Det helsevitenskapelige fakultet: Recent submissions
Now showing items 21-40 of 10559
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Study approaches mediate associations between learning environment and academic performance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-02)Background: While study approaches have been directly associated with students’ academic performance, learning environment factors may play a more indirect role. The aim of this study was (i) to assess learning environment factors as predictors of students’ average exam grades, and (ii) whether study approaches mediated associations between learning environment factors and exam grades.<p> <p>Methods: ... -
Profile of per- and polyfluoroalkyl substances, source appointment, and determinants in Argentinean postpartum women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-13)Background: Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals with potential adverse health effects. Information concerning PFAS concentrations in relation to pregnancy is scarce in South America and non-existent in Argentina. Aim: We aimed to investigate an extended maternal PFAS profile herein serum concentrations in a regional and global view, source appointment, ... -
Medical trainees’ speciality considerations at their transition from under- to postgraduate education: a descriptive, cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-03)Purpose: This paper aims to provide knowledge on medical trainees’ considerations about specialisation as they move from undergraduate to postgraduate medical education; especially their interest in general practice compared to other specialities.<p> <p>Method: We developed and content-validated a questionnaire to examine medical trainees’ speciality considerations and conducted a descriptive, ... -
Tumor versus Tumor Cell Targeting in Metal-Based Nanoparticles for Cancer Theranostics
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-10)The application of metal-based nanoparticles (mNPs) in cancer therapy and diagnostics (theranostics) has been a hot research topic since the early days of nanotechnology, becoming even more relevant in recent years. However, the clinical translation of this technology has been notably poor, with one of the main reasons being a lack of understanding of the disease and conceptual errors in the design ... -
Applicability and Psychometric Properties of General Mental Health Assessment Tools in Autistic People: A Systematic Review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-13)In recent years, there has been a proliferation of instruments for assessing mental health (MH) among autistic people. This study aimed to review the psychometric properties of broadband instruments used to assess MH problems among autistic people. In accordance with the PRISMA guidelines (PROSPERO: CRD42022316571) we searched the APA PsycINFO via Ovid, Ovid MEDLINE, Ovid Embase and the Web of Science ... -
Free Vascularized Fibula Graft as Primary Salvage Procedure for Acute Cervical Osteomyelitis Caused by Epidural Abscess
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-24)Acute cervical osteomyelitis due to an epidural abscess and pyogenic spondylodiscitis in an immunosuppressed patient with progressive myelopathy is a challenge for the reconstructive surgeon. This report presents our novel approach to treat such a condition in a 56-year-old patient in whom antibiotic treatment and decompression of the medulla by laminectomy of C4–C6 failed. Under general anesthesia, ... -
Oral nanotherapeutic formulation of insulin with reduced episodes of hypoglycaemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-02)Injectable insulin is an extensively used medication with potential life-threatening hypoglycaemic events. Here we report on insulin-conjugated silver sulfide quantum dots coated with a chitosan/glucose polymer to produce a responsive oral insulin nanoformulation. This formulation is pH responsive, is insoluble in acidic environments and shows increased absorption in human duodenum explants and ... -
Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-02)Human papillomavirus (HPV) is associated with cellular changes in the cervix leading to cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent cellular changes. Women undergoing the loop electrosurgical excision procedure (LEEP), a treatment for high-grade cervical intraepithelial neoplasia (CIN2+), remain at risk of recurrence. This study assessed the ... -
The prognostic importance of traumatic axonal injury on early MRI: the Trondheim TAI-MRI grading and quantitative models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-19)Objectives We analysed magnetic resonance imaging (MRI) findings after traumatic brain injury (TBI) aiming to improve the grading of traumatic axonal injury (TAI) to better reflect the outcome.<p> <p>Methods Four-hundred sixty-three patients (8–70 years) with mild (n = 158), moderate (n = 129), or severe (n = 176) TBI and early MRI were prospectively included. TAI presence, numbers, and volumes ... -
Critical care nurses' competence in mentoring students in intensive care units—A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-26)Background: Mentors play an important role in the practical education of critical care nursing students in intensive care units, yet little is known about the mentoring competencies of critical care nurses. Aim: The aim of this study was to assess Norwegian critical care nurses’ competence in mentoring students in intensive care units.<p> <p>Design: This study has a descriptive, cross-sectional ... -
