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  • Clinical Lipidomics: Effects of Vitamin D in Human Adipose Tissue 

    Chan, Sze Mang Sammy (Master thesis; Mastergradsoppgave, 2021-05-10)
    Vitamin D is vital for calcium homeostasis and skeletal health, has immunomodulatory effects and is involved in the regulation of differentiation and proliferation of many different cell types. Adipose tissue is an important metabolic organ and a major organ for vitamin D storage. Though, the role of vitamin D and its function in adipose tissue is not fully explored. This thesis applies a solvent ...
  • Molecular modelling of interactions between antipsychotic drugs and receptors mediating antipsychotic effects and important side effects 

    Issifou, Halimatu Sadia T. (Master thesis; Mastergradsoppgave, 2021-05-10)
    Dopamine and serotonin are two neurotransmitters that exert their actions through mediation of dopaminergic and serotonergic receptors respectively. The receptors in focus in the current study, are the dopamine D2 and serotonin 5-HT2A receptors. Common for both receptors is that they are class A G-protein-coupled receptors consisting of seven transmembrane helices embedded in the lipid membrane of ...
  • Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network 

    Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah; Berben, Philippe; Bernkop-Schnürch, Andreas; Butler, James; Ceulemans, Jens; Davies, Nigel; Dupont, Didier; Flaten, Gøril Eide; Fotaki, Nikoletta; Griffin, Brendan T.; Jannin, Vincent; Keemink, Janneke; Kesisoglou, Filippos; Koziolek, Mirko; Kuentz, Martin; Mackie, Alan R.; Meléndez-Martínez, Antonio J.; McAllister, Mark; Müllertz, Anette; O'Driscoll, Caitriona M.; Parrott, Neil; Paszkowska, Jadwiga; Pavek, Petr; Porter, Christopher J.H.; Reppas, Christos; Stillhart, Cordula; Sugano, Kiyohiko; Toader, Elena; Valentová, Kateřina; Vertzoni, Maria; De Wildt, Saskia N.; Wilson, Clive G.; Augustijns, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-18)
    Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption ...
  • Network Analysis: an approach to the study of drug-drug relations. Co-medication in Norwegian elderly and severe drug-drug interactions as examples 

    Askar, Mohsen (Master thesis; Mastergradsoppgave, 2019-05-15)
    Network analysis (NA) has been used for studying many social aspects. Employing of network analysis as an approach in the field of public health, to study the relations between patients or health workers and their potential effects in many medical perspectives, took a good share of researchers’ efforts as well. Few attempts have been conducted to use network analysis to study drug-drug relations ...
  • Collateral sensitivity in clinical mecillinam resistant isolates of Escherichia coli 

    Nguyen, Tammy Tam Hoai Thi (Master thesis; Mastergradsoppgave, 2016-05-13)
    Background The rapid increase in antimicrobial resistance (AMR) has become a major threat to the successful management of infectious diseases. To counteract this global threat, development of novel treatment strategies is essential. A promising strategy may be exploiting collateral sensitivity; a phenomenon that occurs when a microorganism that has developed resistance to one antimicrobial agent, ...
  • Influence of environmental tonicity changes on lipophilic drug release from liposomes 

    Nikolaisen, Trygg Einar (Mastergradsoppgave; Master thesis, 2018-05-15)
    Introduction: Liposomes as drug delivery systems has been widely studied as a way to solubilize poorly soluble drugs, reduce side effects of chemotherapeutics and increase circulation time in vivo. Since the first descriptions of liposomes over 60 years ago, they have shown tendencies to shrink and swell when the external environment of the liposomes is altered. This phenomenon has been studied in ...
  • Topical vaginal therapy: Development of a liposomal hydrogel delivery system for epicatechin 

