Now showing items 21-40 of 5407

    • A quality indicator set for use in rehabilitation team care of people with rheumatic and musculoskeletal diseases; development and pilot testing 

      Johansen, Inger; Klokkerud, Mari; Anke, Audny; Børke, Janne-Birgitte; Glott, Thomas; Hauglie, Uno; Høyem, Audhild; Klovning, Atle; Lande, Karin Anna; Larsen, Mona; Nordvik, Jan Egil; Wigers, Sigrid Hørven; Øyeflaten, Irene Larsen; Hagen, Kåre Birger; Kjeken, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-29)
      <p><i>Background - </i>Systems for monitoring effectiveness and quality of rehabilitation services across health care levels are needed. The purpose of this study was to develop and pilot test a quality indicator set for rehabilitation of rheumatic and musculoskeletal diseases. <p><i>Methods - </i>The set was developed according to the Rand/UCLA Appropriateness Method, which integrates evidence ...
    • Promoter activity of ORF-less gene cassettes isolated from the oral metagenome 

      Tansirichaiya, Supathep; Mullany, Peter; Roberts, Adam P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-10)
      Integrons are genetic elements consisting of a functional platform for recombination and expression of gene cassettes (GCs). GCs usually carry promoter-less open reading frames (ORFs), encoding proteins with various functions including antibiotic resistance. The transcription of GCs relies mainly on a cassette promoter (P<sub>C</sub>), located upstream of an array of GCs. Some integron GCs, called ...
    • Robot-assisted locomotor training did not improve walking function in patients with chronic incomplete spinal cord injury: A randomized clinical trial 

      Piira, Anu Mirjam; Lannem, Anne M.; Sørensen, Marit; Glott, Thomas; Knutsen, Raymond; Jørgensen, Lone; Gjesdal, Knut; Hjeltnes, Nils; Knutsen, Synnøve Fønnebø (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-21)
      <p><i>Objective - </i>To assess the effects of robot-assisted locomotor training in patients with chronic incomplete spinal cord injury. <p><i>Design - </i>Randomized single-blind controlled clinical trial. <p><i>Setting - </i>The intervention site was an outpatient clinic, and pre- and post-evaluations were performed in a rehabilitation hospital. <p><i>Patients - </i>A total of 24 subjects with ...
    • Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study 

      Hjemsæter, Arne Jan; Bramness, Jørgen Gustav; Drake, Robert; Monsbakken, Bent Berntsen; Saltyte Benth, Jurate; Landheim, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      <p><i>Background - </i>This study investigated cause of death, mortality rates and explored if baseline characteristics were associated with risk of death in patients with alcohol use disorder alone or poly-substance use disorders. <p><i>Methods - </i>This was a prospective, longitudinal study of patients followed for 19 years after entering specialized treatment for substance use disorders. At ...
    • The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS 

      Hoem, Gry; Larsen, Kenneth Bowitz; Øvervatn, Aud Karin; Brech, Andreas; Lamark, Trond; Sjøttem, Eva; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-28)
      Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a CGG-repeat expansion in the 5′ UTR of the FMR1 gene on the X-chromosome. Both elevated levels of the expanded FMR1 mRNA and aberrant expression of a polyglycine protein (FMRpolyG) from the CGG-repeat region are hypothesized to trigger the pathogenesis of FXTAS. While increased expression of FMRpolyG leads ...
    • Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer 

      Richardsen, Elin; Andersen, Sigve; Al-Saad, Samer; Rakaee, Mehrdad; Nordby, Yngve; Pedersen, Mona Irene; Ness, Nora; Ingebriktsen, Lise; Fassina, Ambrogio; Tasken, Kristin Austlid; Millls, Ian; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-23)
      Prostate cancer (PC) is a highly heterogenous disease and one of the leading causes of mortality in developed countries. Recently, studies have shown that expression of immune checkpoint proteins are directly or indirectly repressed by microRNAs (miRs) in many types of cancers. The great advantages of using miRs based therapy is the capacity of these short transcripts to target multiple molecules ...
    • Outcome of 881 total hip arthroplasties in 747 patients 21 years or younger: data from the Nordic Arthroplasty Register Association (NARA) 1995-2016 

