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  • Arterial cardiovascular diseases and risk of venous thromboembolism 

    Rinde, Ludvig Balteskard (Doctoral thesis; Doktorgradsavhandling, 2018-12-12)
    Despite differences in epidemiology, pathology, and treatment, growing evidence suggests a bidirectional relationship between venous thromboembolism (VTE), a collective term for pulmonary embolism (PE) and deep vein thrombosis (DVT), and arterial cardiovascular diseases (CVD, i.e., myocardial infarction [MI] and ischemic stroke). The aim of this thesis was to investigate the impact of atherosclerosis, ...
  • Family and community involvement in Indigenous social work. A comparative study 

    Nygård, Reidunn Håøy (Doctoral thesis; Doktorgradsavhandling, 2018-12-07)
    This thesis investigates the relevance of family and community involvement for culturally adequate social work in Indigenous communities. The study is qualitative and comparative. I compare social work within Indigenous communities in Norway and Montana with the aim of adding to the available knowledge regarding culturally adequate social work in these communities. The thesis consists of three ...
  • The hemodynamic aspects of pharmacological manipulation of cardiac contractility and vascular resistance in rewarming from hypothermia 

    Håheim, Brage (Doctoral thesis; Doktorgradsavhandling, 2018-12-07)
    <p><i>Paper I</i> <br>To describe hemodynamic response and phosphorylation of cardiac troponin I during rewarming from deep, stable hypothermia with use of the calcium sensitizer and PDE3 inhibitor levosimendan, compared to animals given placebo. <p> <p><i>Paper II</i> <br>To describe hemodynamic response to lowered systemic vascular resistance by nitroprusside administration during rewarming ...
  • Studies in pathways to care - duration of untreated psychosis and its determining factors in early psychosis 

    Kvig, Erling Inge (Doctoral thesis; Doktorgradsavhandling, 2018-11-23)
    Mange pasienter med en førstegangspsykose får behandling sent i forløpet og har en lang varighet av ubehandlet psykose (VUP). Forsinket behandling kan skyldes både indre (lidelse og pasient relaterte) og ytre (tjeneste og systemrelaterte) faktorer. Til tross for at nyere forskning har dokumentert at en stor del av forsinkelsen skjer mens pasienten mottar behandling i spesialisthelsetjenesten, så er ...
  • Sex differences in pain, fear of pain and placebo analgesia 

    Vambheim, Sara Magelssen (Doctoral thesis; Doktorgradsavhandling, 2018-11-13)
    The hypothesis that males are more responsive to placebo treatment than females was tested experimentally in this thesis. The hypothesis was confirmed and the results showed that the sex difference was related to a difference in males’ and females’ stress response after placebo treatment. Placebo responses on pain unpleasantness and the P2 component was found in males, but not in females. The ...
  • Self-regulating Physical and Mental Activities: Intensive Longitudinal Intervention Studies of Physical Fitness and Happiness 

    Thorsteinsen, Kjærsti (Doctoral thesis; Doktorgradsavhandling, 2018-11-29)
    Being active is a primary necessity in life, but it is also an essential part of what makes life worth living. This thesis explored goal pursuit activities people might not experience as pleasant in the moment, but where the self-chosen activities are still considered good and worthwhile. We hypothesized that online self-regulation interventions would be effective in increasing effortful physical ...
  • Biology of mesenchymal stromal cells: Chondrogenesis, paracrine signalling and cartilage repair 

    Islam, Md Ashraful (Doctoral thesis; Doktorgradsavhandling, 2018-10-12)
    The management of articular cartilage lesions is one of the weighty challenges for orthopaedic surgeons. The use of mesenchymal stem/stromal cells (MSCs) has demonstrated as an alternative cell source for cartilage repair due to their multilineage differentiation potential and hypoimmunogenic properties. Despite the advances in cartilage repair techniques, there is no consensus relating to the most ...
  • Coffee and cancer 

    Lukic, Marko (Doctoral thesis; Doktorgradsavhandling, 2018-10-12)
    <p>You cannot imagine powering through the day without your favorite beverage being on your desk all the time. Have you ever wondered what the consequences might be? </p> <p>It seems that even before you have opened your eyes, there’s already a kettle on the stove or the coffee machine is purring. On the way to work, you have another cup to go from the nearby coffee chop. Long meetings demand ...
  • Norwegian General Practitioners Contribution and Participation in Emergency Medicine 

    Hjortdahl, Magnus (Doctoral thesis; Doktorgradsavhandling, 2018-10-31)
    Summary: The utility of using general practitioners (GPs) in pre-hospital emergency medicine is currently under debate. The aim of this thesis is to examine Norwegian GPs’ contribution and participation in emergency medicine. As there is limited knowledge in this field, we started by conducting focus group interviews with the stakeholders. During the fall 2012 we interviewed emergency technicians ...
  • How to Be a Bad Bug: Virulence Determinants of Enterococcus faecium 

    Wagner, Theresa (Doctoral thesis; Doktorgradsavhandling, 2018-10-18)
    Enterococcus faecium is a ubiquitous bacterium that only recently emerged as a nosocomial pathogen. Infections mostly affect immunocompromised patients and multi-resistance of E. faecium often hampers treatment. This thesis focuses on determinants, which give pathogenic potential to E. faecium. In the first paper, two TirE proteins are described as novel virulence factors of E. faecium. The tirE ...
  • C-reactive protein and other circulating biomarkers in carotid atherosclerosis and cardiovascular disease. The Tromsø Study 1994-2013 

