Recent additions

  • Endothelial function after pancreas transplantation - A single-center observational study 

    Nordheim, Espen; Dahle, Dag Olav; Strøm Halden, Thea Anine; Birkeland, Kåre I.; Åsberg, Anders; Hartmann, Anders; Horneland, Rune; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-06)
    <i>Background</i> - Patients with diabetes mellitus treated with successful pancreas transplantation (PTX) normalize hyperglycemia, but are exposed to immunosuppressive drugs that may impair endothelial function. This study aimed to evaluate endothelial function in single PTX recipients.<p><p> <i>Methods</i> - Flow‐mediated dilatation (FMD) in the brachial artery was measured by ultrasound 8 weeks ...
  • Serum lactate dehydrogenase contributes to prognostic assessment in patients with oligometastatic cancer and brain involvement 

    Nieder, Carsten; Dalhaug, Astrid; Pawinski, Adam (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01)
    <p><i>Background/Aim - </i>The aim of this study was to analyze the prognostic impact of serum lactate dehydrogenase (LDH) in patients with oligometastatic brain metastases, arbitrarily defined as max. Four brain lesions and 5 metastatic lesions overall. <p><i>Patients and Methods - </i>This was a retrospective single institution analysis. Overall, 42 patients were identified from a prospectively ...
  • Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: The Nordic-Baltic Bifurcation Study IV 

    Kumsars, Indulis; Holm, Niels Ramsing; Niemelä, Matti; Erglis, Andrejs; Kervinen, Kari; Christiansen, Evald Høj; Maeng, Michael; Dombrovskis, Andis; Abraitis, Vytautas; Kibarskis, Aleksandras; Trovik, Thor; Latkovskis, Gustavs; Sondore, Dace; Narbute, Inga; Terkelsen, Christian Juhl; Eskola, Markku; Romppanen, Hannu; Laine, Mika; Jensen, Lisette Okkels; Pietila, Mikko; Gunnes, Pål; Hebsgaard, Lasse; Frobert, Ole; Calais, Fredrik; Hartikainen, Juha; Aarøe, Jens; Ravkilde, Jan; Engstrøm, Thomas; Steigen, Terje; Thuesen, Leif; Lassen, Jens F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-19)
    <p><i>Background - </i>It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation. <p><i>Methods ...
  • Is there a seasonal variation of survival after systemic chemotherapy for metastatic castration-resistant prostate cancer in a rural part of North Norway? 

    Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-19)
    The winter darkness or polar night induces endocrine and metabolic mechanisms, which might reduce the efficacy of cancer treatment and thus contribute to shorter survival. Moreover, season-and weather-related treatment delays and irregularities might also cause reduced efficacy of anti-cancer drugs. Therefore, this study evaluated the prognostic impact of timing of chemotherapy (start during winter ...
  • PALLiON - PALLiative care Integrated in ONcology: Study protocol for a Norwegian national cluster-randomized control trial with a complex intervention of early integration of palliative care 

    Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Andersen, Sigve; Brunelli, Cinzia; Dajani, Olav; Ahmed, Herish; Hamre, Hanne Mari; Haukland, Ellinor Christin; Holmberg, Mats; Jordal, Frode; Krogstad, Hilde; Lundeby, Tonje; Løhre, Erik T; Mjåland, Svein; Nordbø, Arve; Paulsen, Ørnulf; Staff, Erik Schistad; Wester, Torunn; Kaasa, Stein; Loge, Jon Håvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)
    <p><i>Background - </i>Several publications have addressed the need for a systematic integration of oncological care focused on the tumor and palliative care (PC) focused on the patient with cancer. The exponential increase in anticancer treatments and the high number of patients living longer with advanced disease have accentuated this. Internationally, there is now a persuasive argument that ...
  • PET imaging of the adenosine A2A receptor in the rotenone-based mouse model of Parkinson’s disease with [18F]FESCH synthesized by a simplified two-step one-pot radiolabeling strategy 

