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Nye registreringer

  • Non-linear optical microscopy as a novel quantitative and label-free imaging modality to improve the assessment of tissue-engineered cartilage 

    Martinez, Inigo Zubiavrre; Islam, Ashraful; Elisabeth, Romijn; Lilledahl, Magnus Borstad (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10)
    Objective: <br>Current systems to evaluate outcomes from tissue-engineered cartilage (TEC) are sub-optimal. The main purpose of our study was to demonstrate the use of second harmonic generation (SHG) microscopy as a novel quantitative approach to assess collagen deposition in laboratory made cartilage constructs. <br>Methods: <br>Scaffold-free cartilage constructs were obtained by condensation ...
  • Violence and child mental health in Brazil: The Itaboraí Youth Study methods and findings 

    Bordin, Isabel AS; Duarte, Cristiane S.; Ribeiro, W.S.; Paula, C.S.; Coutinho, Evandro Silva Freire; Sourander, A; Rønning, John Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-17)
    <p><i>Objectives</i>: To demonstrate a study design that could be useful in low‐resource and violent urban settings and to estimate the prevalence of child violence exposure (at home, community, and school) and child mental health problems in a low‐income medium‐size city.</p> <p><i>Methods</i>: The Itaboraí Youth Study is a Norway–Brazil collaborative longitudinal study conducted in Itaboraí ...
  • Survival in Limited Disease Small Cell Lung Cancer According to N3 Lymph Node Involvement 

    Valan, Christine Damgaard; Slagsvold, Jens Erik; Halvorsen, Tarje Onsøien; Herje, Martin; Bremnes, Roy M.; Brunsvig, Paal Fr.; Brustugun, Odd Terje; Fløtten, Øystein; Levin, Nina; Sundstrøm, Stein Harald; Grønberg, Bjørn Henning (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02)
    Background/Aim: <br>There are several definitions of limited disease (LD) in small cell lung cancer (SCLC), differing with respect to N3 disease accepted. We analyzed patients from a randomized trial comparing two schedules of thoracic radiotherapy (TRT) in LD SCLC to investigate whether there were survival differences between N3 subcategories (n=144). Patients and <br>Methods: <br>Patients ...
  • Routine deferred computed tomography for patients with suspected urolithiasis is low-value healthcare 

    Rosenlund, Ingvild Mathiesen; Førde, Olav Helge; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-23)
    Objective: <br>The aim of this study was to investigate the benefits of deferred routine computed tomography of the kidneys, ureters and bladder (CT KUB) for patients with a self-limiting episode of suspected urolithiasis.<br> Materials and methods: <br>The study comprised a case series of consecutive patients examined with deferred routine CT KUB for control of suspected urolithiasis. Patients ...
  • Kurativ kateterbehandling av atrieflimmer 

    Ohm, Ole-Jørgen; Gjesdal, Knut; Rossvoll, Ole; Bugge, Einar; Berntsen, Rolf Frank; Vist, Gunn Elisabeth; Johansen, Marit; Norderhaug, Inger Natvig (Research report, 2006)
    Atrieflimmer er den hyppigst forekommende hjerterytmeforstyrrelse av klinisk betydning, og berører ca 45 000 pasienter i Norge. Medikamentell behandling gir tilfredsstillende effekt hos flertallet, men man må se etter alternativer for de som ikke tåler eller responderer på medikamenter. For disse kan kateterbehandling med bruk av for eksempel radiofrekvensablasjon være en mulighet. Radiofrekvensablasjon ...
  • Gas embolism during surgery. A complement mediated condition? 

    Storm, Benjamin Stage; Christiansen, Dorte; Dybwik, Knut; Mollnes, Tom Eirik; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-01)
    <p><i>Introduction</i>: Venous air embolism (VAE) may arise during surgical procedures. VAE might be complicated with a systemic inflammatory response, disseminated intervascular coagulation, multi-organ failure and cardiovascular collapse. During a short time-span, three patients at our institution developed signs of VAE in conjunction with gynecological surgery. One died, one developed severe ...
  • Carbon Dioxide Laser Treatment Using Methylene Blue–Assisted Sinus Tract Identification in Hidradenitis Suppurativa 

    Grimstad, Øystein; Ingvarsson, Gisli (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11)
    Keratinocytes and remnant of keratinocytes in nodules, abscesses, and sinus tracts are radically removed in surgical treatment of hidradenitis suppurativa.1 We are now using methylene blue in carbon dioxide laser surgery for patients with moderate to severe hidradenitis lesions (Hurley stage II-III). Methylene blue stains active inflammatory nodules and sinus tracts. We use a modified methylene blue ...
  • An evaluation by the Norwegian Health Care Supervision Authorities of events involving death or injuries in maternity care 

    Johansen, Lars Thomas; Braut, Geir Sverre; Andresen, Jan Fredrik; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-15)
    <p><i>Introduction</i>: We aimed to determine how serious adverse events in obstetrics were assessed by supervision authorities.</p> <p><i>Material and methods</i>: We selected cases investigated by supervision authorities during 2009‐2013. We analyzed information about who reported the event, the outcomes of the mother and infant, and whether events resulted from errors at the individual or ...
  • How clinicians make decisions about CTOs in ACT: a qualitative study 

    Stuen, Hanne Kilen; Landheim, Anne; Rugkåsa, Jorun; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-22)
    <p><i>Background</i>: The first 12 Norwegian assertive community treatment (ACT) teams were piloted from 2009 to 2011. Of the 338 patients included during the teams’ first year of operation, 38% were subject to community treatment orders (CTOs). In Norway as in many other Western countries, the use of CTOs is relatively high despite lack of robust evidence for their effectiveness. The purpose of the ...
  • Transforming growth factor beta (TGF‑β)in adolescent chronic fatigue syndrome 

