Viser treff 1-20 av 5407

    • Kartlegging av prosedyrer for oppdekking av instrumentbord ved kirurgiske inngrep 

      Igesund, Unni; Rasmussen, Guri; Overvåg, Grete; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel, 2019)
    • Bipolar radiofrequency neurotomy for spinal pain - A promising technique but still some steps to go 

      Kvarstein, Gunnvald; Lundeland, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-02)
    • p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance 

      Flem-Karlsen, Karine; Tekle, Christina; Øyjord, Tove Ragnhild; Flørenes, Vivi Ann; Mælandsmo, Gunhild Mari; Fodstad, Øystein; Nunes-Xavier, Caroline Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-09)
      Immunoregulatory protein B7-H3 is involved in the oncogenic and metastatic potential of cancer cells, as well as in drug resistance. Resistance to conventional chemotherapy is an important aspect of melanoma treatment, and a better understanding of how B7-H3 enhances drug resistance may lead to the development of more effective therapies. We investigated the <i>in vitro</i> and <i>in vivo</i> ...
    • Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation 

      Berzaghi, Rodrigo; Akhtar, Muhammad Asad; Islam, Md Ashraful; Pedersen, Brede Dille; Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-17)
      The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ...
    • Exploring why and how encounters with the Norwegian health-care system can be considered culturally unsafe by North Sami-speaking patients and relatives: A qualitative study based on 11 interviews 

      Mehus, Grete; Bongo, Berit Andersdatter; Engnes, Janne Isaksen; Moffitt, Pertice (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
      <p><i>Background - </i>Citizens of Norway have free and equal access to healthcare. Nurses are expected to be culturally sensitive and have cultural knowledge in encounters with patients. Culturally safe care is considered both a process and an outcome, evaluated by whether the patients feel safe, empowered and cared for, or not. All patients request equal access to quality care in Norway, also Sami ...
    • Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study 

      Småbrekke, Silje; Schirmer, Henrik; Melsom, Toralf; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
      <p><i>Background - </i>Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive ...
    • Circulating tumor cell-derived pre-clinical models for personalized medicine 

      Tellez Gabriel, Marta; Cochonneau, Denis; Jubelin, Camille; Heymann, Marie-Françoise; Heymann, Dominique (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-24)
      The main cause of death from cancer is associated with the development of metastases, resulting from the inability of current therapies to cure patients at metastatic stages. Generating preclinical models to better characterize the evolution of the disease is thus of utmost importance, in order to implement effective new cancer biomarkers and therapies. Circulating Tumor Cells (CTCs) are good ...
    • Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche 

      Cuminetti, Vincent; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-18)
      Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differentiation of BM mesenchymal stromal cells, but they seem to be a heterogeneous population with distinct metabolisms, lipid compositions, secretory properties and ...
    • Chlamydia pecorum associated with an outbreak of infectious keratoconjunctivitis in semi-domesticated reindeer in Sweden 

      Sanchez Romano, Javier; Leijon, Mikael; Hagström, Åsa; Jinnerot, Tomas; Rockström, Urlika; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-05)
      Infectious keratoconjunctivitis (IKC), the most common ocular disease in ruminants worldwide, has affected semi-domesticated Eurasian reindeer (<i>Rangifer tarandus tarandus</i>) for over 100 years, both as individual cases and in outbreaks affecting tens to hundreds of animals. Recurrent IKC outbreaks have been affecting a semi-domesticated reindeer herd in Östra Kikkejaure (Norrbotten county, ...
    • Ambiguity and professional accountability in physiotherapy practice. Acquired brain injury rehabilitation across health care levels 

      Irgens, Eirik Lind (Doctoral thesis; Doktorgradsavhandling, 2019-09-10)
      At the time of this study, the Norwegian health care system was in the middle of the implementation of the Coordination reform, initiated in 2012 due to insufficient coordination and an increase in health care service expenditure. Earlier hospital discharge and increased municipal responsibilities for rehabilitation following acquired brain injuries (ABI) challenge the traditional rehabilitation ...
    • Blame it on the weather? The association between pain in fibromyalgia, relative humidity, temperature and barometric pressure 

      Fagerlund, Asbjørn Johansen; Iversen, Maria; Ekeland, Andrea; Moen, Connie Malén; Aslaksen, Per M (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-10)
      Self-reported pain levels in patients with fibromyalgia may change according to weather conditions. Previous studies suggest that low barometric pressure (BMP) is significantly related to increased pain, but that the contribution of changes in BMP has limited clinical relevance. The present study examined whether BMP influenced variability in perceived stress, and if stress levels moderated or ...
    • The Impact of the “Semente” Program on the Family-Focused Practice of Mental Health Professionals in Portugal 

