Mendelian randomisation (MR) studies show that higher body mass index (BMI) and lower 25-hydroxyvitamin D (25[OH]D) increase psoriasis risk. The combined effect of these factors has not been explored using factorial MR. Using cross-sectional data from UK Biobank (UKB, n=398 404) and the Trøndelag Health Study (HUNT, n=86 648), we calculated polygenic risk scores for BMI and 25(OH)D to estimate odds ...

The development of the gut microbiome in infancy is a vulnerable process that may be perturbed by antibiotics or supported by probiotics. Although effects of these “biotics” have been well-studied through DNA sequencing, it remains unclear how the resulting compositional changes affect the microbiome metabolic functions. Additionally, limits in method standardization require careful quality assessment ...

Objective - Intravenous epinephrine administration is preferred during neonatal resuscitation, but may not always be rapidly administered due to lack of equipment or trained staff. We aimed to compare the time to return of spontaneous circulation (ROSC) and post-ROSC haemodynamics between intravenous, endotracheal (ET) and intranasal (IN) epinephrine in severely asphyxic, bradycardic newborn ...

Objective - To describe healthcare professionals’ perception of current early rehabilitation practices and their preconditions, focusing on functional and cognitive stimulation facilitated by nurses and other healthcare professionals in Scandinavian intensive care units (ICUs).<p> <p>Design - Cross-sectional electronic survey administered to healthcare professionals. The survey was developed in ...

Background - Surgical site infections are a major health problem that deteriorates the patients’ health and increases health care costs. A reliable method to identify patients with modifiable risk of surgical site infection is necessary to reduce the incidence of them but data are limited. Hence the objective is to assess the predictive validity of a logistic regression model compared to risk indexes ...

International health and physiotherapy research has developed over the last few decades through the use and further development of a wide range of scientific theories. This enables researchers to address current issues more appropriately and contribute to change. In German-speaking countries, this diversity of scientific grounding has yet to be developed. The common distinction between quantitative ...

<i>Enterococcus faecium</i>, a gut commensal bacterium, has become a significant nosocomial and opportunistic pathogen, linked to infections like urinary tract infections, bacteraemia, and endocarditis. Its success as a pathogen is partly due to its high level of resistance to antibacterial agents. These resistance mechanisms are complicating treatment, especially in strains resistant to vancomycin, ...

In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged ...

Personality disorders (PDs) are prevalent among individuals with chronic pain, but less is known about the prevalence of pain in the PD population. This study therefore sought to explore the prevalence of current or everyday pain among individuals referred to outpatient PD treatment, and further explore the mediating role of negative affect in the relationship between PD severity and current pain. ...

Spesialisering innen hjertesykdommer har over lengre tid vært populært og rekrutteringssterkt, men det er ingen oversikt over hvor mange leger i spesialisering (LIS) i hjertesykdommer som jobber ved norske sykehus. Det er også til en viss grad uvisst hvordan LIS i hjertesykdommer opplever spesialiseringsløpet, arbeidsforholdene og arbeidsmiljø. I et forsøk på å kartlegge disse forholdene sendte ...