Recent additions

  • Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts 

    Lindholm, Evita Maria; Kristian, Alexandr; Nalwoga, Hawa; Kruger, Kristi; Nygård, Ståle; Akslen, Lars A.; Mælandsmo, Gunhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-03-31)
    Several clinical trials have investigated the efficacy of bevacizumab in breast cancer, and even if growth inhibiting effects have been registered when antiangiogenic treatment is given in combination with chemotherapy no gain in overall survival has been observed. One reason for the lack of overall survival benefit might be that appropriate criteria for selection of patients likely to respond ...
  • Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginal Tissue Model 

    Jøraholmen, May Wenche; Damdimopoulou, Pauliina; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-17)
    The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydrogel as secondary vehicle. Although considered ...
  • The pH-Responsive Liposomes—The Effect of PEGylation on Release Kinetics and Cellular Uptake in Glioblastoma Cells 

    Rustad, Eirik André Lindeløff; von Hofsten, Susannah; Kumar, Robin; Lænsman, Eirik Abrahamsen; Berge, Gerd; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-25)
    Nanomedicine has been, to a certain degree, a success story in the development of superior anticancer therapies. However, there are tumors that remain a huge challenge for nanoformulations, for instance, brain tumors such as glioblastoma, the most common and aggressive brain tumor. To utilize the fact that such tumors are characterized by an acidic extracellular environment, we selected pH-responsive ...
  • Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis 

    Starikova, Irina; Al-Haroni, Mohammed; Werner, Guido; Roberts, Adam P.; Nielsen, Kåre M.; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-07-05)
    Objectives: To determine the fitness effects of various mobile genetic elements (MGEs) in Enterococcus faecium and Enterococcus faecalis when newly acquired. We also tested the hypothesis that the biological cost of vancomycin resistance plasmids could be mitigated during continuous growth in the laboratory.<p> <p>Methods: Different MGEs, including two conjugative transposons (CTns) of the Tn916 ...
  • Crosstalk between p38 MAPK and GR Signaling 

    Zeyen Øyås, Lisa; Seternes, Ole Morten; Mikkola, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-19)
    The p38 MAPK is a signaling pathway important for cells to respond to environmental and intracellular stress. Upon activation, the p38 kinase phosphorylates downstream effectors, which control the inflammatory response and coordinate fundamental cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of this signaling pathway has been linked to inflammatory diseases ...
  • Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A&lt;sub&gt;2&lt;/sub&gt;, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines 

    Jantan, Ibrahim; Bukhari, Syed Nasir Abbas; Adekoya, Olayiwola; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-16)
    Arachidonic acid metabolism leads to the generation of key lipid mediators which play a fundamental role during inflammation. The inhibition of enzymes involved in arachidonic acid metabolism has been considered as a synergistic anti-inflammatory effect with enhanced spectrum of activity. A series of 1,3-diphenyl-2-propen-1-one derivatives were investigated for anti-inflammatory related activities ...
  • Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries 

    Kieler, Helle; Artama, Miia; Engeland, Anders; Ericsson, Örjan; Furu, Kari; Gissler, Mika; Nielsen, Rikke Beck; Nørgaard, Mette; Stephansson, Olof; Valdimarsdottir, Unnur; Zoega, Helga; Haglund, Bengt (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-01-12)
    Objective To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs.<p> <p>Design Population based cohort study using data from the national health registers.<p> <p>Setting Denmark, Finland, Iceland, Norway, and Sweden, 1996-2007.<p> ...
  • vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding 

    Tran, Vi Ngoc-Nha; Shams, Alireza; Ascioglu, Sinan; Martinecz, Antal; Liang, Jingyi; Clarelli, Fabrizio; Mostowy, Rafal; Cohen, Ted; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-06)
    Background: As antibiotic resistance creates a signifcant global health threat, we need not only to accelerate the development of novel antibiotics but also to develop better treatment strategies using existing drugs to improve their efcacy and prevent the selection of further resistance. We require new tools to rationally design dosing regimens from data collected in early phases of antibiotic ...
  • Biologics: the role of delivery systems in improved therapy 

    Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-19)
    The beginning of the 21st century saw numerous protein and peptide therapeuticals both on the market and entering the final stages of clinical studies. They represent a new category of biologically originated drugs termed biologics or biologicals. Their main advantages over conventional drugs can be summarized by their high selectivity and potent therapeutic efficacy coupled with limited side ...
  • Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight 

    Rapp, Ellionor; Samuelsen, Ørjan; Sundqvist, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-03)
    This study evaluated the performance of the MBT STAR-Carba kit (Bruker Daltonics), to detect carbapenemase producing Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. in comparison with the RAPIDEC® CARBA NP test (BioMerieux). MBT STAR-Carba allowed the detection of carbapenemases in Enterobacteriaceae and P. aeruginosa.
  • The effect of low-dose naltrexone on medication in inflammatory bowel disease: A quasi experimental before-and-after prescription database study 

    Raknes, Guttorm; Simonsen, Pia; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-27)
    Background and Aims: Low-dose naltrexone [LDN] is a controversial off-label treatment used by many Crohn’s disease [CD] and ulcerative colitis [UC] patients. A small number of preliminary studies indicate that LDN might be beneficial in CD, but evidence is too scarce to demonstrate efficacy. We sought to examine whether initiation of LDN therapy by patients with inflammatory bowel disease [IBD] ...
  • Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study. 

