Now showing items 1-20 of 25

    • Adoption of routine telemedicine in Norwegian hospitals: progress over 5 years 

      Zanaboni, Paolo; Wootton, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-20)
      Background: Although Norway is well known for its early use of telemedicine to provide services for people in rural and remote areas in the Arctic, little is known about the pace of telemedicine adoption in Norway. The aim of the present study was to explore the statewide implementation of telemedicine in Norwegian hospitals over time, and analyse its adoption and level of use. Methods: Data on ...
    • The alternative complement pathway is dysregulated in patients with chronic heart failure 

      Shahini, Negar; Michelsen, Annika E.; Nilsson, Per H.; Ekholt, Karin; Gullestad, Lars; Broch, Kaspar; Dahl, Christen P.; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Yndestad, Arne; Louwe, Mieke C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-14)
      The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement factor D and the alternative pathway inhibitor factor H. These components and the activation product, terminal complement complex (TCC), were measured ...
    • Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis 

      Hellerud, Bernt C; Orrem, Hilde L.; Dybwik, Knut Gustav; Pischke, Søren Erik; Barratt-Due, Andreas; Castellheim, Albert; Fure, Hilde; Bergseth, Grete; Christiansen, Dorte; Nunn, Miles A.; Espevik, Terje; Lau, Corinna; Brandtzæg, Petter; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-27)
      Background<br> Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key molecules of innate immunity, complement component C5, and co-receptor CD14 in the Toll-like receptor system, on the inflammatory response in meningococcal sepsis.<p> Methods ...
    • Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study 

      Bekkelund, Svein Ivar; Johnsen, Stein Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-29)
      <p><i>Background</i>: Creatine kinase (CK) has been associated with reduced inflammation in obesity while inflammation is associated with obesity-related cardiovascular diseases. We investigated the relationship between CK and high sensitive C-reactive protein (hs-CRP) in a general population.</p> <p><i>Methods</i>: CK and hs-CRP were measured in the population-based Tromsø study that included ...
    • Dental caries and preterm birth: a systematic review and meta-analysis 

      Wagle, Madhu; D'Antonio, Francesco; Reierth, Eirik; Basnet, Purusotam; Trovik, Tordis A; Orsini, Giovanna; Manzoli, Lamberto; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-02)
      Objectives:<br> The primary objective of this systematic review was to evaluate the association between dental caries and preterm birth (PTB). The secondary objective was ascertaining the difference between women with dental caries who experienced PTB and those who did not with regard to decayed, missing and filled teeth (DMFT), and decayed, missing and filled surfaces (DMFS) indices. <br>M ...
    • Early self-reported pain in juvenile idiopathic arthritis (JIA) is related to long-term outcomes. Results from the Nordic JIA cohort study. 

      Arnstad, Ellen Dalen; Rypdal, Veronika Gjertsen; Peltoniemi, Suvi; Herlin, T; Berntson, Lillemor; Fasth, Anders; Nielsen, Susan; Glerup, Mia; Ekelund, Maria; Zak, Marek; Aalto, Kristiina; Nordal, Ellen Berit; Romundstad, Pål Richard; Rygg, Marite (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-28)
      <p><i>Objective</i>: To study self‐reported pain early in the disease course of juvenile idiopathic arthritis (JIA) as predictor of long‐term disease outcomes.</p> <p><i>Methods</i>: Consecutive cases of JIA with disease onset 1997‐2000 from defined geographical areas of Norway, Sweden, Finland and Denmark were prospectively enrolled in this population‐based cohort study. Self‐reported, disease‐related ...
    • Effect of a Fracture Liaison Service on the Rate of Subsequent Fracture Among Patients With a Fragility Fracture in the Norwegian Capture the Fracture Initiative (NoFRACT) 

      Andreasen, Camilla; Solberg, Lene Bergendal; Basso, Trude; Borgen, Tove Tveitan; Dahl, Cecilie; Wisløff, Torbjørn; Hagen, Gunhild; Apalset, Ellen M; Gjertsen, Jan-Erik; Figved, Wender; Hübschle, Lars Michael; Stutzer, Jens-Meinhard; Elvenes, Jan; Joakimsen, Ragnar Martin; Syversen, Unni; Eriksen, Erik Fink; Nordsletten, Lars; Frihagen, Frede Jon; Omsland, Tone Kristin; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-07)
      <p><i>Importance</i>: Fragility fracture is a major health issue because of the accompanying morbidity, mortality, and financial cost. Despite the high cost to society and personal cost to affected individuals, secondary fracture prevention is suboptimal in Norway, mainly because most patients with osteoporotic fractures do not receive treatment with antiosteoporotic drugs after fracture ...
    • Fatal poisonings in Northern Finland: causes, incidence, and rural-urban differences 

      Koskela, Lauri; Raatiniemi, Lasse; Bakke, Håkon Kvåle; Ala-Kokko, Tero; Liisanantti, Janne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-08)
      Background: In this study we evaluate differences between rural and urban areas in the causes and incidence of fatal poisonings. <p> Methods: Data from all fatal poisonings that occurred in Northern Finland from 2007 to 2011 were retrieved from Cause of Death Registry death certificates provided by Statistics Finland. The demographics and causes of fatalities were compared between rural and urban ...
    • Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo 

      Genster, Ninette; Østrup, Olga; Schjalm, Camilla; Mollnes, Tom Eirik; Cowland, Jack B.; Garred, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-20)
      Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection. In addition, an immune modulatory role of ficolins has been suggested. Yet, the contribution of ficolins to inflammatory disease processes remains elusive. To address this, ...
    • From wholes to fragments to wholes—what gets lost in translation? 