Dose-Response Effects of MittEcho, a Measurement Feedback System, in an Indicated Mental Health Intervention for Children in Municipal and School Services in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-29)Including routine client feedback can increase the effectiveness of mental health interventions for children, especially when implemented as intended. Rate of implementation, or dose, of such feedback interventions has been shown to moderate results in some studies. Variation in implementation and use of client feedback may also contribute to the mixed results observed within the feedback ... -
Status epilepticus in POLG disease: a large multinational study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-01)We aimed to provide a detailed phenotypic description of status epilepticus (SE) in a large cohort of patients with POLG disease and identify prognostic biomarkers to improve the management of this life-threatening condition. In a multinational, retrospective study with data on patients with POLG disease from seven European countries, we identified those who had SE. The age of SE onset, accompanying ... -
TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-29)Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to mitophagy is unknown. Here, we show that K63-linked polyubiquitination of the key mitophagy regulator TBK1 is essential for its mitophagy functions. This modification is catalyzed by the ubiquitin ligase TRIM5a and is ... -
Plugging of pipes by cohesive particles. Computed tomography investigation and theoretical analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-09)Flow regimes leading to clogging of pipes exist for most multiphase flows with cohesive particles. Although plugging is critical in many industrial and medical applications, there are few records describing the details of the process. To address the problem, we conduct a computed tomography (CT) study of plugging in a cohesive ice slurry. We run experiments for ice concentration of 15%, Re∼3500, ... -
Social inequality in prevalence of NCD risk factors: a cross-sectional analysis from the population-based Tromsø Study 2015-2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-30)Objective We aimed to examine associations between educational level, serving as an indicator of socioeconomic position, and prevalence of WHO-established leading behavioural and biological risk factors for noncommunicable diseases (NCDs), in middle-aged to older women and men.<p> <p>Design Population-based cross-sectional study. <p>Setting All inhabitants of the municipality of Tromsø, Norway, ... -
Being Human under Inhuman Conditions: Meanings of Living with Severe Dissociative States Involving the Experience of Being in Parts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-19)Severe dissociative states involving the experience of being in parts, typically associated with diagnosis such as dissociative identity disorder and other specified dissociative disorders, continue to be a controversial and rarely studied area of research. However, because persons with severe dissociative states are at risk of being harmed instead of helped within psychiatric care, their experiences ... -
The recombination initiation functions DprA and RecFOR suppress microindel mutations in Acinetobacter baylyi ADP1
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-17)Short-Patch Double Illegitimate Recombination (SPDIR) has been recently identified as a rare mutation mechanism. During SPDIR, ectopic DNA single-strands anneal with genomic DNA at microhomologies and get integrated during DNA replication, presumably acting as primers for Okazaki fragments. The resulting microindel mutations are highly variable in size and sequence. In the soil bacterium Acinetobacter ... -
Health-related quality of life among older adults following acute hospitalization: longitudinal analysis of a randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-17)Purpose To describe the longitudinal change of health-related quality of life (HRQoL) over 12 months from acute hospitalization in older adults≥70 years (IMMENSE study), and associated factors, to investigate how a medication optimization intervention infuenced this change.<p> <p>Methods The EQ-5D-3L was used at discharge and 1, 6 and 12 months after discharge during a randomized controlled trial ... -
Maternal death and maternal morbidity in Georgia
(Doctoral thesis; Doktorgradsavhandling, 2024-10-25)Maternal death (MD) and morbidity are indicators for maternal health and healthcare system development. This PhD project aimed to investigate MD, maternal morbidity, and related risk factors in Georgia using data from the Georgian Birth Registry (GBR) and digital health surveillance systems. Paper I, with a case series design, identified direct and indirect causes of MD from 2014 to 2017. Paper ... -
Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)Objective: Many psychiatric disorders are linked to low grade systemic inflammation as measured by systemic cytokine levels. Exploration of cytokines and immune activity and their role in psychiatric symptoms may inform pathobiology and treatment opportunities. The aim of this study is to explore if there are associations between cytokines and psychiatric symptom clusters. Comparison between patients ...