Viser treff 139-158 av 358

    • Helse- og miljørisikovurdering av genmodifisert bomullslinje MON 15985 fra Monsanto (EFSA/GMO/UK/2008/57): Uttalelse fra Faggruppe for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet 

      Berdal, Knut G; Bøhn, Thomas; Clarke, Jihong; Finne, Merethe Aasmo; Holck, Askild Lorentz; Klungland, Helge; Linnestad, Casper; Meadow, Richard; Mikalsen, Arne; Myhr, Anne Ingeborg; Nerland, Audun Helge; Nes, Ingolf; Nielsen, Kaare Magne; Sorteberg, Hilde-Gunn Opsahl; Stabbetorp, Odd Egil; Vikse, Rose (Research report; Forskningsrapport, 2008-11-28)
      <i>Hovedbudskap</i>: Mattilsynet og Direktoratet for naturforvalting (DN) ber Vitenskapskomiteen for mattrygghet om å vurdere den genmodifiserte bomullslinjen MON 15985 til import, prosessering, og til bruk i næringsmidler og fôrvarer. Søknaden gjelder ikke dyrking. Monsanto søkte opprinnelig om godkjenning av bomullslinjen i 2005, men søknaden ble trukket og erstattet av vedlagte søknad i 2008. I ...
    • Helse- og miljørisikovurdering av genmodifisert mais MON 863 til import, prosessering og fôr under EU-direktiv 2001/18 (Notifikasjon C/DE/02/9). Uttalelse fra Faggruppe for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet 

      Andreassen, Åshild Kristine; Brandtzæg, Per; Holck, Askild Lorentz; Junttila, Olavi; Konestabo, Heidi Sjursen; Meadow, Richard; Nielsen, Kaare Magne; Sorteberg, Hilde-Gunn Opsahl; Vikse, Rose (Research report; Forskningsrapport, 2013)
      <p>I forbindelse med forberedelse til implementering av EU-forordning 1829/2003 i norsk rett har Miljødirektoratet (tidligere Direktoratet for Naturforvalting) bedt Mattilsynet om vurderinger av alle genmodifiserte organismer (GMOer) og avledete produkter som inneholder eller består av GMOer som er godkjent under forordning 1829/2003 eller direktiv 2001/18, og som er godkjent for ett eller flere ...
    • High-Intensity Exercise Improves Fatigue, Sleep, and Mood in Patients With Axial Spondyloarthritis: Secondary Analysis of a Randomized Controlled Trial 

      Sveaas, Silje Halvorsen; Dagfinrud, Hanne; Berg, Inger Jorid; Provan, Sella Aarrestad; Johansen, Melissa Woll; Pedersen, Elisabeth; Bilberg, Annelie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-04)
      <i>Objective</i> - Although exercise is recommended in the treatment of axial spondyloarthritis (axSpa), the focus has been on flexibility, and the effect of high-intensity exercises is unknown. The purpose of this study was to investigate the effect of high-intensity exercises on fatigue, sleep, and mood in patients with axSpA.<br><br> <i>Methods</i> - In this secondary analysis of a randomized ...
    • A high-throughput multiplexing and selection strategy to complete bacterial genomes 

      Alonso, Sergio Arredondo; Pöntinen, Anna K.; Cleon, Francois Pierre Alexandre; Gladstone, Rebecca Ashley; Schürch, Anita C.; Johnsen, Pål Jarle; Samuelsen, Ørjan; Corander, Jukka (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-09)
      Background: Bacterial whole-genome sequencing based on short-read technologies often results in a draft assembly formed by contiguous sequences. The introduction of long-read sequencing technologies permits those contiguous sequences to be unambiguously bridged into complete genomes. However, the elevated costs associated with long-read sequencing frequently limit the number of bacterial isolates ...
    • Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates 

      Alves Gama, Joao Pedro; Kloos, Julia Maria; Johnsen, Pål Jarle; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
      Dissemination of bacterial clones carrying plasmid-mediated resistance genes is a major factor contributing to the increasing prevalence of antibiotic resistance. Understanding the evolution of successful clones and the association to mobile resistance elements are therefore crucial. In this study, we determined the sequence of a 145 kb IncC multi-drug resistance plasmid (pK71-77-1-NDM), harbouring ...
    • How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study 

