Collections in this community

Recent additions

  • Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts 

    Lindholm, Evita Maria; Kristian, Alexandr; Nalwoga, Hawa; Kruger, Kristi; Nygård, Ståle; Akslen, Lars A.; Mælandsmo, Gunhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-03-31)
    Several clinical trials have investigated the efficacy of bevacizumab in breast cancer, and even if growth inhibiting effects have been registered when antiangiogenic treatment is given in combination with chemotherapy no gain in overall survival has been observed. One reason for the lack of overall survival benefit might be that appropriate criteria for selection of patients likely to respond ...
  • Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginal Tissue Model 

    Jøraholmen, May Wenche; Damdimopoulou, Pauliina; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-17)
    The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydrogel as secondary vehicle. Although considered ...
  • Functional analysis of signaling pathways activated by Anisomycin and Dexamethasone in two different breast cancer cell lines 

    Brown, Rosaline (Mastergradsoppgave; Master thesis, 2022-05-12)
    While targeted therapy exists for ER-positive breast cancers, the treatment option for TNBC is conventional chemotherapy giving a poorer prognosis. It is therefore of interest to study molecular mechanisms and differences between MCF7 (ER-positive) and MDA-MB-231 (ER, PR, and HER2- negative). These cell lines are in vitro representative models for luminal A (non-aggressive) and basal-like (aggressive) ...
  • The pH-Responsive Liposomes—The Effect of PEGylation on Release Kinetics and Cellular Uptake in Glioblastoma Cells 

    Rustad, Eirik André Lindeløff; von Hofsten, Susannah; Kumar, Robin; Lænsman, Eirik Abrahamsen; Berge, Gerd; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-25)
    Nanomedicine has been, to a certain degree, a success story in the development of superior anticancer therapies. However, there are tumors that remain a huge challenge for nanoformulations, for instance, brain tumors such as glioblastoma, the most common and aggressive brain tumor. To utilize the fact that such tumors are characterized by an acidic extracellular environment, we selected pH-responsive ...
  • Hvor nyttige er nye legemiddelbehandlinger egentlig? 

    Moss, Johan Mikkelborg (Mastergradsoppgave; Master thesis, 2021-05-21)
    Introduksjon: Legemidler blir ofte presentert i media som supermedisiner og gir inntrykket av at helseeffekten er enorm. Hvorvidt fremstillingen i media speiler virkeligheten er uklart. Statens legemiddelverk (SLV) metodevurderer legemidler for å undersøke om de er bedre enn nåværende behandling. Metodevurderingene inneholder ofte informasjon om QALY-gevinst. Hensikt: Primærmålet er å undersøke ...
  • Liposomal formulations for membrane active antimicrobials – Assuring safety through an optimised drug delivery system 

    Pettersen, Ann Kristin (Master thesis; Mastergradsoppgave, 2020-05-13)
    Skin and soft tissue infections (SSTIs) and chronic wounds are major challenges for the healthcare system worldwide. The additional rapid development of antibacterial resistance and lack of successful treatment strategies increase the chance for infected chronic wounds to be fatal for the patient. Therefore, there is a need for more efficient dermal antimicrobial therapies. A class of promising ...
  • Molekylmodelleringsstudium av G-protein koblet østrogenreseptor (GPER) 

    Smith, Maria (Mastergradsoppgave; Master thesis, 2017-05-15)
    G-protein koblet østrogenreseptor (GPER) har vist å ha en fysiologisk rolle i det reproduktive systemet, nervesystemet, endokrine systemet, immunsystemet og karsystemet. Den har også patofysiologisk rolle i flere forskjellige sykdommer inkludert kreft. G-protein koblet østrogenreseptor har blitt identifisert i nesten alle systemer i kroppen. Dermed er det en stor interesse for å få kjennskap til ...
  • The search of new negative allosteric GABAB receptor modulators using in silico and in vitro approaches 

    Hadi, Ali Muataz (Mastergradsoppgave; Master thesis, 2020-05-14)
    γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the CNS. GABA exerts its function on both ionotropic ligand-gated GABAA receptors and metabotropic GABAB G-protein coupled receptors (GPCRs). Disruption in the GABAergic system has been associated with numerous neurological and psychiatric disorders in humans. These include developmental dysfunctions, epilepsy, sleep disorders, ...
  • Microfluidized liposomes for cellular uptake imaging: Optimization 

    Mork, Silje (Mastergradsoppgave; Master thesis, 2020-05-14)
    Liposomes as drug delivery systems exhibit great potential to deliver active molecules to the targeted site depending on their various characteristics. However, these characteristics are dependent on the manufacturing procedures applied to prepare liposomes. Especially difficult is assurance of reproducible production in large volumes. Therefore an efficient up-scalable method for production of ...
  • Bruk av antibakterielle midler blant barn 0-3 år etter fødselssesong og fødselsår i Norge 2004-2017 

    Beckstrøm, Sanna (Mastergradsoppgave; Master thesis, 2019-05-14)
    Bakgrunn: Ettårig periodeprevalens for bruk av antibakterielle midler til barn i Norge er høyest før tre års alder. Forskriving av antibakterielle midler påvirkes av mange faktorer, og kartlegging av disse kan gi mulighet til å målrette intervensjoner for å redusere forskriving. Formål: De primære målene var å undersøke om fødselssesong predikerer alder ved første utlevering av antibakterielle midler, ...
  • Electrospinning of nanofibers with chitosan and B-glucan as active wound healing ingredients: Optimization and characterization 

