Blar i tittel Artikler, rapporter og annet (klinisk medisin)

Viser treff 922-941 av 1796

    • Joint Effect of Multiple Prothrombotic Genotypes and Mean Platelet Volume on the Risk of Incident Venous Thromboembolism 

      Jakobsen, Lisa; Frischmuth, Tobias; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-31)
      Background - A high mean platelet volume (MPV), a marker of increased platelet reactivity, is a risk factor for venous thromboembolism (VTE). Whether established prothrombotic single nucleotide polymorphisms (SNPs) further increase the VTE risk in subjects with high MPV because of biological interaction remains unknown.<p> <p>Aim - To investigate the joint effect of high MPV and prothrombotic ...

    • Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hveem, Kristian; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-03)
      <p><b>Background</b> The impact of the combination of obesity and multiple prothrombotic genotypes on venous thromboembolism (VTE) risk remains unclear. <p><b>Objective</b> To investigate the joint effect of obesity and a genetic risk score (GRS) composed of established prothrombotic single nucleotide polymorphisms (SNPs) on VTE risk using a population-based case–cohort. <p><b>Methods</b> Cases ...

    • Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study 

      Sejrup, Joakim Knutsen; Tøndel, Birgitte Gladsø; Morelli, Vania Maris; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-19)
      Background: Myocardial infarction (MI) is associated with an increased risk of venous thromboembolism (VTE). Obesity is a recognized risk factor for both MI and VTE. Whether obesity further increases the risk of VTE in MI patients is scarcely investigated.<p> <p>Aim: To study the joint effect of MI and obesity on the risk of VTE. <p>Methods: Study participants (n = 29 410) were recruited from ...

    • Joint effects of cancer and variants in the factor 5 gene on the risk of venous thromboembolism 

      Gran, Olga Vikhammer; Smith, Erin N.; Brækkan, Sigrid Kufaas; Jensvoll, Hilde; Solomon, Terry; Hindberg, Kristian; Wilsgaard, Tom; Rosendaal, Frits Richard; Frazer, Kelly A.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09)
      Venous thromboembolism occurs frequently in cancer patients. Two variants in the factor 5 gene (F5), rs6025 encoding for the factor V Leiden mutation R506Q, and rs4524 encoding K858R, have been found to be associated with venous thromboembolism. We assessed the joint effect of active cancer and these two F5 variants on venous thromboembolism risk in a case-cohort study. Cases with a first venous ...

    • Kennedy disease in two sisters with biallelic CAG expansions of the androgen receptor gene 

      Müller, Kai Ivar; Nilssen, Øivind; Nebuchenykh, Maria; Løseth, Sissel; Jonsrud, Christoffer; Hoem, Gry; Van Ghelue, Marijke; Arntzen, Kjell Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-19)
      We present a retrospective 21-year follow-up of two sisters with X-linked biallelic CAG expansions in the androgen receptor (AR) gene causing Kennedy disease. Two sisters inherited CAG expansions from their mother who was a carrier and their father who had Kennedy disease. Genetic testing revealed alleles comprising 43/45, and 43/43 CAG repeats in the younger and older sister, respectively. They ...

    • Ketamine for prehospital trauma analgesia in a low-resource rural trauma system: a retrospective comparative study of ketamine and opioid analgesia in a ten-year cohort in Iraq 

      Losvik, Ole Kristian; Murad, Mudhafar Kareem; Skjerve, Eystein; Husum, Hans (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-09)
      Background Opioid analgesics are used in most trauma systems, and only a few studies report on the use of ketamine for prehospital analgesia. In a low-cost rural trauma system in Iraq paramedics have been using prehospital ketamine analgesia for ten years. This study aims to evaluate the effects of prehospital analgesia on physiologic trauma severity indicators and compare the effect of ketamine ...

    • Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood 

      Brekke, Ole-Lars; Christiansen, Dorte; Kisserli, Aymric; Fure, Hilde; Dahl, Jim André; Donvito, Béatrice; Reveil, Brigitte; Ludviksen, Judith K; Tabary, Thierry; Mollnes, Tom Eirik; Cohen, Jacques H.M. (Journal article; Tidsskriftartikkel, 2019-07-25)
      <i>Aim</i> - To study the role of complement receptor 1 (CR1) for binding of <i>Escherichia coli (E. coli)</i> to erythrocytes, for leukocyte phagocytosis, oxidative burst and complement activation in human whole blood from a CR1 deficient (CR1D) patient and healthy controls with low, medium and high CR1 numbers.<p> <p><i>Methods</i> - Alexa-labelled bacteria were used to quantify ...

    • Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up 

      Gjerstad, Ann Christin; Skrunes, Rannveig; Tøndel, Camilla; Åsberg, Anders; Leh, Sabine; Klingenberg, Claus Andreas; Døllner, Henrik; Hammarström, Clara Louise; Bjerre, Anna Kristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-22)
      Background There is scarce information on biopsy-verifed kidney disease in childhood and its progression to chronic kidney disease stage 5 (CKD 5). This study aims to review biopsy fndings in children, and to investigate risk of kidney replacement therapy (KRT).<p> <p>Methods We conducted a retrospective long-term follow-up study of children included in the Norwegian Kidney Biopsy Registry (NKBR) ...

    • Kinship care for the safety, permanency, and well-being of children removed from the home for maltreatment 

      Winokur, Marc; Holtan, Amy; Valentine, D (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-01-21)
      Every year a large number of children around the world are removed from their homes because they are maltreated. Child welfare agencies are responsible for placing these children in out-of-home settings that will facilitate their safety, permanency, and well-being. However, children in out-of-home placements typically display more educational, behavioral, and psychological problems than do their ...

    • Kinship foster parenting : gender, class and labour-force participation 

      Holtan, Amy; Thørnblad, Renee (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

    • Kjønnsstratifiserte analyser i norske behandlingsstudier: en systematisk kartleggingsoversikt 

      Østbø, Nora Mork; Vist, Gunn Elisabeth; Løchen, Maja-Lisa (Research report; Forskningsrapport, 2022)
      Biologisk kjønn har betydning for kliniske utfall, og kunnskap om kjønnsforskjeller i behandlingsutfall kan bidra til sikrere og mer tilpasset behandling for pasienter. Hensikten med denne kartleggingsoversikten var å undersøke bruken av kjønnsstratifiserte analyser i studier på effekt av behandling i en norsk sammenheng.<p> <p>Vi utførte en kartleggingsoversikt. Det er en type kunnskapsoppsummering ...

    • Knowledge about preventive dentistry versus self-reported competence in providing preventive oral healthcare – a study among Nepalese dentists 

      Wagle, Madhu; Acharya, Ganesh; Basnet, Purusotam; Trovik, Tordis A (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-12)
      Background: Dentists ’ and dental healthcare providers ’ professional knowledge and attitude towards the prevention of oral diseases may have an impact on the oral health of the general population. The aim of this study was to describe Nepalese dentists ’ competency in giving preventive education and treatment to their patients, and to assess their level of knowledge about preventive dental ...

    • The Knowledge of Implementation Strategies: Impact of the Installed Base 

      Pedersen, Rune; Nordheim, Espen Solbakken; Lintvedt, Ove Kumetz Bomhoff; Fagerlund, Asbjørn Johansen; Severinsen, Gro-Hilde; Malm-Nicolaisen, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      This study uses three case studies to investigate how the installed base affects Electronic Health Records (EHR) implementation in European hospitals: i) transition from paper-based records to EHRs; ii) replacement of an existing EHR with a similar system; and iii) replacing existing EHR system with a radically different one. Using a meta-analysis approach, the study employs the theoretical framework ...