      Holsæter, Ann Mari; Wizgird, Kristina; Karlsen, Iselin; Hemmingsen, Jeanette Frimand; Brandl, Martin; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-21)
      Limitations of the anticancer drug product Taxotere® have encouraged researchers to entrap the active ingredient docetaxel (DTX) into nanocarriers such as liposomes. However, until now no DTX-liposome formulation has reached the clinic. Hence, in the present study, different Soy-PC based DTX-liposome formulations were screened in an attempt to identify lipid-compositions with promising DTX-entrapment ...
    • Humoral and cellular immune responses in mice after airway administration of Bacillus thuringiensis Cry1Ab and MON810 cry1Ab-transgenic maize 

      Andreassen, Monica; Rocca, Elena; Bøhn, Thomas; Wikmark, Odd Gunnar; van den Berg, Johnnie; Løvik, Martinus; Traavik, Terje; Nygaard, Unni Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Genetically modified (GM) crops may bring new proteins with immunogenic and allergenic properties into the food and feed chains. The most commonly grown GM maize, MON810, expresses a modified version of the insecticidal Cry1Ab protein originating in the soil bacterium Bacillus thuringiensis(Bt). Immune reactions following inhalation of pollen and debris from such plants have been scarcely studied. ...
    • The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery 

      Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-16)
      Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as drugs absorbed in the olfactory epithelium bypass the blood-brain barrier and reach the brain within minutes. However, the nasal mucosa properties (e.g., tonicity, pH) are not constant ...
    • Identical Miniature Inverted Repeat Transposable Elements Flank Class 1 Integrons in Clinical Isolates of Acinetobacter spp. 

      Domingues, Sara; Toleman, Mark A.; Nielsen, Kåre M.; da Silva, Gabriela J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Miniature inverted repeat transposable elements (MITEs) have been identified flanking class 1 integrons. We have identified and characterized a 439-bp MITE-like structure in seven Acinetobacter species isolates from Portugal and Brazil. The complete sequence similarity of the elements and flanking regions suggests that MITEs may act as mobilizable vectors for the dissemination of integrons.
    • Identifying the drivers of multidrug-resistant Klebsiella pneumoniae at a European level 

      Kachalov, Viacheslav N.; Nguyen, Huyen; Balakrishna, Suraj; Salazar-Vizcaya, Luisa; Sommerstein, Rami; Kuster, Stefan P.; Hauser, Anthony; Abel-Zur Wiesch Genannt Hülsho, Pia Karoline; Klein, E; Kouyos, Roger D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-29)
      Beta-lactam- and in particular carbapenem-resistant Enterobacteriaceae represent a major public health threat. Despite strong variation of resistance across geographical settings, there is limited understanding of the underlying drivers. To assess these drivers, we developed a transmission model of cephalosporin- and carbapenem-resistant <i>Klebsiella pneumoniae</i>. The model is parameterized using ...
    • ‘Illuminating determinants of implementation of non-dispensing pharmacist services in home care: a qualitative interview study’ 

      Bø, Karl-Erik; Halvorsen, Kjell H.; Risør, Torsten; Lehnbom, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-13)
      Objectives - Medication errors are leading causes of hospitalization and death in western countries and WHO encourages health care providers to implement non-dispensing pharmacist services in primary care to improve medication work. However, these services struggle to provide any impact on clinical outcomes. We wanted to explore health care professionals’ views on medication work to illuminate ...
    • Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tablets 

      Larsen, Bjarke Strøm; Kissi, Eric Ofosu; Parreiras Nogueira, Liebert; Genina, Natalja; Tho, Ingunn (Journal article; Tidsskriftartikkel, 2023-11-02)
      <p>This study investigates the influence of drug load and polymer molecular weight on the structure of tablets three-dimensionally (3D) printed from the binary mixture of prednisolone and hydroxypropyl methylcellulose (HPMC). Three different HPMC grades, (AFFINISOLTM HPMC HME 15LV, 90 Da (HPMC 15LV); 100LV, 180 Da (HPMC 100LV); 4M, 500 Da (HPMC 4M)), which are suitable for hot-melt extrusion (HME), ...
    • Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting 

