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  • Progesterone receptors in prostate cancer: Progesterone receptor B is the isoform associated with disease progression 

    Grindstad, Thea K.W.; Richardsen, Elin; Andersen, Sigve; Skjefstad, Kaja Konstanse; Rakaee, Mehrdad; Dønnem, Tom; Ness, Nora; Nordby, Yngve; Bremnes, Roy M.; Al-Saad, Samer; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-27)
    The role of steroid hormones in carcinogenesis of the prostate is to some extent unraveled thorough the effect of androgen deprivation therapy on prostate cancer (PCa) progression. Other members of the steroid hormone family, such as progesterone, are also implicated in PCa, but progesterone’s role remains undefined. This study aimed to examine the distribution of progesterone receptor isoforms ...
  • SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro 

    Tümmler, Conny; Dumitriu, Gianina; Wickström, Malin; Coopman, Peter; Valkov, Andrey Yurjevich; Kogner, Per; Johnsen, John Inge; Moens, Ugo; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-10)
    Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine kinase (SYK) has previously been identified as a promising drug target in various inflammatory diseases and cancers but has so far not ...
  • Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart 

    Pedersen, Tina Myhre; Boardman, Neoma; Hafstad, Anne Dragøy; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
    Although murine models for studying the development of cardiac dysfunction in diabetes mellitus are well established, their reported cardiac phenotypes vary. These reported divergences may, in addition to the severity of different models, also be linked to the methods used for cardiac functional assessment. In the present study, we examined the functional changes using conventional transthoracic ...
  • Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts 

    Dongre, Mitesh; Singh, Bhupender; Aung, Kyaw Min; Larsson, Per; Miftakhova, Regina; Persson, Karina; Askarian, Fatemeh; Johannessen, Mona; Hofsten, Jonas von; Persson, Jenny L.; Erhardt, Marc; Tuck, Simon; Uhlin, Bernt Eric; Wai, Sun Nyunt (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-07)
    Using <i>Caenorhabditis elegans</i> as an infection host model for <i>Vibrio cholerae</i> predator interactions, we discovered a bacterial cytotoxin, MakA, whose function as a virulence factor relies on secretion via the flagellum channel in a proton motive force-dependent manner. The MakA protein is expressed from the polycistronic <i>makDCBA</i> (<i>m</i>otility-<i>a</i>ssociated <i>k</i>illing ...
  • Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling 

    Shen, Peng; Reineke, Lucas C.; Knutsen, Erik; Chen, Meng; Pichler, Martin; Ling, Hui; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
    The antidiabetic drug metformin has been associated with reduced colorectal cancer (CRC) risk and improved prognosis of CRC patients. However, the detailed mechanisms underlying such beneficial effects remain unknown. In this study, we aimed to evaluate metformin activity in CRC models and unveil the underlying molecular mechanisms. We showed that metformin inhibits CRC cell proliferation by arresting ...
  • Storage-induced platelet apoptosis is a potential risk factor for alloimmunization upon platelet transfusion 

    Saris, Anno; Peyron, Ivan; Van Der Meer, Pieter F.; Stuge, Tor Brynjar; Zwaginga, Jaap Jan; van Ham, S Marieke; ten Brinke, Anja (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-05)
    Platelet transfusion can elicit alloimmune responses leading to alloantibody formation against donor-specific polymorphic residues, ultimately resulting in platelet transfusion refractoriness. Universal leukoreduction significantly reduced the frequency of alloimmunization after platelet transfusion, thereby showing the importance of white blood cells (WBCs) in inducing this alloresponse. It is, ...
  • Systemic lupus erythematosus: Definitions, contexts, conflicts, enigmas 

    Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-01)
    Systemic lupus erythematosus (SLE) is an inadequately defined syndrome. Etiology and pathogenesis remain largely unknown. SLE is on the other hand a seminal syndrome that has challenged immunologists, biologists, genetics, and clinicians to solve its nature. The syndrome is characterized by multiple, etiologically unlinked manifestations. Unexpectedly, they seem to occur in different stochastically ...
  • Cardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation 

