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  • Comparison of Compressive Stress-Relaxation Behavior in Osteoarthritic (ICRS Graded) Human Articular Cartilage 

    Kumar, Rajesh; Pierce, David M.; Isaksen, Vidar; Davies, Catharina de Lange; Drogset, Jon O.; Lilledahl, Magnus B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-31)
    Osteoarthritis (OA) is a common joint disorder found mostly in elderly people. The role of mechanical behavior in the progression of OA is complex and remains unclear. The stress-relaxation behavior of human articular ...
  • A role of Sp1 binding motifs in basal and large T-Antigen-induced promoter activities of human polyomavirus HPyV9 and its variant UF-1 

    Moens, Ugo; Song, Xiaobo; Van Ghelue, Marijke; Lednicky, John A.; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-14)
    Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20-50% of the human population have antibodies against this virus. HPyV9 has not yet ...
  • Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: Guidance from the European Centre for Disease Prevention and Control 

    Magiorakos, A.P.; Burns, K.; Rodríguez Baño, J.; Borg, M.; Daikos, G.; Dumpis, U.; Lucet, J.C.; Moro, M.L.; Tacconelli, E.; Simonsen, G. Skov; Szilágyi, E.; Voss, A.; Weber, J.T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
    Background: Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They are associated with high patient morbidity, attributable mortality and ...
  • Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? 

    Sørbye, Sveinung; Pedersen, Mette Kristin; Ekeberg, Bente; Wiliams, Merete E. Johansen; Sauer, Torill; Chen, Ying (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-22)
    Background: The Norwegian Cervical Cancer Screening Program recommends screening every 3 years for women between 25 and 69 years of age. There is a large difference in the percentage of unsatisfactory samples between ...
  • Rho-associated kinase is a therapeutic target in neuroblastoma 

    Dyberg, Cecilia; Fransson, Susanne; Andonova, Teodora; Sveinbjørnsson, Baldur; Lannerholm-Palm, Jessika; Olsen, Thale Kristin; Forsberg, David; Herlenius, Eric; Martinsson, Tommy; Brodin, Bertha; Kogner, Per; Johnsen, John Inge; Wickström, Malin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-24)
    Neuroblastoma is a peripheral neural system tumor that originates from the neural crest and is the most common and deadly tumor of infancy. Here we show that neuroblastoma harbors frequent mutations of genes controlling ...
  • Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort. 

    Richardsen, Elin; Andersen, Sigve; Al-Saad, Samer; Rakaee, Mehrdad; Nordby, Yngve; Pedersen, Mona Irene; Ness, Nora; Grindstad, Thea K.W.; Movik, Ingeborg; Dønnem, Tom; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
    The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation, growth and progression, and is widely used in routine clinicopathological investigation. Prostate cancer is a complex ...
  • High number of kinome-mutations in non-small cell lung cancers associated with reduced immune response and poor relapse-free survival 

    Helland, Åslaug; Brustugun, Odd Terje; Nakken, Sigve; Halvorsen, Ann Rita; Dønnem, Tom; Bremnes, Roy M.; Busund, Lill-Tove; Sun, Jinchang; Lorenz, Susanne; Solberg, Steinar; Jørgensen, Lars Hilmar; Vodak, Daniel; Myklebost, Ola; Hovig, Eivind; Meza, Leonardo Zepeda (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-07)
    Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several ...
  • Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps? 

    Okeke, Malachy Ifeanyi; Okoli, Arinze Stanley; Diaz Canova, Diana Karina; Oludotun, Taiwo G.; Tryland, Morten; Bøhn, Thomas; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-29)
    Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and ...
  • Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study 

    Duell, Eric J.; Lujan-Barroso, Leila; Sala, Núria; Deitz McElyea, Samantha; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Weiderpass, Elisabete; Busund, Lill-Tove; Moi, Line; Muller, David; Aune, Dagfinn; Naccarati, Alessio; Panico, Salavatore; Tagliabue, Giovanna; Tumino, Rosario; Palli, Domenico; Kaaks, Rudolf; Katzke, Verena A.; Boeing, Heiner; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Trichopoulou, Antonia; Lagiou, Pagona; Kotanidou, Anastasia; Travis, Ruth C.; Wareham, Nick; Khaw, Kay-Tee; Quirõs, Jose Ramõn; Rodríguez-Barranco, Miguel; Dorronsoro, Miren; Chirlaque, María Dolores; Ardanaz, Eva; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Rebours, Vinciane; Brennan, Paul; Gunter, Marc; Scelo, Ghislaine; Cote, Greg; Sherman, Stuart; Korc, Murray (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
    Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into ...
  • Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model 

