Nye registreringer

  • Elevating Safe Use of Over-The-Counter Medications in Older Adults: A Narrative Review of Pharmacy Involved Interventions and Recommendations for Improvement 

    Lehnbom, Elin; Berbakov, Maria E.; Hoffins, Emily L.; Moon, Jukrin; Welch, Lauren; Chui, Michelle A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
    Over-the-counter (OTC) medications are products that have been made easily accessible to allow patients to treat common ailments without a prescription and the cost of a doctor’s visit. These medications are generally considered safe; however, there is still a potential for these medications to lead to adverse health outcomes. Older adults (ages 50+) are especially susceptible to these adverse health ...
  • Utvikling av utskrivningsintervensjon med fokus på riktig legemiddelbruk – en kvalitetsforbedringsstudie ved medisinsk avdeling 

    Garcia, Beate Hennie; Aag, Trine Iversen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
    Hensikt - Hensikten med studien var å utvikle en utskrivningsintervensjon med fokus på riktig legemiddelbruk etter sykehusopphold. Involvering av farmasøyt var en forutsetning.<p> <p>Metode - Ved hjelp av forbedringsmetodikken plan-do-study-act (PDSA) har vi utviklet og evaluert en utskrivningsintervensjon hvor farmasøyten er sentral i samarbeid med det tverrfaglige teamet.<p> <p>Resultater - ...
  • Exploring stakeholders' perspectives on the quality of services provided through community pharmacies 

    Jakobsen, Ann Helen; Småbrekke, Lars; Chen, Timothy F.; Halvorsen, Kjell H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-02)
    Introduction - It is important to understand the factors impacting the quality of services provided through community pharmacies. Exploring how key stakeholders perceive good quality in these services is a logical first step. This could also inform the development of quality measures, such as quality indicators (QIs).<p> <p>Aim - To identify key stakeholders' perspectives on the quality of services ...
  • The bacterial magnesium transporter MgtA reveals highly selective interaction with specific cardiolipin species 

    Weikum, Julia; van Dyck, Jeroen F.; Subramani, Saranya; Klebl, David P.; Storflor, Merete; Muench, Stephen P.; Abel, Sören; Sobott, Frank; Morth, Jens Preben (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-23)
    The bacterial magnesium transporter A (MgtA) is a specialized P-type ATPase important for Mg<sup>2+</sup> import into the cytoplasm; disrupted magnesium homeostasis is linked to intrinsic ribosome instability and antibacterial resistance in Salmonella strains. Here, we show that MgtA has functional specificity for cardiolipin 18:1. Still, it reaches maximum activity only in combination with ...
  • Polyethylene glycol (PEG) as a broad applicability marker for LC–MS/MS-based biodistribution analysis of nanomedicines 

    Hyldbakk, Astrid; Hansen, Terkel; Hak, Sjoerd; Borgos, Sven Even F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-13)
    Polyethylene glycol (PEG) conjugation (PEGylation) is a well-established strategy to improve the pharmacokinetic and biocompatibility properties of a wide variety of nanomedicines and therapeutic peptides and proteins. This broad use makes PEG an attractive ‘allround’ candidate marker for the biodistribution of such PEGylated compounds. This paper presents the development of a novel strategy for ...
  • Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tablets 

    Larsen, Bjarke Strøm; Kissi, Eric Ofosu; Parreiras Nogueira, Liebert; Genina, Natalja; Tho, Ingunn (Journal article; Tidsskriftartikkel, 2023-11-02)
    <p>This study investigates the influence of drug load and polymer molecular weight on the structure of tablets three-dimensionally (3D) printed from the binary mixture of prednisolone and hydroxypropyl methylcellulose (HPMC). Three different HPMC grades, (AFFINISOLTM HPMC HME 15LV, 90 Da (HPMC 15LV); 100LV, 180 Da (HPMC 100LV); 4M, 500 Da (HPMC 4M)), which are suitable for hot-melt extrusion (HME), ...
  • A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults 

