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  • UNN-leger gir håp mot smertene 

    Weum, Sven; de Weerd, Louis; Andreassen, Skjalg (Journal article; Tidsskriftartikkel, 2018-11-30)
    <i>Ingress</i>: En ny behandlingsmetode med ultralydveiledet injeksjon av Botox har gitt gode resultater for UNN-pasienter med smerter i hender, rygg og mage.
  • Tidlig ultralyd i svangerskapsomsorgen 

    Lauvrak, Vigdis; Norderhaug, Inger Natvig; Hagen, Gunhild; Movik, Espen; Acharya, Ganesh; Forus, Anne; Hofmann, Bjørn; Johnsen, Synnøve Lian; Kaasen, Anne; Melve, Kari Klungsøyr; Markestad, Trond; Salvesen, Kjell Å; Staff, Annetine; Roksund, Gisle; Klemp, Marianne; Fure, Brynjar (Research report; Forskningsrapport, 2012)
    <p><i>Hovedbudskap</i>: Rutinemessig tidlig ultralydundersøkelse i svangerskapsuke 11 - 13 kan ha samme formål som dagens tilbud om ultralyd i svangerskapsuke 17 - 19. Fordi nakkeoppklaring vil bli observert i svangerskapsuke 11 - 13, vil tidlig ultralyd avdekke flere fostre med risiko for kromosomavvik.</p> <p>Helseeffekter</p> <ul><li>Vi fant ingen dokumentasjon for helsemessig gevinst av ...
  • A nutrition problem solved by a two-step endoscopic removal of a non-adjustable gastric band 

    Johansen, Christer; Norum, Jan; Engebretsen, Bernt E.; Agledahl, Uwe (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-01)
    Bariatric surgery is an effective approach for weight loss and short-term improvement in metabolic disorders. Stenosis is a common complication of gastric banding. Balloon dilatation or gastrotomy has been employed in this setting. Few studies have indicated endoscopic removal of the band a feasible procedure. We present a 60-year-old female who underwent gastric banding in 1985 and suffered from ...
  • Lindring av smerter hos kreftpasienter 

    Kongsgaard, Ulf; Kaasa, Stein; Dale, Ola; Ottesen, Stig; Nordøy, Tone; Hessling, Sten Erik; von Hofacker, Sebastian; Bruland, Øyvind; Lyngstadaas, Anita (Research report; Forskningsrapport, 2005)
    Denne rapporten er en bestilling fra tidligere Sosial-og helsedepartementet om å vurdere kunnskapsgrunnlaget om effekt av palliativ smertebehandling ved kreft, dvs. Effekt av ulike behandlingsmetoder for å lindre smerter hos pasienter med uhelbredelig (ikke-kurabel) kreftsykdom.
  • Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients 

    Yardley, Marianne; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Bjørkelund, Elisabeth; Gullestad, Lars; Nytrøen, Kari (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-28)
    <p><i>Background</i>: The present study explored and compared the immediate responses in markers of inflammation and angiogenesis in maintenance heart transplant (HTx) recipients before, during and after sessions of high-intensity interval training (HIT) versus moderate-intensity continuous training (MICT). The study aimed to explain some of the trigger mechanisms behind HIT in HTx recipients.</p> ...
  • Effekt av fysioterapi ved kneleddsartrose, begrenset til elektroterapi og øvelsesbehandling 

    Bjordal, Jan Magnus; Johansen, Oddmund; Holm, Inger; Zapffe, Knut; Nilsen, Ellen M; Kristiansen, Ivar Sønbø; Linnestad, Kristin Kamilla; Hofmann, Bjørn (Research report; Forskningsrapport, 2004)
    De viktigste symptomene ved kneleddsartrose er leddsmerter, nedsatt bevegelighet og muskelstyrke som etter hvert gir nedsatt funksjon og evne til å utføre dagliglivets aktiviteter. Mange av personene som rammes av kneleddsartrose er også overvektige som igjen kan føre til andre helseplager som kardiovaskulære lidelser og høyt blodtrykk. Fysioterapi, i form av øvelsesbehandling og elektroterapi, ...
  • Team talk and team decision processes: a qualitative discourse analytical approach to 10 real-life medical emergency team encounters 