    Moueffaq, Sabrin (Mastergradsoppgave; Master thesis, 2018-05-15)
    Vaginal infections are common in women of all ages and proper treatment is essential. The vaginal route of administration can be considered as favourable for the local therapy of vaginal infections. There are several vaginal dosage forms currently available; however, all suffer from limitations such as leakage and limited residence time at the site of action resulting in reduced therapeutic effect. ...
  • High-Intensity Exercise Improves Fatigue, Sleep, and Mood in Patients With Axial Spondyloarthritis: Secondary Analysis of a Randomized Controlled Trial 

    Sveaas, Silje Halvorsen; Dagfinrud, Hanne; Berg, Inger Jorid; Provan, Sella Aarrestad; Johansen, Melissa Woll; Pedersen, Elisabeth; Bilberg, Annelie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-04)
    <i>Objective</i> - Although exercise is recommended in the treatment of axial spondyloarthritis (axSpa), the focus has been on flexibility, and the effect of high-intensity exercises is unknown. The purpose of this study was to investigate the effect of high-intensity exercises on fatigue, sleep, and mood in patients with axSpA.<br><br> <i>Methods</i> - In this secondary analysis of a randomized ...
  • Etikk og farmasøytisk praksis i apotek 

    Johannessen, Karen Øvrebø (Mastergradsoppgave; Master thesis, 2021-04-26)
    Etikkrådet for farmasøyter i Norge har en visjon om at alle farmasøyter skal være etisk reflekterte yrkesutøvere. Etiske dilemma oppstår når ulike verdier kommer i konflikt med hverandre og ikke kan forenes i en og samme handling. Apotekene i Norge har i de siste årene forandret seg i takt med nye lover og regler og farmasøytene har etter hvert fått utvidede oppgaver som setter andre krav til yrket. ...
  • LC-MS characterization of pigments in microalgae from different cultivation regimes 

    Stokkeland, Ingunn Møgedal (Master thesis; Mastergradsoppgave, 2019-05-15)
    <p>Background: The Artic University of Norway entered a partnership with a smelting plant to reduce the factory fume CO2-footprint by cultivation of microalgae (diatoms). The biomass produced from the microalgae is rich in lipids, proteins and pigments and can potentially function as fish feed for the aquaculture industry. Before the biomass can be utilized as e.g. fish feed, a thorough investigation ...
  • Antibiotikaforskrivning ved samfunnservervet pneumoni og KOLS-eksaserbasjon ved Universitetssykehuset Nord-Norge 

    Tøndel, Birgitte Gladsø (Master thesis; Mastergradsoppgave, 2019-05-15)
    <p>Bakgrunn: Rasjonell antibiotikaforskrivning, som i denne sammenheng vil si i henhold til Nasjonal faglig retningslinje for antibiotikabruk i sykehus, er et av de viktigste tiltakene vi har for å motvirke resistensutvikling. Forskrivning i henhold til retningslinjer er også assosiert med gunstige pasientutfall. Samfunnservervet pneumoni (community-acquired pneumonia; CAP) og kronisk obstruktiv ...
  • Docetaxel in liposomes: the effect of lipid composition on the achieved drug entrapment 

    Karlsen, Iselin (Mastergradsoppgave; Master thesis, 2018-05-15)
    INTRODUCTION: Docetaxel (DOC) is a potent anticancer drug but has several limitations such as poor solubility. The currently commercially available formulation of DOC is limited by reported serious side effects which either is attributed to the drug itself or the solvent used. Nanomedicine has been used for improving the therapeutic outcome of several drugs, but so far there are none available with ...
  • Evaluation and Late-Stage Fluorination of Small Molecule GnRH-R Antagonists 

    Rustad, Eirik André Lindeløff (Mastergradsoppgave; Master thesis, 2019-05-15)
    Alzheimer’s disease is the most common type of dementia; causing problems with memory, thinking and behaviour. The seemingly protective effect of hormone replacement therapy against Alzheimer’s disease sparked an interest in the role of the sex hormone system. Sex steroid production is dependent on gonadotropins released in the pituitary. The gonadotropin level is controlled by gonadotropin releasing ...
  • Liposomes-in-hydrogel delivery system containing resveratrol for the local treatment of vaginal infections 

    Tostrup, Mia Jonine (Mastergradsoppgave; Master thesis, 2018-05-15)
    Administering drug formulations to the vagina is a challenge since the vagina possesses “self-cleaning” features which allow trapping and rapid removing of foreign particles. Therefore, the residence time of drugs is often too short to offer a sufficient clinical effect. The aim of this project was to develop and optimize a liposomes-in-hydrogel system containing resveratrol for the local treatment ...
  • How will anonymization of simulated clinical data affect the data utility of pharmacoepidemiological studies? 