    Ludvigsen, Stian; Mancusi, Costantino; Kildal, Simon; de Simone, Giovanni; Gerdts, Eva; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)
    Aim of study was to examine experimentally the adult female hypertensive heart in order to determine the role of ovary function in the response of the heart to salt-dependent hypertension. Dahl salt-sensitive rats, age 12 weeks, with/without ovariectomy were fed a standard (0.3% NaCl) or high-salt diet (8%) for 16 weeks. Mean arterial blood pressure monitored noninvasively in conscious state ...
  • Opposite diastolic effects of omecamtiv mecarbil versus dobutamine and ivabradine co-treatment in pigs with acute ischemic heart failure 

    Rønning, Leif; Bakkehaug, Jens P.; Rødland, Lars; Kildal, Anders B.; Myrmel, Truls; How, Ole-Jakob (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-11)
    Acute ischemic cardiogenic shock is associated with poor prognosis, and the impact of inotropic support on diastolic function in this context is unclear. We assessed two suggested new inotropic strategies in a clinically relevant pig model of ischemic acute heart failure (AHF): treatment with the myosin activator omecamtiv mecarbil (OM) or dobutamine and ivabradine (D+I). Left ventricular (LV) ...
  • Large-scale secretome analyses unveil the superior immunosuppresive phenotype of umbilical cord stromal cells as compared to other adult mesenchymal stromal cells 

    Islam, Md Ashraful; Urbarova, Ilona; Bruun, Jack-Ansgar; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-20)
    Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little is known about the divergence of these signalling molecules in different MSC populations. The present study investigated ...
  • The effect of smear layer removal on E. faecalis leakage and bond strength of four resin-based root canal sealers 

    Andriukaitiene, Laura; Song, Xiaobo; Yang, Nannan; Lippo V. J., Lassila; K. Vallittu, Pekka; Kerosuo, Eero (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
    <p><i>Background</i>: The aim of the study was to assess bacterial sealability and bonding ability of methacrylate-based Resilon (RS, SybronEndo), Endo Rez (ER, Ultradent Products Inc), and epoxy-based AH Plus (AH, Dentsply/DeTrey), MTA Fill Apex (MTAF, Angelus Soluções Odontológicas) root canal sealers, and the effect of the smear layer removal on the sealability.</p> <p><i>Methods</i>: One ...
  • Gut Microbiome Associates With Lipid-Lowering Effect of Rosuvastatin in Vivo 

    Liu, Yinhui; Song, Xiaobo; Zhou, Huimin; Zhou, Xue; Xia, Yunlong; Dong, Xin; Zhong, Wei; Tang, Shaoying; Wang, Lili; Wen, Shu; Xiao, Jing; Tang, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
    Background: Statin has been widely used to treat hyperlipidemia because of its high potency in decreasing cholesterol levels. The present study aimed to examine the lipid-lowering effect of rosuvastatin and the composition, diversity and species abundance of gut microbiome in association with rosuvastatin efficacy. <br> <br> TRIAL REGISTRATION: ChiCTR-ORC-17013212 at the First Affiliated Hospital ...
  • Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood 

    Wagner, Theresa; James Peter, Jessin Janice; Paganelli, Fernanda; Willems, Rob J.L.; Askarian, Fatemeh; Pedersen, Torunn Annie; Top, Janetta; de Haas, Carla; van strijp, Jos A. G.; Johannessen, Mona; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-03)
    <i>Enterococcus faecium</i> has undergone a transition to a multidrug-resistant nosocomial pathogen. The population structure of <i>E. faecium</i> is characterized by a sharp distinction of clades, where the hospital-adapted lineage is primarily responsible for bacteremia. So far, factors that were identified in hospital-adapted strains and that promoted pathogenesis of nosocomial <i>E. faecium</i> ...
  • APC mosaicism in a young woman with desmoid type fibromatosis and familial adenomatous polyposis 

