Now showing items 1-20 of 5014

    • Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise 

      Hancock, Matthew; Hafstad, Anne Dragøy; Nabeebaccus, Adam A.; Catibog, Norman; Logan, Angela; Smyrnias, Ioannis; Hansen, Synne Simonsen; Lanner, Johanna; Schröder, Katrin; Murphy, Michael P.; Shah, Ajay M.; Zhang, Min (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-27)
      Regular exercise has widespread health benefits. Fundamental to these beneficial effects is the ability of the heart to intermittently and substantially increase its performance without incurring damage, but the underlying homeostatic mechanisms are unclear. We identify the ROSgenerating NADPH oxidase-4 (Nox4) as an essential regulator of exercise performance in mice. Myocardial Nox4 levels ...
    • Complementary and alternative medicine for treatment of atopic eczema in children under 14 years old: a systematic review and meta-analysis of randomized controlled trials 

      Lu, Chun-Li; Lui, Xue-han; Stub, Trine; Kristoffersen, Agnete Egilsdatter; Liang, Shi-bing; Wang, Xiao; Bai, Xue; Norheim, Arne Johan; Musial, Frauke; Alræk, Terje; Fønnebø, Vinjar; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-26)
      <i>Background</i>: Due to limitations of conventional medicine for atopic eczema (AE), complementary and alternative medicine (CAM) is widely used as an alternative, maintaining, or simultaneous treatment for AE. We aimed to evaluate the beneficial and harmful effects of CAM for children with AE under 14 years old.<p> <p><i>Methods</i>: We searched for randomized trials on CAM in 12 Chinese and ...
    • Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment 

      Houwing, Danielle; Heijkoop, Roy; Olivier, Jocelien; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-06)
      The use of selective serotonin reuptake inhibitors (SSRI) during pregnancy has increased tremendously, but the consequences for the offspring remain largely unclear. Several studies have described potential effects of perinatal SSRI-exposure on neurobehavioral outcomes using simplified rodent test set-ups, however these set-ups only assess a small fraction of the behavior. For translational purposes ...
    • Role of the Complement System in the Pathogenesis of Venous Thromboembolism 

      Høiland, Ina Isabella (Doctoral thesis; Doktorgradsavhandling, 2019-04-02)
      Venous thromboembolism (VTE) is a common disease with serious short- and long-term complications. VTE is a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE) and is the third most common cardiovascular disease, causing significant morbidity and mortality. Despite preventive strategies, the incidence of VTE has been stable or increasing slightly during the last decades, affecting ...
    • Expression and functional properties of selected miRNAs in human cancer tissue and cancer cell lines 

      Johannessen, Charles Walquist (Doctoral thesis; Doktorgradsavhandling, 2019-03-01)
      MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) involved in the regulation of gene expression, and they are often seen dysregulated in cancer. For this reason, it is of great scientific interest to study these ncRNAs to better understand their distribution in human tissues and their mode of function. Based on a comprehensive miRNA microarray from 108 breast cancers in the Norwegian Woman and ...
    • Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs 

      Nøst, Therese Haugdahl; Berg, Vivian; Hanssen, Linda; Rylander, Charlotta; Gaudreau, Eric; Dumas, Pierre; Breivik, Knut; Sandanger, Torkjel M (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-01)
      <p><i>Background</i>: Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks.</p> <p><i>Objectives</i>: To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986–2007, and to compare the measured concentrations of polychlorinated biphenyl ...
    • In Home we trust. An ethnographic study of mental health and the use of traditional medicine in a North Norwegian community 

      Kiil, Mona Anita (Doctoral thesis; Doktorgradsavhandling, 2019-05-24)
      Traditional healing practices used when faced with illness or crisis, exist in many North Norwegian communities. Northern Troms has a historical multi-ethnicity of Sami, Kven and Norwegian. The notion of culture appears ambivalent and ambiguous, particularly concerning the Sami identity, but cultural diversity is nevertheless manifested through the use of traditional healing practices such as reading. ...
    • Procrastination and personal finances: Exploring the roles of planning and financial self-efficacy 

