Background: Breast cancer is a significant public health challenge with diverse treatment outcomes. This underscores the need for better patient selection in clinical trials to improve representativeness and treatment efficacy. This thesis uses data from the Cancer Registry of Norway (CRN) to assess how modifications to eligibility criteria, as outlined in the PALOMA-II randomized controlled trial, ...

The increasing level of AMR require an increase in new antimicrobial drug candidates. By proving that bEVs are a suitable model for the bacterial membrane, it can be applied to the development of new drug candidates. Potentially making the development of new candidates more efficient and reducing cost. To further examine the potential of bEVs, we isolated bEVs from E. coli, a gram-negative bacteria. ...

Biofilm is an extracellular matrix that allows bacteria to attach themselves to surfaces and to each other. Biofilm formation among E. coli causes diseases, and the majority of urinary tract infections (UTI) are caused by biofilm producing E. coli. The biofilm layer among E. coli also play a role in bloodstream infections (BSI). Biofilms adhere to surfaces as indwelling medical devices and increase ...

Bakgrunn: Kirurgisk brann er en ‟never event” på operasjonsstua som kan føre til store pasientskader. På operasjonsstua er de tre forutsetningene for brann til stede i varierende grad, og forebygging av brann er derfor vesentlig. Operasjonssykepleiere har en særlig viktig rolle når det kommer til forebygging av pasientskader på operasjonsstua. <p> <p>Hensikt: Hensikten med oppgaven er å undersøke ...

Bakgrunn: Barseltiden er for mange en periode hvor amming etableres, og flere mødre opplever ammeutfordringer i denne tiden. Familiene blir utskrevet tidlig fra sykehuset, ofte før melkeproduksjonen har kommet i gang. Helsesykepleier har en sentral rolle når det gjelder ammeveiledning gjennom barnets første leveår, og skal støtte og veilede mødre til velfungerende amming. Det foreligger lite forskning ...

This thesis focuses on developing a Machine Learning (ML) model to predict the first hospital admission in older Norwegian patients. Addressing the complexity of predicting all-cause hospitalizations required a comprehensive approach, beginning with a systematic review of existing work. The review highlighted some important gaps in the use of ML for predicting hospitalization such as challenges in ...

<p><i>Background</i> Understanding Multimorbidity Patterns (MPs) is crucial for planning healthcare interventions, allocating resources, and improving patients’ outcomes. <p><i>Objective</i> We aim to demonstrate the use of Network Analysis (NA) to explore the MPs in hospitalized Norwegian older patients. <p><i>Methods</i> We utilized data from the Norwegian Patient Registry (NPR) of all admissions ...

<p><i>Background</i> Parents’ perceptions of their children’s behavior are culturally determined and may differ across cultures. The present study aimed to investigate parents’ perceptions of adolescents’ difficulties and the impact of problems in different cultural contexts in Nepal, and to explore the extent to which they align with child symptoms measured on a problem rating scale. <p><i>Methods</i> ...

Background - Therapeutic relationships are vital for patients with complex and long-term psychosocial needs, yet such patients often face fragmented and unstable relationships within mental healthcare. These patients are more often than others moved between treatment settings and caregiving teams. Statutory obligations strain the relationships with frequent hospitalizations adding to the burden This ...

Dokumentet rapporterer fra prosjektet Kickstart på sykehjem hvor en modell for aktiv læring for sykepleierstudenter i sykehjem ble utviklet, implementert og evaluering. "Kickstart-modellen" går ut på at førsteårs sykepleierstudenter studerer i praksis i sykehjem i læringsceller på to studenter, som støttes av en praksisveileder og et team av kombinerte stillinger mellom praksisplass og utdanningsi ...