Recent additions

  • Factors associated with treatment in primary versus specialist care: A population-based study of people with type 2 and type 1 diabetes 

    Slåtsve, Kristina Barbara; Claudi, Tor; Lappegård, Knut Tore; Jenum, Anne Karen; Larsen, Marthe; Nøkleby, Kjersti; Cooper, John; Sandberg, Sverre; Berg, Tore Julsrud (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-08)
    <p>Aims: The objectives of this study are to identify the proportion and characteristics of people with type 1 and 2 diabetes treated in primary, specialist and shared care and to identify the proportion of persons with type 2 diabetes reaching HbA<sub>1c</sub> treatment targets and the clinical risk factors and general practitioner and practice characteristics associated with treatment in specialist ...
  • States’ Environmental Obligations in Disputed Maritime Areas and the Limits of International Law 

    Constantinos, Yiallourides; Ermolina, Natalia (Chapter; Bokkapittel, 2021)
    There are many cases worldwide where two or more States’ maritime claims over ocean space and marine resources overlap, leading to disputed maritime areas. Many of these disputed maritime areas include rare or fragile marine ecosystems and constitute the habitat of vulnerable species. General environmental provisions under international law are binding upon States in disputed maritime areas. Yet, ...
  • Cerebral blood flow measurements with 15O-water PET using a non-invasive machine-learning-derived arterial input function 

    Kuttner, Samuel; Wickstrøm, Kristoffer Knutsen; Lubberink, Mark; Tolf, Andreas; Burman, Joachim; Sundset, Rune; Jenssen, Robert; Appel, Lieuwe; Axelsson, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-08)
    <p>Cerebral blood flow (CBF) can be measured with dynamic positron emission tomography (PET) of <sup>15</sup>O-labeled water by using tracer kinetic modelling. However, for quantification of regional CBF, an arterial input function (AIF), obtained from arterial blood sampling, is required. In this work we evaluated a novel, non-invasive approach for input function prediction based on machine learning ...
  • Survey of European neurosurgeons’ management of unruptured intracranial aneurysms: inconsistent practice and organization 

    Skodvin, Torbjørn Øygard; Kloster, Roar; Sorteberg, Wilhelm; Isaksen, Jørgen Gjernes (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-01)
    Background - The discovery of an unruptured intracranial aneurysm creates a dilemma between observation and treatment. Neurosurgeons’ routines for risk assessment and treatment decision-making are unknown. The position of evidence-based medicine in European neurosurgery is considered to be weak, high-grade guidelines do not exist and variations between institutions are probable. We aimed to explore ...
  • GFR in healthy aging: An individual participant data meta-analysis of iohexol clearance in european population-based cohorts 

    Eriksen, Bjørn Odvar; Pálsson, Runólfur; Ebert, Natalie; Melsom, Toralf; van der Giet, Markus; Gudnason, Vilmundur; Indridasson, Olafur S.; Inker, Lesley A.; Jenssen, Trond Geir; Levey, Andrew S.; Solbu, Marit Dahl; Tighiouart, Hocine; Schaeffner, Elke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07)
    <i>Background</i> - Population mean GFR is lower in older age, but it is unknown whether healthy aging is associated with preserved rather than lower GFR in some individuals.<br><br> <i>Methods</i> - We investigated the cross-sectional association between measured GFR, age, and health in persons aged 50–97 years in the general population through a meta-analysis of iohexol clearance measurements ...
  • Occurrence of postdural puncture headache - A randomized controlled trial comparing 22G Sprotte and Quincke 

    Sjulstad, Ane Skaare; Odeh, Francis; Baloch, Farid; Berg, Diana Hristova; Arntzen, Kathrine Grønning; Alstadhaug, Karl Bjørnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-12)
    <i>Objective</i> - To assess the incidence of postdural puncture headache (PDPH) using 22-gauge atraumatic needle (Sprotte, 22GS) compared with 22-gauge traumatic needle (Quincke, 22GQ).<br><br> <i>Background</i> - Diagnostic lumbar puncture (dLP) is commonly complicated by PDPH. Despite evidence to support the use of 22GS, European neurologists seem to keep using 22GQ.<br><br> <i>Methods</i> ...
  • Hippocampal growth hormone modulates relational memory and the dendritic spine density in CA1 

