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norskArtikler, rapporter og annet (klinisk medisin)
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Timely empirical antibiotic therapy against sepsis in a rural Norwegian ambulance service: a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-31)Background Early diagnosis and antibiotic therapy in patients with sepsis reduce morbidity and mortality, thus pre-hospital management is likely to affect patient outcomes. Pre-hospital administration may increase the risk of unnecessary use of broad-spectrum antibiotics, but identification of an infectious focus enables more targeted antibiotic therapy. The aim of this study was to investigate ... -
The patient’s voice: a cross-sectional study of physical health and disability in juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-18)Background With increasing focus on patient-reported outcome measures (PROMs) in chronic rheumatic diseases, we aimed to evaluate the self-reported physical and psychosocial health in children with juvenile idiopathic arthritis (JIA) compared to matched population-based controls. Furthermore, we aimed to study the association of patient and physician-reported outcome measures in JIA with ... -
PFAS exposure is associated with an unfavourable metabolic profile in infants six months of age
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-01)Exposure to perfluoroalkyl substances (PFAS) are reported to have numerous negative health effects and children are especially vulnerable. The aim of this study was to investigate whether maternal and infant PFAS burden have any impact on prenatal and postnatal growth, liver and lipid parameters in infants at age six months. Data on diet and growth parameters, as well as blood samples were collected ... -
Exploring the unconventional: health professionals’ experiences into medication-free treatment for patients with severe mental illness
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-14)Background In January 2017, the Norwegian government mandated the establishment of an inpatient unit for“medication-free treatment” for patients with severe mental illness at the University Hospital of North Norway in Tromsø. This study aims to explore the employees’ experiences with this unit.<p> <p>Method Focus group interviews were conducted October 2021 – February 2022. For analysis, the ... -
Stereotactic radiotherapy for patients with bone metastases: a selected group with low rate of radiation treatment during the last month of life?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-01)Background - Complex high-precision radiotherapy, such as stereotactic body radiotherapy (SBRT), should only be offered to patients with sufficiently long survival. In the context of bone metastases radiotherapy, low rates of treatment close to the end of life, e.g. last 30 days (RT30), may serve as a quality of care indicator. While traditional, pain-relieving short-course regimens have been studied ... -
The prevalence of subdural blood products in extremely premature infants with no history of abusive head trauma, studied by magnetic resonance imaging around term-equivalent age
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-14)Background Prematurity and enlarged subarachnoid spaces are both hypothesised to represent an increased risk of subdural haemorrhages (SDHs) in infancy, both with and without a history of abuse.<p> <p>Objective To examine the prevalence of a previous haemorrhage, particularly SDHs, in infants born extremely prematurely around term-equivalent age; to examine intra- and inter-observer agreement ... -
A randomized trial on three different minimally invasive decompression techniques for lumbar spinal stenosis. Five years follow-up from the NORDSTEN-SST
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-24)Purpose The short-term clinical outcome for midline-preserving posterior decompression techniques was comparable. The aim of this study was to evaluate long-term clinical results after three different midline-preserving posterior decompression techniques.<p> <p>Material In the NORDSTEN spinal stenosis trial (NORDSTEN-SST) 437 patients were randomized to three different midline-retaining ... -
Prisforedrag - Norsk Cardiologisk Selskaps forskningspris 2023
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024)Det var en stor ære for meg å motta forskningsprisen. Jeg er takknemlig, ydmyk og stolt overfor Norsk cardiologisk selskap (NCS) og juryen. Få fra miljøet i Tromsø har mottatt prisen, og innenfor fagområdet preventiv kardiologi er det heller ikke mange prismottakere. Jeg ble veldig glad. Det var en stor begivenhet for meg å bli hyllet av mine kolleger, både fra min egen hjertemedisinske avdeling og ... -
Factors Associated With Prescription of Systemic Therapy in Real-world Patients With Metastatic Renal Cell Cancer Managed in a Rural Region
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-03)Background/Aim: Numerous new treatment options have been approved for metastatic renal cell carcinoma (mRCC) in the last decade. Nevertheless, not all patients receive systemic therapy. Certain patients present with very advanced disease, poor Eastern Cooperative Oncology Group performance status (ECOG PS), or severe comorbidity, i.e. factors that lead oncologists to prefer best supportive ... -
Is smokeless tobacco a healthier option in patients with AUD? A follow-up study during treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-20)Introduction - Smoking is negatively related to mental health, but there is a paucity of research on the relationship between the use of smokeless tobacco, such as snus, and mental health outcomes, especially in people with alcohol use disorders (AUD). The aim of the present study was to examine the development of mental distress and quality of life (QoL) among AUD patients in treatment who did or ... -
