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Antimicrobial resistance acquisition via natural transformation: context is everything

Permanent lenke
https://hdl.handle.net/10037/23011
DOI
https://doi.org/10.1016/j.mib.2021.09.009
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article.pdf (650.6Kb)
Publisert versjon (PDF)
Dato
2021-10-26
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Winter, Macaulay; Buckling, Angus; Harms, Klaus; Johnsen, Pål Jarle; Vos, Michiel
Sammendrag
Natural transformation is a process where bacterial cells actively take up free DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. Although this mechanism is known to mediate the uptake of antibiotic resistance determinants in a range of human pathogens, its importance in the spread of antimicrobial resistance is not always appreciated. This review highlights the context in which transformation takes place: in diverse microbiomes, in interaction with other forms of horizontal gene transfer and in increasingly polluted environments. This examination of the abiotic and biotic drivers of transformation reveals that it could be more important in the dissemination of resistance genes than is often recognised.
Forlag
Elsevier
Sitering
Winter, Buckling, Harms, Johnsen, Vos. Antimicrobial resistance acquisition via natural transformation: context is everything. Current Opinion in Microbiology. 2021;64:133-138
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  • Artikler, rapporter og annet (farmasi) [394]
Copyright 2021 The Author(s)

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