      Halvorsen, Vera Baasland; Fenstad, Anne Marie; Engesæter, Lars B.; Nordsletten, Lars; Overgaard, Søren; Pedersen, Alma B.; Kärrholm, Johan; MOHADDES, MAZIAR; Eskelinen, Antti; Mäkelä, Keijo T.; Röhrl, Stephan Maximillian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-15)
      <p><i>Background and purpose — </i>The literature is scarce on the outcome of the youngest patients with total hip arthroplasties (THAs). We analyzed register data, revision risk, and related factors in patients 21 years or younger with THAs in the Nordic Arthroplasty Register Association (NARA). <p><i>Patients and methods — </i>We included all THA patients 21 years or younger reported during 1995 ...
    • Predictors of early mortality after transcatheter aortic valve implantation 

      Kjønås, Didrik; Dahle, Gry; Schirmer, Henrik; Malm, Siri; Eidet, Jo; Aaberge, Lars; Steigen, Terje; Aakhus, Svend; Busund, Rolf; Rösner, Assami (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-23)
      <p><i>Objectives - </i>To investigate whether preoperative echocardiographic evaluation of ventricular function, especially right ventricular systolic and diastolic parameters including speckle-tracking analysis, could aid in the prediction of 30-day mortality after transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis. <p><i>Methods - </i>This is a prospective observational ...
    • Progestin-only and combined oral contraceptives and receptor-defined premenopausal breast cancer risk: The Norwegian Women and Cancer Study 

      Busund, Marit Katinka; Stensland-Bugge, Nora; Braaten, Tonje; Waaseth, Marit; Rylander, Charlotta; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-19)
      Receptor-defined subtypes of breast cancer represent distinct cancer types and have differences in risk factors. Whether the two main hormonal forms of oral contraceptives (OCs); i.e. progestin-only (POC) and combined oral contraceptives (COC), are differentially associated with these subtypes are not well known. The aim of our study was to assess the effect of POC and COC use on hormone receptor-defined ...
    • Relationship between level of CPR training, self-reported skills, and actual manikin test performance—an observational study 

      Lund-Kordahl, Inger; Mathiassen, Maria; Melau, Jørgen; Olasveengen, Theresa M.; Sunde, Kjetil; Fredriksen, Knut (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-10)
      <p><i>Background - </i>Quality of bystander cardiopulmonary resuscitation (CPR) skills may influence out of hospital cardiac arrest (OHCA) outcomes. We analyzed how the level of CPR training related to indicators of good CPR quality and also the relationship between self-reported skills and actual CPR performance. <p><i>Methods - </i>Two hundred thirty-seven persons trained in standardized BLS ...
    • Periodontitis Prevalence and Severity in Adults: A Cross-Sectional Study in Norwegian Circumpolar Communities 

      Holde, Gro Eirin; Oscarson, Nils; Trovik, Tordis A; Tillberg, Anders; Jönsson, Birgitta (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-01)
      <p><i>Background - </i>The aim of this study is to describe the prevalence, severity, and extent of periodontitis in the adult population of circumpolar communities in Norway using data from the Tromstannen–Oral Health in Northern Norway study. <p><i>Methods - </i>In this cross‐sectional survey, data were collected from a randomized population sample (aged 20 to 79 years) in Northern Norway. ...
    • Regulation of Autophagy-related proteins: Roles of post-translational modifications 

      Shrestha, Birendra Kumar (Doctoral thesis; Doktorgradsavhandling, 2019-09-18)
      Autophagy is a cell renovation system that directs almost any type of cell contents for lysosomal degradation and recycling of building blocks. It is fundamental for cellular homeostasis and for determining cell fate in response to stress. Hence, understanding the regulation of autophagy-related proteins is of great importance. This study focuses on the effect of posttranslational modifications on ...
    • Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure 

      Stubnova, Viera; Os, Ingrid; Høieggen, Aud; Solbu, Marit Dahl; Grundtvig, Morten; Westheim, Arne; Atar, Dan; Waldum-Grevbo, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-05)
      <p><i>Background - </i>Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. The purpose of the study was to investigate if SUA was an independent predictor of 5-year all-cause mortality in a propensity score matched cohort of chronic heart failure ...
    • Localized Therapy of Vaginal Infections and Inflammation: Liposomes-In-Hydrogel Delivery System for Polyphenols 

      Jøraholmen, May Wenche; Basnet, Purusotam; Tostrup, Mia; Moueffaq, Sabrin; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-27)
      Natural polyphenols, such as resveratrol (RES) or epicatechin (EPI), are attractive for treatments of various diseases, including vaginal infections and inflammation, because of their strong anti-oxidative and anti-inflammatory properties. However, their low solubility and consequent poor bioavailability limit their therapeutic uses. To overcome these limitations, a vaginal delivery system comprising ...
    • Prognostic Value of Macrophage Phenotypes in Resectable Non–Small Cell Lung Cancer Assessed by Multiplex Immunohistochemistry 