    Robinson, Eirin Guldsten; Gyllensten, Hanna; Johansen, Jeanette Schultz; Havnes, Kjerstin; Granås, Anne Gerd; Bergmo, Trine Strand; Småbrekke, Lars; Garcia, Beate Hennie; Halvorsen, Kjell Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-22)
    Background - Older adults are at greater risk of medication-related harm than younger adults. The Integrated Medication Management model is an interdisciplinary method aiming to optimize medication therapy and improve patient outcomes.<p> <p>Objective - We aimed to investigate the cost effectiveness of a medication optimization intervention compared to standard care in acutely hospitalized older ...
  • Population structure and antimicrobial resistance among Klebsiella isolates sampled from human, animal, and environmental sources in Ghana: a cross-sectional genomic One Health study 

    Calland, Jessica K; Haukka, Kaisa; Kpordze, Stephen W; Brusah, Atanyiwoen; Corbella, Marta; Merla, Cristina; Samuelsen, Ørjan; Feil, Edward J; Sassera, Davide; Karikari, Akosua B; Saba, Courage K S; Thorpe, Harry; Corander, Jukka (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-16)
    Background One Health approaches to address the increasing threat of antimicrobial resistance (AMR) are gaining attention. However, data on the distribution and movement of bacteria and their AMR-associated genes between clinical and non-clinical sources are scarce, especially from low-income and middle-income countries. We aimed to analyse Klebsiella isolates from various sources in Ghana and ...
  • Polymyxin B stabilized DNA micelles for sustained antibacterial and antibiofilm activity against P. aeruginosa 

    Antunes de Sousa, Alexandra Sofia; Borøy, Vegard; Bæverud, Agnethe Hansen; Julin, Kjersti; Bayer, Annette; Strøm, Morten B.; Johannessen, Mona Susan; Skalko Basnet, Natasa; Obuobi, Sybil Akua Okyerewa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-21)
    Nucleic acid-based materials showcase an increasing potential for antimicrobial drug delivery. Although numerous reports on drug-loaded DNA nanoparticles outline their pivotal antibacterial activities, their potential as drug delivery systems against bacterial biofilms awaits further studies. Among different oligonucleotide structures, micellar nanocarriers derived from amphiphilic DNA strands ...
  • Mge-cluster: a reference-free approach for typing bacterial plasmids 

    Alonso, Sergio Arredondo; Gladstone, Rebecca Ashley; Pöntinen, Anna Kaarina; Gama, João Alves; Schürch, Anita C.; Lanza, Val F.; Johnsen, Pål Jarle; Samuelsen, Ørjan; Tonkin-Hill, Gerry; Corander, Jukka (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-10)
    Extrachromosomal elements of bacterial cells such as plasmids are notorious for their importance in evolution and adaptation to changing ecology. However, high-resolution population-wide analysis of plasmids has only become accessible recently with the advent of scalable long-read sequencing technology. Current typing methods for the classification of plasmids remain limited in their scope which ...
  • Suitability of issuing sickness certificates in remote consultations during the COVID-19 pandemic. A mixed method study of GPs' experiences 

    Breivik, Elin; Kristiansen, Eli; Zanaboni, Paolo; Johansen, Monika Alise; Øyane, Nicolas Melchior Frederic; Bergmo, Trine Strand (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)
    Objective - To explore Norwegian GPs’ experiences with and perceived suitability of issuing sickness certifications in remote consultations during the COVID-19 pandemic.<p> <p>Design - We used a mixed methods research design. An online survey with 301 respondents was combined with qualitative interviews with ten GPs.<p> <p>Setting - Norwegian general practice.<p> <p>Results - Most GPs agreed ...
  • Pharmaceutical Care Network Europe definition of quality indicators for pharmaceutical care: a systematic literature review and international consensus development 

    Fujita, Kenji; Halvorsen, Kjell Hermann; Sato, Noriko; Jazbar, Janja; Modamio, Pilar; Waltering, Isabel; De Wulf, Isabelle; Westerlund, Tommy; Chen, Timothy F.; Teichert, Martina (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-30)
    Background Over the past 40 years, the tasks of pharmacists have shifted from logistic services to pharmaceutical care (PhC). Despite the increasing importance of measuring quality of care, there is no general defnition of Quality Indicators (QIs) to measure PhC. Recognising this, a working group in a European association of PhC researchers, the Pharmaceutical Care Network Europe (PCNE), was ...
  • Testing for the fitness benefits of natural transformation during community-embedded evolution 

