Recent additions

  • Clinical Lipidomics: Effects of Vitamin D in Human Adipose Tissue 

    Chan, Sze Mang Sammy (Master thesis; Mastergradsoppgave, 2021-05-10)
    Vitamin D is vital for calcium homeostasis and skeletal health, has immunomodulatory effects and is involved in the regulation of differentiation and proliferation of many different cell types. Adipose tissue is an important metabolic organ and a major organ for vitamin D storage. Though, the role of vitamin D and its function in adipose tissue is not fully explored. This thesis applies a solvent ...
  • Molecular modelling of interactions between antipsychotic drugs and receptors mediating antipsychotic effects and important side effects 

    Issifou, Halimatu Sadia T. (Master thesis; Mastergradsoppgave, 2021-05-10)
    Dopamine and serotonin are two neurotransmitters that exert their actions through mediation of dopaminergic and serotonergic receptors respectively. The receptors in focus in the current study, are the dopamine D2 and serotonin 5-HT2A receptors. Common for both receptors is that they are class A G-protein-coupled receptors consisting of seven transmembrane helices embedded in the lipid membrane of ...
  • Network Analysis: an approach to the study of drug-drug relations. Co-medication in Norwegian elderly and severe drug-drug interactions as examples 

    Askar, Mohsen (Master thesis; Mastergradsoppgave, 2019-05-15)
    Network analysis (NA) has been used for studying many social aspects. Employing of network analysis as an approach in the field of public health, to study the relations between patients or health workers and their potential effects in many medical perspectives, took a good share of researchers’ efforts as well. Few attempts have been conducted to use network analysis to study drug-drug relations ...
  • Collateral sensitivity in clinical mecillinam resistant isolates of Escherichia coli 

    Nguyen, Tammy Tam Hoai Thi (Master thesis; Mastergradsoppgave, 2016-05-13)
    Background The rapid increase in antimicrobial resistance (AMR) has become a major threat to the successful management of infectious diseases. To counteract this global threat, development of novel treatment strategies is essential. A promising strategy may be exploiting collateral sensitivity; a phenomenon that occurs when a microorganism that has developed resistance to one antimicrobial agent, ...
  • Influence of environmental tonicity changes on lipophilic drug release from liposomes 

    Nikolaisen, Trygg Einar (Mastergradsoppgave; Master thesis, 2018-05-15)
    Introduction: Liposomes as drug delivery systems has been widely studied as a way to solubilize poorly soluble drugs, reduce side effects of chemotherapeutics and increase circulation time in vivo. Since the first descriptions of liposomes over 60 years ago, they have shown tendencies to shrink and swell when the external environment of the liposomes is altered. This phenomenon has been studied in ...
  • Topical vaginal therapy: Development of a liposomal hydrogel delivery system for epicatechin 

    Moueffaq, Sabrin (Mastergradsoppgave; Master thesis, 2018-05-15)
    Vaginal infections are common in women of all ages and proper treatment is essential. The vaginal route of administration can be considered as favourable for the local therapy of vaginal infections. There are several vaginal dosage forms currently available; however, all suffer from limitations such as leakage and limited residence time at the site of action resulting in reduced therapeutic effect. ...
  • Etikk og farmasøytisk praksis i apotek 

    Johannessen, Karen Øvrebø (Mastergradsoppgave; Master thesis, 2021-04-26)
    Etikkrådet for farmasøyter i Norge har en visjon om at alle farmasøyter skal være etisk reflekterte yrkesutøvere. Etiske dilemma oppstår når ulike verdier kommer i konflikt med hverandre og ikke kan forenes i en og samme handling. Apotekene i Norge har i de siste årene forandret seg i takt med nye lover og regler og farmasøytene har etter hvert fått utvidede oppgaver som setter andre krav til yrket. ...
  • LC-MS characterization of pigments in microalgae from different cultivation regimes 

    Stokkeland, Ingunn Møgedal (Master thesis; Mastergradsoppgave, 2019-05-15)
    <p>Background: The Artic University of Norway entered a partnership with a smelting plant to reduce the factory fume CO2-footprint by cultivation of microalgae (diatoms). The biomass produced from the microalgae is rich in lipids, proteins and pigments and can potentially function as fish feed for the aquaculture industry. Before the biomass can be utilized as e.g. fish feed, a thorough investigation ...
  • Antibiotikaforskrivning ved samfunnservervet pneumoni og KOLS-eksaserbasjon ved Universitetssykehuset Nord-Norge 

    Tøndel, Birgitte Gladsø (Master thesis; Mastergradsoppgave, 2019-05-15)
    <p>Bakgrunn: Rasjonell antibiotikaforskrivning, som i denne sammenheng vil si i henhold til Nasjonal faglig retningslinje for antibiotikabruk i sykehus, er et av de viktigste tiltakene vi har for å motvirke resistensutvikling. Forskrivning i henhold til retningslinjer er også assosiert med gunstige pasientutfall. Samfunnservervet pneumoni (community-acquired pneumonia; CAP) og kronisk obstruktiv ...
  • Docetaxel in liposomes: the effect of lipid composition on the achieved drug entrapment 

    Karlsen, Iselin (Mastergradsoppgave; Master thesis, 2018-05-15)
    INTRODUCTION: Docetaxel (DOC) is a potent anticancer drug but has several limitations such as poor solubility. The currently commercially available formulation of DOC is limited by reported serious side effects which either is attributed to the drug itself or the solvent used. Nanomedicine has been used for improving the therapeutic outcome of several drugs, but so far there are none available with ...
  • Evaluation and Late-Stage Fluorination of Small Molecule GnRH-R Antagonists 