    Gundrosen, Stine; Thomassen, Gøril; Wisborg, Torben; Aadahl, Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-03)
    <p><i>Objectives</i>: Explore the function of three specific modes of talk (discourse types) in decision-making processes.</p> <p><i>Design</i>: Ten real-life admissions of patients with critical illness were audio/video recorded and transcribed. Activity-type analysis (a qualitative discourse analytical method) was applied.</p> <p><i>Setting</i>: Interdisciplinary emergency teams admitting ...
  • Lumbar total disc replacement: predictors for long-term outcome 

    Furunes, Håvard; Hellum, Christian; Brox, Jens Ivar; Rossvoll, Ivar; Espeland, Ansgar; Berg, Linda; Brøgger, Helga Maria; Småstuen, Milada C; Storheim, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-04)
    Purpose: We aimed to identify patient characteristics associated with favourable long-term outcomes after lumbar total disc replacement (TDR). <br>Methods: We analysed a cohort of 82 patients with degenerative disc and chronic low back pain (LBP) who were treatedwith TDR and originally participated in a randomised trial comparing TDR and multidisciplinary rehabilitation. Potential predictors were ...
  • The Pedicled LICAP Flap Combined with a Free Abdominal Flap In Autologous Breast Reconstructions 

    Sjøberg, Thomas K.; Weerd, Louis de (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-01)
    Background: <br>Previous surgery or slim body configuration can limit the size of the available abdominal flap in autologous breast reconstruction. However, redundant skin and subcutaneous tissue lateral to the mastectomy site can be utilized as the pedicled lateral intercostal artery perforator (LICAP) flap. This study evaluates the combination of a free abdominal flap and a pedicled LICAP ...
  • Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: results from the RED-HF study 

    Ueland, Thor; Gullestad, Lars; Kou, Lei; Aukrust, Pål; Anand, Inder S.; Nordlund, Marianne Sparby; McMurray, John J.; van Veldhuisen, Dirk J.; Warren, David; Bolstad, Nils (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-25)
    <p><i>Aims</i>: Neuroendocrine activation is associated with poor outcome in heart failure (HF). The neuropeptide gastrin‐releasing peptide (GRP), derived from the precursor proGRP1‐125 (proGRP), has recently been implicated in inflammation and wound repair. We investigated the predictive value of proGRP on clinical outcomes in HF patients with reduced ejection fraction.</p> <p><i>Methods and ...
  • Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock 

    Orrem, Hilde L.; Nilsson, Per H.; Pischke, Søren Erik; Grindheim, Guro; Garred, Peter; Seljeflot, Ingebjørg; Husebye, Trygve; Aukrust, Pål; Yndestad, Arne; Andersen, Geir Ø.; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-09)
    Aims: Heart failure (HF) is an impending complication to myocardial infarction. We hypothesized that the degree of complement activation reflects severity of HF following acute myocardial infarction. <br> <br> Methods and results: The LEAF trial (LEvosimendan in Acute heart Failure following myocardial infarction) evaluating 61 patients developing HF within 48 h after percutaneous coronary ...
  • Telemental health in low- and middle-income countries: A systematic review 

    Acharibasam, Jeremiah; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-01)
    <p><i>Introduction</i>: The rising incidence of mental illness and its impact on individuals, families, and societies is becoming a major public health concern, especially in resource-constrained countries. Consequently, there is an increasing demand for mental health services in many middle- and low-income countries (LMIC). Challenges such as inequality in access, lack of staff and hospital beds, ...
  • IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction 

    Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-12)
    <p><i>Background</i>: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory C5aR1, and the C5aR2 and C3aR. We evaluated the effect of the IL-6 receptor (IL-6R)-antagonist tocilizumab on the expression of the ...
  • Design of the GutHeart—targeting gut microbiota to treat heart failure—trial: a Phase II, randomized clinical trial 