    Stormorken, Astrid T.; Berg, Thomas; Norum, Ole-Jacob Anderssen; Hølmebakk, Toto; Åberg, Kristin; Steigen, Sonja Eriksson; Grindedal, Eli Marie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-24)
    Familial adenomatous polyposis (FAP) is usually caused by germline mutations in the adenomatous polyposis coli (APC) gene. The classic form is characterized by hundreds to thousands of adenomas in the colorectum and early onset colorectal cancer (CRC) if left untreated. FAP is also associated with multiple extra-colonic manifestations such as gastroduodenal polyps, osteomas, epidermoid cysts, fibromas ...
  • Updates on old and weary haematopoiesis 

    Konieczny, Joanna; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-29)
    Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow create a specific niche or microenvironment where HSCs nest that allows them to retain their unique characteristics and respond rapidly to external stimuli. Ageing is accompanied ...
  • The enterococcus cassette chromosome, a genomic variation enabler in enterococci 

    Sivertsen, Audun; James Peter, Jessin Janice; Pedersen, Torunn Annie; Wagner, Theresa; Hegstad, Joachim; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-07)
    Enterococcus faecium has a highly variable genome prone to recombination and horizontal gene transfer. Here, we have identified a novel genetic island with an insertion locus and mobilization genes similar to those of staphylococcus cassette chromosome elements SCCmec. This novel element termed the enterococcus cassette chromosome (ECC) element was located in the 3′ region of rlmH and encoded large ...
  • The Genetic Structures of an Extensively Drug Resistant (XDR) Klebsiella pneumoniae and its Plasmids 

    Li, Ling; Yu, Tao; Ma, Yanan; Yang, Zhongjun; Wang, Wenjia; Song, Xiaobo; Shen, Yu; Guo, Tingting; Kong, Jian; Wang, Mingyu; Xu, Hai (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-04)
    Multi-, extensively-, and pan-drug resistant bacteria are a threat to our health today, because their wide resistance spectra make their infections difficult to cure. In this work, we isolated an extensively drug resistant (XDR) <i>Klebsiella pneumoniae</i> 2-1 strain from the stool sample of a patient diagnosed of colorectal cancer. <i>K. pneumoniae</i> 2-1 was found to be resistant to all the ...
  • Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data 

    Dietrichs, Erik Sveberg; Tveita, Torkjel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
    Moderate therapeutic hypothermia procedures are used in post-cardiac arrest care, while in surgical procedures, lower core temperatures are often utilized to provide cerebral protection. Involuntary reduction of core body temperature takes place in accidental hypothermia and ventricular arrhythmias are recognized as a principal cause for a high mortality rate in these patients. We assessed both ...
  • Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a 

    Dębska, Marzena; Małgorzata, Uhrynowska; Guz, Katarzyna; Kopeć, Izabella; Lachert, Elżbieta; Orzińska, Agnieszka; Kretowicz, Piotr; Antoniewicz-Papis, Jolanta; Dębski, Romuald; Łętowska, Magdalena; Husebekk, Anne; Brojer, Ewa (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-15)
    <p><i>Introduction</i>: Pregnant women negative for human platelet antigen 1a (HPA-1a) are at risk of alloimmunization with fetal HPA-1a antigen inherited from the father, and their offspring may develop fetal and neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to analyze the frequency of HPA-1a alloimmunization in pregnant Polish women, the feasibility of using maternal ...
  • Multiple faces of succinate beyond metabolism in blood 

    Grimolizzi, Franco; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-28)
    Succinate is an essential intermediate of the tricarboxylic acid cycle that exerts pleiotropic roles beyond metabolism in both physiological and pathological conditions. Recent evidence obtained in mouse models shows its essential role regulating blood cell function through various mechanisms that include pseudohypoxia responses by hypoxiainducible factor-1α activation, post-translational modifications ...

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