    • Kurativ kateterbehandling av atrieflimmer 

      Ohm, Ole-Jørgen; Gjesdal, Knut; Rossvoll, Ole; Bugge, Einar; Berntsen, Rolf Frank; Vist, Gunn Elisabeth; Johansen, Marit; Norderhaug, Inger Natvig (Research report; Forskningsrapport, 2006)
      Atrieflimmer er den hyppigst forekommende hjerterytmeforstyrrelse av klinisk betydning, og berører ca 45 000 pasienter i Norge. Medikamentell behandling gir tilfredsstillende effekt hos flertallet, men man må se etter alternativer for de som ikke tåler eller responderer på medikamenter. For disse kan kateterbehandling med bruk av for eksempel radiofrekvensablasjon være en mulighet. Radiofrekvensablasjon ...

    • Kvinneforeningene, institusjonsbyggingen og den nasjonale velferdspolitikken. Nord-Norge før 1940 

      Hamran, Torunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2007)
      Hensikten med artikkelen er å belyse lokale kvinneforeningers innsats som institusjonsbyggere, hvilke samarbeidsrelasjoner og politiske maktforhold de inngikk i, og hvilken betydning deres innsats kan ha fått for utformingen av den norske velferdsstaten. Rettighetsaspektet i form av trygder og ytelser og den partipolitiske debatten rundt dette har fått stor plass i deler av den skandinaviske ...

    • Kvinnene, byen og helsepolitikken – Narvik før 1940 

      Hamran, Torunn (Chapter; Bokkapittel, 2005)
      I 1902 ble byen Narvik en realitet, og som så mange andre byer var veksten stor på den tiden. Byene i Norge økte ikke bare i areal og folketall, men også i sine velferdsproblemer. Hvordan Narvik fikk løst noen av oppgavene knyttet til helse og sykdom og hvem som gjorde hva innenfor kommunens grenser, er tema her.

    • The LabBM score is an excellent survival prediction tool in patients undergoing palliative radiotherapy 

      Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)
      Background and aim: The prognostic assessment of patients referred for palliative radiotherapy can be conducted by sitespecific scores. A quick assessment that would cover the whole spectrum could simplify the working day of clinicians who are not specialists for a particular disease site. This study evaluated a promising score, the LabBM (validated for brain metastases), in patients treated for ...

    • Labor curves based on cervical dilatation over time and their accuracy and effectiveness: A systematic scoping review 

      Huurnink, Johanne Mamohau Egenberg; Blix, Ellen; Hals, Elisabeth; Kaasen, Anne; Bernitz, Stine; Lavender, Tina; Ahlberg, Mia; Øian, Pål; Høifødt, Aase Irene; Miltenburg, Andrea Solnes; Pay, Aase Serine Devold (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-22)
      Objectives - This systematic scoping review was conducted to 1) identify and describe labor curves that illustrate cervical dilatation over time; 2) map any evidence for, as well as outcomes used to evaluate the accuracy and effectiveness of the curves; and 3) identify areas in research that require further investigation.<p> <p>Methods - A three-step systematic literature search was conducted for ...

    • The LabPS score: Inexpensive, Fast, and Site-agnostic Survival Prediction 

      Nieder, Carsten; Haukland, Ellinor Christin; Mannsåker, Bård; Dalhaug, Astrid (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04)
      Objectives: To provide a widely applicable, blood-biomarker-based and performance-status-based prognostic model, which predicts the survival of patients undergoing palliative non-brain radiotherapy. This model has already been examined in a cohort of patients treated for brain metastases and performed well.<p> <p>Methods: This was a retrospective single-institution analysis of 375 patients, ...

    • Lack of association between cluster headache and PER3 clock gene polymorphism 

      Ofte, Hilde Karen; Tronvik, Erling Andreas; Alstadhaug, Karl Bjørnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-29)
      Background Cluster headache (CH) is regarded as a chronobiological disorder. The hypothalamic biological clock may thus be involved in the pathophysiology, but few studies have actually investigated this in CH patients. A variable number tandem repeat (VNTR) polymorphism of the PER3 clock gene has been associated to preferred daily rhythm (chronotype) in several studies. We aimed to study the ...