Now showing items 1-20 of 6131

    • Trauma radiology in northern Norway 

      Bågenholm, Anna (Doctoral thesis; Doktorgradsavhandling, 2020-08-27)
      <p><i>Background: </i>This thesis focuses on diagnostic imaging in potentially severely injured patients admitted to the University Hospital of North Norway. Imaging is important for timely initiation of treatment and survival after trauma. The use of standardized whole body computer tomography (SWBCT) is increasing. However, the ionizing radiation used may cause a small risk for induction of cancer ...
    • Diagnostic imaging and ionizing radiation exposure in a level 1 trauma centre population met with trauma team activation: a one-year patient record audit 

      Bågenholm, Anna; Løvhaugen, Pål; Sundset, Rune; Ingebrigtsen, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-15)
      This audit describes ionizing and non-ionizing diagnostic imaging at a regional trauma centre. All 144 patients (males 79.2%, median age 31 years) met with trauma team activation from 1 January 2015 to 31 December 2015 were included. We used data from electronic health records to identify all diagnostic imaging and report radiation exposure as dose area product (DAP) for conventional radiography ...
    • Variation in the practice of tracheal intubation in Europe after traumatic brain injury: a prospective cohort study 

      Gravesteijn, BY; Sewalt, C.; Ercole, Ari; Lecky, Fiona; Menon, David; Steyerberg, Ewout W; Maas, AIR; Lingsma, Hester F; Klimek, Magdalena; Vik, Anne; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røise, Olav; Røe, Cecilie; Schirmer-Mikalsen, Kari; Sandrød, Oddrun; Borgen Lund, Stine (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-13)
      Traumatic brain injury patients frequently undergo tracheal intubation. We aimed to assess current intubation practice in Europe and identify variation in practice. We analysed data from patients with traumatic brain injury included in the prospective cohort study collaborative European neurotrauma effectiveness research in traumatic brain injury (CENTER‐TBI) in 45 centres in 16 European countries. ...
    • Weak rTMS-induced electric fields produce neural entrainment in humans 

      Zmeykina, E; Mittner, Matthias; Paulus, Walter; Turi, Zsolt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-20)
      Repetitive transcranial magnetic stimulation (rTMS) is a potent tool for modulating endogenous oscillations in humans. The current standard method for rTMS defines the stimulation intensity based on the evoked liminal response in the visual or motor system (e.g., resting motor threshold). The key limitation of the current approach is that the magnitude of the resulting electric field remains elusive. ...
    • Theta-gamma cross-frequency transcranial alternating current stimulation over the trough impairs cognitive control 

      Turi, Zsolt; Mittner, Matthias; Lehr, Albert; Bürger, H; Antal, Andrea; Paulus, Walter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
      Cognitive control is a mental process, which underlies adaptive goal-directed decisions. Previous studies have linked cognitive control to electrophysiological fluctuations in the theta band and theta-gamma cross-frequency coupling (CFC) arising from the cingulate and frontal cortices. Yet, to date the behavioral consequences of different forms of theta-gamma CFC remain elusive. Here, we studied the ...
    • Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia 

      Villatoro, Alicia; Konieczny, Joanna; Cuminetti, Vincent; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)
      Acute myeloid leukemia (AML) is a heterogeneous, complex, and deadly disease, whose treatment has hardly evolved for decades and grounds on the use of intensive chemotherapy regimens. Chemotherapy helps reduce AML bulk, but promotes relapse in the long-run by selection of chemoresistant leukemia stem cells (LSC). These may diversify and result in progression to more aggressive forms of AML. <i>In ...
    • Effectiveness and safety in remote monitoring of patients with pacemakers five years after an implant: The Poniente study 

      López-Liria, Remedios; López-Villegas, Antonio; Leal-Costa, César; Peiró, Salvador; Robles-Musso, Emilio; Bautista-Mesa, Rafael; Rocamora-Pérez, Patricia; Lappegård, Knut Tore; Catalán-Matamoros, Daniel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-23)
      Health-related quality of life (HRQoL) and functional capacity values immediately after pacemaker (PM) implantation have been well established; however, not much has been known about its long-term effects. The present study compared the long-term effectiveness and safety of remote monitoring plus a clinic visit versus clinic visits alone during follow-up of adults implanted with PMs. This study was ...
    • Exploring staff conceptions of prevention and management practices in encounters with staff-directed aggression in supported housing following education and training 

      Maagerø-Bangstad, Erlend Rinke; Sælør, Knut Tore; Lillevik, Ole Greger; Ness, Ottar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-08)
      <i>Background</i> - Staff-directed aggression is a concern for service providers in mental healthcare, frequently affecting both the quality of services and staff wellbeing. This also applies to supported housing services for people with mental health problems. Staff themselves consider training to be an important route to improve the prevention and management of staff-directed aggression. The aims ...
    • Adverse events in deceased hospitalised cancer patients as a measure of quality and safety in end-of-life cancer care 

      Haukland, Ellinor Christin; von Plessen, Christian; Nieder, Carsten; Vonen, Barthold (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-01)
      <i>Background</i> - Anticancer treatment exposes patients to negative consequences such as increased toxicity and decreased quality of life, and there are clear guidelines recommending limiting use of aggressive anticancer treatments for patients near end of life. The aim of this study is to investigate the association between anticancer treatment given during the last 30 days of life and adverse ...
    • pypillometry: A Python package for pupillometric analyses 

      Mittner, Matthias (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-02)
      The size of the human pupil is controlled by pairs of constrictor and dilator muscles that allow its opening (dilation) and closing (constriction) in response to varying lighting conditions (Mathôt, 2018). Importantly, it has long been known that the pupil also reacts to psychological important stimuli (Hess & Polt, 1960) and has been a firmly established tool for studying “mental effort” in the ...
    • Objective Versus Subjective Effort in Schizophrenia 