    Nestvold, Janne M.; Wang, Mengyu; Camilio, Ketil Andre; Zinöcker, Severin; Tjelle, Torunn Elisabeth; Lindberg, Alf; Haug, Bengt Erik; Kvalheim, Gunnar; Sveinbjørnsson, Baldur; Rekdal, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-17)
    LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat ...
  • Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses 

    Tusco, Radu; Jacomin, Anne-Claire; Jain, Ashish; Penman, Bridget S.; Larsen, Kenneth Bowitz; Johansen, Terje; Nezis, Ioannis P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-02)
    Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulation of innate ...
  • B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains 

    Dwivedi, Nishant; Hedberg, Annica; Zheng, Ying Yi; Neeli, Indira; Satoh, Minoru; Morel, Laurence; Rekvig, Ole Petter; Radic, Marko (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-30)
    Deimination, a posttranslational modification of arginine to citrulline carried out by peptidylarginine deiminases, may compromise tolerance of self-antigens. Patients with connective tissue autoimmunity, particularly ...
  • Ligand-guided homology modelling of the GABAb2 subunit of the GABAb receptor 

    Freyd, Thibaud; Warszycki, Dawid; Mordalski, Stefan; Bojarski, Andrzej J; Sylte, Ingebrigt; Gabrielsen, Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-21)
    γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, and disturbances in the GABAergic system have been implicated in numerous neurological and neuropsychiatric diseases. The ...
  • High miR-205 expression in normal epithelium is associated with biochemical failure - An argument for epithelial crosstalk in prostate cancer? 

    Nordby, Yngve; Richardsen, Elin; Ness, Nora; Dønnem, Tom; Patel, Hitendra R.H.; Busund, Lill-Tove; Bremnes, Roy M.; Andersen, Sigve (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-24)
    Due to insufficient prognostic tools, failure to predict aggressive prostate cancer (PC) has left patient selection for radical treatment an unsolved challenge. This has resulted in overtreatment with radical therapy. ...
  • Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 

    Perander, Maria; Al-Mahdi, Rania; Jensen, Thomas Clemens; Nunn, Jennifer Ann Lillebo; Kildalsen, Hanne; Johansen, Bjarne Herold; Gabrielsen, Mads; Keyse, Stephen M; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)
    The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-G. However, the regulation of ERK3 and ERK4 phosphorylation and activity ...
  • Ionizing radiation abrogates the pro-tumorigenic capacity of cancer-associated fibroblasts co-implanted in xenografts 

    Grinde, Maria Tunset; Vik, Jørg; Camilio, Ketil Andre; Martinez-Zubiaurre, Inigo; Hellevik, Turid (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-25)
    Cancer-associated fibroblasts (CAFs) are abundantly present in solid tumors and affect tumorigenesis and therapeutic responses. In the context of clinical radiotherapy, the impact of irradiated CAFs to treatment outcomes ...
  • Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer 

    Johannessen, Charles; Moi, Line; Kiselev, Yury; Pedersen, Mona Irene; Dalen, Stig Manfred; Braaten, Tonje; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-26)
    MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional regulators of gene expression and are dysregulated in cancer. Studies of miRNAs to explore their potential as diagnostic and prognostic ...
  • Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease. 

    Horvei, Kjersti Daae; Pedersen, Hege Lynum; Fismen, Silje; Thiyagarajan, Dhivya; Schneider, Andrea; Rekvig, Ole Petter; Winkler, Thomas; Seredkina, Natalya (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-30)
    FcγRIIB<sup>-/-</sup>yaa mice develop severe lupus glomerulonephritis due to lack of an inhibitory immune cell receptor combined with a Y-chromosome linked autoimmune accelerator mutation. In the present study, we have ...
  • Fecal carriage of extended spectrum β-lactamase producing Escherichia coli and Klebsiella pneumoniae after urinary tract infection - A three year prospective cohort study 

    Jørgensen, Silje; Søraas, Arne Vasli; Sundsfjord, Arnfinn; Liestøl, Knut; Leegaard, Truls Michael; Jenum, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-07)
    We have performed a prospective cohort study to investigate the duration of and risk factors for prolonged fecal carriage of ESBL-producing Escherichia coli or Klebsiella pneumoniae in patients with community acquired ...
  • Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014 

    Samuelsen, Ørjan; Overballe-Petersen, Søren; Bjørnholt, Jørgen; Brisse, Sylvain; Doumith, Michel; Woodford, Neil; Hopkins, Katie L.; Aasnæs, Bettina; Haldorsen, Bjørg; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
    The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) is increasing worldwide. Here we present associated patient data and molecular, epidemiological and phenotypic characteristics of all CPE isolates in Norway ...

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