Recent additions

  • Management of patients with metastatic prostate cancer (mPC) in a rural part of North Norway with a scattered population: does living near the department of oncology translate into a different pattern of care and survival? 

    Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor Christin; Norum, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-23)
    The goal of the Norwegian Ministry of Health and Care Services is to offer an equal health-care service with the same outcomes wherever people are living within the country. The aim of this study was to evaluate whether this was true for patients diagnosed with metastatic prostate cancer (mPC) and living in Nordland County, a region with a challenging geography and climate and having, several small ...
  • Health-related quality of life after extracorporeal membrane oxygenation: a single centre's experience 

    Ørbo, Marte; Karlsen, Sidsel Fredheim; Pedersen, Ellinor Phillips; Hermansen, Stig Eggen; Rønning, Per Bjørnerud; Aas, Kathrine Nergård; Næsheim, Torvind; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-07)
    <i>Aims</i>: The aims of this study were to evaluate health-related quality of life (HRQL) among patients treated with extracorpo-real membrane oxygenation (ECMO) in northern Norway over a period of 27years (1988–2015) and to identify variables related to HRQL.<p> <p><i>Methods and results</i>: A retrospective inquiry of the ECMO registry at the University Hospital of North Norway identified 74 ...
  • The Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Study 

    Morelli, Vania Maris; Sejrup, Joakim Knutsen; Småbrekke, Birgit; Rinde, Ludvig B; Grimnes, Gro; Isaksen, Trond; Hansen, John-Bjarne; Hindberg, Kristian; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)
    Stroke is associated with a short-term increased risk of subsequent venous thromboembolism (VTE). It is unclear to what extent this association is mediated by strokerelated complications that are potential triggers for VTE, such as immobilization and infection. We aimed to investigate the role of acute stroke as a trigger for incident VTE while taking other concomitant VTE triggers into account. ...
  • MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer 

    Richardsen, Elin; Andersen, Sigve; Melbø-Jørgensen, Christian; Rakaee, Mehrdad; Ness, Nora; Al-Saad, Samer; Nordby, Yngve; Pedersen, Mona Irene; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-23)
    A large number of miRNAs influence key cellular processes involved in prostate tumorigenesis. Previous studies have demonstrated high expression of miRNAs in human prostate cancer (PC) tissues and cell lines. In previous microarray data, we found miR-141 to be upregulated and miR-145 to be downregulated in PC. In this large PC cohort (n = 535), we explored the prognostic role of miR-141 and miR-145 ...
  • Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men 

    Brovold, Henrik; Lund, Trine; Svistounov, Dmitri; Solbu, Marit Dahl; Jenssen, Trond Geir; Ytrehus, Kirsti; Zykova, Svetlana (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-19)
    Several epidemiological studies have pointed at serum uric acid (SUA) as an independent risk factor for mortality, diabetes, hypertension, cardiovascular and kidney disease; however, no clear pathogenic pathway is established. Uric acid (UA) crystals show pro-inflammatory properties and can thus create or contribute to the state of chronic low-grade inflammation, a widely accepted pathogenic mechanism ...
  • Estimated 8-year cumulative incidence of diabetes mellitus among Sami and non-Sami inhabitants of Northern Norway- The SAMINOR Study 

    Naseribafrouei, Ali; Eliassen, Bent Martin; Melhus, Marita; Svartberg, Johan; Broderstad, Ann Ragnhild (Journal article; Peer reviewed, 2019-06-24)
    <b>Background</b><br> The aim of the study was to estimate and compare the 8-year cumulative incidence of diabetes mellitus (DM) among Sami and non-Sami inhabitants of rural districts in Northern Norway. <br><b>Methods</b><br> Longitudinal study based on linkage of two cross-sectional surveys, the SAMINOR 1 Survey (2003–2004) and the SAMINOR 2 Clinical Survey (2012–2014). Ten municipalities in rural ...
  • The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment 

    Toft, Helge Prytz; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Tilden, Terje; Wampold, Bruce E.; Lien, Lars (Journal article; Peer reviewed, 2018-04-10)
    <b>Background</b><br> Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol ...
  • Validation of diagnostic utility of fasting plasma glucose and HbA1c in stable renal transplant recipients one year after transplantation 