      Kirkengen, Anna Luise (Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2018-05-31)
      The highly demanding and, in a certain sense, unique, working conditions of general practitioners (GPs) are characterized by two phenomena: First, they involve an increasing familiarity with individual patients over time, which promotes a deepening of insight. Second, they enable the GP to encounter all kinds of health problems, which in turn facilitates pattern recognition, at both individual and ...
    • Fronesis som kunnskapsform i legeutdanningen 

      Hovdenak, Sylvi Stenersen (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      I internasjonal forskning ser vi en økende interesse for den aristoteliske kunnskapsformen fronesis, praktisk klokskap, når det gjelder utvikling av profesjonalitet i ulike utdanningskontekster. I artikkelen blir fronesis som kunnskapsform diskutert, problematisert og relatert til dagens profesjonsutdanning i medisin. Videre stilles det grunnleggende spørsmålet om hvorfor fronesis bør ha en sentral ...
    • Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy 

      Paunas, Theodora Ioana Flavia; Finne, Kenneth; Leh, Sabine; Marti, Hans-Peter; Mollnes, Tom Eirik; Berven, Frode; Vikse, Bjørn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-14)
      Background: The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with progression to end-stage renal disease (ESRD) in patients for whom prognosis could not be predicted based on clinical variables. <br> <br> Methods: Based on data from the Norwegian ...
    • Knowledge, attitude and practice on diet and physical activity among mothers with young children in the Jhaukhel-Duwakot Health Demographic Surveillance Site, Nepal 

      Oli, Natalia; Vaidya, Abhinav; Pahkala, Katja; Eiben, Gabriele; Krettek, Alexandra (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-09)
      The prevalence of cardiovascular diseases is increasing in low and middle-income countries; Nepal’s population shows a high prevalence of behavioral risk factors. Our cross-sectional study in the Jhaukhel-Duwakot Health Demographic Surveillance Site (JD-HDSS), located near the capital Kathmandu, explored knowledge, attitude, and practice (KAP) of mothers with young children regarding diet and physical ...
    • Lower attendance rates in BreastScreen Norway among immigrants across all levels of socio-demographic factors: a population-based study 

      Le, Mary Thuy An; Hofvind, Solveig; Tsuruda, Kaitlyn; Braaten, Tonje; Bhargava, Sameer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-03)
      <i>Background:</i> Several studies have shown that immigrants attend mammographic screening less frequently than non-immigrants. Studies have also shown that attendance is influenced by socio-demographic factors. We aimed to describe the relationship between socio-demographic factors and first attendance among immigrant and non-immigrant women invited to BreastScreen Norway.<p> <p><i>Methods:</i> ...
    • Musculoskeletal symptoms among workers in the commercial fishing fleet of Norway 

      Sandsund, Mariann; Øren, Anita; Thorvaldsen, Trine; Holmen, Ingunn; Sønvisen, Signe; Heidelberg, Cecilie Thon; Aasmoe, Lisbeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-25)
      <i>Background</i>: Fishers exposed to unfavourable environmental conditions may suffer negative health ef- fects. This study aimed to identify musculoskeletal symptoms in professional fishers in Norway using data from several sources; register data, telephone survey and questionnaire.<p> <p><i>Materials and methods</i>: Professional fishers (n = 25,971) registered in the period 2008-2013 were ...
    • Omsorg for den samfunnsnyttige kroppen 

      Boge, Jeanne; Kristoffersen, Kjell; Martinsen, Kari (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      Den franske filosofen Michel Foucault argumenterte for at ein har styrt moderne samfunn ved hjelp av samankoplingar mellom kroppslege praksisar og vitskap. Denne styringsforma kalla han disiplinering. I denne artikkelen argumenterer me for at den politiske argumentasjonen i siste halvdel av 1800-talet og starten av 1900-talet, om å legge om frå folkeleg til borgarleg reinsemd, kan ha vore ein lekk ...
    • Pasientrapportert tilfredshet og livskvalitet etter ulike kirurgiske inngrep ved brystkreft 

      Sjåvik, Anniken (Preprint; Manuskript, 2018-09-20)
      Bakgrunn: Primær behandling ved brystkreft er kirurgi. Kirurgiske alternativer ved brystkreft er mastektomi, lumpektomi, mastektomi med primær brystrekonstruksjon (MPR) eller mastektomi med sekundær rekonstruksjon (MSR). For de fleste brystkreftpasienter vil det være flere aktuelle kirurgiske metoder. Kunnskap om postoperativ livskvalitet, tilfredshet og komplikasjoner vil da kunne være veiledende ...
    • På vei mot en ny lege - eller? 

      Iversen, Anita; Risør, Torsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04)
    • Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases 

      Shields, Kelly J.; Mollnes, Tom Eirik; Eidet, Jon Roger; Mikkelsen, Knut; Almdahl, Sven Martin; Bottazzi, Barbara; Lyberg, Torstein; Manzi, Susan; Ahearn, Joseph M; Hollan, Ivana (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-31)
      Purpose: <br> Inflammatory rheumatic diseases (IRD) are associated with accelerated coronary artery disease (CAD), which may result from both systemic and vascular wall inflammation. There are indications that complement may be involved in the pathogenesis of CAD in Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). This study aimed to evaluate the associations between circulating ...
    • Promoting Professional Development in Medical education: perspectives from the Norwegian Medical School in Tromsoe 

      Hovdenak, Sylvi Stenersen; Wiese, Eline F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-16)
      In international research on medical education the concepts of professionalism and professional development have been increasingly focused. The article problematizes and discusses these concepts in relation to the Aristotelian concepts of episteme, techne and phronesis. Phronesis as a form of knowledge is of fundamental importance regarding professionalism and professional development, and can be ...