      Gamst-Klaussen, Thor; Steel, Piers; Svartdal, Frode (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-05)
      Procrastination is related to unhealthy personal financial behaviors, such as postponing retirement savings, last minute shopping, and not paying bills on time. The present paper explores factors that could explain why procrastinators demonstrate more financial problems compared to non-procrastinators. Study 1 (N = 675) focused on planning, as both procrastination and poor financial habits are ...
    • Hjelpen kom for sent. En studie av hvilke erfaringer fosterforeldre som har sagt opp en fosterhjemsavtale har med barneverntjenesten, og hvilke tanker de har om fremtidig fosterhjemsarbeid 

      Wiik, Sandra; Nilsen, Kathrine (Master thesis; Mastergradsoppgave, 2018-05-15)
      Bakgrunn: Det er en stadig økning av antall barn som plasseres i fosterhjem. Dessverre opplever mange av disse å flytte fra det ene omsorgstiltaket til det andre. Det må legges til rette for en mer stabil hverdag for fosterbarna og fosterfamiliene. Formål og problemstilling: Målet med masteroppgaven er å bidra med kunnskap som kan bidra til at flere fosterforeldre blir stående i oppdraget, slik ...
    • Beslutningstaking i barnevern. Norske saksbehandleres risikovurdering og tiltaksanbefaling 

      Eilertsen, Nathalie Zahra Gonzalez (Master thesis; Mastergradsoppgave, 2018-05-15)
      Saksbehandlere i barnevernet står gjennom sitt arbeid, overfor beslutninger som har konsekvenser for barnet, deres familier og deres nettverk. Beslutninger som foretas i en barnevernkontekst er avhengig av saksbehandlernes vurdering av risiko for barnet, og påfølgende tiltaksanbefaling skal reflektere beste alternativ for å håndtere vurdert risiko. De sakene som saksbehandlerne i barnevernet kan ...
    • "Media er ikke interessert i de sakene som går på system". Barnevernsansattes perspektiver på medias fremstilling av barnevernet, mulige konsekvenser og forslag til tiltak. 

      Hadzic, Aldina (Master thesis; Mastergradsoppgave, 2018-05-15)
      Denne masteroppgaven har som formål å vise de resultatene jeg har gjort funnet i undersøkelsen min, og hvilke perspektiver de ansatte i barnevernstjenesten hadde i forhold til medias fremstilling av tjenesten. Problemstillingen er formulert som følger: Barnevernsansattes perspektiver på medias fremstilling av barnevernet, mulige konsekvenser og forslag til tiltak. For å belyse problemstillingen ...
    • Undersøkelse i barnevernet. En kvalitativ studie om saksbehandleres arbeid i undersøkelsesfasen. 

      Ottesen, Nina Rodrigues (Master thesis; Mastergradsoppgave, 2018-04-25)
      Barneverntjenestene i Norge har myndighet til å gjøre store inngrep i private folks liv. Vurderinger og beslutninger som fattes, kan få konsekvenser for de enkelte barn og familier som kommer i kontakt med tjenesten, som kan oppleves både positivt og negativ. Intensjonen bak og grunnlaget for at vi en skal ha en slik tjeneste er å ivareta barns rettigheter, samt for å sikre gode nok oppvekstvillkår ...
    • Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation 

      Kostovski, Emil; Frigato, E; Savikj, Mladen; Dahm, Anders Erik A; Sandset, Per Morten; Mowinckel, Marie-Christine; Skretting, Grethe; Østerud, Bjarne; Bertolucci, C; Iversen, Per Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-09)
      <i>Study design</i>: Crossover double blind, randomized placebo-controlled trial.<p> <p><i>Objectives</i>: Circadian oscillators are located both in the brain and in peripheral organs. Melatonin, the main brain-derived hormone governing circadian variations, is highly associated with daylight patterns. However, in subjects with tetraplegia the melatonin levels are blunted. Here we studied peripheral ...
    • Unsung heroes, flying blind - A metasynthesis of parents' experiences of caring for children with special health care needs at home 