    Rustad, Eirik André Lindeløff (Mastergradsoppgave; Master thesis, 2019-05-15)
    Alzheimer’s disease is the most common type of dementia; causing problems with memory, thinking and behaviour. The seemingly protective effect of hormone replacement therapy against Alzheimer’s disease sparked an interest in the role of the sex hormone system. Sex steroid production is dependent on gonadotropins released in the pituitary. The gonadotropin level is controlled by gonadotropin releasing ...
  • Liposomes-in-hydrogel delivery system containing resveratrol for the local treatment of vaginal infections 

    Tostrup, Mia Jonine (Mastergradsoppgave; Master thesis, 2018-05-15)
    Administering drug formulations to the vagina is a challenge since the vagina possesses “self-cleaning” features which allow trapping and rapid removing of foreign particles. Therefore, the residence time of drugs is often too short to offer a sufficient clinical effect. The aim of this project was to develop and optimize a liposomes-in-hydrogel system containing resveratrol for the local treatment ...
  • How will anonymization of simulated clinical data affect the data utility of pharmacoepidemiological studies? 

    Cheang, Chi Kei (Mastergradsoppgave; Master thesis, 2019-05-14)
    Background: The pressure to share more data and being more transparency of clinical study reports has grown and becomes an important topic in recent years. Before clinical data and clinical results can be shared they must undergo anonymization. How anonymization of clinical data affects the utility is poorly-studied, especially in pharmacoepidemiology. Objective: The aim of the study is to describe ...
  • Characterization of inhibition by vardenafil analogues of ATP-dependent transport of cGMP by the ABCC5 transporter. 

    Kuresh, Farzane (Master thesis; Mastergradsoppgave, 2015-05-27)
    Background: Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports intracellular cGMP out of the cells with high affinity, while PDE5 inhibitors prevent high affinity cGMP efflux by inhibiting ABCC5. Increasing intracellular cGMP levels through inhibition of PDE5 and PDE5 export activity is hypothesized ...
  • Molecular modelling of the androgen metabolising enzyme UDP-glucuronosyltransferase 2B17 

    Trane, Ingmar (Master thesis; Mastergradsoppgave, 2018-05-25)
    The enzyme UDP-glucuronosyltransferase 2B17 (UGT2B17) has a major role in androgen metabolism, being involved in the conjugation of both testosterone and its potent metabolite dihydrotestosterone. The enzyme catalyses the transfer of glucuronic acid from UDP-glucuronic acid to the lipophilic androgen substrate. As a consequence, the water solubility of the substrate is increased, and it is more ...
  • Development of orodispersible films: A new age-appropriate dosage form for children 

    Betoko, Evrard Louis Alain Brice (Master thesis; Mastergradsoppgave, 2015-05-18)
    In the recent years, governmental institutions have given incentives to the pharmaceutical industry in order to develop age-appropriate dosage forms for pediatric use. This has resulted in an interest in design of new and improved dosage form for pediatric patients. One of the many recent approaches is to take advantages of ODFs. Taste masking is a crucial step in the design of not only ODFs but all ...
  • Large scale cultivation of microalgae at Finnfjord AS: The effect of addition of CO2 and flue gas on lipid production and fatty acid composition 

    Ramskjell, Marte (Master thesis; Mastergradsoppgave, 2018-05-15)
    Background: This master’s thesis was a part of a project involving mass cultivation of microalgae at the smelting plant Finnfjord AS. Microalgae are primary producers of the important omega-3 long-chain polyunsaturated fatty acids EPA and DHA. At Finnfjord, the algae use CO2 from the flue gas for their production of lipid and protein rich biomass. The algal biomass can potentially function well as ...
  • Development of self-eliminating linkers for drug conjugates 

    Nergård, Silje Lillemark (Master thesis; Mastergradsoppgave, 2018-05-15)
    Newly discovered compounds through bioprospecting are screened for cytotoxicity, and many of them are found to be highly toxic. Because they are often not specifically toxic only against cancer cells, they are not further studied. These new compounds could be of further interest by temporarily masking a functional group which regulate the anticancer activity of a cytotoxic compound. This means that ...
  • Synthesis of copper and silver nanoparticles with extracts of berries: A green chemistry approach 

    Løkse, Christoffer Jacobsen (Master thesis; Mastergradsoppgave, 2017-05-15)
    Nanoparticles are usually defined as particles in a size range of 1-100 nm, and these particles often have different properties than the non-nanoscale material of the same chemical composition. In recent years, as the interest and use of nanoparticles has increased and so has the interest in understanding their behaviour, impact and fate in the environment. In the last decades, there has been special ...
  • Molecular modeling of 3D structure of the oxytocin receptor. Discovery of novel oxytocin receptor agonists via molecular docking studies. 

    Antobreh, Gloria Tiwaa (Master thesis; Mastergradsoppgave, 2015-05-15)
    Oxytocin has been shown to be implicated in psychiatric diseases such as depression, anxiety disorders, autism post-traumatic stress disorder, and schizophrenia. As a result, oxytocin can be used as a potential treatment for these brain disorders. However, oxytocin is a large peptide, and is therefore unable to cross the blood brain barrier. Thus, the development of new small non-peptide drugs would ...

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