Now showing items 1-20 of 305

    • 3T3 cell lines stably expressing Pax6 or Pax6(5a): a new tool used for identification of common and isoform specific target genes. 

      Kiselev, Yury; Eriksen, Tonje Engevik; Forsdahl, Siri; Nguyen, Lan Huong Thi; Mikkola, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Pax6 and Pax6(5a) are two isoforms of the evolutionary conserved Pax6 gene often co-expressed in specific stochiometric relationship in the brain and the eye during development. The Pax6(5a) protein differs from Pax6 by having a 14 amino acid insert in the paired domain, causing the two proteins to have different DNA binding specificities. Difference in functions during development is proven by the ...
    • Academic detailing as a method of continuing medical education 

      Dyrkorn, Roar; Langaas, Harald Chr.; Giverhaug, Trude; Espnes, Ketil Arne; Rowett, Debra; Spigset, Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      <i>Introduction</i>: Academic detailing is an interactive educational outreach to prescribers to present unbiased, non-commercial, evidence-based information, mostly about medications, with the goal of improving patient care. Academic detailing in Norway is an approach for providing continuing medical education to general practitioners (GPs). The basis of academic detailing is a one-to-one discussion ...
    • An Acylation-Finkelstein Approach to Radioiodination of Bioactives: The Role of Amide Group Anchimeric Assistance 

      Fjellaksel, Richard; Dugalic, Damir; Demissie, Taye Beyene; Riss, Patrick; Hjelstuen, Ole Kristian; Sundset, Rune; Hansen, Jørn H (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-28)
      Herein, we report a straightforward sequential acylation‐Finkelstein approach to achieve iodination of amine containing bioactives. The utility was demonstrated by successful radiolabelling with <sup>123</sup>I in high radiochemical yield. Moreover, microwave‐assisted Finkelstein reaction can be employed to enhance conversion and reaction rates to obtain the desired iodides. The method is of interest ...
    • Adherence to prescription guidelines and achievement of treatment goals among persons with coronary heart disease in Tromsø 7 

      Pedersen, Elisabeth; Garcia, Beate Hennie; Halvorsen, Kjell H.; Eggen, Anne Elise; Schirmer, Henrik; Waaseth, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-21)
      Background - Adherence to clinical practice guidelines for coronary heart disease (CHD) reduces morbidity, mortality and treatment costs. We aimed to describe and compare adherence to prescription guidelines for persons with CHD, and explore its association with treatment goal achievement.<p> <p>Method - We included all participants reporting myocardial infarction, angina, percutaneous coronary ...
    • Aerobic treatment of selective serotonin reuptake inhibitors in landfill leachate 

      Bergersen, Ove; Østnes Hanssen, Kine; Vasskog, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-28)
      Background: Pharmaceuticals used in human medical care are not completely eliminated in the human body and can enter the municipal sewage sludge system and leachate water from landfill both as the parent compound and as their biologically active metabolites. The selective serotonin reuptake inhibitors (SSRIs) have a large potential for unwanted effects on nontarget organisms in the environment. ...
    • All non-adherence is equal, but is some more equal than others? TB in the digital era 

      Stagg, Helen; Flook, Mary; Martinecz, Antal; Kielmann, Karina; Abel zur Wiesch, Pia; Karat, Aaron; Lipman, Marc; Sloan, Derek; Walker, Elizabeth; Fielding, Katherine L (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-02)
      Adherence to treatment for tuberculosis (TB) has been a concern for many decades, resulting in the World Health Organization's recommendation of the direct observation of treatment in the 1990s. Recent advances in digital adherence technologies (DATs) have renewed discussion on how to best address nonadherence, as well as offering important information on dose-by-dose adherence patterns and their ...
    • Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates 

      Paulsen, Marianne Hagensen; Engqvist, Magnus; Ausbacher, Dominik; Anderssen, Trude; Langer, Manuel K-; Haug, Tor; Morello, Glenn Robert; Liikanen, Laura; Blencke, Hans-Matti; Isaksson, Johan; Juskewitz, Eric; Bayer, Annette; Strøm, Morten B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-27)
      We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides. These N,N′-dialkylated-5,5-disubstituted barbiturates consist of an achiral barbiturate scaffold with two cationic groups and two lipophilic side chains. Minimum inhibitory concentrations of 2–8 μg/mL were achieved ...
    • Amphipathic β2,2-Amino Acid Derivatives Suppress Infectivity and Disrupt the Intracellular Replication Cycle of Chlamydia Pneumoniae 

      Hanski, Leena; Ausbacher, Dominik; Tiirola, Terttu; Strøm, Morten B.; Vuorela, Pia M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-09)
      We demonstrate in the current work that small cationic antimicrobial β2,2-amino acid derivatives (Mw < 500 Da) are highly potent against Chlamydia pneumoniae at clinical relevant concentrations (< 5 μM, i.e. < 3.4 μg/mL). C. pneumoniae is an atypical respiratory pathogen associated with frequent treatment failures and persistent infections. This gram-negative bacterium has a biphasic life cycle ...
    • Analysis of Bottlenecks in Experimental Models of Infection 

      Abel, Sören; Schulz Zur Wiesch, Pia; Davis, Brigid M.; Waldor, Matthew K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-11)
    • Anti-angiogenic therapy affects the relationship between tumor vascular structure and function: a correlation study between micro-CT angiography and DCE-MRI 