    Eltoft, Agnethe (Doctoral thesis; Doktorgradsavhandling, 2018-11-07)
    Hjerte- og karsykdom er ledende årsak til død og sykelighet på verdensbasis. I Norge er det årlig ca. 13 000 hjerteinfarkt og 12 000 hjerneslag. Til tross for at den forebyggende og akuttmedisinske behandlingen er betydelig forbedret i løpet av de siste 30 år, forventes en fortsatt økning i hjerte- og karsykdommer på verdensbasis. De tradisjonelle risikofaktorene (alder, kjønn, blodtrykk, kolesterol, ...
  • Supporting doctor-patient communication in oncology: Providing communication aids to cancer patients in an outpatient clinic 

    Amundsen, Anita (Doctoral thesis; Doktorgradsavhandling, 2018-10-10)
    Communication aids can assist patients in obtaining the necessary information about their disease and treatment options. In this study, we explored the effect of two such communication aids: A question prompt list (QPL) and a consultation audio record (CAR) for the patients to bring home. A QPL is a list of suggested questions patients might want to ask their doctor. The Australian QPL “So you ...
  • Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study 

    Kovalenko, Anton Alexandrovich (Doctoral thesis; Doktorgradsavhandling, 2018-11-12)
    <p>Birth defects constitute an important public health issue as they are the main causes of perinatal and infant mortality. To address incomplete data coverage in Russia, the studies described in this thesis all have a registry-based study design, and were based on the linkage of the Murmansk County Birth Registry (MCBR) and the Murmansk Regional Congenital Defects Registry (MRCDR) to investigate ...
  • Determinants of Staphylococcus aureus Colonization and Infection. “Exploring the Role of Cell Wall Anchored Proteins in Adhesion and Immune Evasion” 

    Ajayi, Clement (Doctoral thesis; Doktorgradsavhandling, 2018-11-09)
    Staphylococcus aureus is an efficient human colonizer and pathogen. S.aureus' ability to colonize and/or cause infections in humans is due to its expression of many virulence factors. These virulence factors aid the bacterium in adhering, invading and evading the host´s immune defences. This study focused on exploring the role of two cell wall anchored proteins: Serine-aspartate containing protein ...
  • Diagnostic tests for lung and heart diseases in primary care - from quality assurance to epidemiology 

    Dalbak, Lene Gjelseth (Doctoral thesis; Doktorgradsavhandling, 2018-11-02)
    The use of pulse oximetry and spirometry tests in general practice is increasing. Pulse oximetry is a non-invasive method for measuring oxygen saturation (SpO2). The pulse oximeter is a helpful tool in primary care because it is tolerable for the patient, easy to use and acceptable within the time constraints of a busy practice. Spirometry is used in both diagnosis and monitoring of respiratory ...
  • Attachment problems and mental health issues among long-term unemployed youth who had dropped out of high school 

    Ramsdal, Gro Hilde (Doctoral thesis; Doktorgradsavhandling, 2018-10-01)
    <i>Objectives</i>: We wanted to explore how unemployed youth, between 18 and 25 years of age, who had dropped out of school and were registered at the Norwegian Labour and Welfare Administration (NLWA), would describe and explain critical aspects of their school dropout processes (Study 1). Second, we wanted to investigate critically present knowledge on the role of parent-child attachment in school ...
  • Socio-technical Challenges of Large-Scale EPR Standardization in Healthcare. 

    Ulriksen, Gro-Hilde (Doctoral thesis; Doktorgradsavhandling, 2018-10-05)
    In this thesis I present empirical insight to socio-technical challenges of standardising large-scale healthcare information infrastructures (II). The main focus was how to balance the requirements between technological, organizational, and user related requirements in large-scale IIs, as well as the power balance between the actors, and the need for extensive user involvement in such standardization. ...
  • Triggering mechanisms in the molecular pathogenesis of FXTAS 

    Hoem, Gry (Doctoral thesis; Doktorgradsavhandling, 2018-10-31)
    This study focuses on the triggering mechanisms leading to development of the neurodegenerative disorder Fragile X-associated tremor/ataxia syndrome (FXTAS). FXTAS affects carriers of a “premutation” in the Fragile X Mental Retardation 1 (FMR1) gene on the X chromosome. A premutation in this context, means the presence of 55-200 CGG repeats in the 5’untranslated region of the gene. Unaffected ...
  • Cortical bone and fracture risk: The Tromsø Study 

    Kral, Rita (Doctoral thesis; Doktorgradsavhandling, 2018-03-20)
    Background: The aim of this thesis was to explore the association of the cortical architecture of the proximal femoral shaft with non-vertebral fractures. We tested the hypotheses that: (i) cortical parameters are associated with fracture risk independent of Fracture Risk Assessment Tool (FRAX) or Garvan estimates, (ii) women with fractures that are unidentified by FRAX but identified by cortical ...
  • Allosteric modulation of GABAergic and glutamatergic metabotropic receptors 

    Freyd, Thibaud (Doctoral thesis; Doktorgradsavhandling, 2018-09-10)
    G-protein coupled receptors (GPCRs) are targets for 1/3 of the drugs available on the market making research on this class of proteins a very hot topic in the field of drug discovery. γ-amino butyric acid (GABA) and glutamate are respectively the main inhibitory and the main excitatory neurotransmitters in the mammalian central nervous system (CNS). The GABAB receptor (GABAB-R) and the metabotropic ...

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