between PD severity and current pain. ... -
Spesialistutdanning av kardiologer i Norge - en spørreundersøkelse
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024)Spesialisering innen hjertesykdommer har over lengre tid vært populært og rekrutteringssterkt, men det er ingen oversikt over hvor mange leger i spesialisering (LIS) i hjertesykdommer som jobber ved norske sykehus. Det er også til en viss grad uvisst hvordan LIS i hjertesykdommer opplever spesialiseringsløpet, arbeidsforholdene og arbeidsmiljø. I et forsøk på å kartlegge disse forholdene sendte ... -
β-adrenergic stimulation after rewarming does not mitigate hypothermia-induced contractile dysfunction in rat cardiomyocytes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-25)Victims of severe accidental hypothermia are frequently treated with catecholamines to counteract the hemodynamic instability associated with hypothermia-induced cardiac contractile dysfunction. However, we previously reported that the inotropic effects of epinephrine are diminished after hypothermia and rewarming (H/R) in an intact animal model. Thus, the goal of this study was to investigate the ... -
A practical approach to uveitis screening in children with juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-04)Background - Juvenile idiopathic arthritis (JIA)-associated uveitis typically presents as a silent chronic anterior uveitis and can lead to blindness. Adherence to current screening guidelines is hampered by complex protocols which rely on the knowledge of specific JIA characteristics. The Multinational Interdisciplinary Working Group for Uveitis in Childhood identified the need to simplify screening ... -
How female therapists and their patients deal with being a disputable, unimaginable, or occasional Swede: Explorations of similarity of non- privilege
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-24)In this qualitative study, conducted in Sweden, the authors investigated therapists´ experiences of therapeutic dyads in which both therapist and patient identified with a non-normative ethnicity, migration experience, racial identity, or experience of racialization. Inclusion criteria were based on the concepts of "similarity of nonprivilege" (Fors, 2018) and on Mattsson´s (2005) concept of ... -
Worldwide trends in the underweight and obesity from 1990 to 2022: a pooled analysis of 3,633 population-representative studies with 222 million school-aged children, adolescents, and adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-29)Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million ... -
Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-24)Background - Scientific and clinical interest in extracellular vesicles (EVs) is growing. EVs that expose tissue factor (TF) bind factor VII/VIIa and can trigger coagulation. Highly procoagulant TF-exposing EVs are detectable in the circulation in various diseases, such as sepsis, COVID-19, or cancer. Many in-house and commercially available assays have been developed to measure EV-TF activity and ... -
Cognitive Screening for Mild Cognitive Impairment: Clinician Perspectives on Current Practices and Future Directions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-04)This study surveyed 51 specialist clinicians for their views on existing cognitive screening tests for mild cognitive impairment and their opinions about a hypothetical remote screener driven by artificial intelligence (AI). Responses revealed significant concerns regarding the sensitivity, specificity, and time taken to administer current tests, along with a general willingness to consider adopting ... -
High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-13)MicroRNA-145 (miR-145) has been reported to downregulate the expression of tissue factor and factor XI in vitro and decrease venous thrombus formation in animal models. However, the association between miR-145 and risk of future venous thromboembolism (VTE) in the general population remains unknown. We investigated the association between plasma levels of miR-145 and risk of future VTE in a case-cohort ... -
Extending the Lund-Malmö creatinine-based GFR equation to cystatin C–validation results from the European Kidney Function Consortium (EKFC) cohort of children and adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-08)The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMR<sub>Cys</sub>) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n = 2,293) and adults (n = 7,727). Rescaling was obtained by dividing each biomarker by a Q-value, representing the population-specific median biomarker level among healthy ...
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