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Nye registreringer

  • Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs 

    Steigedal, Tonje S.; Toraskar, Jimita; Redvers, Richard P.; Valla, Marit; Magnussen, Synnøve; Bofin, Anna M.; Opdahl, Signe; Lundgren, Steinar; Eckhardt, Bedrich L.; Lamar, John M.; Doherty, Judy; Hynes, Richard O.; Anderson, Robin L.; Svineng, Gunbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-11)
    Most cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to treatment. Understanding the mechanisms of metastasis is important to improve prognostication, to stratify patients for treatment, and to identify new ...
  • Characterization and pro-inflammatory responses of spore and hyphae samples from various mold species 

    Øya, Elisabeth; Afanou, Komlavi Anani; Malla, Nabin; Uhlig, Silvio; Rolen, Elin; Skaar, Ida; Straumfors, Anne; Winberg, Jan-Olof; Bang, Berit; Schwarze, Per E; Eduard, Wijnand; Holme, Jørn Andreas (Journal article; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-09-18)
    Mold particles from <i>Aspergillus fumigatus, Penicillium chrysogenum, Aspergillus versicolor</i>, and <i>Stachybotrys chartarum</i> have been linked to respiratory‐related diseases. We characterized X‐ray‐inactivated spores and hyphae fragments from these species by number of particles, morphology, and mycotoxin, β‐glucan and protease content/activity. The pro‐inflammatory properties of mold particles ...
  • Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition 

    Haldorsson, Skarphedinn; Rohatgi, Neha; Magnusdottir, Manuela; Choudhary, Kumari; Gudjónsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdòttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild; Gudmundsson, Steinn; Rolfsson, Ottar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-18)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. We performed metabolomics profiling of a breast epithelial cell line and its EMT derived mesenchymal phenotype to create genome-scale metabolic ...
  • Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer 

    Vaysse, Charlotte; Lømo, Jon; Garred, Øystein; Fjeldheim, Frøydis Nyborg; Lofterød, Trygve; Schlichting, Ellen; McTiernan, Anne; Frydenberg, Hanne; Husøy, Anders; Lundgren, Steinar; Fagerland, Morten W; Richardsen, Elin; Wist, Erik; Muller, Catherine; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-03)
    Growing evidence indicates that adiposity is associated with breast cancer risk and negatively affects breast cancer recurrence and survival, a paracrine role of mammary adipose tissue being very likely in this process. In contrast to other adipose depots, occurrence of a sub-inflammatory state of mammary adipose tissue defined by dying adipocytes surrounded by macrophages forming crown-like structures ...
  • Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux 

    Subbotina, Anna; Ravna, Aina Westrheim; Lyså, Roy Andre; Abagyan, Ruben; Bugno, Ryszard; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-17)
    <p><i>Objectives</i>: To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to characterise their inhibitory potencies (<kursiv>K</kursiv><sub>i</sub> values) of PDE5A1‐dependent guanosine cyclic monophosphate (cGMP) hydrolysis.</p> <p><i>Methods</i>: Sildenafil analogues were identified by virtual ligand screening (VLS) ...
  • Optical investigation of osteoarthritic human cartilage (ICRS grade) by confocal Raman spectroscopy: a pilot study 

    Kumar, Rajesh; Grønhaug, Kirsten Marie; Afseth, Nils Kristian; Isaksen, Vidar; Davies, Catharina de Lange; Drogset, Jon Olav; Lilledahl, Magnus Borstad (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
    Biomolecular changes in the cartilage matrix during the early stage of osteoarthritis may be detected by Raman spectroscopy. The objective of this investigation was to determine vibrational spectral differences among different grades (grades I, II, and III) of osteoarthritis in human osteoarthritic cartilage, which was classified according to the International Cartilage Repair Society (ICRS) grading ...
  • Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications 