    Haugland, Kamilla Gjerland; Olberg, Anniken; Lande, Andreas; Kjelstrup, Kirsten Brun; Brun, Vegard Heimly (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02)
    Growth hormone (GH) deficiency is associated with cognitive decline which occur both in normal aging and in endocrine disorders. Several brain areas express receptors for GH although their functional role is unclear. To determine how GH affects the capacity for learning and memory by specific actions in one of the key areas, the hippocampus, we injected recombinant adeno-associated viruses (rAAVs) ...
  • Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis 

    Böhm, JK; Güting, Helge; Thorn, S; Schäfer, Nadine; Rambach, V; Schöchl, Herbert; Grottke, Oliver; Rossaint, Rolf; Stanworth, Simon; Curry, Nicola; Lefering, Rolf; Maegele, Marc; Andelic, Nada; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
    <i>Background</i> - Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood.<br><br> <i>Methods</i> - This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma ...
  • Endotoxin removal in septic shock with the Alteco LPS Adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial - the Asset Study 

    Lipcsey, Miklos; Tenhunen, Jyrki; Pischke, Soeren; Kuitunen, Anne; Flaatten, Hans; De Geer, Lina; Sjölin, Jan; Frithiof, Robert; Chew, Michelle S.; Bendel, Stepani; Kawati, Rafael; Larsson, Anders; Mollnes, Tom Eirik; Tønnessen, Tor Inge; Rubertsson, Sten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08)
    <i>Purpose</i>: Lipopolysaccharides (LPS) are presumed to contribute to the inflammatory response in sepsis. We investigated if extracorporeal Alteco LPS Adsorber for LPS removal in early gram-negative septic shock was feasible and safe. Also, effects on endotoxin level, inflammatory response, and organ function were assessed.<br><br> <i>Methods</i>: A pilot, double-blinded, randomized, Phase ...
  • Cytomegalovirus-SpecificImmunoglobulin G is associated with chronic lung disease in children and adolescents from sub-Saharan Africa with perinatal HIV infection 

    Bowen, Dan Hameiri; Sovershaeva, Evgeniya; Charlton, Bethany; Schive, Cecilie; Odland, Jon Øyvind; McHugh, Grace; Bandason, Tsitsi; Mayin, Justin; Ferrand, Rashida A.; Yindom, Louis-Marie; Rowland-Jones, Sara L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-26)
    In a cross-sectional study of 296 children and adolescents from Zimbabwe living with perinatal human immunodeficiency virus, individuals with the top tertile of cytomegalovirus-specific immunoglobulin G titer had an increased odds of chronic lung disease (odds ratio, 3.33; 95% confidence interval, 1.37–8.85; P = .010).
  • GARP promotes the proliferation and therapeutic resistance of bone sarcoma cancer cells through the activation of TGF-beta 

    Carrillo-Gálvez, Ana Belén; Quintero, Juan Esteban; Rodríguez, René; Menéndez, Sofía T.; González, M. Victoria; Blanco-Lorenzo, Verónica; Allonca, Eva; Farias, Virgínea de Araújo; González-Correa, Juan Elías; Erill-Sagalés, Nadina; Martínez-Zubiaurre, Iñigo; Hellevik, Turid; Sánchez-Hernández, Sabina; Muñoz, Pilar; Zurita, Federico; Martín, Francisco; Rodríguez-Manzaneque, Juan Carlos; Anderson, Per (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-17)
    Sarcomas are mesenchymal cancers with poor prognosis, representing about 20% of all solid malignancies in children, adolescents, and young adults. Radio- and chemoresistance are common features of sarcomas warranting the search for novel prognostic and predictive markers. GARP/LRRC32 is a TGF-β-activating protein that promotes immune escape and dissemination in various cancers. However, if GARP ...
  • Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury 

    Mikolic, Ana; van Klaveren, David; Oude Groeniger, Joost; Wiegers, E; Lingsma, Hester F; Zeldovich, Marina; von Steinbüchel, Nicole; Maas, Andrew I.R.; Roeters van Lennep, Jeanine; Polinder, Suzanne; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-19)
    Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses in the prospective multi-center Collaborative ...
  • Sigma-1 receptor positron emission tomography: A new molecular imaging approach using (S)-(-)-[18F]fluspidine in glioblastoma 

