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Nye registreringer

  • Cortical bone and fracture risk: The Tromsø Study 

    Kral, Rita (Doctoral thesis; Doktorgradsavhandling, 2018-03-20)
    Background: The aim of this thesis was to explore the association of the cortical architecture of the proximal femoral shaft with non-vertebral fractures. We tested the hypotheses that: (i) cortical parameters are associated with fracture risk independent of Fracture Risk Assessment Tool (FRAX) or Garvan estimates, (ii) women with fractures that are unidentified by FRAX but identified by cortical ...
  • Allosteric modulation of GABAergic and glutamatergic metabotropic receptors 

    Freyd, Thibaud (Doctoral thesis; Doktorgradsavhandling, 2018-09-10)
    G-protein coupled receptors (GPCRs) are targets for 1/3 of the drugs available on the market making research on this class of proteins a very hot topic in the field of drug discovery. γ-amino butyric acid (GABA) and glutamate are respectively the main inhibitory and the main excitatory neurotransmitters in the mammalian central nervous system (CNS). The GABAB receptor (GABAB-R) and the metabotropic ...
  • Serum Platinum retention and long-term effects in Testicular cancer survivors 

    Hjelle, Line Veronika (Doctoral thesis; Doktorgradsavhandling, 2018-08-30)
    Today, the majority of testicular cancer patients are cured, and are expected to live 40 to 50 years after treatment. Some of these men experience late effects due to cisplatin treatment, of which second cancer and cardiovascular disease are among the most serious and potentially life threatening. Given the continuously increasing number of cancer survivors, in-depth investigations of treatment-induced ...
  • Venous thromboembolism: incidence, recurrence and mortality 

    Arshad, Nadia (Doctoral thesis; Doktorgradsavhandling, 2018-08-29)
    Deep vein thrombosis (DVT) and pulmonary embolism (PE), collectively referred to as venous thromboembolism (VTE), is associated with substantial morbidity and mortality. To plan and evaluate prevention and treatment strategies for VTE, understanding into the epidemiology and current magnitude of VTE is needed. The aims of this thesis were (i) to assess time-trends in the incidence of VTE in the ...
  • Prognosis in acute aortic dissection. Insights from the International Registry of Acute Aortic Dissection 

    Larsen, Magnus (Doctoral thesis; Doktorgradsavhandling, 2018-06-20)
    <p><i>Background/aims:</i> Acute aortic dissection (AAD) is a rare life-threatening disease that does not easily lend itself to randomized controlled trials. Data regarding the effect of treatment advances in the recent decades is limited. Determinants of follow-up mortality are poorly understood. To include many patients and evaluate contemporary management of AAD, the International Registry ...
  • Infection, inflammation, and risk of venous thromboembolism 

    Grimnes, Gro (Doctoral thesis; Doktorgradsavhandling, 2018-06-18)
    SUMMARY Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is the third most common cardiovascular disease after myocardial infarction and stroke. The incidence of VTE is increasing and VTE contributes to a substantial burden of morbidity and mortality. To be able to prevent VTE in vulnerable subjects, there is a need for more knowledge about the pathophysiology ...
  • The role of steroid hormone receptors in prostate cancer. A study of estrogen- and progesterone receptors in adenocarcinoma of the prostate 

    Grindstad, Thea Karoline Walstad (Doctoral thesis; Doktorgradsavhandling, 2018-06-15)
    Steroid hormones and their receptors are vital for numerous physiological processes in the human body, but also related to the development of several malignancies. One such receptor strongly associated with prostate cancer, is the androgen receptor. Other steroid hormone receptors are also implicated in prostate cancer, their role, however, remains to be defined. Using immunohistochemistry and tissue ...
  • The prevalence and prognostic significance of endocrinology-related biomarkers in non-small cell lung cancer 

    Skjefstad, Kaja Konstanse (Doctoral thesis; Doktorgradsavhandling, 2018-06-22)
    Lung cancer has become a global health issue, and accounts for over 1.6 million annual deaths worldwide. The need for an improved treatment strategy is pivotal to improve its poor prognosis. Non-small cell lung cancer (NSCLC) is the predominant histological subtype of lung cancer. Gender-related discrepancies in overall survival and prognosis have been observed among NSCLC patients. This fact has ...
  • Autism Spectrum Disorders: Complexities associated with sex-differences, screening and diagnosis 

    Øien, Roald Andreas (Doctoral thesis; Doktorgradsavhandling, 2018-06-28)
    The present doctoral thesis examines screening and sex differences in autism spectrum disorders (ASD), and how behavioral, developmental and temperamental features of males and females affect early identification of the disorder. The present doctoral thesis found marked sex differences across all three studies, and furthermore found evidence of difficulties at identifying all children with an ASD ...
  • Angiogenic biomarkers in prostate cancer - A study into the prognostic significance of angiogenesis related growth factor ligands and receptors and miR-205 in a cohort of Norwegian prostatectomy patients 

    Nordby, Yngve (Doctoral thesis; Doktorgradsavhandling, 2018-05-03)
    Background: Prostate cancer is a heterogeneous disease, ranging from indolent and slow growing, to aggressive and lethal. Due to insufficient prognostic tools, there is a significant overtreatment of patients with harmless disease. Differentiating which patients benefit from radical treatments remains a huge challenge, and there is an urgent need to find new and better prognostic tools that may aid ...
  • Methacrylates in polymer-resin based dental materials: Assessment of exposure and biological effects 