    Wyller, Vegard Brunn; Ngyuen, Chinh Bkrong; Ludviksen, Judith Anita; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-04)
    <i>Background</i>: Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a recent meta-analysis of 38 articles found that of 77 diferent cytokines measured in plasma, transforming growth factor beta (TGF-β) was the only one that was elevated in patients ...
  • Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome 

    Thomas, Anub Mathew; Schjalm, Camilla; Nilsson, Per; Lindenskov, Paal Helge H.; Rørtveit, Runa; Solberg, Rønnaug; Saugstad, Ola Didrik; Berglund, Magnus M.; Strömberg, Patrik; Lau, Corinna; Espevik, Terje; Jansen, Johan Høgset; Castellheim, Albert; Mollnes, Tom Eirik; Barratt-Due, Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-27)
    <p><i>Background</i>: Meconium aspiration syndrome (MAS) is a severe lung condition affecting newborns and it can lead to a systemic inflammatory response. We previously documented complement activation and cytokine release in a piglet MAS model. Additionally, we showed ex vivo that meconium-induced inflammation was dependent on complement and Toll-like receptors.</p> <p><i>Objectives</i>: To ...
  • Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes 

    Wibroe, Peter Popp; Anselmo, Aaron C; Nilsson, Per; Sarode, Apoorva; Gupta, Vivek; Urbanics, Rudolf; Szebeni, Janos; Hunter, Alan Christy; Mitragotri, Samir; Mollnes, Tom Eirik; Moghimi, Seyed Moein (Journal article; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-04-10)
    Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are highly reproducible in pigs. Although the underlying mechanisms are poorly understood, roles for both the complement system and reactive macrophages have been implicated. Here, we show the dominance and importance of robust ...
  • Cerebral aneurysm morphology before and after rupture: nation-wide case series of 29 aneurysms 

    Skodvin, Torbjørn Øygard; Johnsen, Liv-Hege; Gjertsen, Øivind; Isaksen, Jørgen Gjernes; Sorteberg, Angelika (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-06)
    <p><i>Background and Purpose</i>: Using postrupture morphology to predict rupture risk of an intracranial aneurysm may be inaccurate because of possible morphological changes at or around the time of rupture. The present study aims at comparing morphology from angiograms obtained prior to and just after rupture and to evaluate whether postrupture morphology is an adequate surrogate for rupture ...
  • Normal magnetic resonance appearances of the temporomandibular joints in children and young adults aged 2–18 years 

    Angenete, Oskar W; Augdal, Thomas Angell; Jellestad, Stig; Rygg, Marite; Rosendahl, Karen (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-12)
    <p><i>Background</i>: Knowledge of normal appearances of the temporomandibular joint (TMJ) is paramount when assessing the joint for disease in juvenile idiopathic arthritis. Reliable features defining normal TMJs in children are limited.</p> <p><i>Objective</i>: To establish reliable normal standards for the TMJ at magnetic resonance imaging (MRI).</p> <p><i>Materials and methods</i>: We ...
  • Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study 

    Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål; Åsvold, Bjørn Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-06)
    <p><i>Background</i>: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals.</p> <p><i>Methods</i>: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control ...
  • Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke 

    Hald, Erin Mathiesen; Rinde, Ludvig Balteskard; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
    <p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ...
  • Prognostic Impact of the Tumor Marker CA 15-3 in Patients With Breast Cancer and Bone Metastases Treated With Palliative Radiotherapy 

    Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor; Mannsåker, Bård; Pawinski, Adam (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-25)
    <p><i>Background</i>: The aim of the study was to explore the prognostic impact of different abnormal blood tests and the tumor marker CA 15-3 as well as established parameters such as disease extent and receptor status in patients with bone metastases from breast cancer who received palliative radiotherapy in addition to contemporary systemic treatment.</p> <p><i>Methods</i>: This was a ...
  • Myocardial infarction and future risk of cancer in the general population—the Tromsø Study 

    Rinde, Ludvig Balteskard; Småbrekke, Birgit; Mathisen Hald, Erin; Brodin, Ellen Elisabeth; Njølstad, Inger; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Vik, Anders; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
    The association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, ...
  • Serum osteoprotegerin and renal function in the general population: The Tromsø Study 

    Vik, Anders; Brodin, Ellen Elisabeth; Mathiesen, Ellisiv B.; Brox, Jan; Jørgensen, Lone; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-03)
    <p><i>Background</i>: Serum osteoprotegerin (OPG) is elevated in patients with chronic kidney disease (CKD) and increases with decreasing renal function. However, there are limited data regarding the association between OPG and renal function in the general population. The aim of the present study was to explore the relation between serum OPG and renal function in subjects recruited from the general ...
  • Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines – Consequences for defining reference values in healthy humans 

    Hennø, Linda Torrissen; Storjord, Elin; Christiansen, Dorte; Bergseth, Grete; Ludviksen, Judith K; Fure, Hilde; Barene, Svein; Nielsen, Erik Waage; Mollnes, Tom Eirik; Brekke, Ole Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-06)
    Cytokines are potentially useful biomarkers of sepsis and other inflammatory conditions. Many cytokines can be released by leukocytes and platelets after sampling. The sampling and processing techniques are consequently critically important to measure the <i>in vivo</i> levels. We therefore examined the effects of four different anticoagulants, EDTA, citrate, lepirudin, heparin compared to serum, ...

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