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  • Calculating the 30-day survival in acute myocardial infarction: should we use the treatment chain or the hospital catchment model? 

    Norum, Jan; Hansen, Tonya Moen; Hovland, Anders; Balteskard, Lise; Haug, Bjørn; Olsen, Frank; Trovik, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-12)
    <p><i>Introduction</i> Acute myocardial infarction (AMI) is a potentially deadly disease and significant efforts have been concentrated on improving hospital performance. A 30-day survival rate has become a key quality ...
  • Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia 

    Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik; Heggelund, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-24)
    Background:<br> The inflammatory response to community-acquired pneumonia (CAP) is orchestrated through activation of cytokine networks and the complement system. We examined the association of multiple cytokines and the ...
  • Clenched fist sydrome: a case report 

    Nissen, Trygve; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-18)
    Background<br> The clenched fist syndrome/psycho-flexed hand, first described in the early 1980s, has not yet entered the major psychiatric textbooks. Curiously, the phenomenon has been illuminated mainly in journals and ...
  • Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses 

    Nilsson, Per; Thomas, Anub Mathew; Bergseth, Grete; Gustavsen, Alice; Volokhina, Elena B.; van den Heuvel, Lambertus P.; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-10)
    The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 into C5a and C5b. The FDA approved indications are ...
  • Headache patients' satisfaction with telemedicine: a 12-month follow-up randomized non-inferiority trial 

    Müller, Kai Ivar; Alstadhaug, Karl Bjørnar; Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-21)
    Background and purpose: We investigated non-acute headache patients’ long-term satisfaction with a telemedicine consultation and consultation preferences in northern Norway. We hypothesized that patients were not less ...
  • Cross-sectional and longitudinal associations between different exercise types and food cravings in free-living healthy young adults 

    Drenowatz, Clemens; Holtet Evensen, Line; Ernstsen, Linda; Blundell, John E.; Hand, Gregory A.; Shook, Robin P.; Hébert, James R.; Burgess, Stephanie; Blair, Steven N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-01)
    <b>Introduction:</b><br> An increase in energy intake due to alterations in hedonic appetite sensations may, at least in part, contribute to lower-than-expected weight loss in exercise interventions. The aim of this ...
  • Increased secondary/primary bile acid ratio in chronic heart failure 

    Mayerhofer, Christiane Caroline; Ueland, Thor; Broch, Kaspar; Vincent, Royce P.; Cross, Gemma F.; Dahl, Christen Peder; Aukrust, Pål; Gullestad, Lars; Hov, Johannes Espolin Roksund; Trøseid, Marius (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-09)
    <p><i>Objective</i> Bile acids (BAs) are now recognized as signaling molecules and emerging evidence suggests that BAs affect cardiovascular function. The gut microbiota has recently been linked to the severity of heart ...
  • mHealth Assessment: Conceptualization of a Global Framework 

    Bradway, Meghan; Carrion, Carme; Vallespin, Barbara; Saadatfard, Omid; Puigdomènech, Elise; Espallargues, Mireia; Kotzeva, Anna (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-02)
    <p><i>Background</i> The mass availability and use of mobile health (mHealth) technologies offers the potential for these technologies to support or substitute medical advice. However, it is worrisome that most assessment ...
  • Elevated Plasma Levels of P‐Selectin Glycoprotein Ligand‐1 Positive Microvesicles in Patients with Unprovoked Venous Thromboembolism 

    Jamaly, Simin; Basavaraj, Manjunath Goolyam; Starikova, Irina; Olsen, Randi; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-31)
    Background<br> Microvesicles (MVs) express antigens from their parental cells and have a highly procoagulant surface. Animal studies suggest that P‐Selectin Glycoprotein Ligand‐1 positive (PSGL‐1+) MVs play a role in the ...
  • Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis 

    Keshari, Ravi Shankar; Silasi, Robert; Popescu, Narcis Ioan; Patel, Maulin Mukeshchandra; Chaaban, Hala; Lupu, Cristina; Coggeshall, K. Mark; Mollnes, Tom Eirik; DeMarco, Steven J.; Lupu, Florea (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-18)
    Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. ...
  • Data on the relation between renal biomarkers and measured glomerular filtration rate 

    Pottel, Hans; Dubourg, Laurence; Schaeffner, Elke; Eriksen, Bjørn Odvar; Melsom, Toralf; Lamb, Edmund J.; Rule, Andrew D.; Turner, Stephen T; Glassock, Richard J.; De Souza, Vandrea; Selistre, Luciano; Goffin, Karolien; Pauwels, Steven; Mariat, Christophe; Flamant, Martin; Bevc, Sebastjan; Delanaye, Pierre; Ebert, Natalie (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10)
    The data presented in this article are related to the research article entitled “The Diagnostic Value of Rescaled Renal Biomarkers Serum Creatinine and Serum Cystatin C and their Relation with Measured Glomerular Filtration ...
  • Properdin binding to complement activating surfaces depends on initial C3b deposition 