      Nygård, Carina; Clancy, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-13)
      <i>Aims and objectives</i>: To aggregate, synthesise and interpret qualitative research studies of parents’ experiences of caring for a child with special health‐care needs at home.<p> <p><i>Background</i>: Advances in the field of medical and nursing science have ensured better survival rates for children with chronic illnesses. Many of these children have significant special health‐care needs. ...
    • Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts 

      Li, Kuanrong; Anderson, Garnet; Viallon, Vivian; Arveux, Patrick; Kvaskoff, Marina; Fournier, Agnès; Krogh, Vittorio; Tumino, Rosario; Sánchez, María-José; Ardanaz, Eva; Chirlaque, Maria-Dolores; Agudo, Antonio; Muller, David C.; Smith, Todd; Tzoulaki, Ioanna; Key, Timothy J.; Bueno-de-Mesquita, Hendrik Bastiaan; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Kaaks, Rudolf; Hüsing, Anika; Fortner, Renée T.; Zeleniuch-Jacquotte, Anne; Sund, Malin; Dahm, Christina C; Overvad, Kim; Aune, Dagfinn; Weiderpass, Elisabete; Romieu, Isabelle; Riboli, Elio; Gunter, Marc J.; Dossus, Laure; Prentice, Ross; Ferrari, Pietro (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-03)
      <p><i>Background</i>: Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction.</p> <p><i>Methods</i>: We built two models, for ER+ (Model<sub>ER+</sub>) and ER- tumors ...
    • Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy 

      Mejlvang, Jakob; Olsvik, Hallvard Lauritz; Svenning, Steingrim; Bruun, Jack-Ansgar; Abudu, Yakubu Princely; Larsen, Kenneth Bowitz; Brech, Andreas; Hansen, Tom Egil; Brenne, Hanne Britt; Hansen, Terkel; Stenmark, Harald Alfred; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-17)
      It is not clear to what extent starvation-induced autophagy affects the proteome on a global scale and whether it is selective. In this study, we report based on quantitative proteomics that cells during the first 4 h of acute starvation elicit lysosomal degradation of up to 2–3% of the proteome. The most significant changes are caused by an immediate autophagic response elicited by shortage of amino ...
    • Knowledge of antibiotics and antibiotic resistance among Norwegian pharmacy customers – a cross-sectional study 

      Waaseth, Marit; Adan, Abdifatah; Røen, Ingrid L.; Eriksen, Karoline; Stanojevic, Tijana; Halvorsen, Kjell H.; Garcia, Beate Hennie; Holst, Lone; Ulshagen, Karen Marie; Blix, Hege Salvesen; Ariansen, Hilde Louise; Nordeng, Hedvig Marie Egeland (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-15)
      <p><i>Background</i>: Antibiotic resistance is a global health threat. Public knowledge is considered a prerequisite for appropriate use of antibiotics and limited spread of antibiotic resistance. Our aim was to examine the level of knowledge of antibiotics and antibiotic resistance among Norwegian pharmacy customers, and to assess to which degree beliefs, attitudes and sociodemographic factors are ...
    • Development of grip strength during the first year after stroke 

      Stock, Roland; Thrane, Gyrd; Askim, Torunn; Anke, Audny; Mork, Paul Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-08)
      <p><i>Objective</i>: To assess recovery of grip strength during the first year post-stroke.</p> <p><i>Design</i>: Exploratory study on a subsample of patients participating in the Norwegian Constraint-Induced Movement Therapy trial.</p> <p><i>Subjects</i>: Eleven patients (mean age 59.1 years; 3 women) with mild to moderate stroke were recruited 7–29 days post-stroke.</p> <p><i>Methods</i>: ...
    • Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals 

