Nye registreringer

  • Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli 

    Podnecky, Nicole L.; Aarag, Elizabeth; Kloos, Julia Maria; Sørum, Vidar; Primicerio, Raul; Roberts, Adam Paul; Rozen, Daniel E.; Samuelsen, Ørjan; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-10)
    There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases susceptibility to other drugs, might enable selection against resistance during treatment. However, the success of this approach would depend on the conservation of CS networks across genetically diverse bacterial strains. Here, ...
  • Considering pharmacy workflow in the context of Australian community pharmacy: a pilot time and motion study 

    Cavaye, D; Lehnbom, Elin; Laba, T-L; El-Boustani, E; Joshi, R; Webster, R (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-04)
    <p><i>Background</i>: Given time pressures on primary care physicians, utilising pharmacists for chronic disease management is of great interest. However, limited data are available on the current workflow in community pharmacies to guide these discussions.</p> <p><i>Objective</i>: This study aimed to test the feasibility of collecting workflow data from Australian community pharmacies using ...
  • An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistance 

    Fjellaksel, Richard; Dugalic, Damir; Demissie, Taye Beyene; Riss, Patrick; Hjelstuen, Ole Kristian; Sundset, Rune; Hansen, Jørn H (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-28)
    Herein, we report a straightforward sequential acylation‐Finkelstein approach to achieve iodination of amine containing bioactives. The utility was demonstrated by successful radiolabelling with <sup>123</sup>I in high radiochemical yield. Moreover, microwave‐assisted Finkelstein reaction can be employed to enhance conversion and reaction rates to obtain the desired iodides. The method is of interest ...
  • Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts 

    Borgan, Eldrid; Lindholm, Evita Maria; Moestue, Siver Andreas; Mælandsmo, Gunhild; Lingjærde, Ole Christian; Gribbestad, Ingrid S; Børresen-Dale, Anne-Lise; Engebråten, Olav; Sørlie, Therese (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-10-23)
    <p>Antiangiogenic therapy with bevacizumab has shown varying results in breast cancer clinical trials. Identifying robust biomarkers for selecting patients who may benefit from such treatment and for monitoring response is important for the future use of bevacizumab.</p> <p>Two established xenograft models representing basal‐like and luminal‐like breast cancer were used to study bevacizumab ...
  • Deciphering the landscape of host barriers to Listeria monocytogenes infection 

    Zhang, Ting; Abel, Sören; Abel zur Wiesch, Pia; Sasabe, Jumpei; Davis, Brigid M.; Higgins, Darren E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-30)
    <i>Listeria monocytogenes</i> is a common food-borne pathogen that can disseminate from the intestine and infect multiple organs. Here, we used sequence tag-based analysis of microbial populations (STAMP) to investigate <i>L. monocytogenes</i> population dynamics during infection. We created a genetically barcoded library of murinized <i>L. monocytogenes</i> and then used deep sequencing to track ...
  • Interaction of CPZEN-45, a novel anti-tubercular drug candidate, with immune cells in vitro 

    Al-Shamkawy, Awfa (Master thesis; Mastergradsoppgave, 2016-05-26)
    Tuberculosis (TB) is an infectious disease that represents a serious global threat, with estimations suggesting that one third of the world’s population is infected. Treating TB today requires long treatment duration and medicines must be administered orally in large doses, which leads to non-compliant patients. CPZEN-45 is a novel anti-TB drug candidate in pre-clinical development, in which pulmonary ...
  • Characterization of a novel class of mutation (Short Patch Illegitimate Recombination) in Acinetobacter baylyi 

    Lunnan, Asbjørn (Master thesis; Mastergradsoppgave, 2013-05-20)
    In prokaryotes, genetic variability contributes to the adaptation to novel environmental conditions, to resistance against threats such as antimicrobial agents and viruses, and ultimately to bacterial evolution through selection and drift. Genetic variability is mainly generated through mutations, e.g. point mutations, deletions, insertions, inversions, and duplications/amplifications. In addition, ...
  • A characterization and comparison of the microRNA expression profile in breast cancer cell lines and exosomes 

