Now showing items 1-20 of 1016

    • A 4-year follow-up of patients with medication-overuse headache previously included in a randomized multicentre study. 

      Salvesen, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The aim of this study was to evaluate the longterm outcome in 61 patients with medication-overuse headache (MOH) who 4 years previously had been included in a randomized open-label prospective multicentre study. Sixty patients still alive after 4 years were invited to a follow-up investigation. Fifty patients (83%) participated. Sixteen visited a neurologist, 22 were interviewed through telephone, ...
    • ABCC9-related intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9 

      Smeland, Marie Falkenberg; McClenaghan, Conor; Roessler, Helen I.; Savelberg, Sanne; Hansen, Geir Åsmund Myge; Hjellnes, Helene; Arntzen, Kjell Arne; Müller, Kai Ivar; Dybesland, Andreas R.; Harter, Theresa; Sala-Rabanal, Monica; Emfinger, Chris H.; Huang, Yan; Singareddy, Soma S.; Gunn, Jamie; Wozniak, David F.; Kovacs, Attila; Massink, Maarten; Tessadori, Federico; Kamel, Sarah M.; Bakkers, Jeroen; Remedi, Maria S.; Van Ghelue, Marijke; Nichols, Colin G.; van Haaften, Gijs (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-01)
      Mutations in genes encoding K<sub>ATP</sub> channel subunits have been reported for pancreatic disorders and Cantú syndrome. Here, we report a syndrome in six patients from two families with a consistent phenotype of mild intellectual disability, similar facies, myopathy, and cerebral white matter hyperintensities, with cardiac systolic dysfunction present in the two oldest patients. Patients are ...
    • Acceptability of an mHealth app intervention for persons with type 2 diabetes and its associations with initial self-management: Randomized controlled trial 

      Torbjørnsen, Astrid; Småstuen, Milada Cvancarova; Jenum, Anne Karen; Årsand, Eirik; Ribu, Lis (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-21)
      <p><i>Background</i>: Mobile health interventions are increasingly used in health care. The level of acceptability may indicate whether and how such digital solutions will be used.</p> <p><i>Objective</i>: This study aimed to explore associations between the level of acceptability of a mobile diabetes app and initial ability of self-management for patients with type 2 diabetes.</p> <p><i>Methods</i>: ...
    • Acceptability, feasibility, and cost of telemedicine for nonacute headaches: A randomized study comparing video and traditional consultations 

      Müller, Kai Ivar; Alstadhaug, Karl Bjørnar; Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-30)
      <b>Backgr ound:</b> The feasibility of telemedicine in diagnosing and treating nonacute headaches, such as primary headaches (migraine and tension-type) and medication-overuse headaches has not been previously investigated. By eliminating the need of travel to specialists, telemedicine may of fer significant time and money ...
    • Accuracy of physical examination for chronic lumbar radiculopathy 

      Iversen, Trond; Solberg, Tore; Romner, Bertil; Wilsgaard, Tom; Nygaard, Øystein Petter; Waterloo, Knut; Brox, Jens Ivar; Ingebrigtsen, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Clinical examination of patients with chronic lumbar radiculopathy aims to clarify whether there is nerve root impingement. The aims of this study were to investigate the association between findings at clinical examination and nerve root impingement, to evaluate the accuracy of clinical index tests in a specialised care setting, and to see whether imaging clarifies the cause of chronic ...
    • Achieving hidradenitis suppurativa response score is associated with significant improvement in clinical and patient-reported outcomes: Post hoc analysis of pooled data from PIONEER I and II 

      Kimball, Alexandra Boer; Tzellos, Thrasyvoulos; Calimlim, Brian M; Teixeira, Henrique D; Geng, Ziqian; Okun, Martin M (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-07)
      Hidradenitis Suppurativa Clinical Response (HiSCR), is a validated tool that has been used to assess the efficacy of adalimumab among patients with hidradenitis suppurativa. We evaluated the clinical meaning of HiSCR by relating it to patient-reported outcomes to give further context to its achievement in a post hoc analysis of integrated data from two phase 3 clinical trials (PIONEER I and II). ...
    • Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery 

      Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)
      <i>Objective</i>: To explore monocyte and dendritic cell immune responses, and their association with future CD4<sup>+</sup> gain in treated HIV patients with suboptimal CD4<sup>+</sup> recovery.<p> <p><i>Design</i>: A cross-sectional study of HIV-infected, virally suppressed individuals on antiretroviral therapy for at least 24 months; 41 immunological nonresponders (INRs) (CD4+ cell count <400 ...
    • Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: A Prospective Pilot Study 

      Ozolina, Agnese; Sarkele, Marina; Sabelnikovs, Olegs; Skesters, Andrejs; Jaunalksne, Inta; Serova, Jelena; Ievins, Talins; Bjertnæs, Lars J.; Vanags, Indulis (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-28)
      Introduction: Coagulation and fibrinolysis remain sparsely addressed with regards to acute respiratory distress syndrome (ARDS). We hypothesized that ARDS development might be associated with changes in plasma coagulation and fibrinolysis. Our aim was to investigate the relationships between ARDS diagnosis and plasma concentrations of tissue factor (TF), tissue plasminogen activator (t-PA), and ...
    • Activity-related pain in patients with chronic musculoskeletal disorders 

      Damsgård, Elin; Thrane, Gyrd; Anke, Audny; Fors, Terese; Røe, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      Purpose. Activity related pain may be a barrier to rehabilitation in patients with chronic musculoskeletal disorders. This study investigated patients’ reports of increased pain during activity, and the association between such pain and psychological factors and pain variables. Method. Questionnaires from 232 adults with chronic musculoskeletal pain measured pain intensity, spread of pain and ...
    • Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock 