    Arranz, Lorena; Arriero Sanchez, Maria Del Mar; Villatoro, Alicia (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-03)
    Interleukin-1β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both physiological and pathological conditions. It is produced by different cell subsets, and drives a wide range of inflammatory responses in numerous target cells. Enhanced IL-1β signaling is a common event in patients of hematological malignancies. Recent body of evidence obtained in preclinical models shows the ...
  • MicroRNAs as potential biomarkers in Merkel cell carcinoma 

    Konstantinell, Aelita Gloria Virginia; Coucheron, Dag H; Sveinbjørnsson, Baldur; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-26)
    Merkel cell carcinoma (MCC) is a rare and aggressive type of skin cancer associated with a poor prognosis. This carcinoma was named after its presumed cell of origin, the Merkel cell, which is a mechanoreceptor cell located in the basal epidermal layer of the skin. Merkel cell polyomavirus seems to be the major causal factor for MCC because approximately 80% of all MCCs are positive for viral DNAs. ...
  • Elucidating the small regulatory RNA repertoire of the sea anemone Anemonia viridis based on whole genome and small RNA sequencing 

    Urbarova, Ilona; Patel, Hardip; Forêt, Sylvain; Karlsen, Bård Ove; Jørgensen, Tor Erik; Hall-Spencer, Jason M.; Johansen, Steinar Daae (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-27)
    Cnidarians harbor a variety of small regulatory RNAs that include microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), but detailed information is limited. Here, we report the identification and expression of novel miRNAs and putative piRNAs, as well as their genomic loci, in the symbiotic sea anemone <i>Anemonia viridis</i>. We generated a draft assembly of the <i>A. viridis</i> genome with ...
  • LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment 

    Sveinbjørnsson, Baldur; Camilio, Ketil Andre; Haug, Bengt Erik; Rekdal, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-08)
    The oncolytic peptide LTX-315, which has been <i>de novo</i> designed based on structure– activity relationship studies of host defense peptides, has the ability to kill human cancer cells and induce specific anticancer immune response when injected locally into tumors established in immunocompetent mice. The oncolytic effect of LTX-315 involves perturbation of plasma membrane and the mitochondria ...
  • A taxonomy update for the Family Polyomaviridae 

    Calvignac-Spencer, Sébastien; Feltkamp, Mariet CW; Daugherty, Matthew D; Moens, Ugo; Ramqvist, Torbjörn; Johne, Reimar; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-29)
    Many distinct polyomaviruses infecting a variety of vertebrate hosts have recently been discovered, and their complete genome sequence could often be determined. To accommodate this fast-growing diversity, the International Committee on Taxonomy of Viruses (ICTV) <i>Polyomaviridae</i> Study Group designed a host- and sequence-based rationale for an updated taxonomy of the family <i>Polyomaviridae</i>. ...
  • Antibiotics to outpatients in Norway—Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study. 

    Haugen, Pål; Simonsen, Gunnar Skov; Primicerio, Raul; Furberg, Anne-Sofie; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-29)
    High antibiotic consumption rates are associated to high prevalence of antimicrobial resistance. Geographical differences in dispensing rates of antibiotics are frequently analysed using statistical methods addressing the central tendency of the data. Yet, examining extreme quantiles may be of equal or greater interest if the problem relates to the extremes of consumption rates, as is the case for ...
  • Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo 

    Tümmler, Conny; Snapkov, Igor; Wickström, Malin; Moens, Ugo; Ljungblad, Linda; Elfman, Maria; Winberg, Jan-Olof; Kogner, Per; Johnsen, John Inge; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-27)
    Pro-inflammatory cells, cytokines, and chemokines are essential in promoting a tumor supporting microenvironment. Chemerin is a chemotactic protein and a natural ligand for the receptors CMKLR1, GPR1, and CCRL2. The chemerin/CMKLR1 axis is involved in immunity and inflammation, and it has also been implicated in obesity and cancer.<p> In neuroblastoma, a childhood tumor of the peripheral nervous ...
  • Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response 

