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  • Epidemiology of cervical cancer and high risk of HPV infection with a focus on Arkhangelsk City and County, Northwest Russia 

    Roik, Elena Evgenievna (Doctoral thesis; Doktorgradsavhandling, 2019-01-25)
    Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. It is also known as important risk factor for cervical cancer. Generally speaking, finding any cancer at an early stage is often believed to be the most important factor for longer survival. However, age at diagnosis, residence (i.e., accessibility to health care) and cell type of the tumor (less or ...
  • Cognitive function and mild cognitive impairment in a general population: roles of cardiovascular and genetic risk factors and magnetic resonance volumetry. The Tromsø Study 

    Rogne, Sigbjørn Olav (Doctoral thesis; Doktorgradsavhandling, 2018-12-14)
    Alzheimers sykdom er den vanligste årsaken til demens, dernest karsykdom som forårsaker vaskulær demens. De fleste som får Alzheimers demens etter 65 års alder (late onset Alzheimer’s Dementia, LOAD), har ikke sykdommen i familien fra tidligere. Men opptil 25 % av dem som får LOAD, har biologiske slektninger med LOAD. Personer i familier med opphopning av LOAD, har økt risiko for å få LOAD. Det er ...
  • Overweight/obesity, body composition and bone mass in late adolescence: the relation with birth weight, childhood body mass index and growth. The Tromsø Study: Fit Futures, a longitudinal cohort study 

    Evensen, Elin Kristin (Doctoral thesis; Doktorgradsavhandling, 2019-02-07)
    <i>Background and aim</i>: High prevalence of childhood overweight/obesity is a major health concern due to related immediate and long-term health problems. Early identification of children at risk is of interest, as preventing or delaying the onset of obesity may influence future health. The aim of this thesis was to study how early life factors such as birth weight, childhood body mass index (BMI, ...
  • Three essays on measuring health-related quality of life: external and internal relationships of the EQ-5D-5L 

    Gamst-Klaussen, Thor (Doctoral thesis; Doktorgradsavhandling, 2019-01-18)
    The use of quality-adjusted life years (QALYs) as a commensurable health outcome measure has been encouraged by health authorities in many countries in order to aid decisions on healthcare priorities. A key methodological challenge is to estimate the weights used for valuing health-related quality of life, i.e. the “Q” in QALY, based on people’s preferences. Such generic preference-based measures ...
  • Systems Epidemiology Approach in Endometrial Cancer. The NOWAC Study 

    Gavrilyuk, Oxana (Doctoral thesis; Doktorgradsavhandling, 2018-12-12)
    Endometrial cancer (EC) is one of the most common gynecologic cancers with extensively rising incidence worldwide. Norway is among the countries with the highest rates of EC. Although, most of the established risk factors for EC are well described, there are few studies from Norway investigating them in a cohort design. Moreover, modern clinical medicine, especially oncology, is moving towards ...
  • Hearing in rock musicians 

    Størmer, Carl Christian Lein (Doctoral thesis; Doktorgradsavhandling, 2018-12-14)
    Musicians are known to have an increased prevalence of hearing loss and tinnitus due to noise-induced cochlear damage. Rock music is popularly considered a major culprit in terms of excessive sound levels, but the literature on hearing in rock musicians is sparse. In this dissertation the hearing levels of a large number of rock musicians are assessed in relation to factors such as degree of exposure, ...
  • Arterial cardiovascular diseases and risk of venous thromboembolism 

    Rinde, Ludvig Balteskard (Doctoral thesis; Doktorgradsavhandling, 2018-12-12)
    Despite differences in epidemiology, pathology, and treatment, growing evidence suggests a bidirectional relationship between venous thromboembolism (VTE), a collective term for pulmonary embolism (PE) and deep vein thrombosis (DVT), and arterial cardiovascular diseases (CVD, i.e., myocardial infarction [MI] and ischemic stroke). The aim of this thesis was to investigate the impact of atherosclerosis, ...
  • Family and community involvement in Indigenous social work. A comparative study 

    Nygård, Reidunn Håøy (Doctoral thesis; Doktorgradsavhandling, 2018-12-07)
    This thesis investigates the relevance of family and community involvement for culturally adequate social work in Indigenous communities. The study is qualitative and comparative. I compare social work within Indigenous communities in Norway and Montana with the aim of adding to the available knowledge regarding culturally adequate social work in these communities. The thesis consists of three ...
  • The hemodynamic aspects of pharmacological manipulation of cardiac contractility and vascular resistance in rewarming from hypothermia 

    Håheim, Brage (Doctoral thesis; Doktorgradsavhandling, 2018-12-07)
    <p><i>Paper I</i> <br>To describe hemodynamic response and phosphorylation of cardiac troponin I during rewarming from deep, stable hypothermia with use of the calcium sensitizer and PDE3 inhibitor levosimendan, compared to animals given placebo. <p> <p><i>Paper II</i> <br>To describe hemodynamic response to lowered systemic vascular resistance by nitroprusside administration during rewarming ...
  • Studies in pathways to care - duration of untreated psychosis and its determining factors in early psychosis 

    Kvig, Erling Inge (Doctoral thesis; Doktorgradsavhandling, 2018-11-23)
    Mange pasienter med en førstegangspsykose får behandling sent i forløpet og har en lang varighet av ubehandlet psykose (VUP). Forsinket behandling kan skyldes både indre (lidelse og pasient relaterte) og ytre (tjeneste og systemrelaterte) faktorer. Til tross for at nyere forskning har dokumentert at en stor del av forsinkelsen skjer mens pasienten mottar behandling i spesialisthelsetjenesten, så er ...
  • Sex differences in pain, fear of pain and placebo analgesia 