      Doesum, Karin van; Maia, Teresa M; Pereira, Catarina; Loureiro, Monica; Marau, Joana; Toscano, Lurdes; Lauritzen, Camilla; Reedtz, Charlotte (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-07)
      <p><i>Background - </i>Children of parents with mental illness (COPMI) are a high-risk group. There is a strong association between parents’ psychiatric disorders and the incidence of psychopathology in their children. These children need to be identified and supported by mental health workers early, and hence, clinical practice in adult mental health services needs to change from a focus on individual ...
    • Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study 

      Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-14)
      In recent years, low dose naltrexone (LDN) has been used as an off-label therapy for several chronic diseases. Results from small laboratory and clinical studies indicate some beneficial effects of LDN in autoimmune diseases, but clinical research on LDN in rheumatic disease is limited. Using a pharmacoepidemiological approach, we wanted to test the hypothesis that starting LDN leads to reduced ...
    • A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults 

      Bramness, Jørgen Gustav; von Soest, Tilmann (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)
      <p><i>Background - </i>A small number of studies have shown that the use of cannabis increases the risk of bronchial asthma. There is, however, a paucity of longitudinal studies which are able to control for known risk factors of bronchial asthma. <p><i>Methods - </i>Survey data from a population-based longitudinal study encompassing 2602 young adults followed for 13 years were coupled with individual ...
    • Inequalities in the Use of eHealth Between Socioeconomic Groups Among Patients With Type 1 and Type 2 Diabetes: Cross-Sectional Study 

      Hansen, Anne Helen; Bradway, Meghan; Brož, Jan; Claudi, Tor; Henriksen, Øystein; Wangberg, Silje C; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-29)
      <p><i>Background - </i>The prevalence of diabetes and the use of electronic health (eHealth) are increasing. People with diabetes need frequent monitoring and follow-up of health parameters, and eHealth services can be highly valuable. However, little is known about the use of eHealth in different socioeconomic groups among people with diabetes. <p><i>Objective - </i>The aim of this study was to ...
    • Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous 

      Nieder, Carsten; Guckenberger, Matthias; Gaspar, Laurie E.; Rusthoven, Chad G.; De Ruysscher, Dirk; Sahgal, Arjun; Nguyen, Timothy; Grosu, Anca L.; Mehta, Minesh P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-15)
      <p><i>Background - </i>Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over the last decade. It is not trivial to find the optimal balance of over- versus undertreatment in these patients. Several recent trials, including the randomized QUARTZ ...
    • Identifying eating habits in Finnish children: A cross-sectional study 

      De Oliveira Figueiredo, Rejane Augusta; Viljakainen, Jannina; Viljakainen, Heli; Roos, Eva; Rounge, Trine Ballestad; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-15)
      <p><i>Background - </i>We aimed to identify different eating habits among Finnish children and to evaluate their association with meal patterns, breakfast consumption, and socio-demographic characteristics in a large, nationwide cohort of children. <p><i>Methods - </i>We evaluated 10,569 children aged 9–14 years into the Finnish Health in Teens cohort in a cross-sectional design. The hierarchical ...
    • Manually assisted body-weight supported locomotor training does not re-establish walking in non-walking subjects with chronic incomplete spinal cord injury: A randomized clinical trial 

      Piira, Anu Mirjam; Lannem, Anne M.; Sørensen, Marit; Glott, Thomas; Knutsen, Raymond; Jørgensen, Lone; Gjesdal, Knut; Hjeltnes, Nils; Knutsen, Synnøve Fønnebø (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-28)
      <p><i>Objective - </i>To assess the effects of manually assisted body-weight supported locomotor training in subjects with chronic incomplete spinal cord injury. <p><i>Design - </i>Randomized controlled clinical trial. <p><i>Subjects - </i>Twenty subjects with American Spinal Injury Association Impairment Scale grades C or D and > 2 years post-injury. <p><i>Methods - </i>Random allocation to 60 ...
    • 3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice 

      Boardman, Neoma Tove; Rossvoll, Line; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-02)
      Physical activity is an efficient strategy to delay development of obesity and insulin resistance, and thus the progression of obesity/diabetes-related cardiomyopathy. In support of this, experimental studies using animal models of obesity show that chronic exercise prevents the development of obesity-induced cardiac dysfunction (cardiomyopathy). Whether exercise also improves the tolerance to ...
    • Change in prevalence and severity of metabolic syndrome in the Sami and non-Sami population in rural Northern Norway using a repeated cross-sectional population-based study design: the SAMINOR Study 

      Michalsen, Vilde Lehne; Kvaløy, Kirsti; Svartberg, Johan; Siri, Susanna Ragnhild; Melhus, Marita; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-14)
      <p><i>Objective - </i>To examine the change in both the prevalence and severity of metabolic syndrome (MetS) in the Sami and non-Sami in Northern Norway due to a lack of knowledge regarding the development of MetS in this population. <p><i>Design - </i>Repeated cross-sectional study. <p><i>Setting - </i>The study is based on data from the SAMINOR 1 Survey (2003–2004, n=6550) and the SAMINOR 2 ...