    Schröder, Susann; Lai, Thu Hang; Toussaint, Magali; Kranz, Mathias; Chovsepian, Alexandra; Shang, Qi; Dukić-Stefanović, Sladjana; Deuther-Conrad, Winnie; Teodoro, Rodrigo; Wenzel, Barbara; Moldovan, Rareş-Petru; Pan-Montojo, Francisco; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)
    The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) is regarded as a particularly appropriate target for non-dopaminergic treatment of Parkinson’s disease (PD). An increased A<sub>2A</sub>R availability has been found in the human striatum at early stages of PD and in patients with PD and dyskinesias. The aim of this small animal positron emission tomography/magnetic resonance (PET/MR) imaging ...
  • Identification of surface proteins in a clinical Staphylococcus haemolyticus isolate by bacterial surface shaving 

    Wolden, Runa; Pain, Maria; Karlsson, Roger; Karlsson, Anders; Fredheim, Elizabeth G. Aarag; Cavanagh, Jorunn Pauline (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-07)
    <p><i>Background - </i>The skin commensal <i>Staphylococcus haemolyticus</i> is an emerging nosocomial pathogen. Despite its clinical relevance, published information about <i>S. haemolyticus</i> virulence factors is scarce. In this study, the adhesive and biofilm forming properties of ten clinical and ten commensal <i>S. haemolyticus</i> strains were examined using standard adhesion and biofilm ...
  • Special issue on e-health services 

    Wynn, Rolf; Gabarron, Elia; Johnsen, Jan-Are Kolset; Traver, Vicente (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-22)
    The importance of e-health to citizens, patients, health providers, governments, and other stakeholders is rapidly increasing. E-health services have a range of advantages. For instance, e-health may improve access to services, reduce costs, and improve self-management. E-health may allow previously underserved populations to gain access to services. Services utilizing apps, social media, or online ...
  • Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study 

    Sejrup, Joakim Knutsen; Morelli, Vania Maris; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-27)
    <p><i>Background - </i>The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated. <p><i>Aim - </i>To study the combined effect of MI and ...
  • Methods and Measures Used to Evaluate Patient-Operated Mobile Health Interventions: Scoping Literature Review 

    Bradway, Meghan; Gabarron, Elia; Johansen, Monika Alise; Zanaboni, Paolo; Jardim, Patricia; Joakimsen, Ragnar Martin; Pape-Haugaard, Louise; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-30)
    <i>Background</i>: Despite the prevalence of mobile health (mHealth) technologies and observations of their impacts on patients’ health, there is still no consensus on how best to evaluate these tools for patient self-management of chronic conditions. Researchers currently do not have guidelines on which qualitative or quantitative factors to measure or how to gather these reliable data.<p><p> ...
  • Role of microRNAs in venous thromboembolism 

    Morelli, Vania Maris; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-09)
    MicroRNAs (miRNAs) are non-coding RNAs that execute their function by targeted downregulation of gene expressions. There is growing evidence from epidemiological studies and animal models suggesting that the expression level of miRNAs is dysregulated in venous thromboembolism (VTE). In this review, we summarize the current knowledge on the role of miRNAs as biomarkers for VTE and provide general ...
  • Study of the effects of 3 h of continuous cardiopulmonary resuscitation at 27°C on global oxygen transport and organ blood flow 

    Nilsen, Jan Harald; Valkov, Sergei; Mohyuddin, Rizwan; Schanche, Torstein Lindahl; Kondratiev, Timofei V.; Næsheim, Torvind; Sieck, Gary C.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-16)
    <i>Aims</i>: Complete restitution of neurologic function after 6 h of pre-hospital resuscitation and in-hospital rewarming has been reported in accidental hypothermia patients with cardiac arrest (CA). However, the level of restitution of circulatory function during long-lasting hypothermic cardiopulmonary resuscitation (CPR) remains largely unknown. We compared the effects of CPR in replacing ...
  • Posterior reversible encephalopathy syndrome, a clinically diverse and challenging disorder 

    Chruickshank, Therese; Thoresen, Hanne; Benjaminsen, Espen; Odeh, Francis (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-14)
    The characterizing features of Posterior reversible encephalopathy syndrome (PRES) are broad and diverse, making early recognition and diagnosis challenging tasks. To illustrate the heterogeneous nature of PRES, we present three cases and discuss their clinical and radiological presentation.
  • Electronic Health Use in a Representative Sample of 18,497 Respondents in Norway (The Seventh Tromsø Study - Part 1): Population-Based Questionnaire Study 