    Toussaint, Magali; Deuther-Conrad, Winnie; Kranz, Mathias; Fischer, Steffen; Ludwig, Friedrich-Alexander; Juratli, Tareq A.; Patt, Marianne; Wünsch, Bernhard; Schackert, Gabriele; Sabri, Osama; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
    Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is involved in signaling pathways assumed to control the proliferation of cancer cells and thus could serve as candidate for molecular characterisation of ...
  • Prehospital tourniquets in civilians: A systematic review 

    Eilertsen, Kenneth A.; Winberg, Morten; Jeppesen, Elisabeth; Hval, Gyri; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)
    Objectives: Terrorist attacks and civilian mass-casualty events are frequent, and some countries have implemented tourniquet use for uncontrollable extremity bleeding in civilian settings. The aim of this study was to summarize current knowledge on the use of prehospital tourniquets to assess whether their use increases the survival rate in civilian patients with life-threatening hemorrhages from ...
  • Are the Relationships of Lean Mass and Fat Mass With Bone Microarchitecture Causal or Due to Familial Confounders? A Novel Study of Adult Female Twin Pairs 

    Bui, Minh; Zebaze, Roger; Li, Shuai; Hopper, John L.; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-01)
    It is not known whether the relationships of lean mass (LM) and fat mass (FM) with bone microarchitecture and geometry are causal and/or are because of confounders, including familial confounders arising from genetic and environment effects shared by relatives. We tested the hypotheses that: (i) LM is associated with cortical bone traits, (ii) FM is associated with trabecular bone traits, and (iii) ...
  • Evaluating a centralised cancer support centre in the remote region of Northern Norway 

    Ervik, Bente; Andersen, Sigve; Skirbekk, Helge; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-20)
    Introduction: Being diagnosed with cancer and undergoing treatment is a life-changing experience, and many cancer patients find the physical, emotional and social effects of the disease to be stressful. This study explores the experiences of cancer patients and their relatives from all parts of Northern Norway visiting the centralised cancer support centre. <p> <p>Methods: In a comprehensive ...
  • Choice of immunoassay to evaluate porcine cytokine levels 

    Ueland, Nora Lamark; Ludvigsen, Judith K.; Hellerud, Bernt C; Mollnes, Tom Eirik; Skjeflo, Espen Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-06)
    <i>Background</i> - In order to adequately monitor cytokines in experimental models, currently available methods and commercially available kits should be compared.<br><br> <i>Aim</i> - To compare the plasma and tissue concentrations of IL-1β, IL-6, IL-8, IL-10, and TNF as a measure of systemic inflammation in septic pigs.<br><br> <i>Methods</i> - Cytokines were quantified from blood and tissue ...
  • STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage: Protocol for a randomised controlled trial 

    Larsen, Kristin Tveitan; Forfang, Elisabeth; Pennlert, Johanna; Glader, Eva-Lotta; Kruuse, Christina; Wester, Per; Ihle-Hansen, Hege; Carlsson, Maria; Berge, Eivind; Al-Shahi Salman, Rustam; Wyller, Torgeir Bruun; Rønning, Ole M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-03)
    Background and aims - Many patients with prior intracerebral haemorrhage have indications for antithrombotic treatment with antiplatelet or anticoagulant drugs for prevention of ischaemic events, but it is uncertain whether such treatment is beneficial after intracerebral haemorrhage. STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage will assess (i) the effects of long-term antithrombotic ...
  • Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome 

    Berg, Leif Kyrre; Goll, Rasmus; Fagerli, Erik; Ludviksen, Judith K; Fure, Hilde; Odd Sverre, Moen; Sørbye, Sveinung; Mollnes, Tom Eirik; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-24)
    Background: It has been proposed that irritable bowel syndrome (IBS) is a low-grade mucosal inflammatory disease. <p> <p>Objective: To characterize the intestinal inflammatory profile in IBS patients with or without fructose intolerance.<p> <p>Design: Patients referred to colonoscopy with IBS complaints were screened for participation. IBS patients diagnosed according to the Rome II criteria ...
  • Tracking of serum 25-hydroxyvitamin D during 21 years 

    Kubiak, Julia Magdalena; Kamycheva, Elena; Jorde, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
    Background/objectives - Our objective was to evaluate the degree of tracking for serum levels of 25-hydroxyvitamin D [25(OH)D] over time, by using data from three previously conducted surveys of the Tromsø study collected in the years 1994/1995 (Tromsø 4), 2007/2008 (Tromsø 6), and 2015/2016 (Tromsø 7).<p> <p>Subjects/methods - Subjects with valid 25(OH)D measurements in all three surveys were ...

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