      Orrem, Hilde L.; Nilsson, Per H.; Pischke, Søren Erik; Grindheim, Guro; Garred, Peter; Seljeflot, Ingebjørg; Husebye, Trygve; Aukrust, Pål; Yndestad, Arne; Andersen, Geir Ø.; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-09)
      Aims: Heart failure (HF) is an impending complication to myocardial infarction. We hypothesized that the degree of complement activation reflects severity of HF following acute myocardial infarction. <br> <br> Methods and results: The LEAF trial (LEvosimendan in Acute heart Failure following myocardial infarction) evaluating 61 patients developing HF within 48 h after percutaneous coronary ...
    • Acute infection as a trigger for incident venous thromboembolism: Results from a population- based case- crossover study 

      Grimnes, Gro; Isaksen, Trond; Tichelaar, Ynse Ieuwe Gerardus Vladimir; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-21)
      Background:<br> A bidirectional relation exists between acute infection and immobilization, and both are triggers for venous thromboembolism (VTE). To what extent the association between infection and VTE‐risk is explained by immobilization is unknown. <br>Aims:<br> To investigate the impact of hospitalization with acute infection on the VTE‐risk in patients with and without concomitant ...
    • The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations 

      Stenberg, Thor Allan; Kildal, Anders Benjamin; Sanden, Espen; How, Ole-Jakob; Hagve, Martin; Ytrehus, Kirsti; Larsen, Terje; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistance 

      Fjellaksel, Richard; Dugalic, Damir; Demissie, Taye Beyene; Riss, Patrick; Hjelstuen, Ole Kristian; Sundset, Rune; Hansen, Jørn H (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-28)
      Herein, we report a straightforward sequential acylation‐Finkelstein approach to achieve iodination of amine containing bioactives. The utility was demonstrated by successful radiolabelling with <sup>123</sup>I in high radiochemical yield. Moreover, microwave‐assisted Finkelstein reaction can be employed to enhance conversion and reaction rates to obtain the desired iodides. The method is of interest ...
    • Addition of marine omega-3 fatty acids to statins in familial hypercholesterolemia does not affect in vivo or in vitro endothelial function 

      Hande, Liv Nesse; Thunhaug, Hilde; Enebakk, Terje; Ludviksen, Judith K; Pettersen, Kristin; Hovland, Anders; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-29)
      <i>Background</i> - Prestatin trials reported positive effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in cardiovascular disease, whereas recent studies and meta-analyses have not reproduced these results. The effect of n-3 PUFA in patients with familial hypercholesterolemia (FH), a group with particularly high risk of cardiovascular disease, is not well established.<p><p> <i>Objective</i> ...
    • Adherence and factors affecting satisfaction in long-term telerehabilitation for patients with chronic obstructive pulmonary disease: a mixed methods study 

      Hoaas, Hanne; Andreassen, Hege K; Lien, Linda Aarøen; Hjalmarsen, Audhild; Zanaboni, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-25)
      <i>Background</i>: Telemedicine may increase accessibility to pulmonary rehabilitation in chronic obstructive pulmonary disease (COPD), thus enhancing long-term exercise maintenance. We aimed to explore COPD patients’ adherence and experiences in long-term telerehabilitation to understand factors affecting satisfaction and potential for service improvements.<p> <p><i>Methods</i>: A two-year pilot ...
    • Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus 

      Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Lekva, Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      <i>Aims</i> - The risk of gestational diabetes mellitus (GDM) is increased in overweight and obese women potentially involving secreted mediators from adipose tissue. Our main aim was to evaluate if circulating adipokines and monocyte/macrophage markers were dysregulated in GDM and the influence body mass and indices of glucose metabolism had on this association. We further explored if early detection ...
    • Adjacent Disc Degeneration After Lumbar Total Disc Replacement or Non-operative Treatment: A Randomized Study With Eight-year Follow-up 

      Furunes, Håvard; Hellum, Christian; Espeland, Ansgar; Brox, Jens Ivar; Småstuen, Milada C; Berg, Linda; Storheim, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-15)
      <p><i>Study Design</i>: A randomized controlled multicenter trial with 8-year follow-up.</p> <p><i>Objective</i>: The aim of this study was to assess the long-term development of adjacent disc degeneration (ADD) after lumbar total disc replacement (TDR) or nonoperative treatment, and to analyze the association between ADD development and clinical outcome.</p> <p><i>Summary of Background ...
    • Adolescent self-harm and suicidal behavior and young adult outcomes in indigenous and non-indigenous people 

      Eckhoff, Christian; Sørvold, Maria Therene; Kvernmo, Siv (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-18)
      The aim of this study was to examine the associations between self-harm and suicidal behavior in indigenous Sami and non-Sami adolescents and mental health and social outcomes in young adulthood. Data were obtained by linking the Norwegian Patient Registry (2008–2012), the National Insurance Registry (2003–2013), and the Norwegian Arctic Adolescent Health Study, a school-based survey inviting all ...
    • Adoption of routine telemedicine in Norway: The current picture 

      Zanaboni, Paolo; Knarvik, Undine; Wootton, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Adoption of telemedicine : from pilot stage to routine delivery 

      Zanaboni, Paolo; Wootton, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Today there is much debate about why telemedicine has stalled. Teleradiology is the only widespread telemedicine application. Other telemedicine applications appear to be promising candidates for widespread use, but they remain in the early adoption stage. The objective of this debate paper is to achieve a better understanding of the adoption of telemedicine, to assist those trying to move applications ...