    Olaussen, Julie Wik (Mastergradsoppgave; Master thesis, 2020-05-14)
    Wound healing is a complex and highly regulated process, vital for preserving the barrier function of the skin. However, several underlying pathologies have the ability to influence the cascade of events involved in this process, resulting in the development of chronic wounds. The heterogeneous nature of chronic wounds increases the requirements of novel wound dressings. Hence, the development of ...
  • High throughput lipolysis-permeation in vitro model employing the mucus-PVPA barriers to assess drug absorption from lipid-based delivery systems 

    Brurok, Sunniva (Mastergradsoppgave; Master thesis, 2020-05-14)
    In vitro lipolysis models are commonly used to assess the performance of lipid-based drug delivery systems (LbDDSs) in terms of their drug absorption potential; however, this in vitro approach has not always shown to correlate well with in vivo data. Several studies suggest that adding an absorption step to the in vitro lipolysis model would give a better estimation of absorption for drugs incorporated ...
  • Virtual screening and in vitro evaluation of putative positive allosteric modulators of the GABAB receptor 

    Issifou, Ibrahim Toure (Mastergradsoppgave; Master thesis, 2020-05-14)
    -aminobutyric acid (GABA) is the chief inhibitory neurotransmitter of the central nervous system (CNS). GABA exhibits its function by binding to either the ionotropic GABAA receptor or the metabotropic GABAB receptor, causing a decrease in activity in the nervous system. Disruption in the GABAergic system has been associated with various neurological conditions, including Alzheimer’s disease, anxiety, ...
  • Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis 

    Starikova, Irina; Al-Haroni, Mohammed; Werner, Guido; Roberts, Adam P.; Nielsen, Kåre M.; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-07-05)
    Objectives: To determine the fitness effects of various mobile genetic elements (MGEs) in Enterococcus faecium and Enterococcus faecalis when newly acquired. We also tested the hypothesis that the biological cost of vancomycin resistance plasmids could be mitigated during continuous growth in the laboratory.<p> <p>Methods: Different MGEs, including two conjugative transposons (CTns) of the Tn916 ...
  • Crosstalk between p38 MAPK and GR Signaling 

    Zeyen Øyås, Lisa; Seternes, Ole Morten; Mikkola, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-19)
    The p38 MAPK is a signaling pathway important for cells to respond to environmental and intracellular stress. Upon activation, the p38 kinase phosphorylates downstream effectors, which control the inflammatory response and coordinate fundamental cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of this signaling pathway has been linked to inflammatory diseases ...
  • Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A&lt;sub&gt;2&lt;/sub&gt;, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines 

    Jantan, Ibrahim; Bukhari, Syed Nasir Abbas; Adekoya, Olayiwola; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-16)
    Arachidonic acid metabolism leads to the generation of key lipid mediators which play a fundamental role during inflammation. The inhibition of enzymes involved in arachidonic acid metabolism has been considered as a synergistic anti-inflammatory effect with enhanced spectrum of activity. A series of 1,3-diphenyl-2-propen-1-one derivatives were investigated for anti-inflammatory related activities ...
  • Utvikling av skriftlig legemiddelinformasjon til pasienter med epilepsi 

    Brunvoll, Kristin F. (Master thesis; Mastergradsoppgave, 2015-05-15)
    Medikamentell behandling av epilepsi er oftest både livsviktig og livslang, derfor er god etterlevelse av behandlingen viktig for god sykdomskontroll. På bakgrunn av dette kan man dermed anta at dårlig etterlevelse er en vanlig årsak til anfallsgjennombrudd ved epilepsi, som igjen kan ha sammenheng med informasjonen pasienter får om sine legemidler Den overordnede hensikten med studien var å utvikle ...
  • Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries 

    Kieler, Helle; Artama, Miia; Engeland, Anders; Ericsson, Örjan; Furu, Kari; Gissler, Mika; Nielsen, Rikke Beck; Nørgaard, Mette; Stephansson, Olof; Valdimarsdottir, Unnur; Zoega, Helga; Haglund, Bengt (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-01-12)
    Objective To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs.<p> <p>Design Population based cohort study using data from the national health registers.<p> <p>Setting Denmark, Finland, Iceland, Norway, and Sweden, 1996-2007.<p> ...
  • vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding 

    Tran, Vi Ngoc-Nha; Shams, Alireza; Ascioglu, Sinan; Martinecz, Antal; Liang, Jingyi; Clarelli, Fabrizio; Mostowy, Rafal; Cohen, Ted; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-06)
    Background: As antibiotic resistance creates a signifcant global health threat, we need not only to accelerate the development of novel antibiotics but also to develop better treatment strategies using existing drugs to improve their efcacy and prevent the selection of further resistance. We require new tools to rationally design dosing regimens from data collected in early phases of antibiotic ...
  • Lipidomics of marine microalgae with industrial potential 

    Myhre, Torbjørn N. (Mastergradsoppgave; Master thesis, 2021-05-11)
    Two species diatoms, Porosira glacialis and Coscinodicus radiatus were cultivated under red-, white- or blue light. The biomass from cultivation was extracted for lipids which were subsequently analyzed using UHPLC-MS and the software lipidsearch. The aim was to investigate omega-3 long chain fatty acid content differences in the different cultivations. Findings suggest that blue light cultivation ...

View more