      Knudsen, Per Kristian; Brandtzæg, Petter; Høiby, Ernst Arne; Bohlin, Jon; Samuelsen, Ørjan; Steinbakk, Martin; Abrahamsen, Tore G; Müller, Fredrik; Gammelsrud, Karianne Wiger (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-07)
      We prospectively studied the consequences of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in a cohort of children with cystic fibrosis (CF) and a cohort of children with cancer compared to healthy children with no or low antibiotic exposure. The study was conducted in Norway in a low resistance prevalence setting. Sixty longitudinally collected faecal ...
    • Impact of mucin on drug diffusion: Development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin 

      Falavigna, Margherita; Stein, Paul C.; Flaten, Gøril Eide; Di Cagno, Massimiliano Pio (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-17)
      Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates all mucosal tissues can compromise drugs from reaching the epithelial site, thus affecting their absorption and therapeutic effect. Therefore, the effect of the mucus layer on drug ...
    • Impact of multiple stressors on sea bed fauna in a warming Arctic 

      Jørgensen, Lis Lindal; Primicerio, Raul; Ingvaldsen, Randi Brunvær; Fossheim, Maria; Strelkova, Natalia; Thangstad, Trude Hauge; Manushin, Igor; Zakharov, Denis (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-03)
      The Arctic Barents Sea is experiencing a record temperature increase, a poleward shift in the distributions of commercial fish stocks, and invasion by the snow crab, a new predator. To evaluate benthic community vulnerability when exposed to seawater warming, bottom trawling, and predation from a new predator, we used a trait-based approach and applied this to an extensive dataset of >450 megabenthic ...
    • Implementation of a shared medication list in primary care - a controlled pre-post study of medication discrepancies 

      Jøsendal, Anette Vik; Bergmo, Trine Strand; Granås, Anne Gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)
      Background: Access to medicines information is important when treating patients, yet discrepancies in medication records are common. Many countries are developing shared medication lists across health care providers. These systems can improve information sharing, but little is known about how they afect the need for medication reconciliation. The aim of this study was to investigate whether an ...
    • Implications of GM crops in subsistence-based agricultural systems in Africa 

      Aheto, Denis; Bøhn, Thomas; Breckling, Broder; van den Berg, Johnnie; Ching, Lim Li; Wikmark, Odd Gunnar (Chapter; Bokkapittel, 2013)
      <p>Africa has deep contentions on the use of GM crops in agriculture, similar to those found in Europe and elsewhere. However, it is apparent that the debate is most protracted on the continent with two entrenched viewpoints i.e. the pro-GMO and anti-GMO groups. The challenge for an acceptable consensus is attributable to a complexity of issues relative to the introduction of GM maize into small-scale ...
    • Improved Permeability of Acyclovir: Optimization of Mucoadhesive Liposomes Using the Phospholipid Vesicle-Based Permeation Assay 

      Naderkhani, Elenaz; Erber, Astrid; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-01-06)
    • In plastico: laboratory material newness affects growth and reproduction of Daphnia magna reared in 50-ml polypropylene tubes 

      Cuhra, Marek; Bøhn, Thomas; Cuhra, Petr (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-20)
      Plastic laboratory materials are found to affect vital parameters of the waterflea Daphnia magna. The main responsible factor is defined as “newness” of the materials. Juvenile D. magna were raised individually in; a) new laboratory-standard 50 ml polypropylene tubes, and; b) identical tubes which had been washed and aerated for several weeks. Newness had significant effects on growth and fecundity ...
    • In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate 

      Tryland, Morten; Okeke, Malachy Ifeanyi; Nilssen, Øivind; Moens, Ugo; Traavik, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-05-12)
      Background: Poxvirus-vectored vaccines against infectious diseases and cancer are currently under development. We hypothesized that the extensive use of poxvirus-vectored vaccine in future might result in co-infection and recombination between the vaccine virus and naturally occurring poxviruses, resulting in hybrid viruses with unpredictable characteristics. Previously, we confirmed that ...