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  • Pasientrapportert tilfredshet og livskvalitet etter ulike kirurgiske inngrep ved brystkreft 

    Sjåvik, Anniken (Preprint; Manuskript, 2018-09-20)
    Bakgrunn: Primær behandling ved brystkreft er kirurgi. Kirurgiske alternativer ved brystkreft er mastektomi, lumpektomi, mastektomi med primær brystrekonstruksjon (MPR) eller mastektomi med sekundær rekonstruksjon (MSR). For de fleste brystkreftpasienter vil det være flere aktuelle kirurgiske metoder. Kunnskap om postoperativ livskvalitet, tilfredshet og komplikasjoner vil da kunne være veiledende ...
  • Springboard to an academic career—A national medical student research program 

    Jacobsen, Geir Wenberg; Ræder, Helge; Stien, Marianne Heldal; Munthe, Ludvig Andre; Skogen, Vegard (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-30)
    Over the last decades there has been a decline in the recruitment of medical students into academia in all medical fields. Concurrently, medical research has increasingly included other disciplines in multidisciplinary convergence, introducing an unmet recruitment gap and requirement for medical researchers. To counteract the trend and recruit students to academic medicine, a national intercalated ...
  • Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy 

    Paunas, Theodora Ioana Flavia; Finne, Kenneth; Leh, Sabine; Marti, Hans-Peter; Mollnes, Tom Eirik; Berven, Frode; Vikse, Bjørn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-14)
    Background: The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with progression to end-stage renal disease (ESRD) in patients for whom prognosis could not be predicted based on clinical variables. <br> <br> Methods: Based on data from the Norwegian ...
  • Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis 

    Hellerud, Bernt C; Orrem, Hilde L.; Dybwik, Knut Gustav; Pischke, Søren Erik; Barratt-Due, Andreas; Castellheim, Albert; Fure, Hilde; Bergseth, Grete; Christiansen, Dorte; Nunn, Miles A.; Espevik, Terje; Lau, Corinna; Brandtzæg, Petter; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-27)
    Background<br> Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key molecules of innate immunity, complement component C5, and co-receptor CD14 in the Toll-like receptor system, on the inflammatory response in meningococcal sepsis.<p> Methods ...
  • Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy 

    Abraityte, Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika E.; Christensen, Geir Arve; Aukrust, Pål; Yndestad, Arne; Fiane, Arnt; Andreassen, Arne; Aakhus, Svend; Dahl, Christen Peder; Gullestad, Lars; Broch, Kaspar; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-14)
    The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in plasma and myocardium of DCM patients and evaluated their effects on NFAT luciferase activity in neonatal mouse cardiomyocytes. Elevated circulating Wnt5a (n = 102) was associated ...
  • Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo 

    Genster, Ninette; Østrup, Olga; Schjalm, Camilla; Mollnes, Tom Eirik; Cowland, Jack B.; Garred, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-20)
    Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection. In addition, an immune modulatory role of ficolins has been suggested. Yet, the contribution of ficolins to inflammatory disease processes remains elusive. To address this, ...
  • The alternative complement pathway is dysregulated in patients with chronic heart failure 

    Shahini, Negar; Michelsen, Annika E.; Nilsson, Per H.; Ekholt, Karin; Gullestad, Lars; Broch, Kaspar; Dahl, Christen P.; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Yndestad, Arne; Louwe, Mieke C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-14)
    The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement factor D and the alternative pathway inhibitor factor H. These components and the activation product, terminal complement complex (TCC), were measured ...
  • Fatal poisonings in Northern Finland: causes, incidence, and rural-urban differences 

    Koskela, Lauri; Raatiniemi, Lasse; Bakke, Håkon Kvåle; Ala-Kokko, Tero; Liisanantti, Janne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-08)
    Background: In this study we evaluate differences between rural and urban areas in the causes and incidence of fatal poisonings. <p> Methods: Data from all fatal poisonings that occurred in Northern Finland from 2007 to 2011 were retrieved from Cause of Death Registry death certificates provided by Statistics Finland. The demographics and causes of fatalities were compared between rural and urban ...
  • Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases 

    Shields, Kelly J.; Mollnes, Tom Eirik; Eidet, Jon Roger; Mikkelsen, Knut; Almdahl, Sven Martin; Bottazzi, Barbara; Lyberg, Torstein; Manzi, Susan; Ahearn, Joseph M; Hollan, Ivana (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-31)
    Purpose: <br> Inflammatory rheumatic diseases (IRD) are associated with accelerated coronary artery disease (CAD), which may result from both systemic and vascular wall inflammation. There are indications that complement may be involved in the pathogenesis of CAD in Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). This study aimed to evaluate the associations between circulating ...
  • Fronesis som kunnskapsform i legeutdanningen 

    Hovdenak, Sylvi Stenersen (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
    I internasjonal forskning ser vi en økende interesse for den aristoteliske kunnskapsformen fronesis, praktisk klokskap, når det gjelder utvikling av profesjonalitet i ulike utdanningskontekster. I artikkelen blir fronesis som kunnskapsform diskutert, problematisert og relatert til dagens profesjonsutdanning i medisin. Videre stilles det grunnleggende spørsmålet om hvorfor fronesis bør ha en sentral ...
  • Adoption of routine telemedicine in Norwegian hospitals: progress over 5 years 

    Zanaboni, Paolo; Wootton, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-20)
    Background: Although Norway is well known for its early use of telemedicine to provide services for people in rural and remote areas in the Arctic, little is known about the pace of telemedicine adoption in Norway. The aim of the present study was to explore the statewide implementation of telemedicine in Norwegian hospitals over time, and analyse its adoption and level of use. Methods: Data on ...
  • På vei mot en ny lege - eller? 

    Iversen, Anita; Risør, Torsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04)