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  • Following the fate of dye-containing liposomes in vitro 

    Cauzzo, Jennifer; Nystad, Mona; Holsæter, Ann Mari; Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)
    The rather limited success of translation from basic research to clinical application has been highlighted as a major issue in the nanomedicine field. To identify the factors influencing the applicability of nanosystems as drug carriers and potential nanomedicine, we focused on following their fate through fluorescence-based assays, namely flow cytometry and imaging. These methods are often used to ...
  • Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study 

    Høgli, June Utnes; Garcia, Beate Hennie; Svendsen, Kristian; Skogen, Vegard; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-15)
    <i>Background</i> - Norwegian guideline recommendations on first-line empirical antibiotic prescribing in hospitalised patients with community-acquired pneumonia (CAP) are penicillin G/V in monotherapy, or penicillin G in combination with gentamicin (or cefotaxime) in severely ill patients. The aim of this study was to explore how different empirical antibiotic treatments impact on length of hospital ...
  • The Vaginal-PVPA: A Vaginal Mucosa-Mimicking In Vitro Permeation Tool for Evaluation of Mucoadhesive Formulations 

    Falavigna, Margherita; Pattacini, Martina; Wibel, Richard; Sonvico, Fabio; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-19)
    Drug administration to the vaginal site has gained increasing attention in past decades, highlighting the need for reliable in vitro methods to assess the performance of novel formulations. To optimize formulations destined for the vaginal site, it is important to evaluate the drug retention within the vagina as well as its permeation across the mucosa, particularly in the presence of vaginal fluids. ...
  • The record-warm Barents Sea and 0-group fish response to abnormal conditions 

    Eriksen, Elena; Bagøien, Espen; Strand, Espen; Primicerio, Raul; Prokhorova, Tatiana; Trofimov, Alexander; Prokopchuk, Irina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-25)
    The Barents Sea is a nursery area for many commercially and ecologically important fish stocks, and this whole region is presently subject to rapid climatic change from a cold period in the 1980s to a record warm period in the latest decade, with a peak in 2016. The present study focuses exclusively on year 2016, which was characterized by record warm air and seawater and an exceptionally large ...
  • Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates 

    Alves Gama, Joao Pedro; Kloos, Julia Maria; Johnsen, Pål Jarle; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
    Dissemination of bacterial clones carrying plasmid-mediated resistance genes is a major factor contributing to the increasing prevalence of antibiotic resistance. Understanding the evolution of successful clones and the association to mobile resistance elements are therefore crucial. In this study, we determined the sequence of a 145 kb IncC multi-drug resistance plasmid (pK71-77-1-NDM), harbouring ...
  • ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo 

    Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-21)
    Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo-β-lactamase (MBL) families. The recent introduction of SBL carbapenemase inhibitors has provided alternative therapeutic options. Unfortunately, ...
  • Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors 

    Eksteen, Jacobus Johannes; Ausbacher, Dominik; Vasskog, Terje; Rekdal, Øystein; Svendsen, John Sigurd Mjøen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-06)
    Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a ...
  • Impact of mucin on drug diffusion: Development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin 

    Falavigna, Margherita; Stein, Paul C.; Flaten, Gøril Eide; Di Cagno, Massimiliano Pio (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-17)
    Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates all mucosal tissues can compromise drugs from reaching the epithelial site, thus affecting their absorption and therapeutic effect. Therefore, the effect of the mucus layer on drug ...
  • Characterization of inhibition by vardenafil analogues of ATP-dependent transport of cGMP by the ABCC5 transporter. 

    Kuresh, Farzane (Master thesis; Mastergradsoppgave, 2015-05-27)
    Background: Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports intracellular cGMP out of the cells with high affinity, while PDE5 inhibitors prevent high affinity cGMP efflux by inhibiting ABCC5. Increasing intracellular cGMP levels through inhibition of PDE5 and PDE5 export activity is hypothesized ...
  • Molecular modelling of the androgen metabolising enzyme UDP-glucuronosyltransferase 2B17 

    Trane, Ingmar (Master thesis; Mastergradsoppgave, 2018-05-25)
    The enzyme UDP-glucuronosyltransferase 2B17 (UGT2B17) has a major role in androgen metabolism, being involved in the conjugation of both testosterone and its potent metabolite dihydrotestosterone. The enzyme catalyses the transfer of glucuronic acid from UDP-glucuronic acid to the lipophilic androgen substrate. As a consequence, the water solubility of the substrate is increased, and it is more ...
  • Development of orodispersible films: A new age-appropriate dosage form for children 

    Betoko, Evrard Louis Alain Brice (Master thesis; Mastergradsoppgave, 2015-05-18)
    In the recent years, governmental institutions have given incentives to the pharmaceutical industry in order to develop age-appropriate dosage forms for pediatric use. This has resulted in an interest in design of new and improved dosage form for pediatric patients. One of the many recent approaches is to take advantages of ODFs. Taste masking is a crucial step in the design of not only ODFs but all ...
  • Large scale cultivation of microalgae at Finnfjord AS: The effect of addition of CO2 and flue gas on lipid production and fatty acid composition 