    Nikolaisen, Marlen Aas (Master thesis; Mastergradsoppgave, 2013-05-20)
    Breast cancer is the leading cause in cancer deaths among woman worldwide, and one in ten women will experience the disease during their lifetime. Breast cancer accounted for 23% of the total new cancer incidences and 14% of the total cancer deaths in Norway in 2008. One way to potentially improve long-term cancer survival statistics is earlier detection. That includes the discovery and characterization ...
  • Development of COFRADIC HPLC system for proteomics. Sorting of N-terminal peptides 

    Banki, Maryam Ghazi Ali (Master thesis; Mastergradsoppgave, 2014-05-20)
    Proteomics, the study of the proteins constituting the proteome, has featured in the past few years as an essential tool in a number of diverse areas of therapeutic research for detection of the initial stage of a disease, for consideration of therapy response and for disintegrating fundamental pathophysiological mechanisms. Proteomics has a wide range of applications such as diabetes research, ...
  • Interaksjonen mellom glukokortikoidreseptoren og Pax6 under genregulering i sebrafiskembryo og mammalske celler i kultur 

    Skaue, Lillann Wilsgård (Master thesis; Mastergradsoppgave, 2013-05-20)
    Det er kjent at glukokortikoidreseptoren (GR) og Pax6 som begge er transkripsjonsfaktorer og blant annet er viktig for normal embryoutvikling, har noen felles målgener blant matriks metalloproteinasene (MMP.) MMPer sørger for remodellering av ekstracellulær matriks (ECM) og er svært viktige under embryogenesen. Fra før av er det kjent at både GR og Pax6 regulerer uttrykket MMP2 og MMP9. I ...
  • Zebrafish as a model system for safety pharmacology, using a glucocorticoid and an antimicrobial peptide as test substances 

    Albert, Ingrid (Master thesis; Mastergradsoppgave, 2013-05-20)
    The zebrafish is an exciting model organism with a lot to offer and many possible areas of application. Toxicity assays using zebrafish embryos are becoming increasingly popular with the pharmaceutical industry as a tool to bridge the gap between conventional cell based screens and animal testing. The main aim of this project was to explore the zebrafish as a model system for use in safety pharmacology, ...
  • The regulation of steroid receptor coactivator-3 (SRC-3) activity by ERK3-MK5 signal pathway. A study in lung cancer cells 

    Almahi, Eslaem (Master thesis; Mastergradsoppgave, 2013-05-19)
    Background: Protein kinases and phosphatases persistently regulate various signal pathways that mediate many cellular processes. The mitogen activated protein kinases (MAPKs) are key components in the transduction of extracellular stimuli to biological responses. The dysregulation of MAPKs activity promotes the occurrence of diverse diseases, including cancer, making MAPKs signaling pathways attractive ...
  • Legemiddelsamstemming i UNN Tromsø. Kvalitet av legemiddellister i Universitetssykehuset Nord Norge Tromsø etter innføring av prosedyrer for legemiddelsamstemming 

    Muse, Ibrahim Moallin (Master thesis; Mastergradsoppgave, 2017-05-16)
    Bakgrunn: Uoverensstemmelser (UOr) mellom legemiddelopplysninger som registreres ved pasientinnleggelse og legemidler i bruk før innleggelse er velkjent, og kan føre til feil legemiddelbruk, svikt i behandling og i verste fall økt sykelighet og død. Legemiddelsamstemming (LMS) er ett av innsatsområdene i pasientsikkerhetsprogrammet” I trygge hender”, og har som mål å sikre at registrerte opplysninger ...
  • Isolation, characterization and chondrogenic differentiation of adult stem cell-derived MUSE-cells 

