Docetaxel Liposomes - A formulation Screening Study

Abstract

<p>Docetaxel (DOC) is a potent anticancer drug with several limitations, including poor solubility and the reported serious side effects, attributed to either the drug itself or the solvent used. Thus, it is interesting to entrap the drug into liposomes in order to solubilize the drug and improve the therapeutic outcome. <p>The fist aim of this study was to establish a small-scale screening method for preparing and characterizing DOC-liposomes. Secondly, the established methods were applied to investigate the effect of lipid composition on the liposomal drug entrapment.