Recent additions

  • Characterization of inhibition by vardenafil analogues of ATP-dependent transport of cGMP by the ABCC5 transporter. 

    Kuresh, Farzane (Master thesis; Mastergradsoppgave, 2015-05-27)
    Background: Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports intracellular cGMP out of the cells with high affinity, while PDE5 inhibitors prevent high affinity cGMP efflux by inhibiting ABCC5. Increasing intracellular cGMP levels through inhibition of PDE5 and PDE5 export activity is hypothesized ...
  • Molecular modelling of the androgen metabolising enzyme UDP-glucuronosyltransferase 2B17 

    Trane, Ingmar (Master thesis; Mastergradsoppgave, 2018-05-25)
    The enzyme UDP-glucuronosyltransferase 2B17 (UGT2B17) has a major role in androgen metabolism, being involved in the conjugation of both testosterone and its potent metabolite dihydrotestosterone. The enzyme catalyses the transfer of glucuronic acid from UDP-glucuronic acid to the lipophilic androgen substrate. As a consequence, the water solubility of the substrate is increased, and it is more ...
  • Development of orodispersible films: A new age-appropriate dosage form for children 

    Betoko, Evrard Louis Alain Brice (Master thesis; Mastergradsoppgave, 2015-05-18)
    In the recent years, governmental institutions have given incentives to the pharmaceutical industry in order to develop age-appropriate dosage forms for pediatric use. This has resulted in an interest in design of new and improved dosage form for pediatric patients. One of the many recent approaches is to take advantages of ODFs. Taste masking is a crucial step in the design of not only ODFs but all ...
  • Large scale cultivation of microalgae at Finnfjord AS: The effect of addition of CO2 and flue gas on lipid production and fatty acid composition 

    Ramskjell, Marte (Master thesis; Mastergradsoppgave, 2018-05-15)
    Background: This master’s thesis was a part of a project involving mass cultivation of microalgae at the smelting plant Finnfjord AS. Microalgae are primary producers of the important omega-3 long-chain polyunsaturated fatty acids EPA and DHA. At Finnfjord, the algae use CO2 from the flue gas for their production of lipid and protein rich biomass. The algal biomass can potentially function well as ...
  • Development of self-eliminating linkers for drug conjugates 

    Nergård, Silje Lillemark (Master thesis; Mastergradsoppgave, 2018-05-15)
    Newly discovered compounds through bioprospecting are screened for cytotoxicity, and many of them are found to be highly toxic. Because they are often not specifically toxic only against cancer cells, they are not further studied. These new compounds could be of further interest by temporarily masking a functional group which regulate the anticancer activity of a cytotoxic compound. This means that ...
  • Synthesis of copper and silver nanoparticles with extracts of berries: A green chemistry approach 

    Løkse, Christoffer Jacobsen (Master thesis; Mastergradsoppgave, 2017-05-15)
    Nanoparticles are usually defined as particles in a size range of 1-100 nm, and these particles often have different properties than the non-nanoscale material of the same chemical composition. In recent years, as the interest and use of nanoparticles has increased and so has the interest in understanding their behaviour, impact and fate in the environment. In the last decades, there has been special ...
  • Molecular modeling of 3D structure of the oxytocin receptor. Discovery of novel oxytocin receptor agonists via molecular docking studies. 

    Antobreh, Gloria Tiwaa (Master thesis; Mastergradsoppgave, 2015-05-15)
    Oxytocin has been shown to be implicated in psychiatric diseases such as depression, anxiety disorders, autism post-traumatic stress disorder, and schizophrenia. As a result, oxytocin can be used as a potential treatment for these brain disorders. However, oxytocin is a large peptide, and is therefore unable to cross the blood brain barrier. Thus, the development of new small non-peptide drugs would ...
  • Large scale cultivation of microalgae at Finnfjord AS: The effect of different storage treatments on lipid and fatty acid stability 

    Aronsen, Simen (Master thesis; Mastergradsoppgave, 2018-05-15)
    The Arctic University of Norway and the ferrosilicon smeltery Finnfjord AS has started a microalgal mass cultivation project where sequestration of CO2 and NOx from factory fumes are used in the production of diatom biomass. Primary application of the produced biomass is fish feed. This requires information regarding lipid content and storage stability. In this study the lipid content, fatty acid ...
  • Improved chronic wound therapy: surface charged deformable liposomes for dermal delivery of curcumin 

    Gagnat, Eivind (Master thesis; Mastergradsoppgave, 2018-05-15)
    Chronic wounds are today representing a major challenge in global healthcare due the difficulty to treat as well as the costs for the society. Therefore, improving chronic wound therapy is an urgent need. Curcumin, a polyphenol compound, has shown to have potential in wound therapy due to its anti-inflammatory, anti-infectious and anti-oxidant properties. However, the poor water solubility, low ...
  • Liposomes as Potential Carrier for Bioactive β2,2- Amino Acid Derivatives - A Feasibility Study 

    Azumah, Joseph (Master thesis; Mastergradsoppgave, 2015-05-13)
    The emergence of antibiotic resistant bacterial strains is a rising global problem that does not only result in fatal infections of previously treatable cases, but increases also the economic burden of health care systems. The same applies for cancer as treatment of some cancer types is difficult and also resistance to treatment is an increasing problem in cancer chemotherapy. Novel treatment ...
  • Quantitative Phosphoprotein Analysis in Adipose Tissue 

    Assignon, Edmund Theodore Fiifi (Master thesis; Mastergradsoppgave, 2016-05-13)
    Background: Mass spectrometry-based proteomics has increasingly been the choice of method for the global analysis of the composition, modification and dynamics of proteins. Quantitative analysis of the proteome with tandem mass tag is a technique for calculating the relative abundance of the proteome in tissues and organelles. In this thesis, present a novel bottom-up method for the quantitative ...
  • Polymer-coated liposomes for hydration of oral mucosa. Investigation of water adsorption, retention, and release properties. 