    Mayerhofer, Christiane Caroline; Awoyemi, Ayodeji Olawale; Moscavitch, Samuel D.; Lappegård, Knut Tore; Hov, Johannes Espolin Roksund; Aukrust, Pål; Hovland, Anders; Lorenzo, Andrea; Halvorsen, Sigrun; Seljeflot, Ingebjørg; Gullestad, Lars; Trøseid, Marius; Broch, Kaspar (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-07)
    <p><i>Aims</i>: Heart failure (HF) is a multifactorial disease. Current treatments target only a fraction of the putative pathophysiological pathways. In patients with HF, reduced cardiac output and congestion cause increased gut wall permeability. It has been suggested that leakage of microbial products is detrimental to the heart, at least partly through activation of systemic inflammatory pathways, ...
  • Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestation 

    Lekva, Tove; Godang, Kristin; Michelsen, Annika E.; Qvigstad, Elisabeth; Normann, Kjersti R.; Norwitz, Errol R.; Tore, Henriksen; Bollerslev, Jens; Roland, Marie; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-06)
    Early detection and treatment of women at risk for gestational diabetes mellitus (GDM) could improve perinatal and long-term outcomes in GDM women and their offspring. We explored if a 75 g oral glucose tolerance test (OGTT) at 14-16 weeks of gestation could identify women who will (1) develop GDM or give birth to large-for-gestational-age (LGA) babies in 1031 pregnant women from the STORK study ...
  • Evaluation of hypoglycaemia with non-invasive sensors in people with type 1 diabetes and impaired awareness of hypoglycaemia 

    Elvebakk, Ole; Tronstad, Christian; Birkeland, Kåre I.; Jenssen, Trond Geir; Bjørgaas, Marit Ragnhild Rokne; Frøslie, Kathrine Frey; Godang, Kristin; Kalvøy, Håvard; Martinsen, Ørjan Grøttem; Gulseth, Hanne Løvdal (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-03)
    People with type 1 diabetes and impaired awareness of hypoglycaemia (IAH) are prone to severe hypoglycaemia. Previous attempts to develop non-invasive hypoglycaemia alarm systems have shown promising results, but it is not known if such alarms can detect severe hypoglycaemia in people with IAH. We aimed to explore whether a combination of non-invasive sensors could reliably evaluate hypoglycaemia ...
  • Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients 

    Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-27)
    Background: <br>There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted to a psychiatric hospital.<br> Methods: <br>Demographic data, clinical data and blood samples, including 27 cytokines, were collected from 98 patients above 60 years, ...
  • Social media for health promotion in diabetes: study protocol for a participatory public health intervention design 

    Gabarron, E.; Bradway, M.; Fernandez-Luque, L.; Chomutare, T.; Hansen, A. H.; Wynn, R.; Årsand, E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-05)
    BACKGROUND: Participatory health approaches are increasingly drawing attention among the scientific community, and could be used for health promotion programmes on diabetes through social media. The main aim of this project is to research how to best use social media to promote healthy lifestyles with and within the Norwegian population. <br> <br> METHODS: The design of the health promotion ...
  • Analysing mHealth usage logs in RCTs: Explaining participants’ interactions with type 2 diabetes self-management tools 

    Bradway, Meghan; Pfuhl, Gerit; Joakimsen, Ragnar Martin; Ribu, Lis; Grøttland, Astrid; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-30)
    <p><i>Background</i>: The Introduction of mobile health (mHealth) devices to health intervention studies challenges us as researchers to adapt how we analyse the impact of these technologies. For interventions involving chronic illness self-management, we must consider changes in behaviour in addition to changes in health. Fortunately, these mHealth technologies can record participants’ interactions ...
  • Staphylococcus aureus Membrane-derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models 

    Askarian, Fatemeh; Lapek Jr., John D.; Dongre, Mitesh; Tsai, Chih-Ming; Kumaraswamy, Monika; Kousha, Armin; Valderrama, J. Andrés; Ludviksen, Judith K; Cavanagh, Jorunn Pauline; Uchiyama, Satoshi; Mollnes, Tom Eirik; Gonzalez, David J.; Wai, Sun Nyunt; Victor, Nizet; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-20)
    <i>Staphylococcus aureus</i> produces membrane-derived vesicles (MVs), which share functional properties to outer membrane vesicles. Atomic force microscopy revealed that <i>S. aureus</i>-derived MVs are associated with the bacterial surface or released into the surrounding environment depending on bacterial growth conditions. By using a comparative proteomic approach, a total of 131 and 617 proteins ...

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