    Jernström, Sandra Johanna; Hongisto, Vesa; Leivonen, Suvi-Katri; Due, Eldri Undlien; Tadele, Dagim Shiferaw; Edgren, Henrik; Kallioniemi, Olli; Perälä, Merja; Mælandsmo, Gunhild; Sahlberg, Kristine Kleivi (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-21)
    Background<br> Approximately 15%–20% of all diagnosed breast cancers are characterized by amplified and overexpressed HER2 (= ErbB2). These breast cancers are aggressive and have a poor prognosis. Although improvements in treatment have been achieved after the introduction of trastuzumab and lapatinib, many patients do not benefit from these drugs. Therefore, in-depth understanding of the mechanisms ...
  • CRISPR/Cas9—Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development 

    Okoli, Arinze Stanley; Okeke, malachy ifeanyi; Tryland, Morten; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-22)
    : The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, simplicity and low cost have made the CRISPR/Cas9 system preferable to other guided site-specific nuclease-based systems such as TALENs (Transcription Activator-like Effector ...
  • Comparison of Compressive Stress-Relaxation Behavior in Osteoarthritic (ICRS Graded) Human Articular Cartilage 

    Kumar, Rajesh; Pierce, David M.; Isaksen, Vidar; Davies, Catharina de Lange; Drogset, Jon O.; Lilledahl, Magnus B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-31)
    Osteoarthritis (OA) is a common joint disorder found mostly in elderly people. The role of mechanical behavior in the progression of OA is complex and remains unclear. The stress-relaxation behavior of human articular cartilage in clinically defined osteoarthritic stages may have importance in diagnosis and prognosis of OA. In this study, we investigated differences in the biomechanical responses ...
  • A role of Sp1 binding motifs in basal and large T-Antigen-induced promoter activities of human polyomavirus HPyV9 and its variant UF-1 

    Moens, Ugo; Song, Xiaobo; Van Ghelue, Marijke; Lednicky, John A.; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-14)
    Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20-50% of the human population have antibodies against this virus. HPyV9 has not yet been associated with any disease and little is known about the route of infection, transmission, host cell tropism, and genomic variability in circulating strains. Recently, the ...
  • Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: Guidance from the European Centre for Disease Prevention and Control 

    Magiorakos, A.P.; Burns, K.; Rodríguez Baño, J.; Borg, M.; Daikos, G.; Dumpis, U.; Lucet, J.C.; Moro, M.L.; Tacconelli, E.; Simonsen, G. Skov; Szilágyi, E.; Voss, A.; Weber, J.T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
    Background: Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They are associated with high patient morbidity, attributable mortality and hospital costs. Patients who are “at-risk” may be carriers of these multidrug-resistant Enterobacteriaceae (MDR-E). The purpose of this guidance is to raise awareness and identify ...
  • Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? 

    Sørbye, Sveinung; Pedersen, Mette Kristin; Ekeberg, Bente; Wiliams, Merete E. Johansen; Sauer, Torill; Chen, Ying (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-22)
    Background: The Norwegian Cervical Cancer Screening Program recommends screening every 3 years for women between 25 and 69 years of age. There is a large difference in the percentage of unsatisfactory samples between laboratories that use different brands of liquid-based cytology. We wished to examine if inadequate ThinPrep samples could be satisfactory by processing them with the SurePath ...
  • Rho-associated kinase is a therapeutic target in neuroblastoma 

    Dyberg, Cecilia; Fransson, Susanne; Andonova, Teodora; Sveinbjørnsson, Baldur; Lannerholm-Palm, Jessika; Olsen, Thale Kristin; Forsberg, David; Herlenius, Eric; Martinsson, Tommy; Brodin, Bertha; Kogner, Per; Johnsen, John Inge; Wickström, Malin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-24)
    Neuroblastoma is a peripheral neural system tumor that originates from the neural crest and is the most common and deadly tumor of infancy. Here we show that neuroblastoma harbors frequent mutations of genes controlling the Rac/Rho signaling cascade important for proper migration and differentiation of neural crest cells during neuritogenesis. RhoA is activated in tumors from neuroblastoma ...

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