Nye registreringer

  • Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18 

    Cook, Sarah; Malyutina, S; Kudryavtsev, Alexander; Averina, Maria; Bobrova, Natalia; Boytsov, S; Brage, S; Clark, TG; Diez Benavente, S; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Hughes, A; Johansen, Heidi; Kholmatova, Kamila; Kichigina, A; Kontsevaya, Anna; Kornev, M; Leong, D; Magnus, Per; Mathiesen, Ellisiv B.; McKee, M; Morgan, K; Nilssen, Odd-Ragnar; Plakhov, I; Quint, JK; Rapala, A; Ryabikov, A; Saburova, Lyudmila; Schirmer, Henrik; Shapkina, M; Shiekh, Suhail; Shkolnikov, VM; Stylidis, Michael; Voevoda, Mikhail; Westgate, Kate; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-04)
    Russia has one of the highest rates of cardiovascular disease in the world. The International Project on Cardiovascular Disease in Russia (IPCDR) was set up to understand the reasons for this. A substantial component of this study was the Know Your Heart Study devoted to characterising the nature and causes of cardiovascular disease in Russia by conducting large cross-sectional surveys in two Russian ...
  • Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: a case report 

    Jebsen, Nina Louise; Apelseth, Torunn Oveland; Haugland, Hans Kristian; Rekdal, Øystein; Patel, Hamina; Gjertsen, Bjørn Tore; Jøssang, Dag Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-10)
    <p><i>Background - </i>Desmoid tumors are intermediary malignant, fibrous lesions occurring in various soft tissues. Surgical treatment is relentlessly challenging because of the propensity for local aggressive behavior and high risk of recurrence. Consequently, a wide range of oncological drugs and radiation therapy are being used; however, outcomes are unpredictable. We investigated whether local ...
  • Loss of life years due to unavailable helicopter emergency medical service: a single base study from a rural area of Norway 

    Zakariassen, Erik; Østerås, Øyvind; Nystøyl, Dag Ståle; Breidablik, Hans Johan; Solheim, Eivind; Brattebø, Guttorm; Ellensen, Vegard Skalstad; Hoff, Jana Midelfart; Hordnes, Knut; Aksnes, Arne; Heltne, Jon-Kenneth; Hunskaar, Steinar; Hotvedt, Ragnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-29)
    <i>Background</i>: Despite the potential benefits of physician-staffed Helicopter Emergency Medical Service (HEMS), many dispatches to primary HEMS missions in Norway are cancelled before patient encounter. Information is sparse regarding the health consequences when medically indicated HEMS missions are cancelled and the patients are treated by a GP and ambulance staff only. We aimed to estimate ...
  • Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 

    Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
    <p><i>Introduction - </i>Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currently undergoing clinical trials in several human malignancies, including triple-negative breast cancer ...
  • Postprandial changes in gene expression of cholesterol influx and efflux mediators after intake of SFA compared to n-6 PUFA in subjects with and without familial hypercholesterolemia: secondary outcomes of a randomized controlled trial 

    Øyri, Linn Kristin Lie; Narverud, Ingunn; Bogsrud, Martin Prøven; Hansson, Patrik; Leder, Lena; Byfuglien, Marte Gjeitung; Veierød, Marit Bragelien; Thoresen, Magne; Ulven, Stine Marie; Holven, Kirsten Bjørklund (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-13)
    The long-term cholesterol-lowering effect of replacing intake of SFA with PUFA is well established, but has not been fully explained mechanistically. We examined the postprandial response of meals with different fat quality on expression of lipid genes in peripheral blood mononuclear cells (PBMC) in subjects with and without familial hypercholesterolaemia (FH). Thirteen subjects with FH (who had ...
  • Early maladaptive schemas as predictors of maternal bonding to the unborn child 

    Nordahl, Dag; Høifødt, Ragnhild Sørensen; Bohne, Agnes; Landsem, Inger Pauline; Wang, Catharina Elisabeth Arfwedson; Thimm, Jens (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-11)
    <p><i>Background - </i>The quality of an expectant mother’s bonding to the fetus has been shown to be associated with important developmental outcomes. Previous studies suggest that bonding quality is predicted by, for example, social support, psychological well-being, and depression. However, little is known regarding the role of maternal cognition in maternal-fetal bonding. Early maladaptive schemas ...
  • The effect of white matter hyperintensities on regional brain volumes and white matter microstructure, a population-based study in HUNT 

    Vangberg, Torgil Riise; Eikenes, Live; Håberg, Asta K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-04)
    Even though age-related white matter hyperintensities (WMH) begin to emerge in middle age, their effect on brain micro- and macrostructure in this age group is not fully elucidated. We have examined how presence of WMH and load of WMH affect regional brain volumes and microstructure in a validated, representative general population sample of 873 individuals between 50 and 66 years. Presence of WMH ...
  • Identifying decisions in optometry: A validation study of the decision identification and classification taxonomy for use in medicine (DICTUM) in optometric consultations 

    Sundling, Vibeke; Stene, Hege Anita; Eide, Hilde; Ofstad, Eirik Hugaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-18)
    <i>Objective</i> - The aim of this study was to assess the validity and reliability of the Decision Identification and Classification Taxonomy for Use in Medicine (DICTUM) applied to optometry, to compare decisions in medical and optometric consultations, and to describe decisions in optometry. <p> <p><i>Methods</i> - The study had a cross-sectional design. Data was collected from January to ...
  • Effect of genetically low 25-hydroxyvitamin D on mortality risk: Mendelian randomization analysis in 3 large European cohorts 