Genetics of hip dysplasia - a systematic literature review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-01)Background - Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2–3% of all newborns. DDH increases the risk of osteoarthritis and is the cause of 30% of all total hip arthroplasties in adults < 40 years of age. We aim to explore the genetic background of DDH in order to improve diagnosis and personalize treatment.<p> <p>Methods - We conducted a structured literature ... -
Impact of the VTE-PREDICT calculator on clinicians’ decision making in fictional patients with venous thromboembolism: a randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-11)Background - After 3 months of anticoagulation for venous thromboembolism (VTE), the decision needs to be made whether to stop anticoagulation or extend treatment indefinitely. The VTE-PREDICT calculator can be used to estimate individual risks of VTE recurrence and bleeding to guide this decision.<p> <p>Objectives - To evaluate the impact of predicted individual risks of recurrence and bleeding ... -
Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-02)Background - While inflammation is associated with cognitive impairment in severe mental illnesses (SMI), there is substantial heterogeneity and evidence of transdiagnostic subgroups across schizophrenia (SZ) and bipolar (BD) spectrum disorders. There is however, limited knowledge about the longitudinal course of this relationship.<p> <p>Methods - Systemic inflammation (C-Reactive Protein, CRP) ... -
Appetite Loss in Patients with Advanced Cancer Treated at an Acute Palliative Care Unit
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-10)Appetite loss is prevalent in patients with advanced cancer and negatively affects their quality of life. However, understanding of the factors associated with appetite loss is limited. The current study aims to explore characteristics and therapeutic interventions used for patients with and without appetite loss admitted to an acute palliative care unit. Patient characteristics and patientreported ... -
Exploring the barriers to diagnosing malnutrition in patients with cancer: A study on oncologists' perspectives
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-05)Background and aim: Patients with cancer are at high risk of malnutrition, yet relevant ICD-10 codes for malnutrition are underutilized in cancer clinics. Understanding oncologists' perspectives is crucial for optimizing malnutrition diagnosis codes and enhancing nutritional practices to improve patient care. This study aims to explore oncologists' perspectives on the use and feasibility of the ... -
All that glitters is not gold: high uptake on PSMA PET in non-prostate cancers does not mean that treatment with [<177Lu]Lu-PSMA-radioligand will be successful
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-15)Background The main objective is to discuss why treatment of non-prostate cancers with [<sup>177</sup>Lu]Lu-PSMAradioligand achieved only low tumor dose in most published cases, despite high uptake on PSMA PET. We use a patient with renal cell carcinoma as an illustrative example. Furthermore, we discuss how the problem with early washout and low tumor dose might be overcome by using a radionuclide ... -
Urban-rural disparities in fatal and non-fatal paediatric injuries after trauma – A national retrospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-20)Introduction: Paediatric trauma is a leading cause of death, with correlations between trauma outcomes and geographical locations. Certain rural regions of Norway face a higher risk of trauma-related fatalities compared to the nationwide population. Among adults, the risk of both fatal and non-fatal injuries rises with increased rurality. The study aimed to investigate whether there is an ... -
Robotic assisted simple prostatectomy mitigates perioperative morbidity compared to open simple prostatectomy - a single institution report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-10)Background According to the guidelines of the European Association of Urology, open simple prostatectomy should be offered to men with a prostate size exceeding 80 mL suffering from moderate to severe LUTS in the absence of a transurethral enucleation technique. However, open simple prostatectomy is associated with complications such as bleeding, blood transfusions and increased length of stay ... -
Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-20)Background - This study aimed to develop a novel positron emission tomography (PET) tracer, [<sup>68</sup>Ga]Ga-TD-01, for CXCR4 imaging. To achieve this goal, the molecular scaffold of TIQ15 was tuned by conjugation with the DOTA chelator to make it suitable for <sup>68</sup>Ga radiolabeling.<p> <p>Methods - A bifunctional chelator was prepared by conjugating the amine group of TIQ15 with ... -
The incidence of fractures in children under two years of age: a systematic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-09)Background - Epidemiological research on fractures in children under the age of two is of great importance to help understand differences between accidental and abusive trauma.<p> <p>Objective - This systematic review aimed to evaluate studies reporting on the incidence of fractures in children under two years of age, excluding birth injuries. Secondary outcome measures included fracture location, ...
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