    Ramskjell, Marte (Master thesis; Mastergradsoppgave, 2018-05-15)
    Background: This master’s thesis was a part of a project involving mass cultivation of microalgae at the smelting plant Finnfjord AS. Microalgae are primary producers of the important omega-3 long-chain polyunsaturated fatty acids EPA and DHA. At Finnfjord, the algae use CO2 from the flue gas for their production of lipid and protein rich biomass. The algal biomass can potentially function well as ...
  • Development of self-eliminating linkers for drug conjugates 

    Nergård, Silje Lillemark (Master thesis; Mastergradsoppgave, 2018-05-15)
    Newly discovered compounds through bioprospecting are screened for cytotoxicity, and many of them are found to be highly toxic. Because they are often not specifically toxic only against cancer cells, they are not further studied. These new compounds could be of further interest by temporarily masking a functional group which regulate the anticancer activity of a cytotoxic compound. This means that ...
  • Synthesis of copper and silver nanoparticles with extracts of berries: A green chemistry approach 

    Løkse, Christoffer Jacobsen (Master thesis; Mastergradsoppgave, 2017-05-15)
    Nanoparticles are usually defined as particles in a size range of 1-100 nm, and these particles often have different properties than the non-nanoscale material of the same chemical composition. In recent years, as the interest and use of nanoparticles has increased and so has the interest in understanding their behaviour, impact and fate in the environment. In the last decades, there has been special ...
  • Molecular modeling of 3D structure of the oxytocin receptor. Discovery of novel oxytocin receptor agonists via molecular docking studies. 

    Antobreh, Gloria Tiwaa (Master thesis; Mastergradsoppgave, 2015-05-15)
    Oxytocin has been shown to be implicated in psychiatric diseases such as depression, anxiety disorders, autism post-traumatic stress disorder, and schizophrenia. As a result, oxytocin can be used as a potential treatment for these brain disorders. However, oxytocin is a large peptide, and is therefore unable to cross the blood brain barrier. Thus, the development of new small non-peptide drugs would ...
  • Large scale cultivation of microalgae at Finnfjord AS: The effect of different storage treatments on lipid and fatty acid stability 

    Aronsen, Simen (Master thesis; Mastergradsoppgave, 2018-05-15)
    The Arctic University of Norway and the ferrosilicon smeltery Finnfjord AS has started a microalgal mass cultivation project where sequestration of CO2 and NOx from factory fumes are used in the production of diatom biomass. Primary application of the produced biomass is fish feed. This requires information regarding lipid content and storage stability. In this study the lipid content, fatty acid ...
  • Improved chronic wound therapy: surface charged deformable liposomes for dermal delivery of curcumin 

    Gagnat, Eivind (Master thesis; Mastergradsoppgave, 2018-05-15)
    Chronic wounds are today representing a major challenge in global healthcare due the difficulty to treat as well as the costs for the society. Therefore, improving chronic wound therapy is an urgent need. Curcumin, a polyphenol compound, has shown to have potential in wound therapy due to its anti-inflammatory, anti-infectious and anti-oxidant properties. However, the poor water solubility, low ...
  • Liposomes as Potential Carrier for Bioactive β2,2- Amino Acid Derivatives - A Feasibility Study 

    Azumah, Joseph (Master thesis; Mastergradsoppgave, 2015-05-13)
    The emergence of antibiotic resistant bacterial strains is a rising global problem that does not only result in fatal infections of previously treatable cases, but increases also the economic burden of health care systems. The same applies for cancer as treatment of some cancer types is difficult and also resistance to treatment is an increasing problem in cancer chemotherapy. Novel treatment ...
  • Quantitative Phosphoprotein Analysis in Adipose Tissue 

    Assignon, Edmund Theodore Fiifi (Master thesis; Mastergradsoppgave, 2016-05-13)
    Background: Mass spectrometry-based proteomics has increasingly been the choice of method for the global analysis of the composition, modification and dynamics of proteins. Quantitative analysis of the proteome with tandem mass tag is a technique for calculating the relative abundance of the proteome in tissues and organelles. In this thesis, present a novel bottom-up method for the quantitative ...
  • Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiota 

    Tepekule, Burcu; Abel zur Wiesch, Pia; Kouyos, Roger D.; Bonhoeffer, Sebastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-30)
    To understand how antibiotic use affects the risk of a resistant infection, we present a computational model of the population dynamics of gut microbiota including antibiotic resistance-conferring plasmids. We then describe how this model is parameterized based on published microbiota data. Finally, we investigate how treatment history affects the prevalence of resistance among opportunistic ...

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