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Dacarbazine and the Agonistic TRAIL Receptor-2 Antibody Lexatumumab Induce Synergistic Anticancer Effects in Melanoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Mapatumumab and lexatumumab (targeting death receptor 4 (DR4) and 5 (DR5), respectively) are agonistic TRAIL receptor antibodies that induce apoptosis in a wide range of cancer cells. The potency of mapatumumab and lexatumumab was assessed in mono therapy protocols, and the ability to sensitize for dacarbazine (DTIC) treatment was explored in ten different melanoma cell lines. Our data indicated ... -
Deciphering the landscape of host barriers to Listeria monocytogenes infection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-30)<i>Listeria monocytogenes</i> is a common food-borne pathogen that can disseminate from the intestine and infect multiple organs. Here, we used sequence tag-based analysis of microbial populations (STAMP) to investigate <i>L. monocytogenes</i> population dynamics during infection. We created a genetically barcoded library of murinized <i>L. monocytogenes</i> and then used deep sequencing to track ... -
Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-07)The topical administration of exogenous human epidermal growth factor (hEGF) is a promising approach for improved chronic wound therapy. To develop therapeutically superior hEGF formulation, we prepared hEGF-containing neutral (NDLs), cationic (CDLs) and anionic (ADLs) deformable liposomes (DLs), respectively, since it is expected that the liposomal surface charge can affect both the liposomal ... -
Dermal Application of Chloramphenicol - The Effect of Liposomes and Chitosan Hydrogel Formulations on ex vivo Permeation and Antimicrobial Activity
(Conference object; Konferansebidrag, 2017)Liposomes solubilize lipophilic drugs in the phospholipid membrane, and entrap hydrophilic drugs in its aqueous core. These vesicles provide a sustained- and targeted- drug release, and protect from degradation. Liposomes retain the drug onto/in the skin and improve skin drug deposition. Due to their liquid nature, a secondary vehicle, such as a hydrogel, is needed to obtain a necessary retention ... -
Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-14) -
Detecting rare gene transfer events in bacterial populations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-03)This study evaluated the performance of the MBT STAR-Carba kit (Bruker Daltonics), to detect carbapenemase producing Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. in comparison with the RAPIDEC® CARBA NP test (BioMerieux). MBT STAR-Carba allowed the detection of carbapenemases in Enterobacteriaceae and P. aeruginosa. -
Detection of DHCMT long-term metabolite glucuronides with LC-MSMS as an alternative approach to conventional GC-MSMS analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-17)Dehydrochloromethyltestosterone (DHCMT) is one of the most detected illicit used anabolic–androgenic steroids in professional sports. Therefore, a fast and accurate analysis of this substance is of great importance for a constructive fight against doping abuse. The conventional method for the analysis of this drug, GC-MSMS, is very sensitive and selective but also very time- and resource-consuming. ... -
Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-17)Background: The regional lymph node involvement is a major prognostic factor in patients with non-small cell lung cancer (NSCLC) undergoing surgical resection. Disease relapse is common, suggesting that early disseminated disease is already present in the regional lymph nodes at the time of surgery, and that the current nodal staging classification might be suboptimal. Early detection of disseminated ... -
Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-22)Background: There is no standardized procedure or consensus to which tests should be performed to judge compatibility/ incompatibility of intravenous drugs. The purpose of this study was to establish and evaluate a test program of methods suitable for detection of physical incompatibility in Y-site administration of total parenteral nutrition (TPN) and drugs. Methods: Eight frequently used methods ... -
Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-24)Objectives: The objective of the present study was to utilize dual asymmetric centrifugation (DAC) as a novel processing approach for the production of liposomes-in-hydrogel formulations. <br>Materials and Methods: Lipid films of phosphatidylcholine, with and without chloramphenicol (CAM), were hydrated and homogenized by DAC to produce liposomes in the form of vesicular phospholipid gels with a ... -
Development and validation of a simple online-SPE method coupled to high-resolution mass spectrometry for the analysis of stanozolol-N-glucuronides in urine samples
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-17)Stanozolol is still the most commonly used illicit anabolic‐androgenic steroid (AAS) in professional sports. Therefore, accurate and fast analysis and long detection windows are of great interest in the field of antidoping analysis. In this work, a very simple, fast, and highly sensitive online solid‐phase extraction method coupled with liquid chromatography–high‐resolution tandem mass spectrometry ... -
Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Development of a novel beta-glucan supplemented hydrogel spray formulation and wound healing efficacy in a db/db diabetic mouse model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-30)To relieve the severe economic and social burdens and patient suffering caused by the increasing incidence of chronic wounds, more effective treatments are urgently needed. In this study, we focused on developing a novel sprayable wound dressing with the active ingredient β-1,3/1,6-glucan (βG). Since βG is already available as the active ingredient in a commercial wound healing product provided as ... -
Differential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer xenograft
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Direct and indirect risk associated with the use of dietary supplements among persons with dementia in a Norwegian memory clinic
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-12)Background: The use of dietary supplements (DS) is common among persons with dementia. Direct risks associated with DS use include adverse events and DS-drug interactions. A direct risk is a risk caused by the treatment itself. Indirect risks are related to the treatment setting, such as the conditions of use, and not to the treatment itself. Because dementia symptoms may reduce a person’s ability ... -
Direct small RNA signatures in extracellular vesicles from breast cancer cell lines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-31)Breast cancer is a heterogeneous disease, and different subtypes of breast cancer show distinct cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. Understanding the molecular features responsible for this heterogeneity is important for correct diagnosis and better treatment strategies. Extracellular vesicles (EVs) and their associated molecules ... -
Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients Involving Six Different Hospitals in Denmark.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-23)The diversity of OXA-48-like carbapenemases are continually expanding. In this study, we describe the dissemination and characteristics of a novel class D carbapenemase (CHDL) named OXA-436. In total, six OXA-436-producing Enterobacteriaceae isolates including Enterobacter asburiae (n=3), Citrobacter freundii (n=2) and Klebsiella pneumoniae (n=1) were identified in four patients in the period between ... -
Docetaxel Liposomes - A formulation Screening Study
(Conference object; Konferansebidrag, 2019)<p>Docetaxel (DOC) is a potent anticancer drug with several limitations, including poor solubility and the reported serious side effects, attributed to either the drug itself or the solvent used. Thus, it is interesting to entrap the drug into liposomes in order to solubilize the drug and improve the therapeutic outcome. <p>The fist aim of this study was to establish a small-scale screening method ...