      Rakaee, Mehrdad; Busund, Lill-Tove; Jamaly, Simin; Paulsen, Erna-Elise; Richardsen, Elin; Andersen, Sigve; Al-Saad, Samer; Bremnes, Roy M.; Dønnem, Tom; Kilvær, Thomas Karsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-10)
      Macrophages are important inflammatory cells that regulate innate and adaptive immunity in cancer. Tumor-associated macrophages (TAMs) are thought to differentiate into two main phenotypes: proinflammatory M1 and protumorigenic M2. Currently, the prognostic impact of TAMs and their M1 and M2 phenotypes is unclear in non–small cell cancer (NSCLC). The present study was set up to evaluate an approach ...
    • Rationale for a Swedish cohort consortium 

      Sundström, Johan; Björkelund, Cecilia; Giedraitis, Vilmantas; Hansson, Per-Olof; Högman, Marieann; Janson, Christer; Koupil, Ilona; Kristenson, Margareta; Trolle Lagerros, Ylva; Leppert, Jerzy; Lind, Lars; Lissner, Lauren; Johansson, Ingegerd; Ludvigsson, Jonas F.; Nilsson, Peter M.; Olsson, Håkan; Pedersen, Nancy L.; Rosenblad, Andreas; Rosengren, Annika; Sandin, Sven; Snäckerström, Tomas; Stenbeck, Magnus; Söderberg, Stefan; Weiderpass, Elisabete; Wanhainen, Anders; Wennberg, Patrik; Fortier, Isabel; Heller, Susanne; Storgärds, Maria; Svennblad, Bodil (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-08)
      We herein outline the rationale for a Swedish cohort consortium, aiming to facilitate greater use of Swedish cohorts for world-class research. Coordination of all Swedish prospective population-based cohorts in a common infrastructure would enable more precise research findings and facilitate research on rare exposures and outcomes, leading to better utilization of study participants’ data, better ...
    • Prevalence and correlates of self-reported disordered eating: A cross-sectional study among 90 592 middle-aged Norwegian women 

      Sigstad, Marie; Rosenvinge, Jan H; Skeie, Guri; Rylander, Charlotta (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-23)
      Disordered eating (DE) is extensively studied among adolescents and young women. However, there is growing evidence that DE as well as the clinical eating disorders may occur at any age from childhood to advanced years. This study aimed to determine the prevalence and correlates of DE in a representative sample of middle-aged women from Norway. The study included 90 592 women (median age: 55 years) ...
    • Terapeuters erfaringer fra arbeidet med å initiere til nettverkssamtale ved akutteam i psykiatrien 

      Grønnbakk, Gro (Master thesis; Mastergradsoppgave, 2016-10-03)
      Bakgrunn: Bakgrunn for studien er interessen for nettverksarbeid og det arbeidet som ligger til grunn før nettverkssamtalen eventuelt kan iverksettes. Tidligere forskning har i stor grad fokusert på nytteverdien av nettverkssamtaler, men vi vet mindre om utfordringer knyttet til å initiere slike samtaler. Problemstilling: Hvilke erfaringer har terapeuter ved akutteam med å initiere til ...
    • The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma 

      Mauseth, Brynjar; Camilio, Ketil Andre; Shi, Jihua; Hammarström, Clara Louise; Rekdal, Øystein; Sveinbjørnsson, Baldur; Line, Pål Dag (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-21)
      LTX-401 is a novel oncolytic compound designed for the local treatment of solid tumors. In the present study, we have examined the applicability and efficacy of LTX-401 in a rat model JM1 hepatocellular carcinoma, with particular interest in its ability to induce antitumor immunity. LTX-401 induces necrotic cell death followed by the release of immunogenic cell death mediators such as high-mobility ...
    • Associations Between the Use of eHealth and Out-of-Hours Services in People With Type 1 Diabetes: Cross-Sectional Study 

      Hansen, Anne Helen; Claudi, Tor; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-21)
      <p><i>Background - </i>Despite the increasing prevalence of diabetes and the increasing use of eHealth, little is known about the association between provider-based health services and eHealth among people with diabetes. This is the second study in a project exploring the associations between the use of eHealth and the use of provider-based health services. <p><i>Objective - </i>The objective of ...