    Aspelund, Thor; Grübler, Martin R.; Smith, Albert V.; Gudmundsson, Elias F.; Keppel, Martin; Cotch, Mary Frances; Harris, Tamara B.; Jorde, Rolf; Grimnes, Guri; Joakimsen, Ragnar Martin; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; März, Winfried; Kleber, Marcus E.; Tomaschitz, Andreas; Grove-Laugesen, Diana; Rejnmark, Lars; Swart, Karin M.A.; Brouwer, Ingeborg A.; Lips, Paul; van Schoor, Natasja M.; Sempos, Christopher T.; Durazo-Arvizu, Ramón A.; Škrabáková, Zuzana; Dowling, Kirsten G.; Cashman, Kevin D.; Kiely, Mairead; Pilz, Stefan; Gudnason, Vilmundur; Eiríksdóttir, Gudny (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-02)
    The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D ...
  • Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model 

    Camilio, Ketil Andre; Wang, Meng-Yu; Mauseth, Brynjar; Waagene, Stein; Kvalheim, Gunnar; Rekdal, Øystein; Sveinbjørnsson, Baldur; Mælandsmo, Gunhild M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
    <i>Background</i> - Immunochemotherapy, the combined use of immunotherapy and chemotherapy, has demonstrated great promise in several cancers. LTX-315 is an oncolytic peptide with potent immunomodulatory properties designed for the local treatment of solid tumors. By inducing rapid immunogenic cell death through the release of danger-associated molecular pattern molecules (DAMPs), LTX-315 is capable ...
  • Pain-relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice 

    Hansson, Per; Jensen, Troels Staehelin; Kvarstein, Gunnvald; Strömberg, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-01)
    <p><i>Context - </i>Clinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. <p><i>Objective - </i>To determine whether treatment and re‐treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. <p><i>Methods - </i>Three ...
  • A novel scale-space approach for multinormality testing and the k-sample problem in the high dimension low sample size scenario 

    Hindberg, Kristian; Hannig, Jan; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
    Two classical multivariate statistical problems, testing of multivariate normality and the <i>k</i>-sample problem, are explored by a novel analysis on several resolutions simultaneously. The presented methods do not invert any estimated covariance matrix. Thereby, the methods work in the High Dimension Low Sample Size situation, i.e. when <i>n</i> ≤ <i>p</i>. The output, a significance map, is ...
  • Kartlegging av prosedyrer for oppdekking av instrumentbord ved kirurgiske inngrep 

    Igesund, Unni; Rasmussen, Guri; Overvåg, Grete; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel, 2019)
  • Bipolar radiofrequency neurotomy for spinal pain - A promising technique but still some steps to go 

    Kvarstein, Gunnvald; Lundeland, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-02)
  • p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance 

    Flem-Karlsen, Karine; Tekle, Christina; Øyjord, Tove Ragnhild; Flørenes, Vivi Ann; Mælandsmo, Gunhild Mari; Fodstad, Øystein; Nunes-Xavier, Caroline Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-09)
    Immunoregulatory protein B7-H3 is involved in the oncogenic and metastatic potential of cancer cells, as well as in drug resistance. Resistance to conventional chemotherapy is an important aspect of melanoma treatment, and a better understanding of how B7-H3 enhances drug resistance may lead to the development of more effective therapies. We investigated the <i>in vitro</i> and <i>in vivo</i> ...
  • Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation 

    Berzaghi, Rodrigo; Akhtar, Muhammad Asad; Islam, Md Ashraful; Pedersen, Brede Dille; Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-17)
    The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ...
  • Exploring why and how encounters with the Norwegian health-care system can be considered culturally unsafe by North Sami-speaking patients and relatives: A qualitative study based on 11 interviews 

    Mehus, Grete; Bongo, Berit Andersdatter; Engnes, Janne Isaksen; Moffitt, Pertice (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
    <p><i>Background - </i>Citizens of Norway have free and equal access to healthcare. Nurses are expected to be culturally sensitive and have cultural knowledge in encounters with patients. Culturally safe care is considered both a process and an outcome, evaluated by whether the patients feel safe, empowered and cared for, or not. All patients request equal access to quality care in Norway, also Sami ...
  • Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study 

    Småbrekke, Silje; Schirmer, Henrik; Melsom, Toralf; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
    <p><i>Background - </i>Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive ...
  • Circulating tumor cell-derived pre-clinical models for personalized medicine 

    Tellez Gabriel, Marta; Cochonneau, Denis; Jubelin, Camille; Heymann, Marie-Françoise; Heymann, Dominique (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-24)
    The main cause of death from cancer is associated with the development of metastases, resulting from the inability of current therapies to cure patients at metastatic stages. Generating preclinical models to better characterize the evolution of the disease is thus of utmost importance, in order to implement effective new cancer biomarkers and therapies. Circulating Tumor Cells (CTCs) are good ...
  • Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche 

    Cuminetti, Vincent; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-18)
    Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differentiation of BM mesenchymal stromal cells, but they seem to be a heterogeneous population with distinct metabolisms, lipid compositions, secretory properties and ...

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