    Nilsen, Bo Wold (Doctoral thesis; Doktorgradsavhandling, 2018-05-04)
    Materials used in dentistry are largely polymer-resin based dental materials (PRMs). PRMs contain methacrylates and organic additives that may cause adverse effects in exposed patients and dental personnel. The purpose of this thesis was to study biological effects of one of the most commonly used methacrylate in PRMs, and to investigate how patients and dental health personnel may be exposed to ...
  • Antibiotic Therapy for Neonatal Sepsis - Studies on epidemiology, gentamicin safety, and early adverse effects of antibiotics 

    Fjalstad, Jon Widding (Doctoral thesis; Doktorgradsavhandling, 2018-05-25)
    Objectives: The overall aim of this thesis was to investigate different aspects of antibiotic therapy for neonatal sepsis. Material and Methods: The epidemiology of early onset sepsis (EOS) and systemic antibiotic exposure in the first week of life was studied in a nationwide population-based study from the Norwegian Neonatal Network between 2009-2011. A high-dose extended-interval gentamicin ...
  • Atrial Fibrillation: A prospective population study of risk factors and complications. The Tromsø Study 

    Tiwari, Sweta (Doctoral thesis; Doktorgradsavhandling, 2018-04-26)
    Background: Atrial Fibrillation (AF) is the most common arrhythmia associated with increased mortality and morbidity. It increases the lifetime risk of stroke and heart failure and affects one’s quality of life and cognition. Objective: To investigate diastolic dysfunction as risk factor for AF and AF as a risk factor for stroke and cognitive decline. Methods: Participants from the Tromsø Study ...
  • Upbringing by relatives. Incorporating new understandings and perspectives into the study of kinship foster care 

    Skoglund, Jeanette (Doctoral thesis; Doktorgradsavhandling, 2018-06-27)
    Oppvekst i slekt er en praksisform som har lange tradisjoner i den private sfære. Slektsfosterhjem derimot, som kategori og tiltak i barnervernet er et realtivt nytt fenomen. I forskning har oppvekst i og blant slektninger primært blitt utforsket blant antropologer. Med institusjonaliseringen og kategoriseringen av slektsfosterhjem har fenomenet blitt aktuelt også innenfor barnevernrelatert forskning. ...
  • Predicting rupture of intracranial aneurysms: morphological and hemodynamic parameters. 

    Skodvin, Torbjørn Øygard (Doctoral thesis; Doktorgradsavhandling, 2018-04-27)
    BACKGROUND: Because of extended use of cerebral imaging, unruptured intracranial aneurysms are increasingly discovered as incidental findings. Management of unruptured aneurysms is controversial because patients and clinicians must weigh the risks of prophylactic endovascular or surgical treatment against the uncertain risk of rupture. We aimed to investigate the use of hemodynamic and morphological ...
  • Red Cell Distribution Width (RDW) and future risk of arterial cardiovascular diseases 

    Lappegård, Jostein (Doctoral thesis; Doktorgradsavhandling, 2018-05-28)
    Myocardial infarction (MI) and stroke rank as the top two killers on the world health organization’s causes of death statistics. Awareness of risk factors is important for targeted prevention of disease, and identification of novel risk factors can further improve the preventive measures. Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, could ...
  • Red cell distribution width and risk of venous thromboembolism 

    Ellingsen, Trygve Sølberg (Doctoral thesis; Doktorgradsavhandling, 2018-06-11)
    Venous thromboembolism (VTE) is a collective term for deep vein thrombosis and pulmonary embolism. VTE is the third most common cardiovascular disease, causing significant morbidity and mortality. The incidence of VTE has been stable or slightly increasing during the last decades, affecting 1-2 per 1000 individuals each year. Up to half of all VTE patients have no obvious cause of the disease. Thus, ...
  • Perioperative quality assurance in neurosurgery 

    Sjåvik, Kristin (Doctoral thesis; Doktorgradsavhandling, 2018-06-08)
    Abstract Background Perioperative treatment for common neurosurgical conditions such as chronic subdural hematomas (CSDH) and meningiomas vary. The perioperative period is by definition the time span from 24 hours before surgery until 30 days postoperatively. Even if the surgical treatment in the operation theater can be exactly the same, complication rates differ, and results vary. The aim of ...
  • Oxidative stress and inflammation as risk factors for accelerated age-related GFR decline and albuminuria in the general population 

    Schei, Jørgen (Doctoral thesis; Doktorgradsavhandling, 2018-06-08)
    The prevalence of chronic kidney disease (CKD) increases rapidly with age, affecting more than one-third of people over 70 years old. The age-related glomerular filtration rate (GFR) decline is an important risk factor for CKD and kidney failure. Identifying novel risk factors for early kidney disease, manifested as accelerated GFR decline or low-grade albuminuria, may suggest underlying pathologic ...
  • Mapping the experience and use of traditional healing in Northern Norway. Among conventional health care providers, users and traditional healers 

    Larsen, Anette Iren Langås (Doctoral thesis; Doktorgradsavhandling, 2018-05-31)
    The aim of this research project was to improve the knowledge of the people in Northern Norway (the Sami, Kven, and Norwegians) understanding of health, including the use of traditional healing. We conducted 60 semi-structured interviews and 7 focus group interviews. The participants were health personnel, healers, and users of traditional healing. Both the Sami and Norwegians often used traditional ...

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