      Zhou, Heng; Mondragón, Laura; Xie, Wei; Mauseth, Brynjar; Leduc, Marion; Sauvat, Allan; Gomes-da-Silva, Lígia C.; Forveille, Sabrina; Iribarren, Kristina; Souquere, Sylvie; Bezu, Lucillia; Liu, Peng; Zhao, Liwei; Zitvogel, Laurence; Sveinbjørnsson, Baldur; Eksteen, Jacobus Johannes; Rekdal, Øystein; Kepp, Oliver; Kroemer, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-23)
      Abstract Oncolytic peptides and peptidomimetics are being optimized for the treatment of cancer by selecting agents with high cytotoxic potential to kill a maximum of tumor cells as well as the capacity to trigger anticancer immune responses and hence to achieve long-term effects beyond therapeutic discontinuation. Here, we report on the characterization of two novel oncolytic peptides, DTT-205 ...
    • The Psychological Science Accelerator: Advancing Psychology Through a Distributed Collaborative Network 

      Moshontz, Hannah; Campbell, Lorne; Ebersole, Charles R.; IJzerman, Hans; Urry, Heather L.; Forscher, Patrick S.; Grahe, Jon E.; McCarthy, Randy J.; Musser, Erica D.; Antfolk, Jan; Castille, Christopher M.; Evans, Thomas Rhys; Fiedler, Susann; Flake, Jessica Kay; Forero, Diego A.; Janssen, Steve M. J.; Keene, Justin Robert; Protzko, John; Aczel, Balazs; Álvarez Solas, Sara; Ansari, Daniel; Awlia, Dana; Baskin, Ernest; Batres, Carlota; Borras-Guevara, Martha Lucia; Brick, Cameron; Chandel, Priyanka; Chatard, Armand; Chopik, William J.; Clarance, David; Coles, Nicholas A.; Corker, Katherine S.; Dixson, Barnaby James Wyld; Dranseika, Vilius; Dunham, Yarrow; Fox, Nicholas W.; Gardiner, Gwendolyn; Garrison, S. Mason; Gill, Tripat; Hahn, Amanda C.; Jaeger, Bastian; Kačmár, Pavol; Kaminski, Gwenaël; Kanske, Philipp; Kekecs, Zoltan; Kline, Melissa; Koehn, Monica A.; Kujur, Pratibha; Levitan, Carmel A.; Miller, Jeremy K.; Okan, Ceylan; Olsen, Jerome; Oviedo-Trespalacios, Oscar; Özdoğru, Asil Ali; Pande, Babita; Parganiha, Arti; Parveen, Noorshama; Pfuhl, Gerit; Pradhan, Sraddha; Ropovik, Ivan; Rule, Nicholas O.; Saunders, Blair; Schei, Vidar; Schmidt, Kathleen; Messiah Singh, Margaret; Sirota, Miroslav; Steltenpohl, Crystal N.; Stieger, Stefan; Storage, Daniel; Sullivan, Gavin Brent; Szabelska, Anna; Tamnes, Christian K.; Vadillo, Miguel A.; Valentova, Jaroslava V.; Vanpaemel, Wolf; Varella, Marco A. C.; Vergauwe, Evie; Verschoor, Mark; Vianello, Michelangelo; Voracek, Martin; Williams, Glenn P.; Wilson, John Paul; Zickfeld, Janis H.; Arnal, Jack D.; Aydin, Burak; Chen, Sau-Chin; DeBruine, Lisa M.; Fernandez, Ana Maria; Horstmann, Kai T.; Isager, Peder M.; Jones, Benedict; Kapucu, Aycan; Lin, Hause; Mensink, Michael C.; Navarrete, Gorka; Silan, Miguel A.; Chartier, Christopher R. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
      Concerns about the veracity of psychological research have been growing. Many findings in psychological science are based on studies with insufficient statistical power and nonrepresentative samples, or may otherwise be limited to specific, ungeneralizable settings or populations. Crowdsourced research, a type of large-scale collaboration in which one or more research projects are conducted across ...