    Winter, Macaulay; Harms, Klaus; Johnsen, Pål Jarle; Buckling, Angus; Vos, Michiel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-01)
    Natural transformation is a process where bacteria actively take up DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. The evolutionary benefits of transformation are still under debate. One main explanation is that foreign allele and gene uptake facilitates natural selection by increasing genetic variation, analogous to meiotic ...
  • A new preparation method for preparation of liposomes-in-hydrogels primed for treatment of skin diseases 

    Ingebrigtsen, Sveinung Gaarden; Johansen, Kurt Jonny; Skalko-Basnet, Natasa; Holsæter, Ann Mari (Conference object; Konferansebidrag, 2014)
    <p>Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization. <p>Liposome formulations for topical application needs a vehicle to assure the desirable ...
  • Chapter 11 - Hydrogels as intrinsic antimicrobials 

    Vanić, Željka; Skalko-Basnet, Natasa (Chapter; Bokkapittel, 2019-10-25)
    Hydrogels are currently applied as the vehicles for drugs or active substances, rather than the active contributors to therapeutic activities. With increasing challenges related to antimicrobial resistance against many antibiotics, natural origin hydrogels have become attractive as more than just vehicles. Although many natural polymers exhibit intrinsic antimicrobial properties, these properties ...
  • Knowledge and need for information about non-prescription analgesics - A cross-sectional study among pharmacy customers 

    Knutsen, Vera S.; Oland, Oda; Eriksen, Karoline; Holst, Lone; Garcia, Beate Hennie; Waaseth, Marit (Conference object; Konferansebidrag, 2019)
    <p>Pain is among the most common causes for seeking drug treatment. There is widespread use of non-prescription analgesics, and previous studies suggest that the level of knowledge about these drugs is low. <p>The aim of the study was to describe the level of knowledge about nonprescription analgesics among pharmacy customers, thereby identifying population groups in high need of information. ...
  • Dermal Application of Chloramphenicol - The Effect of Liposomes and Chitosan Hydrogel Formulations on ex vivo Permeation and Antimicrobial Activity 

    Holsæter, Ann Mari; Ingebrigtsen, Sveinung Gaarden; Skalko-Basnet, Natasa (Conference object; Konferansebidrag, 2017)
    Liposomes solubilize lipophilic drugs in the phospholipid membrane, and entrap hydrophilic drugs in its aqueous core. These vesicles provide a sustained- and targeted- drug release, and protect from degradation. Liposomes retain the drug onto/in the skin and improve skin drug deposition. Due to their liquid nature, a secondary vehicle, such as a hydrogel, is needed to obtain a necessary retention ...
  • Docetaxel Liposomes - A formulation Screening Study 

    Karlsen, Iselin; Skalko-Basnet, Natasa; Holsæter, Ann Mari (Conference object; Konferansebidrag, 2019)
    <p>Docetaxel (DOC) is a potent anticancer drug with several limitations, including poor solubility and the reported serious side effects, attributed to either the drug itself or the solvent used. Thus, it is interesting to entrap the drug into liposomes in order to solubilize the drug and improve the therapeutic outcome. <p>The fist aim of this study was to establish a small-scale screening method ...
  • Internet Use for Obtaining Medicine Information: Cross-sectional Survey 

    Bergmo, Trine Strand; Sandsdalen, Vilde; Manskow, Unn Sollid; Småbrekke, Lars; Waaseth, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)
    Background: The internet is increasingly being used as a source of medicine-related information. People want information to facilitate decision-making and self-management, and they tend to prefer the internet for ease of access. However, it is widely acknowledged that the quality of web-based information varies. Poor interpretation of medicine information can lead to anxiety and poor adherence to ...
  • ‘Illuminating determinants of implementation of non-dispensing pharmacist services in home care: a qualitative interview study’ 

    Bø, Karl-Erik; Halvorsen, Kjell H.; Risør, Torsten; Lehnbom, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-13)
    Objectives - Medication errors are leading causes of hospitalization and death in western countries and WHO encourages health care providers to implement non-dispensing pharmacist services in primary care to improve medication work. However, these services struggle to provide any impact on clinical outcomes. We wanted to explore health care professionals’ views on medication work to illuminate ...

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