    Bowitz, Stina Sand (Master thesis; Mastergradsoppgave, 2014-12-15)
    Ailments from a dehydrated mouth may result in problems with food intake, such as chewing and swallowing, with smiling and appearance, and some of them may cause pain. A system to increase hydration of oral mucosa will reduce patient ailments, or the frequency of them, and increase quality of life. The focus of this thesis is to study the potential of polymer coated liposomal systems for hydration ...
  • β-cyclodextrin polymers as cholesterol sequestrating agents 

    Fadeev, Nikolay Olegovich (Master thesis; Mastergradsoppgave, 2018-08-19)
    Summary Elevated serum cholesterol blood levels is one of the central risk factors for cardiovascular diseases. Lowering blood cholesterol have significant impact on lowering cardiovascular disease events. Inhibiting cholesterol absorption in small intestine can significantly lower serum cholesterol levels and thereby - lower cardiovascular events. Β-cyclodextrin (βCD)-dextran polymer is expected ...
  • Bruk av kosttilskudd blant pasienter over 70 år ved Nordlandssykehuset i Bodø 

    Ramstad, Elise Sørensen (Master thesis; Mastergradsoppgave, 2019-05-14)
    Bruk av kosttilskudd er vanlig i den generelle befolkningen. Kosttilskudd er ikke underlagt de samme lover og reguleringer som legemidler, og det er kjent at kosttilskudd kan gi bivirkninger og interagere med legemidler. Eldre mennesker er en spesielt utsatt gruppe for bivirkninger og interaksjoner. Formålet med studien er å kartlegge bruk av kosttilskudd blant pasienter over 70 år, undersøke om ...
  • Isolation and Characterisation of Halogenated and Bioactive Compounds from Thalassospira sp. and Alteromonas sp. 

    Ali, Nadia Ghazi (Master thesis; Mastergradsoppgave, 2019-05-15)
    Bacterial natural products have contributed with a large part of the bioactive compounds that lead to drugs, and the biggest portion of the marketed antibiotics are bacterial products or their derivatives. Marine bacteria are not yet investigated to the same extend as their terrestrial counterparts. Therefore, they are considered a promising source for novel bioactive metabolites for drug development, ...
  • Development of a homologous gene replacement approach to study ciprofloxacin resistance in clinical Escherichia coli isolates 

    Valla, Sanne Ekroll (Master thesis; Mastergradsoppgave, 2017-05-15)
    Urinary tract infections are common amongst infectious diseases in humans, and often these infections are caused by uropathogenic Escherichia coli. Effective antimicrobial treatment of infections are medical achievements that should not be taken for granted, as antimicrobial resistance has developed and causes treatments to become ineffective. Further, resistance traits can be spread between unrelated ...
  • Reseptpliktige legemidler og samtidig bruk av lavdose naltrekson (LDN) hos pasienter med kronisk inflammatorisk tarmsykdom. En kvasieksperimentell reseptregisterstudie 

    Simonsen, Pia (Master thesis; Mastergradsoppgave, 2017-05-15)
    BAKGRUNN: Naltrekson er en ikke-selektiv opioidantagonist som tradisjonelt brukes til å behandle opioid- og alkoholavhengighet. Lavdose naltrekson (LDN), 3-5 mg/dag, har senere blitt brukt som «off-label» tilleggsbehandling i flere autoimmune sykdommer, inkludert kronisk inflammatorisk tarmsykdom (IBD). FORMÅL: Formålet med denne studien er å undersøke om det er en assosiasjon mellom bruk av LDN og ...
  • Etablering av et system for å studere funksjonelle konsekvenser av kreftspesifikke DDR2 mutasjoner 

    Aburayya, Mahmoud (Master thesis; Mastergradsoppgave, 2014-05-20)
    Discoidin domene reseptor 2 (DDR2) er en unik reseptor tyrosinkinase (RTK) som aktiveres av ulike typer kollagen. DDR2 er involvert i regulering av celledifferensiering, remodelering av ekstracellulær matriks, cellemigrasjon, og celleproliferasjon. Nye studier viser at DDR2 er mutert i flere kreftformer, og spesielt lungekreft. Konsekvensen av disse kreftspesifikke mutasjoner er i midlertidig ikke ...
  • Melt processability of amorphous solid dispersions during hot-melt extrusion. Screening using vacuum compression moulding and evaluation by rheology and solid-state analysis 

    Ekblad, Nicklas (Master thesis; Mastergradsoppgave, 2018-05-15)
    Soluplus is a suitable excipient for innovative manufacturing techniques such as hot-melt extrusion (HME). While Soluplus is useful for forming amorphous solid dispersions (ASD’s) during HME, the resulting extrudates are often stiff and brittle. In order to achieve suitable dosage forms, with optimal downstream processability, an efficient screening for suitable formulations is required. Vacuum ...
  • A study of Fez1 and Fez2: Localization and knock-out 

    Schäfer, Helene Bekkeli (Master thesis; Mastergradsoppgave, 2016-05-11)
    Autophagy is a fundamental cellular process where cell components get digested in autolysosomes and are recycled. Dysregulation of autophagy is involved in major diseases like cancer, neurodegeneration, inflammation and ischemia. In this thesis we have worked with fasciculation and elongation zeta (Fez) proteins, which are reported to inhibit autophagy. There are at least two mammalian Fez proteins, ...

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