    Ussif, Mohammed Al-Amin; Åsberg, Anders; Strøm Halden, Thea Anine; Nordheim, Espen; Hartmann, Anders; Jenssen, Trond Geir (Journal article; Peer reviewed, 2019-01-10)
    <b>Background</b><br> The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low sensitivity early after renal transplantation. PTDM diagnosed with an oral glucose tolerance test (OGTT) is highly predictable for long-term patient mortality. HbA1c was introduced for ...
  • Screening for hepatitis C in a general adult population in a low-prevalence area: the Tromsø study 

    Kileng, Hege; Gutteberg, Tore Jarl; Goll, Rasmus; Paulssen, Eyvind Jakob (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)
    <i>Background - </i>Chronic hepatitis C virus (HCV) infection can progress to cirrhosis and end-stage liver disease in a substantial proportion of patients. The infection is frequently asymptomatic, leaving many infected individuals unaware of the diagnosis until complications occur. This advocates the screening of healthy individuals. The aim of this study was to estimate the prevalence of HCV ...
  • Seasonal variations in objectively assessed physical activity among people with COPD in two Nordic countries and Australia: a cross-sectional study 

    Hoaas, Hanne; Zanaboni, Paolo; Hjalmarsen, Audhild; Morseth, Bente; Dinesen, Birthe; Burge, Angela T.; Cox, Narelle S.; Holland, Anne E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-05)
    <i>Purpose</i>: Seasons and weather conditions might influence participation in physical activity and contribute to differences between countries. This study aimed at investigating whether there were differences in physical activity levels between Norwegian, Danish and Australian people with chronic obstructive pulmonary disease (COPD), and establishing if any variations in physical activity were ...
  • Personalized treatment of hepatitis C genotype 1a in Norway and Sweden 2014-2016: a study of treatment outcome in patients with or without resistance-based DAA-therapy 

    Kileng, Hege; Kjellin, Midori; Akaberi, Dario; Bergfors, Assar; Duberg, Ann-Sofi; Wesslen, Lars; Danielsson, Astrid; Kristiansen, Magnhild Gangsøy; Gutteberg, Tore Jarl; Goll, Rasmus; Lannergård, Anders; Lennerstrand, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-05)
    <i>Objectives</i>: Resistance-associated substitutions (RASs) may impair treatment response to direct-acting antivirals (DAA) in hepatitis C virus (HCV) treatment. We investigated the effects of baseline NS3-RASs (Q80K and R155K) and clinically relevant NS5A-RASs in patients with HCV genotype (GT) 1a infection on treatment outcome, with or without resistance-based DAA-treatment. This multi-center ...
  • Lower respiratory tract infections appear to be the most important risk factor for current asthma in subarctic schoolchildren. 

    Hansen, Tonje Elisabeth; Evjenth, Bjørg; Holt, jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
    <p><i>Aim - </i>The aim of this study was to identify possible risk factors for current asthma revealed by two studies in Northern Norway in 1985 and 2008 and to evaluate these factors contributing to the increased prevalence of asthma over these 23 years. <p><i>Methods - </i>As part of the ‘Asthma and allergy study among schoolchildren in Nordland county’ we performed a case–control study (70.0% ...
  • Agreement between preload reserve measured by impedance cardiography and echocardiography during pregnancy 

    Liang, Huan; Vårtun, Åse; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-05)
    <i>Purpose</i>: Accurate assessment of cardiac function is important during pregnancy. Echocardiography and impedance cardiography (ICG) are commonly used noninvasive methods to measure stroke volume (SV) and cardiac output (CO). The diference in stroke volume (ΔSV) or cardiac output (ΔCO) measured at baseline and after passive leg raising (PLR) is a measure of preload reserve that predicts volume ...
  • Soluble erythropoietin receptor levels associate with inflammatory mediators but not with disease activity or cumulative organ damage in patients with systemic lupus erythematosus 