      Kim, Eugene; Cebulla, Jana; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)
      Purpose: To compare the effects of two anti-angiogenic drugs, bevacizumab and a cytosolic phospholipase A2-α inhibitor (AVX235), on the relationship between vascular structure and dynamic contrast enhanced (DCE)-MRI measurements in a patient-derived breast cancer xenograft model. Methods: Mice bearing MAS98.12 tumors were randomized into three groups: bevacizumab-treated (n=9), AVX235-treated ...
    • Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model 

      Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø; Engebråten, Olav; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-07)
      <b>Background</b> <br> Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, making it unresponsive to current targeted therapies. Here, we evaluated the anti-angiogenic effects of a specific cPLA2α inhibitor, AVX235, in a patient-derived ...
    • Antibacterial use by birth year and birth season in children 0-2 years in Norway 

      Beckstrøm, Sanna; Svendsen, Kristian; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)
      Introduction: Consumption of antibacterials in children follows seasonal cycles, and time to first treatment depends on birth season. The aim of this study was to describe dispensing rate, one-year periodic prevalence, and age at first prescription in children aged 0-2 years in Norway. Methods: We used data from the Norwegian prescription database and included all dispensed prescriptions on systemic ...
    • Antibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works better 

      Colzi, Ilaria; Troyan, Anna N.; Perito, Brunella; Casalone, Enrico; Romoli, Riccardo; Pieraccini, Giuseppe; Skalko-Basnet, Natasa; Adessi, Alessandra; Rossi, Federico; Gonnelli, Cristina; Ristori, Sandra (Journal article; Tidsskriftartikkel; Preprint; Peer reviewed; Manuskript, 2015-06-25)
      To date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nanocarriers, such as liposomes, is considered a viable option, though with some drawbacks related to limited affinity between conventional liposomes ...
    • Antibiotikaresistens - kunnskapshull, utfordringer og aktuelle tiltak. Rapport fra tverrsektoriell ekspertgruppe 

      Steinbakk, Martin; Sunde, Marianne; Urdal, Anne Margrete; Barkbu, Kjersti Nilsen; Sørum, Henning; Lunestad, Bjørn Tore; Bonhorst, Janne Øvrebø; Nielsen, Kaare Magne; Lindbæk, Morten; Bjørnholt, Jørgen (Research report; Forskningsrapport, 2014)
    • Antimicrobial resistance acquisition via natural transformation: context is everything 

      Winter, Macaulay; Buckling, Angus; Harms, Klaus; Johnsen, Pål Jarle; Vos, Michiel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-26)
      Natural transformation is a process where bacterial cells actively take up free DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. Although this mechanism is known to mediate the uptake of antibiotic resistance determinants in a range of human pathogens, its importance in the spread of antimicrobial resistance is not always appreciated. ...
    • Are ready for Market Genetically Modified, Conventional and Organic Soybeans Substantially Equivalent as Food and Feed? 

      Bøhn, Thomas; Cuhra, Marek; Traavik, Terje; Fagan, John (Chapter; Bokkapittel, 2015)
      Important compositional elements, including residues of herbicides, were investigated in commercial soy varieties grown within the same geographical area. These included genetically modified, conventional and organic soybeans. Feed made from these soybeans was subsequently fed to the model organism Daphnia magna, while measuring the fitness performance (survival, growth and reproduction) during the ...
    • Aspects of statin prescribing in Norwegian counties with high, average and low statin consumption : an individual-level prescription database study 

      Sakshaug, Solveig; Hartz, Ingeborg; Furu, Kari; Skurtveit, Svetlana; Engeland, Anders; Eggen, Anne Elise; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-12-05)
      Background: A previous study has shown that variations in threshold and intensity (lipid goal attainment) of statins for primary prevention contribute to regional differences in overall consumption of statins in Norway. Our objective was to explore how differences in prevalences of use, dosing characteristics, choice of statin and continuity of therapy in individual patients adds new information ...
    • Assessing Potentially Inappropriate Medications in Nursing Home Residents by NORGEP-NH Criteria 

      Halvorsen, Kjell H.; Kucukcelik, Sinan; Garcia, Beate Hennie; Svendsen, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-05)
      <p><i>Background</i>: Nursing home residents often have several conditions that necessitate the use of multiple medicines. This study investigates the prevalence of potentially inappropriate medications (PIMs) and its associations with sex, age, number of medicines, and study location (rural/urban).</p> <p><i>Methods:</i> A cross-sectional study of long-term care residents from six nursing ...
    • Assessing the probability of detection of horizontal gene transfer events in bacterial populations 

      Townsend, Jeffrey P.; Bøhn, Thomas; Nielsen, Kaare Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Experimental approaches to identify horizontal gene transfer (HGT) events of non-mobile DNA in bacteria have typically relied on detection of the initial transformants or their immediate offspring. However, rare HGT events occurring in large and structured populations are unlikely to be detected in a short time frame. Population genetic modeling of the growth dynamics of bacterial genotypes is ...
    • An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital 

      Høgli, June Utnes; Garcia, Beate Hennie; Skjold, frode; Skogen, Vegard; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-27)
      Background:<br> Appropriate antibiotic prescribing is associated with favourable levels of antimicrobial resistance (AMR) and clinical outcomes. Most intervention studies on antibiotic prescribing originate from settings with high level of AMR. In a Norwegian hospital setting with low level of AMR, the literature on interventions for promoting guideline-recommended antibiotic prescribing in ...