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  • Renal sympathetic denervation, potential effects on blood pressure and glucose metabolism in patients with severe treatment resistant hypertension. The Re-shape CV-risk study 

    Miroslawska, Atena (Doctoral thesis; Doktorgradsavhandling, 2021-06-23)
    <p>Background: Denervation of renal sympathetic nerves (RDN) is a mini-invasive endovascular procedure introduced as an antihypertensive treatment with a potentially beneficial effect on insulin resistance. In this open-label non-randomized study we investigated non-diabetic patients with true treatment-resistant hypertension defined as office systolic blood pressure (BP)>140 mmHg and (mean) daytime ...
  • Hippocampal plasticity: Development of connectivity and growth hormone modulation of place cells and behavior 

    Haugland, Kamilla Gjerland (Doctoral thesis; Doktorgradsavhandling, 2021-06-17)
    The hippocampus is remarkably plastic and has the ability to modify its processes throughput the lifetime. During development, the hippocampus is exceedingly plastic as new neurons and connections are taking form. Nevertheless, the neural circuits of the hippocampus keep modifying in the adult. The factors contributing to hippocampal plasticity are still elusive. In this thesis, I present three ...
  • Combined effects of cancer and prothrombotic genotypes on the risk of venous thromboembolism 

    Skille, Hanne (Doctoral thesis; Doktorgradsavhandling, 2021-06-18)
    Venous thromboembolism (VTE), a collective term for deep vein thrombosis and pulmonary embolism, is a severe and multifactorial disease. Heritability has been found to explain up to 60% of VTE events, however, the role of genetics on VTE in cancer is scarcely studied. VTE occurs frequently in cancer patients and is a common cause of morbidity and mortality in this patient group. The aim of the present ...
  • Immunological biomarkers in prostate cancer - A retrospective cohort study utilizing immunohistochemistry on tissue microarrays for evaluation of immune biomarker expression and experimental in vitro assays 

    Ness, Nora (Doctoral thesis; Doktorgradsavhandling, 2021-06-11)
    <p><i>Background:</i> Prostate cancer is a very common, but particularly heterogenic cancer form. Whilst some patients have a very aggressive course with a fatal outcome, the majority of patients have slow-growing disease with low risk of death or significant symptoms. Unfortunately, doctors do not possess sufficient prognostic tools, and there is a high risk of overtreatment with unnecessary ...
  • Horizontal transfer, selection and maintenance of antibiotic resistance determinants 

    Kloos, Julia Maria (Doctoral thesis; Doktorgradsavhandling, 2021-06-11)
    Scientific abstract Antibiotic resistance, especially in Gram-negative pathogens, represents a substantial clinical and financial burden to our society. The presented work investigated mechanisms and evolutionary dynamics that promote the emergence and maintenance of resistance in bacteria. In the first study, conserved collateral susceptibility changes were identified across resistant uropathogenic ...
  • Identifying and treating predictors of psychotic symptoms - How findings from Experience Sampling research can help to improve the treatment of psychosis and the prediction of relapse 

    Lüdtke, Thies (Doctoral thesis; Doktorgradsavhandling, 2021-06-10)
    The present thesis aims at using insights from ESM studies (i.e., frequent ecologically valid self-reports for approximately one week) to improve the treatment and the prediction psychotic symptoms. ESM indicates that warning signs, such as negative affect, worrying, sleep problems, or aberrant salience precede rapidly fluctuating psychotic symptoms throughout the day. Assuming underlying causal ...
  • Continuous physical activity recording - Consumer-based activity trackers in epidemiological studies 

    Henriksen, André (Doctoral thesis; Doktorgradsavhandling, 2021-06-04)
    Physical activity is an important modifiable lifestyle factor that can improve general health and reduce the risk of disease. Currently, collecting data on physical activity in epidemiological studies are generally limited to long-term but self-reported and inaccurate physical activity questionnaires and/or using short-term but objective and more accurate accelerometers. Consumer-based activity ...
  • Advancing Quantitative PET Imaging with Machine Learning 

    Kuttner, Samuel (Doctoral thesis; Doktorgradsavhandling, 2021-05-28)
    Medical imaging with positron emission tomography (PET) plays an important role in the detection, staging, and treatment response assessment in cancer, neurological and cardiovascular conditions, inflammation and infection. PET imaging is based on measuring the distribution of injected radioactive tracers, designed to follow specific biological pathways. One of the main advantages with PET is that ...
  • The influence of lifestyle on peak bone mass in Norwegian boys and girls between 15-19 years of age. The Tromsø study, Fit Futures 

    Nilsen, Ole Andreas (Doctoral thesis; Doktorgradsavhandling, 2021-05-28)
    <p>Background: Osteoporotic fractures constitute a major health- and economic burden worldwide and because of an aging population the burden is estimated to rise. The individual consequences of fractures are severe. Norway has one of the highest fracture incidences in the world. The etiology of fracture risk at old age is less optimal bone mass accumulation in childhood and adolescence, rapid ...
  • Prediction of unfavorable outcome in Juvenile Idiopathic Arthritis (JIA) and assessment of the long-term outcomes in JIA-associated uveitis – A prospective Nordic multicenter study of JIA from childhood to adulthood 

    Rypdal, Veronika Gjertsen (Doctoral thesis; Doktorgradsavhandling, 2021-05-21)
    Juvenile idiopathic arthritis (JIA) is a chronic childhood disease with joint inflammation as the main feature. The course and outcomes are heterogeneous with a large span in disease severity. There is increasing evidence that early aggressive treatment may modify the disease course in JIA. Precise determination of disease prognosis is therefore sought to guide early decisions on which children need ...
  • Development of a prognostic model for unfavorable outcome after lumbar microdiscectomy 