    Jones, Heather; Raymond, Warren David; Eilertsen, Gro Østli; Nossent, Johannes (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-14)
    The erythropoietin receptor (EpoR) stimulates erythrocyte proliferation after erythropoietin binding. EpoR belongs to the cytokine receptor superfamily and can be found on macrophages and endothelial cells. As there are no data on the role of EpoR systemic autoimmune diseases, we investigated the role of soluble EpoR (sEpoR) in patients with systemic lupus erythematosus (SLE). In a cross-sectional ...
  • Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway 

    Storjord, Elin; Dahl, Jim André; Landsem, Anne; Ludviksen, Judith K; Karlsen, Marlene; Karlsen, Bård Ove; Brekke, Ole-Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-10)
    <i>Background</i>: Lifestyle factors, including a low intake of carbohydrates, dieting, alcohol consumption, cigarette smoking and stress are some of the possible triggers of attacks in acute intermittent porphyria (AIP). The influence of lifestyle factors, including energy intake, diet and alcohol consumption on the biochemical disease activity in AIP and biochemical nutritional markers were ...
  • Psychological distance of climate change and mental health risks assessment of smallholder farmers in Northern Ghana: Is habituation a threat to climate change? 

    Acharibasam, Jeremiah Wezanamo; Anuga, Samuel Weniga (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-06)
    Although strong evidence shows climate change has physical impacts on human health, the mental health impacts appear unclear. The study aims to understand and explain the dynamic correlates between climate change and farmers’ emotional regulation practices, given psychological distance. Using 180 smallholder farmers in Northern Ghana, structural equation linear regression analysis showed that ...
  • Bruk av medikamenter for alkoholbrukslidelser i Norge 2004–16 

    Heldal, Anne Taraldsen; Skurtveit, Svetlana; Lobmaier, Philipp Paul K.; Vederhus, John-Kåre; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-08)
    <p><i>Bakgrunn - </i>Alkoholbrukslidelser forårsaker alvorlig sykelighet og tidlig død. Livstidsprevalens estimeres til 7–10 % i den norske befolkningen. Mange pasienter kommer ikke inn i behandlingsapparatet, og det antas at få av dem som kommer i behandling får medikamentell behandling. På markedet er det flere medikamenter som kan hjelpe til med å redusere mengde inntatt alkohol og å opprettholde ...
  • A novel combination of peripheral nerve blocks for arthroscopic shoulder surgery 

    Musso, Dario; Flohr-Madsen, Sandra; Meknas, Khaled; Wilsgaard, Tom; Ytrebø, Lars Marius; Klaastad, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-04)
    <p><i>Background - </i>Interscalene brachial plexus block is currently the gold standard for intra‐ and post‐operative pain management for patients undergoing arthroscopic shoulder surgery. However, it is associated with block related complications, of which effect on the phrenic nerve have been of most interest. Side effects caused by general anesthesia, when this is required, are also a concern. ...
  • A randomised placebo-controlled trial examining the effect on hand supination after the addition of a suprascapular nerve block to infraclavicular brachial plexus blockade 

    Flohr-Madsen, Sandra; Ytrebø, Lars Marius; Valen, Katrin; Wilsgaard, Tom; Klaastad, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-11)
    Some surgeons believe that infraclavicular brachial plexus blocks tends to result in supination of the hand/forearm, which may make surgical access to the dorsum of the hand more difficult. We hypothesised that this supination may be reduced by the addition of a suprascapular nerve block. In a double‐blind, randomised, placebo‐controlled study, our primary outcome measure was the amount of supination ...
  • Minimum effective volume of ropivacaine 7.5mg/ml for an ultrasound-guided infraclavicular brachial plexus block 

    Flohr-Madsen, Sandra; Ytrebø, Lars Marius; Kregnes, Sylvia Beate; Wilsgaard, Tom; Klaastad, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-02-18)
    <p><i>Background - </i>Ultrasound guidance has been shown to reduce the minimum effective volume (MEV) of local anaesthetics for several peripheral nerve blocks. Although the lateral sagittal infraclavicular block (LSIB) is a well‐established anaesthesia method, MEV for this technique has not been established. Our aim with this study was to determine the MEV using ropivacaine 7.5 mg/ml for the LSIB ...

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