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  • LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment 

    Sveinbjørnsson, Baldur; Camilio, Ketil Andre; Haug, Bengt Erik; Rekdal, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-08)
    The oncolytic peptide LTX-315, which has been <i>de novo</i> designed based on structure– activity relationship studies of host defense peptides, has the ability to kill human cancer cells and induce specific anticancer ...
  • A taxonomy update for the Family Polyomaviridae 

    Calvignac-Spencer, Sébastien; Feltkamp, Mariet CW; Daugherty, Matthew D; Moens, Ugo; Ramqvist, Torbjörn; Johne, Reimar; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-29)
    Many distinct polyomaviruses infecting a variety of vertebrate hosts have recently been discovered, and their complete genome sequence could often be determined. To accommodate this fast-growing diversity, the International ...
  • Antibiotics to outpatients in Norway—Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study. 

    Haugen, Pål; Simonsen, Gunnar Skov; Primicerio, Raul; Furberg, Anne-Sofie; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-29)
    High antibiotic consumption rates are associated to high prevalence of antimicrobial resistance. Geographical differences in dispensing rates of antibiotics are frequently analysed using statistical methods addressing the ...
  • Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo 

    Tümmler, Conny; Snapkov, Igor; Wickström, Malin; Moens, Ugo; Ljungblad, Linda; Elfman, Maria; Winberg, Jan-Olof; Kogner, Per; Johnsen, John Inge; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-27)
    Pro-inflammatory cells, cytokines, and chemokines are essential in promoting a tumor supporting microenvironment. Chemerin is a chemotactic protein and a natural ligand for the receptors CMKLR1, GPR1, and CCRL2. The ...
  • Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response 

    Jernström, Sandra Johanna; Hongisto, Vesa; Leivonen, Suvi-Katri; Due, Eldri Undlien; Tadele, Dagim Shiferaw; Edgren, Henrik; Kallioniemi, Olli; Perälä, Merja; Mælandsmo, Gunhild; Sahlberg, Kristine Kleivi (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-21)
    Background<br> Approximately 15%–20% of all diagnosed breast cancers are characterized by amplified and overexpressed HER2 (= ErbB2). These breast cancers are aggressive and have a poor prognosis. Although improvements ...
  • CRISPR/Cas9—Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development 

    Okoli, Arinze Stanley; Okeke, malachy ifeanyi; Tryland, Morten; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-22)
    : The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, ...
  • Comparison of Compressive Stress-Relaxation Behavior in Osteoarthritic (ICRS Graded) Human Articular Cartilage 

    Kumar, Rajesh; Pierce, David M.; Isaksen, Vidar; Davies, Catharina de Lange; Drogset, Jon O.; Lilledahl, Magnus B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-31)
    Osteoarthritis (OA) is a common joint disorder found mostly in elderly people. The role of mechanical behavior in the progression of OA is complex and remains unclear. The stress-relaxation behavior of human articular ...
  • A role of Sp1 binding motifs in basal and large T-Antigen-induced promoter activities of human polyomavirus HPyV9 and its variant UF-1 

    Moens, Ugo; Song, Xiaobo; Van Ghelue, Marijke; Lednicky, John A.; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-14)
    Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20-50% of the human population have antibodies against this virus. HPyV9 has not yet ...
  • Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: Guidance from the European Centre for Disease Prevention and Control 

    Magiorakos, A.P.; Burns, K.; Rodríguez Baño, J.; Borg, M.; Daikos, G.; Dumpis, U.; Lucet, J.C.; Moro, M.L.; Tacconelli, E.; Simonsen, G. Skov; Szilágyi, E.; Voss, A.; Weber, J.T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
    Background: Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They are associated with high patient morbidity, attributable mortality and ...
  • Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? 

    Sørbye, Sveinung; Pedersen, Mette Kristin; Ekeberg, Bente; Wiliams, Merete E. Johansen; Sauer, Torill; Chen, Ying (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-22)
    Background: The Norwegian Cervical Cancer Screening Program recommends screening every 3 years for women between 25 and 69 years of age. There is a large difference in the percentage of unsatisfactory samples between ...
  • Rho-associated kinase is a therapeutic target in neuroblastoma 

    Dyberg, Cecilia; Fransson, Susanne; Andonova, Teodora; Sveinbjørnsson, Baldur; Lannerholm-Palm, Jessika; Olsen, Thale Kristin; Forsberg, David; Herlenius, Eric; Martinsson, Tommy; Brodin, Bertha; Kogner, Per; Johnsen, John Inge; Wickström, Malin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-24)
    Neuroblastoma is a peripheral neural system tumor that originates from the neural crest and is the most common and deadly tumor of infancy. Here we show that neuroblastoma harbors frequent mutations of genes controlling ...
  • Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort. 

