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  • Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors 

    Czarna, Anna Lucja; Jinhua, Wang; Zelencova, Diana; Liu, Yao; Deng, Xianming; Choi, Hwan Geun; Zhang, Tinghu; Zhou, Wenjun; Chang, Jae Won; Kildalsen, Hanne; Seternes, Ole Morten; Gray, Nathanael S.; Engh, Richard Alan; Rothweiler, Ulli (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-10)
    DYRK1A is one of five members of the dual-specificity tyrosine (Y) phosphorylation-regulated kinase (DYRK) family. The DYRK1A gene is located in the Down syndrome critical region and regulates cellular processes related to proliferation and differentiation of neuronal progenitor cells during early development. This has focused research on its role in neuronal degenerative diseases, including ...
  • The competitive edge of an invading specialist 

    Bøhn, Thomas; Amundsen, Per-Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2001-08-01)
    Introduced species represent major threats to native and natural biodiversity. On the other hand, biologists may increase the understanding of ecological interactions by following communities during establishment of exotic species. Accordingly, feeding ecology and habitat use were studied in native whitefish (<i>Coregonus lavaretus</i>) and recently invading vendace (<i>C. albula</i>) in two lake ...
  • Invasion-mediated changes in the population biology of a dimorphic whitefish Coregonus lavaretus population 

    Bøhn, Thomas; Amundsen, Per-Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2004-02-26)
    Population biology changes in native dimorphic whitefish <i>Coregonus lavaretus</i> were studied over a decade in the subarctic Pasvik watercourse, where large biotric changes occurred due to an invasion by vendace <i> C. albula</i>. Although initially recorded in the upstream part of the watercourse, where it is now the dominant pelagic species, the vendace subsequently also colonised the downstream ...
  • Mimicking regional and fasted/fed state conditions in the intestine with the mucus-PVPA in vitro model: The impact of pH and simulated intestinal fluids on drug permeability 

    Falavigna, Margherita; Klitgaard, Mette; Steene, Erik; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-27)
    Intestinal drug absorption following oral administration can be influenced by regional conditions (absorbing surface area, bacterial flora, motility, pH, mucus thickness) and food intake, all of which affect drug solubility and permeability. Therefore, it is crucial to assess the impact of these conditions on the drugability of drugs and formulations. In this study, the ability of the liposome-based ...
  • Assessing Potentially Inappropriate Medications in Nursing Home Residents by NORGEP-NH Criteria 

    Halvorsen, Kjell H.; Kucukcelik, Sinan; Garcia, Beate Hennie; Svendsen, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-05)
    <p><i>Background</i>: Nursing home residents often have several conditions that necessitate the use of multiple medicines. This study investigates the prevalence of potentially inappropriate medications (PIMs) and its associations with sex, age, number of medicines, and study location (rural/urban).</p> <p><i>Methods:</i> A cross-sectional study of long-term care residents from six nursing ...
  • Escherichia coli Sequence Type 410 Is Causing New International High-Risk Clones 

    Roer, Louise; Overballe-Petersen, Søren; Hansen, Frank; Schønning, Kristian; Wang, Mikala; Røder, Bent L; Hansen, , Dennis S; Justesen, Ulrik S; Andersen, Leif P; Fulgsang-Damgaard, David; Hopkins, Katie L; Woodford, Neil; Falgenhauer, Linda; Chakraborty, Trinad; Samuelsen, Ørjan; Sjöström, Karin; Johannesen, Thor B; Ng, Kim; Nielsen, Jens; Ethelberg, Steen; Stegger, Marc; Hammerum, Anette M.; Hasman, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-18)
    <i>Escherichia coli</i> sequence type 410 (ST410) has been reported worldwide as an extraintestinal pathogen associated with resistance to fluoroquinolones, third-generation cephalosporins, and carbapenems. In the present study, we investigated national epidemiology of ST410 <i>E. coli</i> isolates from Danish patients. Furthermore, <i>E. coli</i> ST410 was investigated in a global context to provide ...
  • Complete Genome Sequence of Pseudomonas aeruginosa K34-7, a Carbapenem-Resistant Isolate of the High-Risk Sequence Type 233 

    Taiaroa, George; Samuelsen, Ørjan; Kristensen, Tom; Økstad, Ole Andreas; Heikal, Adam (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-02)
    Carbapenem-resistant Pseudomonas aeruginosa is defined as a “critical” priority pathogen for the development of new antibiotics. Here we report the complete genome sequence of an extensively drug-resistant, Verona integron-encoded metallo-β-lactamase-expressing isolate belonging to the high-risk sequence type 233.
  • Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress 

    Hegge, Beate; Sjøttem, Eva; Mikkola, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-02)
    <i><p>Background</i>: The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highest-grade astrocytic glioma. The aim of the present study was to develop a PAX6 knock out cell line as a tool for molecular studies of the roles PAX6 have in attenuating ...
  • Glyphosate-Residues in Roundup-Ready Soybean Impair Daphnia magna Life-Cycle 

    Cuhra, Marek; Traavik, Terje; Dando, Mickael; Primicerio, Raul; Holderbaum, Daniel Ferreira; Bøhn, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-30)
    Herbicide tolerant plants such as Roundup-Ready soybean contain residues of glyphosate herbicide. These residues are considered safe and previous animal-feeding-studies have failed to find negative effects related to such chemical residues. The present study tests 8 experimental soy- meal diets as feed in groups (each containing 20 individuals) of test-animals (D. magna). The diets have different ...
  • Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer 