    Harboe, Morten; Johnson, Christina; Nymo, Stig Haugset; Ekholt, Karin; Schjalm, Camilla; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Hellerud, Bernt C; Ekdahl, Kristina Nilsson; Mollnes, Tom Eirik; Nilsson, Per (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-09)
    Two functions have been assigned to properdin; stabilization of the alternative convertase, C3bBb, is well accepted, whereas the role of properdin as pattern recognition molecule is controversial. The presence of ...
  • Time trends in incidence rates of venous thromboembolism in a large cohort recruited from the general population 

    Arshad, Nadia; Isaksen, Trond; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-17)
    Changes in the incidence of venous thromboembolism (VTE) during the last two decades have not been extensively studied. Therefore, we studied time trends in the incidence rates (IRs) of deep vein thrombosis (DVT) and ...
  • Limb girdle muscular dystrophy type 2I: No correlation between clinical severity, histopathology and glycosylated α-dystroglycan levels in patients homozygous for common FKRP mutation 

    Alhamidi, Maisoon; Brox, Vigdis; Stensland, Eva; Liset, Merete; Lindal, Sigurd; Nilssen, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07)
    <p>Limb girdle muscular dystrophy type 2I (LGMD2I) is a progressive disorder caused by mutations in the FuKutin-Related Protein gene (FKRP). LGMD2I displays clinical heterogeneity with onset of severe symptoms in early ...
  • Visceral fat is strongly associated with post-transplant diabetes mellitus and glucose metabolism 1 year after kidney transplantation 

    Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Åsberg, Anders; Godang, Kristin; Hartmann, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-16)
    Body composition after kidney transplantation is linked to glucose metabolism, and impaired glucose metabolism is associated with increased risk of cardiovascular events and death. One year after transplantation we ...
  • Neuropsychological functioning in a national cohort of severe traumatic brain injury: demographic and acute injury-related predictors 

    Sigurdardottir, Solrun; Andelic, Nada; Wehling, Eike; Røe, Cecilie; Anke, Audny; Skandsen, Toril; Holthe, Øyvor; Jerstad, Tone; Aslaksen, Per Matti; Schanke, Anne-Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
    Objectives: To determine the rates of cognitive impairment 1 year after severe traumatic brain injury (TBI) and to examine the influence of demographic, injury severity, rehabilitation, and subacute functional outcomes on ...
  • Preserving the legacy of reirradiation: A narrative review of historical publications 

    Nieder, Carsten; Langendijk, Johannes A.; Guckenberger, Matthias; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-21)
    The purpose of this study is to illustrate the historical development of reirradiation during several decades of the 20th century, in particular between 1920 and 1960. <br> <br> Methods and materials: We chose the ...
  • Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function 

    Pischke, Søren Erik; Gustavsen, Alice; Orrem, Hilde Lang; Egge, Kjetil Hagene; Courivaud, Frederic A. A.; Fontenelle, Hugues; Despont, Alain; Bongoni, Anjan K.; Rieben, Robert; Tønnessen, Tor Inge; Nunn, Miles A.; Scott, Helge; Skulstad, Helge; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-03)
    Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 antibodies, different inhibitors ...
  • A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities 

    Beukelman, Timothy; Anink, Janneke; Berntson, Lillemor; Duffy, Ciaran; Ellis, Justine A.; Glerup, Mia; Guzman, Jaime; Horneff, Gerd; Kearsley-Fleet, Lianne; Klein, Ariane; Klotsche, Jens; Magnusson, Bo; Minden, Kirsten; Munro, Jane E.; Niewerth, Martina; Nordal, Ellen; Ruperto, Nicolino; Santos, Maria José; Schanberg, Laura E.; Thomson, Wendy; Suijlekom-Smit, Lisette van; Wulffraat, Nico; Hyrich, Kimme (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-19)
    Background: To characterize the existing national and multi-national registries and cohort studies in juvenile idiopathic arthritis (JIA) and identify differences as well as areas of potential future collaboration. ...
  • Epidermal growth factor receptor signaling enhances the proinflammatory effects of staphylococcus aureus gamma-toxin on the mucosa 

    Gillman, Aaron N.; Breshears, Laura M.; Kistler, Charles K.; Finnegan, Patrick M.; Torres, Victor J.; Schlievert, Patrick M.; Peterson, Marnie L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-28)
    Staphylococcus aureus (S. aureus) produces many different exotoxins including the gamma-toxins, HlgAB and HlgCB. Gamma-toxins form pores in both leukocyte and erythrocyte membranes, resulting in cell lysis. The genes ...

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