    Cheang, Chi Kei (Mastergradsoppgave; Master thesis, 2019-05-14)
    Background: The pressure to share more data and being more transparency of clinical study reports has grown and becomes an important topic in recent years. Before clinical data and clinical results can be shared they must undergo anonymization. How anonymization of clinical data affects the utility is poorly-studied, especially in pharmacoepidemiology. Objective: The aim of the study is to describe ...
  • Dyes in Disguise: characterization of fluorescently labeled liposomes 

    Cauzzo, Jennifer; Nystad, Mona; Holsæter, Ann Mari; Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)
    The rather limited success of translation from basic research to clinical application has been highlighted as a major issue in the nanomedicine field. To identify the factors influencing the applicability of nanosystems as drug carriers and potential nanomedicine, we focused on following their fate through fluorescence-based assays, namely flow cytometry and imaging. These methods are often used to ...
  • Predicting oral absorption of fenofibrate in lipid-based drug delivery systems by combining in vitro lipolysis with the mucus-PVPA permeability model 

    Falavigna, Margherita; Klitgaard, Mette; Berthelsen, Ragna; Mullertz, Anette; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-08)
    The aim of this work was to develop a new in vitro lipolysis-permeation model to predict the in vivo absorption of fenofibrate in self-nanoemulsifying drug delivery systems (SNEDDSs). More specifically, the in vitro intestinal lipolysis model was combined with the mucus-PVPA (Phospholipid Vesicle-based Permeation Assay) in vitro permeability model. Biosimilar mucus (BM) was added to the surface of ...
  • Tn1 transposition in the course of natural transformation enables horizontal antibiotic resistance spread in Acinetobacter baylyi 

    Kloos, Julia Maria; Johnsen, Pål Jarle; Harms, Klaus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-03)
    Transposons are genetic elements that change their intracellular genomic position by transposition and are spread horizontally between bacteria when located on plasmids. It was recently discovered that transposition from fully heterologous DNA also occurs in the course of natural transformation. Here, we characterize the molecular details and constraints of this process using the replicative transposon ...
  • Barrierer mot etterlevelse av retningslinjer for helsepersonell i sykehus 

    Evenstad, Berit; Larsen, Lill Sverresdatter; Gravningen, Kirsten Midttun (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-28)
    <p><i>Bakgrunn:</i> Kunnskapsbaserte faglige retningslinjer skal bidra til å kvalitetssikre helsetjenesten. Tidligere forskning viser et gap mellom anbefalinger i retningslinjer og klinisk praksis. Få studier har undersøkt etterlevelsen av retningslinjer blant helsepersonell på sykehus etter avsluttet implementering. Denne studien tar utgangspunkt i «Keisersnittprosjektet», et kvalitetsforbedringsprosjekt ...
  • Biomimicry of microbial polysaccharide hydrogels for tissue engineering and regenerative medicine - A review 

    Ng, Jian Yao; Obuobi, Sybil Akua Okyerewa; Chua, Mei Ling; Zhang, Chi; Hong, Shiqi; Kumar, Yogesh; Gokhale, Rajeev; Ee, Pui Lai Rachel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-29)
    Hydrogels as artificial biomaterial scaffolds offer a much favoured 3D microenvironment for tissue engineering and regenerative medicine (TERM). Towards biomimicry of the native ECM, polysaccharides from Nature have been proposed as ideal surrogates given their biocompatibility. In particular, derivatives from microbial sources have emerged as economical and sustainable biomaterials due to their ...

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