    Kiselev, Yury; Andersen, Sigve; Johannessen, Charles; Fjukstad, Bjørn; Olsen, Karina Standahl; Stenvold, Helge; Al-Saad, Samer; Dønnem, Tom; Richardsen, Elin; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
    Lung cancer is the leading cause of cancer deaths. Novel predictive biomarkers are needed to improve treatment selection and more accurate prognostication. PAX6 is a transcription factor with a proposed tumour suppressor function. Immunohistochemical staining was performed on tissue microarrays from 335 non-small cell lung cancer (NSCLC) patients for PAX6. Multivariate analyses of clinico-pathological ...
  • Fractional integral-like processing in retinal cones reduces noise and improves adaptation 

    Martinecz, Antal; Niitsuma, Mihoko (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-04)
    In the human retina, rod and cone cells detect incoming light with a molecule called rhodopsin. After rhodopsin molecules are activated (by photon impact), these molecules activate the rest of the signalling process for a brief period of time until they are deactivated by a multistage process. First, active rhodopsin is phosphorylated multiple times. Following this, they are further inhibited by the ...
  • Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge 

    Ternullo, Selenia; Basnet, Purusotam; Holsæter, Ann Mari; Flaten, Gøril Eide; de Weerd, Louis; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-07)
    The topical administration of exogenous human epidermal growth factor (hEGF) is a promising approach for improved chronic wound therapy. To develop therapeutically superior hEGF formulation, we prepared hEGF-containing neutral (NDLs), cationic (CDLs) and anionic (ADLs) deformable liposomes (DLs), respectively, since it is expected that the liposomal surface charge can affect both the liposomal ...
  • First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor 

    Fjellaksel, Richard; Oteiza, Ana; Martin, armas maria montserrat; Riss, Patrick; Hjelstuen, Ole Kristian; Kuttner, Samuel; Hansen, Jørn H; Sundset, Rune (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-09)
    <p><i>Objectives</i>: In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.</p> <p><i>Results</i>: We have used a simple, robust and high-yielding procedure to radiolabel an alpha-halogenated bioactive compound with high radiochemical yield. Literature ...
  • Estimating treatment prolongation for persistent infections 

    Martinecz, Antal; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-09)
    Treatment of infectious diseases is often long and requires patients to take drugs even after they have seemingly recovered. This is because of a phenomenon called persistence, which allows small fractions of the bacterial population to survive treatment despite being genetically susceptible. The surviving subpopulation is often below detection limit and therefore is empirically inaccessible but can ...
  • Mucus-PVPA (mucus Phospholipid Vesicle-based Permeation Assay): An artificial permeability tool for drug screening and formulation development 

    Falavigna, Margherita; Klitgaard, Mette; Brase, Christina; Ternullo, Selenia; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-26)
    The mucus layer covering all mucosal surfaces in our body is the first barrier encountered by drugs before their potential absorption through epithelial tissues, and could thus affect the drugs’ permeability and their effectiveness. Therefore, it is of key importance to have in vitro permeability models that can mimic this specific environment. For this purpose, the novel mucus phospholipid vesicle-based ...
  • Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model 

    Zykov, Ilya Nikolaevich; Samuelsen, Ørjan; Jakobsen, Lotte; Småbrekke, Lars; Andersson, Dan I.; Sundsfjord, Arnfinn; Frimodt-Møller, Niels (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-25)
    Fosfomycin has become an attractive treatment alternative for urinary tract infections (UTIs) due to increasing multidrug resistance (MDR) in <i>Escherichia coli</i>. In this study, we evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) indices of fosfomycin and its <i>in vivo</i> activity in an experimental murine model of ascending UTI. Subcutaneous administration of fosfomycin showed that ...
  • Physical stability of an all-in-one parenteral nutrition admixture for preterm infants upon mixing with micronutrients and drugs 

    Staven, Vigdis; Wang, Siri; Grønlie, Ingrid; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-07)
    <p><I>Objectives</I>: The main objective was to investigate Y-site compatibility of intravenous drugs with one standard total parenteral nutrition (TPN) admixture for preterm infants. Since micro-precipitation was observed in the water phase after addition of trace elements, the concentration effect on micro-precipitation formation developed as a sub-goal.</p> <p><I>Methods</I>: Seven drugs ...
  • Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice 

    Grip, Jostein; Engstad, Rolf Einar; Skjæveland, Ingrid; Skalko-Basnet, Natasa; Isaksson, Johan; Basnet, Purusotam; Holsæter, Ann Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-01)
    The increased prevalence of chronic wounds requires novel treatment options. The aim of this study was to develop a beta-glucan (βG)-loaded nanofiber wound dressing. Nanofibers were prepared using the needle-free Nanospider™ technology, an electrospinning method which enables the production of nanofibers at an industrial scale. The βG was selected as active ingredient based on its confirmed wound ...
  • Drug permeability profiling using cell-free permeation tools: Overview and applications 

    Berben, Philippe; Bauer-Brandl, Annette; Brandl, Martin; Faller, Bernard; Flaten, Gøril Eide; Jacobsen, Ann-Cathrine; Brouwers, Joachim; Augustijns, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-13)
    Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are ...
  • Dual-specificity MAP kinase phosphatases in health and disease 

    Seternes, Ole Morten; Kidger, Andrew M; Keyse, Stephen M (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-08)
    It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions ...

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