    Werner, David Andreas Thomas (Doctoral thesis; Doktorgradsavhandling, 2021-05-11)
    The aim of this thesis was to develop a prognostic model for unfavorable outcome 12 months after surgical treatment of a lumbar disc herniation (lumbar microdiscectomy). While the surgical procedure is rather uniform, with little technical variation, the reported outcomes are quite heterogenous. This might be due to different expectations by patients, or due to suboptimal surgical indication as ...
  • Studies on the Chain of Survival in Out-of-Hospital Cardiac Arrest 

    Lund-Kordahl, Inger (Doctoral thesis; Doktorgradsavhandling, 2021-05-20)
    <p><i>Background:</i> Sudden death due to out-of-hospital cardiac arrest (OHCA) remains a major health issue with estimated 250-300.000 cases in Europe/year. Survival after OHCA depends on a well-functioning Chain of Survival. The Chain of Survival concept of early access, early cardiopulmonary resuscitation (CPR), early defibrillation and good post-resuscitation care is the documented and recommended ...
  • Exploring the roles of TRIM27 and TRIM32 in autophagy 

    Garcia Garcia, Juncal (Doctoral thesis; Doktorgradsavhandling, 2021-05-21)
    <p>Tripartite motif family proteins (TRIMs) are a wide family of E3 ligases involved in the control of several cellular processes such as intracellular signaling, innate immunity, transcription, cell cycle regulation and carcinogenesis. In recent years, some members of this family have been found to have a role in autophagy. <p>The central theme of this thesis is the role of two TRIM proteins in ...
  • Causes and Consequences of Gender Roles 

    Olsson, Maria (Doctoral thesis; Doktorgradsavhandling, 2021-05-03)
    This dissertation addresses the pervasive issue of women’s underrepresentation in agentic work and the equally important (but underexamined) issue of men’s underrepresentation in communal unpaid work. First, I review research and identify what conditions need to be met in order for counterstereotypical role models to break down some of the barriers to women’s entry into agentic work (Chapter 2). One ...
  • The role of ovarian reserve markers in fertility and fertility treatment 

    Bhide, Priya (Doctoral thesis; Doktorgradsavhandling, 2021-05-14)
    Ovarian reserve is a key component influencing reproductive function and fertility. Serum anti-Mullerian hormone (AMH) and antral follicle count (AFC) are established quantitative markers of ovarian reserve. The overall aim of this thesis comprising four work packages was to study the role of AMH and AFC on different aspects of fertility and fertility treatment. Their specific objectives were: 1) To ...
  • The development journey of an artificial intestinal model predicting oral drug absorption: the mucus-PVPA model 

    Falavigna, Margherita (Doctoral thesis; Doktorgradsavhandling, 2021-04-23)
    Oral drug administration is the most convenient route to systemically deliver drugs because of its cost-effectiveness, ease of administration and high patient compliance. However, when a drug is orally administered it will be exposed to the different physiological processes and environments found along the gastrointestinal (GI) tract, which will determine its ability of being absorbed and reach the ...
  • We Ran a Hospital. The Norwegian Nurses efforts During the Korean War and the Impact of their Experiences on Norwegian Nursing and Theatre Nursing 

    Lockertsen, Jan-Thore (Doctoral thesis; Doktorgradsavhandling, 2021-04-23)
    <p>During the Korean War (1951-53), Norway operated and staffed a surgical field hospital at the front along the 38th parallel. The Norwegian Mobile Army Surgical Hospital – NORMASH – was a part of the United Nations peace-enforcing force to stop aggression from North-Korea towards South-Korea. <p>NORMASH was staffed only with civilian volunteers. Without any training as a military group or in war ...
  • Studies of sleep and seasonal variations in patients with chronic musculoskeletal pain 

    Abeler, Karin (Doctoral thesis; Doktorgradsavhandling, 2021-04-19)
    <p><i>Background/aims:</i> Chronic pain is a major health problem, and contributing factors include poor sleep and mental distress. In the subarctic city of Tromsø, clinical impression also suggests worse pain in winter. We aimed to examine whether sleep in patients with chronic musculoskeletal pain differs from pain-free controls, and how psychological processes are related to sleep in these groups. ...
  • Metacognition and decision-making in schizophrenia: Exploring how aberrant processing and representation of uncertainty may explain cognitive-behavioral biases 

    Kreis, Isabel Viola (Doctoral thesis; Doktorgradsavhandling, 2021-04-13)
    The cognitive profile associated with schizophrenia has long been a research subject of interest. A plethora of studies have not only revealed cognitive deficits but also cognitive biases, meaning qualitative deviations in the way information is processed and evaluated. Such biases are for example reflected in findings of diminished metacognitive accuracy, or premature and disadvantageous decision-making. ...
  • Biomarkers of major bleeding after incident venous thromboembolism 

    Johnsen, Håkon Sandbukt (Doctoral thesis; Doktorgradsavhandling, 2021-03-23)
    Major bleeding (MB) events are feared and potentially fatal complications of anticoagulant treatment in patients with venous thromboembolism (VTE). Even though several clinical risk factors are associated with MB risk, the predictive power of currently available risk assessment models remain limited for VTE. The aim of this thesis was to identify biomarkers of MB risk during the first year after an ...

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