    Vambheim, Sara Magelssen (Doctoral thesis; Doktorgradsavhandling, 2018-11-13)
    The hypothesis that males are more responsive to placebo treatment than females was tested experimentally in this thesis. The hypothesis was confirmed and the results showed that the sex difference was related to a difference in males’ and females’ stress response after placebo treatment. Placebo responses on pain unpleasantness and the P2 component was found in males, but not in females. The ...
  • Self-regulating Physical and Mental Activities: Intensive Longitudinal Intervention Studies of Physical Fitness and Happiness 

    Thorsteinsen, Kjærsti (Doctoral thesis; Doktorgradsavhandling, 2018-11-29)
    Being active is a primary necessity in life, but it is also an essential part of what makes life worth living. This thesis explored goal pursuit activities people might not experience as pleasant in the moment, but where the self-chosen activities are still considered good and worthwhile. We hypothesized that online self-regulation interventions would be effective in increasing effortful physical ...
  • Biology of mesenchymal stromal cells: Chondrogenesis, paracrine signalling and cartilage repair 

    Islam, Md Ashraful (Doctoral thesis; Doktorgradsavhandling, 2018-10-12)
    The management of articular cartilage lesions is one of the weighty challenges for orthopaedic surgeons. The use of mesenchymal stem/stromal cells (MSCs) has demonstrated as an alternative cell source for cartilage repair due to their multilineage differentiation potential and hypoimmunogenic properties. Despite the advances in cartilage repair techniques, there is no consensus relating to the most ...
  • Coffee and cancer 

    Lukic, Marko (Doctoral thesis; Doktorgradsavhandling, 2018-10-12)
    <p>You cannot imagine powering through the day without your favorite beverage being on your desk all the time. Have you ever wondered what the consequences might be? </p> <p>It seems that even before you have opened your eyes, there’s already a kettle on the stove or the coffee machine is purring. On the way to work, you have another cup to go from the nearby coffee chop. Long meetings demand ...
  • Norwegian General Practitioners Contribution and Participation in Emergency Medicine 

    Hjortdahl, Magnus (Doctoral thesis; Doktorgradsavhandling, 2018-10-31)
    Summary: The utility of using general practitioners (GPs) in pre-hospital emergency medicine is currently under debate. The aim of this thesis is to examine Norwegian GPs’ contribution and participation in emergency medicine. As there is limited knowledge in this field, we started by conducting focus group interviews with the stakeholders. During the fall 2012 we interviewed emergency technicians ...
  • How to Be a Bad Bug: Virulence Determinants of Enterococcus faecium 

    Wagner, Theresa (Doctoral thesis; Doktorgradsavhandling, 2018-10-18)
    Enterococcus faecium is a ubiquitous bacterium that only recently emerged as a nosocomial pathogen. Infections mostly affect immunocompromised patients and multi-resistance of E. faecium often hampers treatment. This thesis focuses on determinants, which give pathogenic potential to E. faecium. In the first paper, two TirE proteins are described as novel virulence factors of E. faecium. The tirE ...
  • C-reactive protein and other circulating biomarkers in carotid atherosclerosis and cardiovascular disease. The Tromsø Study 1994-2013 

    Eltoft, Agnethe (Doctoral thesis; Doktorgradsavhandling, 2018-11-07)
    Hjerte- og karsykdom er ledende årsak til død og sykelighet på verdensbasis. I Norge er det årlig ca. 13 000 hjerteinfarkt og 12 000 hjerneslag. Til tross for at den forebyggende og akuttmedisinske behandlingen er betydelig forbedret i løpet av de siste 30 år, forventes en fortsatt økning i hjerte- og karsykdommer på verdensbasis. De tradisjonelle risikofaktorene (alder, kjønn, blodtrykk, kolesterol, ...
  • Supporting doctor-patient communication in oncology: Providing communication aids to cancer patients in an outpatient clinic 

    Amundsen, Anita (Doctoral thesis; Doktorgradsavhandling, 2018-10-10)
    Communication aids can assist patients in obtaining the necessary information about their disease and treatment options. In this study, we explored the effect of two such communication aids: A question prompt list (QPL) and a consultation audio record (CAR) for the patients to bring home. A QPL is a list of suggested questions patients might want to ask their doctor. The Australian QPL “So you ...
  • Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study 

    Kovalenko, Anton Alexandrovich (Doctoral thesis; Doktorgradsavhandling, 2018-11-12)
    <p>Birth defects constitute an important public health issue as they are the main causes of perinatal and infant mortality. To address incomplete data coverage in Russia, the studies described in this thesis all have a registry-based study design, and were based on the linkage of the Murmansk County Birth Registry (MCBR) and the Murmansk Regional Congenital Defects Registry (MRCDR) to investigate ...
  • Determinants of Staphylococcus aureus Colonization and Infection. “Exploring the Role of Cell Wall Anchored Proteins in Adhesion and Immune Evasion” 

    Ajayi, Clement (Doctoral thesis; Doktorgradsavhandling, 2018-11-09)
    Staphylococcus aureus is an efficient human colonizer and pathogen. S.aureus' ability to colonize and/or cause infections in humans is due to its expression of many virulence factors. These virulence factors aid the bacterium in adhering, invading and evading the host´s immune defences. This study focused on exploring the role of two cell wall anchored proteins: Serine-aspartate containing protein ...

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