    Haldorsen, Bjørg; Giske, Christian G; Hansen, Dennis S; Helgason, Kristjan Orri; Kahlmeter, Gunnar; Löhr, Iren Høyland; Matuschek, Erika; Österblad, Monica; Rantakokko-Jalava, Kaisu; Wang, Mikala; Småbrekke, Lars; Samuelsen, Ørjan; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-24)
    Objectives: To examine performance of EUCAST disc diffusion and supplementary MIC methods for detection of Enterobacteriaceae with reduced susceptibility to meropenem using EUCAST screening recommendations.<p> <p>Methods: Sixty-one Nordic laboratories delivered data on EUCAST disc diffusion (n " 61), semi-automated meropenem MIC (n " 23; VITEK2, n " 20 and Phoenix, n " 3) and gradient meropenem ...
  • Detection of DHCMT long-term metabolite glucuronides with LC-MSMS as an alternative approach to conventional GC-MSMS analysis 

    Göschl, Lorenz; Gmeiner, Günter; Gärtner, Peter; Steinacher, Michael; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-17)
    Dehydrochloromethyltestosterone (DHCMT) is one of the most detected illicit used anabolic–androgenic steroids in professional sports. Therefore, a fast and accurate analysis of this substance is of great importance for a constructive fight against doping abuse. The conventional method for the analysis of this drug, GC-MSMS, is very sensitive and selective but also very time- and resource-consuming. ...
  • Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics 

    Soltys, Marek; Zuza, David; Boleslavska, Tereza; Akhlasova, Sarah Machac; Balouch, Martin; Kovacik, Pavel; Beranek, Josef; Skalko-Basnet, Natasa; Flaten, Gøril Eide; Stefanec, Frantisek (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-08)
    The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted ...
  • Self-medication Behavior with antibiotics: a national cross-sectional survey in Sri Lanka 

    Zawahir, Shukry; Lekamwasam, Sarath; Halvorsen, Kjell H.; Rose, Grenville; Aslani, Parisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-14)
    <b><p>Background</b> Antibiotic self-medication is common in low- and middle-income countries. This study aimed to evaluate the Sri Lankan public’s knowledge about and attitudes toward antibiotic use and self-medication, and factors associated with self-medication. <b><p>Methods</b> A national cross-sectional, interviewer-administered, survey of a random household sample (N = 1100) was ...
  • Influensavaksine, en spørreundersøkelse blant apotekkunder 

    Waaseth, Marit; Forsdahl, Siri; Halvorsen, Kjell H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-06)
    <p><i>Hensikt: </i>Å kartlegge apotekkunders erfaring med og vilje til å ta influensavaksine, samt utvalgte faktorers sammenheng med ­vaksineringsvilje, inkludert sannsynlighet for å ta covid-19-vaksine. <p><i>Materiale og metode: </i>Masterstudenter i apotekpraksis intervjuet apotekkunder ved hjelp av spørreskjema. Spørsmålene omfattet erfaring med influensavaksine, risikogruppestatus, vaksineringsvilje, ...
  • Perspectives for systems biology in the management of tuberculosis 

    Kontsevaya, Irina; Lange, Christoph; Comella-Del-barrio, Patricia; Coarfa, Cristian; Dinardo, Andrew R.; Gillespie, Stephen H.; Hauptmann, Matthias; Leschczyk, Christoph; Mandalakas, Anna M.; Martinecz, Antal; Merker, Matthias; Niemann, Stefan; Reimann, Maja; Rzhepishevska, Olena; Schaible, Ulrich E.; Scheu, Katrin M.; Schurr, Erwin; Abel zur Wiesch, Pia; Heyckendorf, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-25)
    Standardised management of tuberculosis may soon be replaced by individualised, precision medicineguided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biological systems that can provide insights into mechanisms underlying tuberculosis, identify novel ...
  • Integrating the clinical pharmacist into the emergency department interdisciplinary team: A study protocol for a multicentre trial applying a non-randomised stepped-wedge study design 

    Vesela, Renata; Elenjord, Renate; Lehnbom, Elin; Ofstad, Eirik Hugaas; Johnsgård, Tine; Zahl-Holmstad, Birgitte; Risør, Torsten; Wisløff, Torbjørn; Røslie, Lars; Filseth, Ole Magnus; Valle, Per Christian; Svendsen, Kristian; Frøyshov, Hanne Mathilde; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
    Introduction: The ‘emergency department (ED) pharmacist’ is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations. In Norway, few EDs are equipped with ED pharmacists, and research describing effects on patients has not been conducted. The aim of this study is to investigate the impact ...
  • Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer 

    Fleten, Karianne Giller; Eksteen, Johannes J.; Mauseth, Brynjar; Camilio, Ketil André; Vasskog, Terje; Sveinbjørnsson, Baldur; Rekdal, Øystein; Mælandsmo, Gunhild Mari; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-24)
    Oncolytic peptides represent a novel, promising cancer treatment strategy with activity in a broad spectrum of cancer entities, including colorectal cancer (CRC). Cancer cells are killed by immunogenic cell death, causing long-lasting anticancer immune responses, a feature of particular interest in non-immunogenic CRC. Oncolytic peptides DTT-205 and DTT-304 were administered by intratumoral injection ...
  • Drug-Drug-Gene Interactions: A Call for Clinical Consideration 

    Bruckmüller, Henrike; Cascorbi, Ingolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)
    It is widely accepted that both comedications and genetic factors may contribute to variation of drug response. Clinical decision support systems increasingly consider recommendations on drug– drug interactions (DDIs) during electronic prescribing, and some guidelines on drug–gene-interactions (DGI) have been implemented in drug labels. Potentially synergistically or antagonistically ...

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