      Kreis, Isabel Viola; Moritz, Steffen; Pfuhl, Gerit (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)
      <i>Background and Objectives</i>: Performance on cognitive tasks is often impaired in individuals with schizophrenia (SCZ), possibly resulting from either cognitive deficits (e.g., limited working memory capacity) or diminished mental effort or both. Investment of mental effort itself can be affected by cognitive resources, task load, and motivational factors and has thus proven difficult to measure. ...
    • Clinical characteristics, echocardiographic indices of heart failure and mortality in a general population. The Tromsø Study 

      Stylidis, Michael (Doctoral thesis; Doktorgradsavhandling, 2020-08-21)
      <p><i>Background - </i>Ageing of the general population, declining incidence of myocardial infarction (MI) and improvements in medical treatment have resulted in an increase in heart failure (HF) prevalence. At the same time, number of studies linked to all-cause mortality and HF, co-existing HF and chronic obstructive pulmonary disease (COPD) are scarce. <p><i>Objective - </i>To study long-term ...
    • Å medvirke når barnevernet undersøker. En studie av barn og foreldres medvirkning i barnevernets undersøkelsesarbeid 

      Havnen, Karen J Skaale; Christiansen, Øivin; Ljones, Eirinn Hesvik; Lauritzen, Camilla; Paulsen, Veronika; Jarlby, Frederikke; Vis, Svein Arild (Research report; Forskningsrapport, 2020-04)
      Dette er den femte delrapporten fra prosjektet «Barnevernets undersøkelsesarbeid – fra bekymring til beslutning». Denne delrapporten dreier seg om barn og foreldres medvirkning i barnevernets undersøkelsesarbeid. Problemstillingene belyses ved hjelp av kvantitative og kvalitative data fra 1123 undersøkelsessaker, samt intervjuer med barn, foreldre og kontaktpersoner i 12 saker. Intervjuene følger ...
    • Cost-utility analysis of telemonitoring versus conventional hospital-based follow-up of patients with pacemakers. The NORDLAND randomized clinical trial 

      Lopez-Villegas, Antonio; Catalán-Matamoros, Daniel; Peiró, Salvador; Lappegård, Knut Tore; Lopez-Liria, Remedios (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-29)
      <i>Introduction</i> - The aim of our study was to perform an economic assessment in order to check whether or not telemonitoring of users with pacemakers offers a cost-effective alternative to traditional follow-up in outpatient clinics.<p> <p><i>Methods</i> - We used effectiveness and cost data from the NORDLAND trial, which is a controlled, randomized, non-masked clinical trial. Fifty patients ...
    • Physical activity and mental distress among adolescents. Results from the Tromsø Study: Fit Futures 

      Opdal, Ida Marie (Doctoral thesis; Doktorgradsavhandling, 2020-08-21)
      The onset of experiencing symptoms of mental distress, such as depression and anxiety, is most common during the adolescent years, and is concurrent with a measured decrease in physical activity levels. Research on the association between physical activity and mental distress among adolescents find contradictory results, and the field is in need of more longitudinal research with validated measurements. ...
    • Quantification of porosity in composite resins delivered by injectable syringes using X-ray microtomography 

      Nilsen, Bo Wold; Mouhat, Mathieu; Jokstad, Asbjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-06)
      <i>Objective</i>: To assess whether composite polymer resin delivered in compules include pores and the possible effect on the amount of porosity in dental restorations.<p> <p><i>Method and materials</i>: Original compules containing unpolymerised composite polymer resin (CPR) were scanned in a micro-CT. Four products were examined, which comprised universal composites (Herculite XRV Ultra, Ceram.X ...
    • ‘Fixing my life’: young people’s everyday efforts towards recovery from persistent bodily complaints 

      Kvamme, Maria Fredriksen; Wang, Catharina Elisabeth Arfwedson; Waage, Trond; Risør, Mette Bech (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-23)
      Little is known about the perspectives of young people suffering from medically unexplained symptoms. This study aims to explore the experiences and strategies of young Norwegians related to incipient and persistent health complaints affecting everyday life functioning. The study draws on field notes, video material and interview transcripts from a multi-sited ethnographic study of healthcare services ...
    • A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer 

      Bjerkli, Inger-Heidi; Hadler-Olsen, Elin Synnøve; Nginamau, Elisabeth Sivy; Laurvik, Helene; Søland, Tine Merete; Costea, Daniela Elena; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the individual patient, especially for patients with low-stage disease. In addition, we wanted to investigate whether an alternative scoring model with fewer options would compromise the ...
    • Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains 

      Norvoll Magnussen, Synnøve; Toraskar, Jimita Prashant; Wilhelm, Imola; Hasko, Janos; Figenschau, Stine; Molnar, Judit; Seppola, Marit; Steigen, Sonja Eriksson; Steigedal, Tonje S.; Hadler-Olsen, Elin Synnøve; Krizbai, Istvan; Svineng, Gunbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-22)
      This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introduction of more targeted breast cancer treatments, a prolonged survival has resulted during the last decade. Consequently, an increased number of patients ...
    • Using the Job Demands–Resources Model to Evaluate Work-Related Outcomes Among Norwegian Health Care Workers 

      Kaiser, Sabine; Patras, Joshua; Adolfsen, Frode; Richardsen, Astrid Marie; Martinussen, Monica (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-01)
      The job demands-resources (JD-R) model was used to evaluate work-related outcomes among 489 health care professionals working in public health services for children and their families in Norway. In accordance with the JD-R model, the relationship of job demands and job resources with different outcomes (turnover intention, job satisfaction, and service quality) should be mediated through burnout and ...