    Johansen, Lars-Arne (Master thesis; Mastergradsoppgave, 2016-05-13)
    Articular cartilage is coating the layers of freely movable joints, enabling a smooth surface and acts resisting to forces. The tissue is aneural and avascular, and has a poor ability to selfrenew in cases of tissue damage. Therefore, cartilage lesions often lead to degenerative disorders such as osteoarthritis (OA). OA is considered the most common form of arthritis affecting people worldwide, ...
  • Chitosan Lecithin Nanoparticles with New Chemical Entity. Antimicrobial Evaluation 

    Hemmingsen, Lisa Myrseth (Master thesis; Mastergradsoppgave, 2015-05-13)
    Chronic wounds are often colonized with biofilm-producing bacteria, such as Staphylococcus epidermidis, and these wounds often have high degree of complexity and are often challenging to treat. There is a high resistance to the traditional antimicrobial treatments and that is why these infections sometimes are persistent. Photodynamic therapy (PDT) is proposed as a potential solution to the problems ...
  • Collateral sensitivity in clinical Escherichia coli isolates resistant to ciprofloxacin 

    Lam, Chon Kit (Master thesis; Mastergradsoppgave, 2016-05-13)
    The increase in antimicrobial resistance in bacteria is a serious problem in public heath limiting the efficacy of available antimicrobials for treatment of infections. E. coli is the most frequent cause of uncomplicated urinary tract infections. Ciprofloxacin is an important antimicrobial for treatment of uncomplicated urinary tract infections. Unfortunately, resistance to ciprofloxacin is commonly ...
  • Karakteristika ved ulike behandlingskategorier av diabetes. Kvinner og kreft-studien 

    Sandvik, Line Anita (Master thesis; Mastergradsoppgave, 2016-05-12)
    Overvekt og fedme øker i samfunnet og hånd i hånd går den nye folkesykdommen type 2 diabetes. Type 2 diabetes er en alvorlig kronisk sykdom som rammer mange mennesker i hele verden. Det estimeres en fordobling av forekomsten av diabetes fra år 2000 og til år 2030. På grunnlag av dette er det viktigere enn noen gang å finne løsninger og metoder for å eventuelt forebygge eller utsette sykdommen. Det ...
  • Chitosan Lecithin Nanoparticles with New Chemical Entity. Nanotoxicity Evaluation 

    Kangu, Lloyd Mbugua (Master thesis; Mastergradsoppgave, 2016-05-12)
    Chronic skin wounds are an exponentially increasing problem on a world basis, and are often hard to treat due to bacterial biofilm formation and resistance to different antibiotic treatments. Antimicrobial photodynamic therapy (aDPT) shows promise in resolving this issue, but clinical based treatments have yet to be established although photodynamic therapy is used for other conditions. A new ...
  • Metallo-β-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding 

    Skagseth, Susann; Akhter, Sundus; Paulsen, Marianne H; Muhammad, Zeeshan; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-14)
    Bacterial resistance is compromising the use of β-lactam antibiotics including carbapenems. The main resistance mechanism against β-lactams is hydrolysis of the β-lactam ring mediated by serine- or metallo-β-lactamases (MBLs). Although several inhibitors of MBLs have been reported, none has been developed into a clinically useful inhibitor. Mercaptocarboxylic acids are among the most prominent ...
  • Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (IMMENSE study): study protocol for a randomised controlled trial 

    Johansen, Jeanette Schultz; Havnes, Kjerstin; Halvorsen, Kjell H.; Haustreis, Stine-Mari; Skaue, Lillann Wilsgård; Kamycheva, Elena; Mathiesen, Liv; Viktil, Kirsten Kilvik; Granås, Anne Gerd; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-23)
    Introduction:<br> Drug-related problems (DRPs) are common in the elderly, leading to suboptimal therapy, hospitalisations and increased mortality. The integrated medicines management (IMM) model is a multifactorial interdisciplinary methodology aiming to optimise individual medication therapy throughout the hospital stay. IMM has been shown to reduce readmissions and drug-related hospital ...

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