    Richardsen, Elin; Andersen, Sigve; Al-Saad, Samer; Rakaee, Mehrdad; Nordby, Yngve; Pedersen, Mona Irene; Ness, Nora; Grindstad, Thea K.W.; Movik, Ingeborg; Dønnem, Tom; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
    The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation, growth and progression, and is widely used in routine clinicopathological investigation. Prostate cancer is a complex ...
  • High number of kinome-mutations in non-small cell lung cancers associated with reduced immune response and poor relapse-free survival 

    Helland, Åslaug; Brustugun, Odd Terje; Nakken, Sigve; Halvorsen, Ann Rita; Dønnem, Tom; Bremnes, Roy M.; Busund, Lill-Tove; Sun, Jinchang; Lorenz, Susanne; Solberg, Steinar; Jørgensen, Lars Hilmar; Vodak, Daniel; Myklebost, Ola; Hovig, Eivind; Meza, Leonardo Zepeda (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-07)
    Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several ...
  • Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps? 

    Okeke, Malachy Ifeanyi; Okoli, Arinze Stanley; Diaz Canova, Diana Karina; Oludotun, Taiwo G.; Tryland, Morten; Bøhn, Thomas; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-29)
    Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and ...
  • Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study 

    Duell, Eric J.; Lujan-Barroso, Leila; Sala, Núria; Deitz McElyea, Samantha; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Weiderpass, Elisabete; Busund, Lill-Tove; Moi, Line; Muller, David; Aune, Dagfinn; Naccarati, Alessio; Panico, Salavatore; Tagliabue, Giovanna; Tumino, Rosario; Palli, Domenico; Kaaks, Rudolf; Katzke, Verena A.; Boeing, Heiner; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Trichopoulou, Antonia; Lagiou, Pagona; Kotanidou, Anastasia; Travis, Ruth C.; Wareham, Nick; Khaw, Kay-Tee; Quirõs, Jose Ramõn; Rodríguez-Barranco, Miguel; Dorronsoro, Miren; Chirlaque, María Dolores; Ardanaz, Eva; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Rebours, Vinciane; Brennan, Paul; Gunter, Marc; Scelo, Ghislaine; Cote, Greg; Sherman, Stuart; Korc, Murray (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
    Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into ...
  • Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model 

    Nestvold, Janne M.; Wang, Mengyu; Camilio, Ketil Andre; Zinöcker, Severin; Tjelle, Torunn Elisabeth; Lindberg, Alf; Haug, Bengt Erik; Kvalheim, Gunnar; Sveinbjørnsson, Baldur; Rekdal, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-17)
    LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat ...
  • Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses 

    Tusco, Radu; Jacomin, Anne-Claire; Jain, Ashish; Penman, Bridget S.; Larsen, Kenneth Bowitz; Johansen, Terje; Nezis, Ioannis P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-02)
    Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulation of innate ...
  • B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains 

    Dwivedi, Nishant; Hedberg, Annica; Zheng, Ying Yi; Neeli, Indira; Satoh, Minoru; Morel, Laurence; Rekvig, Ole Petter; Radic, Marko (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-30)
    Deimination, a posttranslational modification of arginine to citrulline carried out by peptidylarginine deiminases, may compromise tolerance of self-antigens. Patients with connective tissue autoimmunity, particularly ...
  • Ligand-guided homology modelling of the GABAb2 subunit of the GABAb receptor 

    Freyd, Thibaud; Warszycki, Dawid; Mordalski, Stefan; Bojarski, Andrzej J; Sylte, Ingebrigt; Gabrielsen, Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-21)
    γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, and disturbances in the GABAergic system have been implicated in numerous neurological and neuropsychiatric diseases. The ...
  • High miR-205 expression in normal epithelium is associated with biochemical failure - An argument for epithelial crosstalk in prostate cancer? 

    Nordby, Yngve; Richardsen, Elin; Ness, Nora; Dønnem, Tom; Patel, Hitendra R.H.; Busund, Lill-Tove; Bremnes, Roy M.; Andersen, Sigve (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-24)
    Due to insufficient prognostic tools, failure to predict aggressive prostate cancer (PC) has left patient selection for radical treatment an unsolved challenge. This has resulted in overtreatment with radical therapy. ...

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