    Wynn, Rolf; Oyeyemi, Sunday Oluwafemi; Budrionis, Andrius; Ruiz, Luis Marco; Yigzaw, Kassaye Yitbarek; Bellika, Johan Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-05)
    <p><i>Background:</i> Electronic health (eHealth) services may help people obtain information and manage their health, and they are gaining attention as technology improves, and as traditional health services are placed under increasing strain. We present findings from the first representative, large-scale, population-based study of eHealth use in Norway. <p><i>Objective:</i> The objectives of ...
  • Impact of Illness on Electronic Health Use (The Seventh Tromsø Study - Part 2): Population-Based Questionnaire Study 

    Ruiz, Luis Marco; Wynn, Rolf; Oyeyemi, Sunday Oluwafemi; Budrionis, Andrius; Yigzaw, Kassaye Yitbarek; Bellika, Johan Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-05)
    <p><i>Background:</i> Patients who suffer from different diseases may use different electronic health (eHealth) resources. Thus, those who plan eHealth interventions should take into account which eHealth resources are used most frequently by patients that suffer from different diseases. <p><i>Objective:</i> The aim of this study was to understand the associations between different groups of chronic ...
  • The association between health information seeking on the internet and physician visits (The Seventh Tromsø Study - Part 4): Population-based questionnaire study 

    Yigzaw, Kassaye Yitbarek; Wynn, Rolf; Ruiz, Luis Marco; Budrionis, Andrius; Oyeyemi, Sunday Oluwafemi; Fagerlund, Asbjørn Johansen; Bellika, Johan Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-05)
    Background: The internet is being widely used for seeking health information. However, there is no consensus on the association between health information seeking on the internet and the use of health care services. Objective: We examined the association between health information seeking via the internet and physician visits. In addition, we investigated the association between online health ...
  • Rapid identification of pathogens, antibiotic resistance genes and plasmids in blood cultures by nanopore sequencing 

    Taxt, Arne Michael; Avershina, Ekaterina; Frye, Stephan Alfons; Naseer, Mohammed Umaer; Ahmad, Rafi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
    Bloodstream infections (BSI) and sepsis are major causes of morbidity and mortality worldwide. Blood culture-based diagnostics usually requires 1–2 days for identification of bacterial agent and an additional 2–3 days for phenotypic determination of antibiotic susceptibility pattern. With the escalating burden of antimicrobial resistance (AMR) rapid diagnostics becomes increasingly important to ...
  • Laeverin Protein Expression in Normal and Preeclamptic Placentas using Tissue Microarray Analysis 

    Nystad, Mona; Sitras, Vasilis; Nordbakken, Cecilie Valborg; Pedersen, Mona Irene; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-21)
    <p><i>Introduction - </i>Laeverin is a placenta‐specific protein that is normally expressed in the plasma membrane of human trophoblasts. In previous studies, we showed higher expression levels of laeverin gene in preeclamptic compared with normal placentas and found that laeverin protein was ectopically expressed in the cytoplasm of the preeclamptic placentas. Our objective was to investigate ...
  • Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA) 

    Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-13)
    <i>Purpose</i> - The purpose of this study was to validate a new prognostic model (GI-GPA) originally derived from a multi-center database (USA, Canada, Japan).<p><p> <i>Patients and Methods</i> - This retrospective study included 92 German and Norwegian patients treated with individualized approaches, always including brain radiotherapy. Information about age, extracranial spread, number of brain ...
  • Triple use of autologous amnion graft in the treatment of meningomyelocele and split cord malformation 

    de Weerd, Louis; Sjåvik, Kristin; Pedersen, Lars Kjelsberg; Weum, Sven; Hennig, Rune (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-20)
    This article describes the triple use of autologous amnion graft as a new procedure in the treatment of myelomeningocele and in myelomeningocele with split cord malformation. The first amnion graft was used as a physical and mechanical barrier to protect the myelomeningocele (MMC) from desiccation and mechanical stress directly after birth. A second graft was used as a dura substitute to close the ...

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